这是用户在 2025-4-14 20:51 为 https://clinicaltrials.gov/search?intr=Dexmedetomidine&cond=Sleep%20Disorder&viewType=Table&sort=@re... 保存的双语快照页面,由 沉浸式翻译 提供双语支持。了解如何保存?
U.S. flag

An official website of the United States government
一个美国政府的官方网站

Skip to main page content

Search Results  搜索结果

Viewing 1-51 out of 51 studies
正在查看 1-51 共 51 项研究

Showing results for: Sleep Disorder | Dexmedetomidine
显示结果为: 睡眠障碍 | 布托啡诺

Synonyms of conditions or disease (7)   条件或疾病的同义词 (7)
 
Clear (51)   清空 (51)
Study Title   研究标题 NCT Number   NCT 编号 Age   年龄 Conditions   条件 Interventions   干预措施 Outcome Measures   结果衡量标准 Study Start   研究开始
1
Dexmedetomidine Premedication for Post-anaesthesia Sleep Disturbance
术前使用 dexmedetomidine 对术后睡眠障碍的影响
NCT06281561
23 Years to 45 Years (Adult )
23 岁至 45 岁(成人)
  • Postoperative Sleep Disturbance
    术后睡眠障碍
  • Drug: Normal Saline  药物: 生理盐水
  • Drug: Dexmedetomidine  药物: 德美多定
  • Change from baseline sleep quality at after intervention
    干预后与基线相比的睡眠质量变化
  • Pittsburgh sleep quality index(PSQI)
    堪培拉睡眠质量指数(PSQI)
  • Early recovery evaluated by Aldrete rating scale
    早期恢复由 Aldrete 评分评估
  • (and 1 more…)  (还有 1 项...)
2024-05-01
2
The Effect of Nocturnal Dexmedetomidine on Postoperative Sleep Quality and Fatigue After Major Surgery in Elderly Patients: DEXSLEEP Study
术后老年患者大型手术后夜间德美多定对睡眠质量和疲劳的影响:DEXSLEEP 研究
NCT06480539
60 Years and older (AdultOlder Adult )
60 岁及以上(成人、老年人)
  • Postoperative Fatigue  术后疲劳
  • Postoperative Sleep Disturbances
    术后睡眠障碍
  • Surgical Stress Response  手术应激反应
  • Drug: Placebo  药物: 安慰剂
  • Drug: Dexmedetomidine  药物: 布托啡诺
  • Quality of Recovery (QoR)
    恢复质量 (QoR)
  • Sleep-wake cycle (MCTQ)  睡眠-觉醒周期 (MCTQ)
  • Sleep pattern (CSD)  睡眠模式 (CSD)
  • (and 11 more…)  (和另外 11 个……)
2024-06-06
3
Effect of Propofol on Postoperative Sleep Quality in Elderly Patients With Sleep Disorders
丙泊酚对老年睡眠障碍患者术后睡眠质量的影响
NCT05325762
60 Years to 85 Years (AdultOlder Adult )
60 岁至 85 岁(成人、老年人)
  • Sleep Disorder  睡眠障碍
  • Drug: Propofol  药物: 丙泊酚
  • Drug: Dexmedetomidine  药物: 德美多定
  • Drug: Saline  药物: 氯化钠
  • Sleep improvement efficiency
    睡眠改善效率
  • Safety of drug use  药物使用的安全性
  • Sleep scale assessment  睡眠量表评估
2022-12-01
4
Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
德美多定-埃克赛丁组合和大范围非心脏手术后的睡眠障碍
New  新的
NCT06859892
18 Years and older (AdultOlder Adult )
18 岁及以上(成人、老年人)
  • Adults  成人
  • Major Noncardiac Surgery  非心脏手术
  • Dexmedetomidine  德西地米松
  • 2 more  两个更多
  • Drug: Dexmedetomidine-esketamine combination
    药物: 去甲艾司洛尔-埃克赛坦尼组合
  • Drug: Placebo  药物: 阳性对照剂
  • Incidence of sleep disturbances within 3 days after surgery
    手术后 3 天内睡眠障碍的发生率
  • Quality of recovery at 24 hours after surgery
    术后 24 小时恢复质量
  • Subjective sleep quality in the first 3 nights after surgery.
