老年上尿路尿路上皮癌手术联合放疗效果和基于机器学习的生存预测的研究

• 临床研究 •

孙微波
孙明霞
李海婷
李子园
田勤
马丽佳
申林锘
高宇奎
闫泽晨

中华实验外科杂志,2024，41(03) : 602-605.DOI: 10.3760/cma.j.cn421213-20230806-01289

目的探讨老年上尿路尿路上皮癌手术联合放疗效果和基于机器学习的生存预测的研究。方法通过监测、流行病学和最终结果的数据库搜集数据。采用倾向性得分匹配两组信息。采用单因素和多因素Cox回归分析比较未放疗与放疗两组上尿路尿路上皮癌特异性生存和总生存。开发6种机器学习模型，建立预测放疗后5年肿瘤特异性生存（CSS）机器学习模型。结果根据CSS单因素和多因素分析，未接受放疗的肿瘤特异性生存降低[95%置信区间（CI）：1.151～1.618]，年龄80岁以上（95%CI：1.052～1.278）、单身（95%CI：1.134～2.321）、离异（95%CI：1.255～1.877）、T3～4（95%CI：1.572～2.382）、N2～3分期（95%CI：1.162～1.987），未接受化疗（95%CI：1.108～1.608）、浸润性尿路上皮癌（95%CI：1.082～2.185）和N1（95%CI：1.229～2.282）特异性生存降低。相对于其他5种机器学习模型，极端梯度提升（XGBoost）模型最优，该模型的准确度为0.922，精度为0.923，灵敏度为0.931，F1得分为0.901，曲线下面积（AUC）为0.901。结论通过筛选肿瘤特异性生存的相关因素，进一步选出术后放疗生存的最佳的机器学习预测模型。

引用本文：孙微波,孙明霞,李海婷,等. 老年上尿路尿路上皮癌手术联合放疗效果和基于机器学习的生存预测的研究.中华实验外科杂志,2024，41(03) : 602-605. DOI: 10.3760/cma.j.cn421213-20230806-01289