    第 1 至第 3 个晚上术后睡眠质量。
  • (and 3 more…)  (还有 3 个更多……)
2025-03-18
5
Providing "Good Sleep" for ICU Sedation
提供“优质睡眠”用于 ICU 镇静
NCT01342328
18 Years to 45 Years (Adult )
18 岁至 45 岁(成人)
  • Sleep Disorders  睡眠障碍
  • Other: Normal saline infusion
    其他: 生理盐水输注
  • Drug: Dexmedetomidine  药物: 德美多昔布
  • Drug: Propofol  药物: 异丙酚
  • Compare the electroencephalography features of sleep produced by three sleep-induced regimens
    比较由三种睡眠诱导方案产生的睡眠的脑电图特征
  • Compare the magnetoencephalography features of sleep produced by three sleep induced regimens
    比较由三种睡眠诱导方案产生的睡眠的脑磁图特征
2012-05
6
DISE in Pediatric Sleep Disordered Breathing
DISE 在儿科睡眠呼吸障碍中的应用
NCT06756971
1 Month to 18 Years (ChildAdult )
1 个月至 18 岁(儿童、成人)
  • Sleep Disordered Breathing
    睡眠呼吸紊乱
  • Drug Induced Sleep Disorder
    药物引起的睡眠障碍
  • Drug: Propofol  药物: 丙泊酚
  • Drug: Dexmedetomidine  药物: 德美多咪定
  • Comparing Dexmedetomidine and Propofol for successful DISE (Drug Induced Sleep Endoscopy) procedure in-terms regarding which drug works better without causing side effects
    比较地塞米松和丙泊酚在药物诱导睡眠内镜检查中的有效性,看哪种药物在不引起副作用的情况下更有效
2022-06-01
7
Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients
用于减少心脏手术患者术后谵妄的 dexmedetomidine
NCT06619912
18 Years and older (AdultOlder Adult )
18 岁及以上(成人,老年人)
  • Postoperative Delirium  术后谵妄
  • Preoperative Sleep Disorder
    术前睡眠障碍
  • Drug: Dexmedetomidine nasal spray
    药物: 布托啡诺鼻喷雾剂
  • Postoperative delirium occurrence
    术后谵妄发生率
  • Delirium severity measurement
    谵妄严重程度测量
  • Duration of delirium  持续的谵妄
  • (and 5 more…)  (和另外 5 项……)
2025-03-03
8
Investigation of Sleep in the Intensive Care Unit
重症监护病房的睡眠研究
NCT03355053
50 Years and older (AdultOlder Adult )
50 岁及以上(成人,老年人)
  • Delirium  谵妄
  • Sleep  睡眠
  • Drug: Dexmedetomidine  药物: 德瓦度胺
  • Drug: Placebo  药物: 醒脑静注射液
  • In-hospital Delirium-free days (IH-DFDs)
    院内无谵妄日数(IH-DFDs)
  • ICU-Delirium-free days (ICU-DFDs)
    重症监护病房无谵妄日数(ICU-DFDs)
  • Sleep Quantity-quality (SQ) score
    睡眠质量和数量(SQ)评分
  • (and 2 more…)  (和更多...)
2018-05-29
9
Double-Blind, Placebo-Controlled, Crossover Study With Roll-over Extension of Two RE03 Doses for PTSD Sleep Disturbances
双盲、安慰剂对照、交叉研究,包含两种 RE03 剂量的延续试验,用于治疗 PTSD 睡眠障碍
NCT06685965
18 Years to 64 Years (Adult )
18 岁到 64 岁(成人)
  • Posttraumatic Stress Disorder (PTSD)
    创伤后应激障碍(PTSD)
  • Sleep Disturbances and Insomnia
    睡眠障碍和失眠
  • Drug: RE03  药物: RE03
  • Drug: Placebo  药物: 安慰剂
  • Time spent in sleep stages N2 + N3 [%]
    睡眠阶段 N2+N3 所占时间[%]
  • REM fragmentation index  REM 期片段化指数
  • REM density  REM 密度
  • (and 2 more…)  (和更多...)
2025-04-01
10
A Pilot Study of Effect of Dexmedetomidine on Sleep and Inflammation in Critically Ill Patients
一项关于地塞米松对重症患者睡眠和炎症影响的试点研究
NCT00405847
21 Years to 85 Years (AdultOlder Adult )
21 岁至 85 岁(成人,老年人)
  • Sleep  睡眠
  • Critical Illness  重症疾病
  • Drug: Dexmedetomidine  药物: 德美他淀
  • Sleep disruption (Arousals, awakenings and sleep efficiency measured by polysomnography)
    睡眠中断(通过多导睡眠图测量的觉醒、觉醒次数和睡眠效率)
  • Circulating levels of Inflammatory cytokines (TNF-alpha, IL-1, IL-6, IL-10)
    循环中的炎症细胞因子水平(TNF-α、IL-1、IL-6、IL-10)
2006-07
11
Dex as Analgesic Adjuvant in OSA Patients
Dex 作为镇痛辅助剂在 OSA 患者中的应用
NCT03613558
18 Years and older (AdultOlder Adult )
18 岁及以上 (成人, 老年成人)
  • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
  • Drug: Dexmedetomidine  药物: 德美他淀
  • Drug: Placebo  药物: 安慰剂
  • Pain Score  疼痛评分
  • Pain Score  疼痛评分
  • Nausea  恶心
  • (and 5 more…)  (和另外 5 项……)
2014-07
12
Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea
有阻塞性睡眠呼吸暂停病史的儿童中使用 dexmedetomidine 和 propofol
NCT01344759
12 Months to 25 Years (ChildAdult )
12 个月至 25 岁(儿童、成人)
  • Sleep Apnea, Obstructive  阻塞性睡眠呼吸暂停
  • Drug: Dexmedetomidine  药物: 德美他淀
  • Drug: Propofol  药物: 异丙酚
  • Cross Sectional Area of the Pharyngeal Airway
    咽气道的横截面积
  • Obstructive Index Until Recovery Room Discharge
    恢复室出院前的阻塞指数
  • Respiratory Disturbance Index
    呼吸障碍指数
  • (and 2 more…)  (和更多...)
2009-06
13
Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea
高风险阻塞性睡眠呼吸暂停患者的 dexmedetomidine 补充镇痛
NCT04608331
18 Years to 80 Years (AdultOlder Adult )
18 岁至 80 岁(成人,老年人)
  • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
  • Analgesia  镇痛
  • Dexmedetomidine  德西地米松
  • 2 more  两个更多
  • Drug: Dexmedetomidine  药物: 德美他淀
  • Drug: Placebo  药物: 安慰剂
  • The percentage of non-rapid eye movement stage 2 (N2) sleep.
    非快速眼动第二阶段(N2)睡眠的比例。
  • Total sleep duration.  总睡眠时间。
  • Sleep efficiency.  睡眠效率。
  • (and 8 more…)  (以及另外 8 项…)
2021-01-29
14
Sedative Effects in Obstructive Sleep Apnea
镇静作用在阻塞性睡眠呼吸暂停中的应用
NCT01733043
18 Years and older (AdultOlder Adult )
18 岁及以上(成人,老年人)
  • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
  • Drug: Dexmedetomidine  药物: 德美多昔康
  • Drug: Placebo  药物: 阳性对照剂
  • Apnea Hypopnea Index  呼吸暂停低通气指数
  • Sleep Architecture  睡眠结构
2015-03
15
Does Nightly Dexmedetomidine Improve Sleep and Reduce Delirium in ICU Patients?
每晚使用德西地米松能否改善 ICU 患者的睡眠并减少谵妄?
NCT01791296
18 Years to 80 Years (AdultOlder Adult )
18 岁至 80 岁(成人,老年人)
  • Sleep Deprivation  睡眠剥夺
  • Delirium  谵妄
  • Drug: Dexmedetomidine  药物: 德美多咪定
  • Other: Placebo  其他: 酒精安慰剂
  • Development of delirium  发展谵妄
  • Development of subsyndromal delirium
    次综合征谵妄的发生发展
2011-01
16
Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep
使用地塞米松诱导睡眠以减少 ICU 神经功能障碍
NCT02856594
60 Years and older (AdultOlder Adult )
60 岁及以上(成人,老年人)
  • Postoperative Delirium  术后谵妄
  • Sleep  睡眠
  • Anesthesia  麻醉
  • Drug: Dexmedetomidine  药物: 地塞米松
  • Drug: Placebo  安慰剂
  • Incidence of Delirium  发生率谵妄
  • ICU Delirium/Coma-free Days
    ICU 谵妄/昏迷日数
  • Severity of Delirium  谵妄严重程度
  • (and 5 more…)  (还有更多…)
2017-03-06
17
Sedation in Patients at Risk for Upper Airway Collapse
上气道塌陷风险患者的镇静
NCT01045122
18 Years to 75 Years (AdultOlder Adult )
18 岁至 75 岁(成人,老年人)
  • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
  • Drug: Propofol  药物: 丙泊酚
  • Drug: Dexmedetomidine  药物: 德美他淀
  • Respiratory Disturbance Index
    呼吸紊乱指数
2006-12
18
Dexmedetomidine Added to Propofol for Drug Induced Sleep Endoscopy
使用地佐辛与丙泊酚进行药物诱导睡眠内镜检查
NCT03091894
18 Years and older (AdultOlder Adult )
18 岁及以上(成人,老年人)
  • Obstructive Sleep Apnea of Adult
    成人阻塞性睡眠呼吸暂停
  • Drug: Propofol  药物: 丙泊酚
  • Drug: Dexmedetomidine  药物: 德美多西泮
  • success of sedation  镇静成功的程度
  • time until sufficient sedation
    达到足够镇静的时间
2017-04-09
19
Dexmedetomidine Cycling and Sleep in the Pediatric ICU
儿科 ICU 中的地塞米松循环和睡眠
NCT05003102
12 Years to 17 Years (Child )
12 岁至 17 岁(儿童)
  • Critical Illness  重症疾病
  • Sedation Complication  镇静并发症
  • Delirium  谵妄
  • Drug: Dexmedetomidine Hydrochloride - Cycling
    药物: 氢化可的松地美他嗪 - 轮换
  • Drug: Fentanyl - PICU Standard
    药物: 芬太尼 - 儿科重症监护标准
  • Drug: Dexmedetomidine Hydrochloride - PICU Standard
    药物: 氯化去甲肾上腺素 - 儿科重症监护标准
  • Change in total sleep time as seen via an 8-lead polysomnogram
    通过 8 导联多导睡眠图观察到的总睡眠时间的变化
  • Change in total time in different stages of sleep as seen via an 8-lead polysomnogram
    通过 8 导联多导睡眠图观察到的不同睡眠阶段的总时间的变化
  • Change in arousal index as seen via an 8-lead polysomnogram
    通过 8 导联多导睡眠图观察到的觉醒指数的变化
  • (and 2 more…)  (和另外 2 项…)
2023-02-20
20
Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy
减少术后激动并为接受扁桃体切除术和腺样体切除术的儿童提供镇痛
NCT00468052
2 Years to 10 Years (Child )
2 岁至 10 岁(儿童)
  • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
  • Drug: dexmedetomidine  药物: 德美他淀
  • Drug: fentanyl  药物: 芬太尼
  • Emergence Agitation and Pain
    苏醒时激动和疼痛
  • Duration of Agitation  激动的持续时间
  • Hemodynamic Stability  心动稳定
  • (and 4 more…)  (和另外 4 项...)
2007-03
21
Efficacy and Stability of Dexmedetomidine Sedation Compared to Propofol Sedation in the Drug Induced Sleep Endoscopy
在药物诱导睡眠内镜检查中,地塞米松镇静与丙泊酚镇静的疗效和稳定性比较
NCT03892122
18 Years to 65 Years (AdultOlder Adult )
18 岁至 65 岁(成人,老年人)
  • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
  • Drug: Propofol Fresenius  药物: 普鲁泊福费森
  • Drug: Dexmedetomidine  药物: 德美多咪定
  • oxygen saturation variation during DISE
    DISE 期间的血氧饱和度变化
  • hert rate variation during DISE
    DISE 期间的心率变化
  • systolic and diastolic blood pressure variation during DISE
    DISE 期间收缩压和舒张压的变化
  • (and 2 more…)  (还有更多...)