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贡献者信息

孙微波

河南省人民医院　郑州大学人民医院　河南大学人民医院肿瘤中心，郑州　450003

孙明霞

河南省人民医院　郑州大学人民医院　河南大学人民医院肿瘤中心，郑州　450003

李海婷

河南省人民医院　郑州大学人民医院　河南大学人民医院医学影像科，郑州　450003

李子园

河南省人民医院　郑州大学人民医院　河南大学人民医院医学影像科，郑州　450003

田勤

河南省人民医院　郑州大学人民医院　河南大学人民医院医学影像科，郑州　450003

马丽佳

河南省人民医院　郑州大学人民医院　河南大学人民医院医学影像科，郑州　450003

申林锘

郑州大学肿瘤分子外科研究所，郑州　450052

高宇奎

皖南医学院第一附属医院泌尿外科，芜湖　241001

闫泽晨

郑州大学第一附属医院泌尿外科医学部，郑州　450052

通信作者

通信作者：闫泽晨，E-mail: yanzechen@foxmail.com

yanzechen@foxmail.com

关键词

上尿路肿瘤,机器学习,预后分析

基金项目

河南省医学科技攻关计划联合共建项目（JJ901781）

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历史

出版日期：2024年03月08日

收稿日期：2023年08月06日

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Dear Professor Sun: Here is a copy of the decision letter for manuscript "Single-cell RNA Sequencing Analysis of the Tumor Microenvironment and Heterogeneity of Retroperitoneal Dedifferentiated Liposarcoma" by Zechen Yan, Yukui Gao, Yongkun Luan, Chengzhi Huang, Luyang Zhao, Yu Wang, Qi Yu, Tonghu Liu, Weibo Sun, Yilin Ren, Zhiyuan Li, Congcong Zhu, Dandan Fan, Guibo Li, and Zhilei Bian [Paper #CDDIS-25-2424-T], which you were a Contributing Author. You can now use a single sign-on for all your accounts, view the status of all your manuscript submissions and reviews, access usage statistics for your published articles and download a record of your refereeing activity for the Nature journals. In addition, NPG encourages all authors and reviewers to associate an Open Researcher and Contributor Identifier (ORCID) to their account. ORCID is a community-based initiative that provides an open, non-proprietary and transparent registry of unique identifiers to help disambiguate research contributions. Sincerely, Mauro Piacentini, Yufang Shi and Hans-Uwe Simon Editors-in-Chief, Cell Death & Disease 亲爱的太阳教授：这是手稿的决策信的副本，“单细胞RNA测序分析分析肿瘤微环境和腹膜递不同的脂肪肉瘤的异质性”，Zechen Yan，Yukui Gao，Yukui Gao，Yongkun Luan，Yongkun Luan，luang Zhao，luyang Zhao，yu yu yu yu yu yu yu yu yu yu yu， Yilin Ren，Zhiyuan Li，Congcong Zhu，Dandan Fan，Guibo Li和Zhilei Bian [Paper＃cddis-25-2424-t]，您是一位贡献者。现在，您可以为所有帐户使用单个登录，查看所有手稿提交和评论的状态，访问已发表文章的使用统计信息，并下载自然期刊的裁判活动记录。此外，NPG鼓励所有作者和审稿人将开放研究人员和撰稿人标识符（OrcID）与他们的帐户联系起来。 OrcID是一项基于社区的计划，它提供了一个开放的，非专有和透明的注册表，并提供了唯一的标识符，以帮助消除研究贡献。真挚地， Mauro Piacentini，Yufang Shi和Hans-uwe Simon 主持人，细胞死亡与疾病
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Dear Professor Sun, Please note that you are listed as a co-author on the manuscript "Single-cell RNA Sequencing Analysis of the Tumor Microenvironment and Heterogeneity of Retroperitoneal Dedifferentiated Liposarcoma" (reference number: CDDIS-25-2424-T), which was recently submitted to Cell Death & Disease. The corresponding author is solely responsible for communicating with the journal and managing communication between co-authors. Please contact the corresponding author directly with any queries you may have related to this manuscript. You can now use a single sign-on for all your accounts, view the status of all your manuscript submissions and reviews, access usage statistics for your published articles and download a record of your refereeing activity for the Nature journals. Please check your account regularly and ensure that we have your current contact information. In addition, Springer Nature encourages all authors and reviewers to associate an Open Researcher and Contributor Identifier (ORCID) to their account. ORCID is a community-based initiative that provides an open, non-proprietary and transparent registry of unique identifiers to help disambiguate research contributions. Should you wish to publish your ORCID with this manuscript, please use the link below to access your account listed as co-author and attach your ORCID following https://www.springernature.com/gp/researchers/orcid/orcid-for-nature-research">these instructions. Please note that it must be linked prior to acceptance, it will not be possible to add/modify ORCIDs at proof, and you may not receive further notification before an accept decision is made. Please ensure the ORCID is linked to your account associated with this manuscript, and not to any other account you may have on our system. 亲爱的太阳教授，请注意，您被列为手稿“肿瘤微环境的单细胞RNA测序分析和腹膜后反向分化的脂肪肉瘤的异质性”（参考编号：CDDIS-25-2424-T），最近提交给细胞死亡和疾病。相应的作者完全负责与期刊进行交流并管理合着者之间的沟通。请与您可能与本手稿相关的任何查询直接与通讯作者联系。现在，您可以为所有帐户使用单个登录，查看所有手稿提交和评论的状态，访问已发表文章的使用统计信息，并下载自然期刊的裁判活动记录。请定期检查您的帐户，并确保我们有您当前的联系信息。此外，Springer Nature鼓励所有作者和审稿人将开放研究人员和撰稿人标识符（OrcID）与他们的帐户联系起来。 OrcID是一项基于社区的计划，它提供了一个开放的，非专有和透明的注册表，并提供了唯一的标识符，以帮助消除研究贡献。如果您希望使用此手稿发布您的ORCID，请使用以下链接访问您作为共同作者列出的帐户，并在https://www.springernature com.com/gp/researchers/gp/researchers/orcid/orcid/orcid-for-nature-nature-nature-research-research-research-compland of tocrifie off tocriptions中，请注意，请注意，请注意，请注意，请注意，请注意，请注意，请注意。在做出的决定之前，请勿再收到通知。
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Dear Professor Sun, Please note that you are listed as a co-author on the manuscript "Single-cell RNA Sequencing Analysis of the Tumor Microenvironment and Heterogeneity of Retroperitoneal Dedifferentiated Liposarcoma" (reference number: CDDIS-25-2424-T), which was recently submitted to Cell Death & Disease. The corresponding author is solely responsible for communicating with the journal and managing communication between co-authors. Please contact the corresponding author directly with any queries you may have related to this manuscript. You can now use a single sign-on for all your accounts, view the status of all your manuscript submissions and reviews, access usage statistics for your published articles and download a record of your refereeing activity for the Nature journals. Please check your account regularly and ensure that we have your current contact information. In addition, Springer Nature encourages all authors and reviewers to associate an Open Researcher and Contributor Identifier (ORCID) to their account. ORCID is a community-based initiative that provides an open, non-proprietary and transparent registry of unique identifiers to help disambiguate research contributions. Should you wish to publish your ORCID with this manuscript, please use the link below to access your account listed as co-author and attach your ORCID following https://www.springernature.com/gp/researchers/orcid/orcid-for-nature-research">these instructions. Please note that it must be linked prior to acceptance, it will not be possible to add/modify ORCIDs at proof, and you may not receive further notification before an accept decision is made. Please ensure the ORCID is linked to your account associated with this manuscript, and not to any other account you may have on our system. Dear Professor Sun, Please note that you are listed as a co-author on the manuscript "Single-cell RNA Sequencing Analysis of the Tumor Microenvironment and Heterogeneity of Retroperitoneal Dedifferentiated Liposarcoma" (reference number: CDDIS-25-2424-T), which was recently submitted to Cell Death & Disease. The corresponding author is solely responsible for communicating with the journal and managing communication between co-authors. Please contact the corresponding author directly with any queries you may have related to this manuscript. You can now use a single sign-on for all your accounts, view the status of all your manuscript submissions and reviews, access usage statistics for your published articles and download a record of your refereeing activity for the Nature journals. Please check your account regularly and ensure that we have your current contact information. In addition, Springer Nature encourages all authors and reviewers to associate an Open Researcher and Contributor Identifier (ORCID) to their account. ORCID is a community-based initiative that provides an open, non-proprietary and transparent registry of unique identifiers to help disambiguate research contributions. Should you wish to publish your ORCID with this manuscript, please use the link below to access your account listed as co-author and attach your ORCID following https://www.springernature.com/gp/researchers/orcid/orcid-for-nature-research">these instructions. Please note that it must be linked prior to acceptance, it will not be possible to add/modify ORCIDs at proof, and you may not receive further notification before an accept decision is made. Please ensure the ORCID is linked to your account associated with this manuscript, and not to any other account you may have on our system.
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