2019-03-22
22
Impacts of Low-Dose Dexmedetomidine on Sleep Quality in Mechanically Ventilated ICU Patients
低剂量 dexmedetomidine 对机械通气 ICU 患者睡眠质量的影响
NCT03335527
18 Years and older (AdultOlder Adult )
18 岁及以上(成人,老年人)
  • Aged  老年
  • Postoperative Period  术后时期
  • Intensive Care Units  加护病房
  • 3 more  3 更多
  • Drug: Dexmedetomidine  药物: 德美多昔布
  • Drug: Placebo (normal saline)
    药物: 安慰剂(生理盐水)
  • Sleep quality during the night of surgery.
    手术当晚的睡眠质量。
  • Incidence of delirium within the first 7 days after surgery.
    术后 7 天内发生谵妄的频率。
  • Sleep quality within the first 7 days after surgery.
    术后 7 天内的睡眠质量。
  • (and 12 more…)  (和更多...)
2017-11-17
23
Dexmedetomidine Versus Propofol Sedation for Drug-Induced Sleep Endoscopy in Pediatric Obstructive Sleep Apnea
在儿科阻塞性睡眠呼吸暂停中,地塞米松丁与丙泊酚镇静用于药物诱导的睡眠内镜检查的比较
NCT05303987
3 Years to 11 Years (Child )
3 岁至 11 岁(儿童)
  • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
  • Drug: Propofol sedation  药物: 丙泊酚镇静
  • Drug: Dexmedetomidine sedation
    药物: 德美多定镇静
  • Mean obstruction score at the tongue base
    舌根部位的平均阻塞评分
2022-10-05
24
Dexmedetomidine for Postoperative Analgesia After Bariatric Surgery
德美多昔定用于胃肠道手术后的镇痛
NCT02213159
18 Years to 70 Years (AdultOlder Adult )
18 岁至 70 岁(成人,老年人)
  • Obesity  肥胖
  • Sleep Apnea  睡眠呼吸暂停
  • Diabetes  糖尿病
  • 1 more  1 更多
  • Drug: Dexmedetomidine  舒必利
  • Drug: Morphine  吗啡
  • Total dose of morphine consumed in Post Anesthesia Care Unit (PACU)
    术后恢复室(PACU)内消耗的吗啡总量
  • Time to first morphine requirement in PACU
    PACU 内首次需要吗啡的时间
  • Numeric Rating Scale (NRS) for Pain
    疼痛数字评分量表(NRS)
  • (and 8 more…)  (以及其他 8 项)
2014-07
25
Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA
在高风险 OSA 患者中,小剂量 Dexmedetomidine-Esketamine 补充镇痛
NCT06566482
18 Years to 80 Years (AdultOlder Adult )
18 岁至 80 岁(成人,老年人)
  • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
  • Surgery  手术
  • Dexmedetomidine  德西地米松
  • 2 more  两个更多
  • Drug: Dexmedetomidine-esketamine combination
    药物: 右美托咪定-埃克塞塔明组合
  • Drug: Placebo  药物: 安慰剂
  • Subjective sleep quality during the first night after surgery.
    手术后的第一个晚上主观睡眠质量。
  • Sleep structure parameters during the first night after surgery.
    手术后的第一个晚上睡眠结构参数。
  • Cumulative subjective sleep quality score after surgery
    手术后的累积主观睡眠质量评分
  • (and 3 more…)  (和另外 3 项…)
2024-09-11
26
A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial
使用丙泊酚或地塞米松进行镇静的内镜诊断手术结果比较:一项前瞻性随机试验
NCT01895348
20 Years to 60 Years (Adult )
20 岁至 60 岁(成人)
  • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
  • Drug: Propofol  药物: 异丙酚
  • Drug: propofol-remifentanil
    药物: 丙泊酚-瑞芬太尼
  • Drug: Dexmedetomidine-remifentanil
    药物: 德美多昔定-瑞芬太尼
  • Desaturation rate  脱饱和率
2012-07
27
Opioid-Free Anesthetic for Tonsillectomy
无阿片类镇痛剂麻醉用于扁桃体切除术
NCT04528173
2 Years to 18 Years (ChildAdult )
2 岁到 18 岁(儿童,成人)
  • Anesthesia  麻醉
  • Opioid Use  使用阿片类药物
  • Tonsillitis  扁桃体炎
  • 2 more  两个更多
  • Drug: Ketorolac  药物: 培氟芬
  • Drug: Dexmedetomidine  药物: 德美多咪定
  • Drug: Morphine  药物: 吗啡
  • 1 more  1 更多
  • Mean FLACC (Face, Legs, Activity, Cry, Consolability) Pain Score
    平均 FLACC (面部、腿部、活动、哭声、安抚) 疼痛评分
  • Number of Participants With Nausea, Vomiting, Pruritis
    出现恶心、呕吐、瘙痒的参与者数量
  • Number of Participants Who Sought Unplanned Medical Attention
    寻求未计划医疗关注的参与者数量
  • (and 5 more…)  (和另外 5 项……)
2020-07-22
28
Dexmedetomidine Enhancing the Recovery After Cardiac Surgery
依托咪酯促进心脏手术后的恢复
New  新的
NCT06907277
40 Years to 65 Years (AdultOlder Adult )
40 岁至 65 岁 (成人, 老年成人)
  • Post-cardiac Surgery  心脏手术后
  • Drug: Dexmedetomidine  药物: 德美松
  • Drug: Fentanyl  药物: 芬太尼
  • Drug: Lidocain  药物: 利多卡因
  • Significant Enhancement of Post Operative Recovery Levels After Dexmedetomidine Administration in Cardiac Surgery.
    在心脏手术中,地塞米松 administration 后术后恢复水平显著提升。
2024-08-30
29
DexmedetOmidine Complement Treats Chronic insOmnia and Improves Circadian Rhythm (DOCTOR)
氯胺酮补充治疗慢性失眠并改善昼夜节律(DOCTOR)
NCT04635098
18 Years to 65 Years (AdultOlder Adult )
18 岁至 65 岁(成人,老年人)
  • Chronic Insomnia  慢性失眠
  • Drug: dexmedetomidine  药物: 德美他明
  • Drug: saline  药物: 生理盐水
  • Sleep efficiency  睡眠效率
  • BMAL1
  • Brain functional connectivity
    脑功能连接性
  • (and 14 more…)  (以及其他 14 项…)
2021-05-14
30
The Comparison of Dexmedetomidine and Midazolam for the Sleep in Intensive Care Unit
背景比较地西泮和咪达唑仑在重症监护病房中的睡眠效果
NCT01966315
18 Years and older (AdultOlder Adult )
18 岁及以上(成人,老年人)
  • Poor Quality Sleep  睡眠质量差
  • Sleep Deprivation  睡眠剥夺
  • Sleep Arousal Disorders  睡眠觉醒障碍
  • 1 more  1 更多
    • The differences of sleep stage, sleep efficiency, arousal index and delirium between dexmedetomidine group and midazolam group
      地塞米松组和咪达唑仑组在睡眠阶段、睡眠效率、觉醒指数和谵妄方面的差异
    2013-10
    31
    Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle
    使用德森奈定作为重症监护病房睡眠促进捆绑包的一部分减少谵妄天数
    New  新的
    NCT06824077
    18 Years and older (AdultOlder Adult )
    18 岁及以上 (成人, 老年成人)
    • Sleep  睡眠
    • Delirium  谵妄
    • ICU Hospitalization  ICU 住院
    • Drug: Dexmedetomidine  药物: 地塞米松
    • Other: Control (placebo) group
      其他: 阴性对照组
    • Recruitment rate  招募率
    • Protocol Adherence  协议依从性
    2025-03-01
    32
    Clinical Study of Perioperative Sleep Disorders in Cardiac Surgery
    心脏手术 perioperative 睡眠障碍 的临床研究
    New  新的
    NCT06778811
    40 Years to 75 Years (AdultOlder Adult )
    40 岁至 75 岁(成人、老年人)
    • Sleep Wake Disorders  睡眠觉醒障碍
    • Esketamine and the Quality of Recovery
      埃克塞塔明和恢复质量
    • Dexmedetomidine  德西地米松
    • Drug: Intraoperative infusion of dexmedetomidine
      药物: 术中使用 dexmedetomidine 输注
    • Drug: Intraoperative infusion of esketamine
      手术期间输注埃克塞塔明
    • Drug: Saline control  药物: 生理盐水对照
    • Sleep Quality  睡眠质量
    • postoperative pain  术后疼痛
    • Record postoperative analgesic medications used and the amount used for postoperative pain
      记录术后镇痛药物的使用情况及术后疼痛使用的剂量
    • (and 3 more…)  (还有 3 个更多……)
    2024-10-11
    33
    Safety and Efficacy of Esmketamine Versus Dexmedetomidine
    艾斯梅凯特尼与德美他明的安全性和有效性
    NCT04877639
    3 Years to 12 Years (Child )
    3 岁至 12 岁(儿童)
    • Osa Syndrome  阻塞性睡眠呼吸暂停综合症
    • Drug: Esmketamine,Dexmedetomidine
      药物: 艾司氯胺酮,德美达明
    • Onset time, Vital signs  起始时间,生命体征
    2021-05-01
    34
    The Addition of Dexmedetomidine on Postoperative Sleep for Middle-aged and Elderly Patients With Gastric Cancer
    胃癌中老年患者术后添加 Dexmedetomidine 对睡眠的影响
    NCT03117023
    55 Years and older (AdultOlder Adult )
    55 岁及以上(成人,老年人)
    • Gastric Cancer  胃癌
    • Drug: dexmedetomidine  药物: 德美他淀
    • sleep time  睡眠时间
    • pain score  疼痛评分
    • daily sufentanil consumption
      每日舒芬太尼消耗量
    • (and 3 more…)  (还有 3 个更多……)
    2017-04-15
    35
    Minimizing ICU Neurological Dysfunction With Dexmedetomidine-induced Sleep (MINDDS II)
    通过地西泮诱导睡眠减轻 ICU 神经功能障碍(MINDDS II)
    NCT06192615
    60 Years and older (AdultOlder Adult )
    60 岁及以上(成人,老年人)
    • Delirium  谵妄
    • Drug: Intravenous Dexmedetomidine
      药物: 静脉注射德美他明
    • Drug: Sublingual Dexmedetomidine
      舌下给药去甲肾上腺素异丁酯
    • Drug: Intravenous Placebo
      静脉给药安慰剂
    • 1 more  1 更多
    • Delirium  谵妄
    • Delirium  谵妄
    • Delirium Severity  混乱严重程度
    • (and 9 more…)  (和 9 个其他项目…)
    2025-01-06
    36
    The Effect of Dexmedetomidine on Airway Complications After Deep or Awake Extubation
    深度或清醒拔管后地塞米松对气道并发症的影响
    NCT02162433
    3 Years to 16 Years (Child )
    3 岁至 16 岁(儿童)
    • Adenotonsillar Hypertrophy
      腺样体和扁桃体肥大
    • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
    • Tonsillitis  扁桃体炎
    • 1 more  1 更多
    • Drug: Normal Saline  药物: 生理盐水
    • Drug: Dexmedetomidine  药物: 德美他淀
    • Number of Participants With Respiratory Complications
      出现呼吸道并发症的参与者数量
    • Number of Participants With Emergence Agitation
      有 emergence agitation 的参与者数量
    • Number of Participants With Postoperative Nausea and Vomiting (PONV)
      有术后恶心和呕吐 (PONV) 的参与者数量
    • (and 4 more…)  (还有更多...)
    2015-03
    37
    Establishment of Ideal IV Sedative Regimen for Successful Fiberoptic Bronchoscopy in Assessing the Site, Severity of Sleep Apnea Syndrome
    建立理想的静脉镇静方案以成功进行纤维支气管镜检查以评估睡眠呼吸暂停综合征的部位和严重程度
    NCT02148432
    20 Years to 60 Years (Adult )
    20 岁至 60 岁(成人)
    • Sleep Apnea Syndrome  睡眠呼吸暂停综合征
    • Drug: dexmedetomidine infusion rate, 0.5 mcg/kg/hr
      药物:dexmedetomidine 输注速率,0.5 mcg/kg/hr
    • Drug: dexmedetomidine infusion rate, 1.0 mcg/kg/hr
      药物: 1.0 mcg/kg/hr 的 Dexmedetomidine 滴注速率
    • Desaturation rate  脱饱和率
    2014-05-19
    38
    Intranasal Dexmedetomidine and Zolpidem for Treatment of Primary Insomnia
    丙泊酚和唑吡坦治疗原发性失眠
    NCT05615727
    18 Years to 25 Years (Adult )
    18 岁至 25 岁(成人)
    • Insomnia  睡眠障碍
    • Drug: Dexmedetomidine  药物: 德美多咪定
    • Drug: Zolpidem  药物: 唑吡坦
    • Other: Placebo  其他: 阳性对照
    • Sleep onset latency  入睡潜伏期
    • Incidence of wakening after sleep onset; Sleep quality; Wake time during sleep
      睡眠开始后的醒来频率;睡眠质量;睡眠中的清醒时间
    2022-09-01
    39
    Sleep Intervention During Acute Lung Injury
    急性肺损伤期间的睡眠干预
    NCT01050699
    18 Years to 85 Years (AdultOlder Adult )
    18 岁至 85 岁(成人,老年人)
    • Critical Illness  重症疾病
    • Sleep  睡眠
    • Acute Lung Injury  急性肺损伤
    • 1 more  1 更多
    • Drug: Dexmedetomidine  药物: 德美他淀
    • Drug: Midazolam and Fentanyl
      药物:咪达唑仑和芬太尼
    • Specific Aim 1: To assess the short-term effect of an α2 adrenergic agent on sleep quality in critically ill patients with ALI/ARDS.
      具体目标 1:评估α2 肾上腺素能受体激动剂在急性呼吸窘迫综合征(ALI/ARDS)重症患者中对睡眠质量的短期影响。
    • Specific Aim 2: To assess the short-term effect of an α2 adrenergic agent on sleep-modulating inflammatory cytokines in critically ill patients with ALI/ARDS.
      具体目标 2:评估α2 肾上腺素能受体激动剂在急性呼吸窘迫综合征(ALI/ARDS)重症患者中对睡眠调节炎症细胞因子的短期影响。
    • Specific aim 3: To determine the effect of α2 adrenergic agent on the in-vitro production of sleep-modulating inflammatory cytokines by peripheral blood mononuclear cells of patients with ALI/ARDS.
      具体目标 3:确定α2 肾上腺素能受体激动剂对急性呼吸窘迫综合征(ALI/ARDS)患者外周血单核细胞中睡眠调节炎症细胞因子的体外生产的影响。
    2009-08
    40
    Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children
    Dexmedetomidine 和褪黑素用于诱导儿童的睡眠 EEG
    NCT04665453
    1 Year to 20 Years (ChildAdult )
    1 岁到 20 岁(儿童,成人)
    • Electroencephalography  电生理图
    • Child  儿童
    • Dexmedetomidine  德西地米松
    • 3 more  3 更多
    • Diagnostic Test: Electroencephalography
      诊断测试: 脑电图
    • Diagnostic Test: Monitoring of vital functions
      监测生命体征
    • Drug: Melatonin 0,1mg/kg oral syrup
      药物: 0.1mg/kg 口服安眠糖浆
    • 2 more  两个更多
    • Comparison of the three medical interventions on sleep initiation
      三种医疗干预措施在睡眠启动方面的比较
    • Comparison of the three medical interventions on the depth of sleep and the most prominent sleep stage on EEG
      三种医疗干预措施在睡眠深度和 EEG 上最显著的睡眠阶段方面的比较
    • Comparison of the three medical interventions on respiratory rate
      三种医疗干预措施在呼吸频率方面的比较
    • (and 3 more…)  (和另外三项...)
    2020-09-01
    41
    Dexmedetomidine-esketamine Combined Nasal Administration and Perioperative Sleep Quality
    舒必利和埃克塞塔明联合鼻腔给药及围手术期睡眠质量
    NCT05732064
    50 Years and older (AdultOlder Adult )
    50 岁及以上(成人,老年人)
    • Breast Cancer  乳腺癌
    • Perioperative Period  术中时期
    • Dexmedetomidine  德西地米松
    • 2 more  两个更多
    • Drug: Dexmedetomidine  药物: 德美他淀
    • Drug: Esketamine  药物: 埃克塞塔明
    • Drug: Normal saline  药物: 生理盐水
    • Subjective sleep quality (the night of surgery)
      手术当晚的睡眠质量
    • Subjective sleep quality (the night before and the first night after surgery)
      手术前一晚和手术后第一晚的主观睡眠质量
    • Objective sleep quality - total sleep time
      总睡眠时间 - 睡眠质量
    • (and 5 more…)  (和另外 5 项……)
    2023-05-22
    42
    How Your Patients' Non-REM Sleep Changes On Sedatives in the Intensive Care Units
    患者在重症监护室使用镇静剂时非 REM 睡眠的变化
    NCT00826553
    18 Years and older (AdultOlder Adult )
    18 岁及以上(成人、老年人)
    • Delirium  谵妄
    • Respiratory Failure  呼吸衰竭
    • Drug: Dexmedetomidine  药物: 德美他淀
    • Drug: GABA agonist  药物: GABA 激动剂
    • Time spent in standard sleep stages (N1, N2, N3, REM).
      标准睡眠阶段所花费的时间(N1、N2、N3、REM)。
    • Time spent in atypical sleep.
      不典型的睡眠时间。
    • Presence of burst suppression.
      带发散抑制的出现。
    2009-01
    43
    Brain Tumor Surgery and Postoperative Delirium
    脑肿瘤手术及术后谵妄
    New  新的
    NCT06863064
    18 Years to 80 Years (AdultOlder Adult )
    18 岁至 80 岁(成人,老年人)
    • Brain Tumor  脑肿瘤
    • Drug: Dexmedetomidine  药物: 德美他淀
    • Drug: Normal Saline  药物: 生理盐水
    • Assessment and Documentation of Delirium
      术后 3 天内谵妄的发生率
    • Assessment and Documentation of Delirium
      术后 3 天内谵妄的发生率
    • Assessment and Documentation of Delirium
      术后 3 天内谵妄的发生率
    • (and 2 more…)  (和更多...)
    2025-03-01
    44
    Sedation Complications in Urology During Spinal Anesthesia With Dexmedetomidine or Midazolam Regarding OSA Risk
    腹部麻醉期间使用 Dexmedetomidine 或 Midazolam 与睡眠呼吸暂停风险相关的镇静并发症
    NCT04817033
    18 Years to 80 Years (AdultOlder Adult )
    18 岁至 80 岁(成人,老年人)
    • Anesthesia  麻醉
    • Anesthesia Complication  麻醉并发症
    • Osa Syndrome  阻塞性睡眠呼吸暂停综合症
    • 5 more  还有 5 个
    • Procedure: Spinal anesthesia with intraoperative dexmedetomidine sedation
      脊椎麻醉并术中使用 dexmedetomidine 镇静
    • Procedure: Spinal anesthesia with intraoperative midazolam sedation
      脊椎麻醉并术中使用 midazolam 镇静
    • Drug: Dexmedetomidine  药物: 德美他淀
    • 1 more  1 更多
    • Airway complications  呼吸道并发症
    • Coughing and restlessness
      咳嗽和烦躁
    • Cardiorespiratory polygraphy
      心肺多导图记录
    • (and 7 more…)  (还有 7 个…)
    2021-04-01
    45
    Effect of Ketorolac on Post Adenotonsillectomy Pain
    哌替啶对腺样体切除术后疼痛的影响
    NCT03467750
    2 Years to 18 Years (ChildAdult )
    2 岁到 18 岁(儿童,成人)
    • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
    • Drug: Ketorolac  药物: 喷他佐辛
    • Drug: Standard of Care  药物: 标准护理
    • Post-Anesthesia Care Unit (PACU) Morphine Requirements
      术后恢复室(PACU)吗啡需求量
    • Face, Legs, Activity, Cry, Consolability (FLACC) Scale Score
      面部、腿部、活动、哭泣、安抚评分量表(FLACC)评分
    • Post-Anesthesia Care Unit (PACU) Recovery Time
      术后恢复室(PACU)恢复时间
    • (and 2 more…)  (和更多...)
    2018-07-19
    46
    Dexmedetomidine After Cardiac Surgery for Prevention of Delirium
    心脏手术后使用 dexmedetomidine 预防谵妄
    NCT03477344
    65 Years and older (Older Adult )
    65 岁及以上(老年人)
    • ICU Delirium  重症监护谵妄
    • Drug: Dexmedetomidine  药物: 戊乙奎醚
    • Drug: Sodium chloride 0.9%
      药物: 0.9% 氯化钠
    • Delirium  谵妄
    • agitation with be assessed using the Richmond agitation and sedation score
      兴奋性将使用 Richmond 躁动-镇静评分进行评估
    • length of ICU stay  ICU 住院时间
    • (and 13 more…)  (和另外 13 项……)
    2019-01-04
    47
    Efficacy of Opioid-free Anesthesia in Reducing Postoperative Respiratory Depression in Children Undergoing Tonsillectomy
    在儿童扁桃体切除术中减少术后呼吸抑制的无阿片类麻醉疗效
    NCT02987985
    up to 12 Years (Child )
    至多 12 岁(儿童)
    • Anesthesia  麻醉
    • General Anesthesia  全身麻醉
    • Analgesics, Opioid  镇痛药,阿片类
    • 14 more  14 项更多
    • Drug: Acetaminophen, gabapentin
      药物: 对乙酰氨基酚, 加巴喷丁
    • Drug: Acetaminophen  药物: 对乙酰氨基酚
    • Drug: Ketamine , Lidocaine , Dexmedetomidine
      药物: 咪达唑仑 , 利多卡因 , 右美托咪定
    • 4 more  4 个更多
    • Respiratory depression  呼吸抑制
    • Quantified opioid consumption
      量化使用的阿片类药物量
    • Pediatric Agitation Emergence Delirium (PAED) scale
      儿童激动症 Emergence 谵妄量表
    • (and 3 more…)  (还有 3 个更多……)
    2017-10-15
    48
    Correlation Endoscopic View of Airway Obstruction With RRa in OSA Patients Under DEX Monitored With SedLine EEG
    与 OSA 患者在 DEX 监测下使用 SedLine EEG 观察的呼吸气道阻塞内窥镜视图的相关性研究
    NCT02639884
    19 Years and older (AdultOlder Adult )
    19 岁及以上(成人,老年人)
    • Obstructive Sleep Apnea (OSA)
      阻塞性睡眠呼吸暂停(OSA)
    • Device: SedLine EEG  设备: SedLine EEG
    • Device: RRa monitoring  设备:RRa 监测
    • Number of Subjects in Which Electroencephalogram (EEG) Signals is Collected
      收集脑电图(EEG)信号的受试者数量
    • Number of Subjects in Which Acoustic Respiratory Rate (RRa) Signals is Collected
      收集声门呼吸率(RRa)信号的受试者数量
    2015-12
    49
    Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Small Tonsils
    为患有小腺样体儿童阻塞性睡眠呼吸暂停综合征提供个性化手术治疗
    NCT06258837
    2 Years to 17 Years (Child )
    2 岁至 17 岁(儿童)
    • Otolaryngological Disease
      耳鼻喉疾病
    • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
    • Procedure: DISE-Directed Surgery
      手术: DISE-导向手术
    • Procedure: Adenotonsillectomy
      程序:腺样体扁桃体切除术
    • Change from Baseline Polysomnography Measures: Obstructive Apnea-Hypopnea Index (oAHI) at 6 months
      从基线多导睡眠图测量:6 个月时的阻塞性呼吸暂停低通气指数(oAHI)
    • Change from Baseline Polysomnography Measures: Total Apnea-Hypopnea Index (AHI) at 6 months
      从基线多导睡眠图测量:6 个月时的总呼吸暂停低通气指数(AHI)
    • Change from Baseline Polysomnography Measures: REM Apnea-Hypopnea Index (REM AHI) at 6 months
      从基线多导睡眠图测量:6 个月时的 REM 呼吸暂停低通气指数(REM AHI)
    • (and 10 more…)  (还有 10 条更多…)
    2024-10-04
    50
    Postoperative Sleep Quality in Patients Undergoing Thoracic Surgery With Different Types of Anesthesia Management
    胸部手术患者在不同麻醉管理方式下的术后睡眠质量
    NCT01725607
    18 Years to 65 Years (AdultOlder Adult )
    18 岁至 65 岁(成人,老年人)
    • General Anesthesia, Thoracic Epidural Anesthesia
      全身麻醉, 胸部硬膜外麻醉
    • Drug: general anesthesia combined with dexmedetomidine infusion
      药物:全身麻醉结合 dexmedetomidine 输注
    • Procedure: general anesthesia combined with TEA
      程序:全身麻醉结合 TEA
    • inflammatory cytokine secretion and postoperative sleep quality
      炎症细胞因子分泌和术后睡眠质量
    • amine secretion during the surgical period and hemodynamic stability
      手术期间的胺分泌和血流稳定性
    2013-01
    51
    Treatment of Obstructive Sleep Apnea With Personalized Surgery in Children With Down Syndrome (TOPS-DS)
    为患有唐氏综合症的儿童治疗阻塞性睡眠呼吸暂停的个性化手术 (TOPS-DS)
    NCT05508971
    2 Years to 17 Years (Child )
    2 岁至 17 岁(儿童)
    • Obstructive Sleep Apnea  阻塞性睡眠呼吸暂停
    • Down Syndrome  唐氏综合症
    • Procedure: DISE-Directed Surgery
      手术: DISE-导向手术
    • Procedure: Adenotonsillectomy
      程序:腺样体扁桃体切除术
    • Change from Baseline Polysomnography Measures: oAHI at 6 months
      从基线多导睡眠图测量:6 个月时的 oAHI
    • Change from Baseline Polysomnography Measures: AHI at 6 months
      基线多导睡眠图测量的变化:6 个月时的 AHI
    • Change from Baseline Polysomnography Measures: REM AHI at 6 months
      从基线多导睡眠图测量:6 个月时的 REM AHI
    • (and 10 more…)  (还有 10 条更多…)
    2023-08-02
    * Study has passed its completion date and status has not been verified in more than two years.  该研究已超过完成日期,状态在两年内未被验证。
    studies per page  每页研究