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 第 1 页

年龄相关性黄斑变性的自噬
AutophagySCU 生物学CSCI升级版 生物学1区SCI基础版 生物1区IF 14.6
Kaarniranta K, Blasiak J, Liton P, Boulton M, Klionsky DJ, Sinha D. Kaarniranta K, et al. Autophagy. 2023 Feb;19(2):388-400. doi: 10.1080/15548627.2022.2069437. Epub 2022 May 1. Autophagy. 2023. PMID: 35468037 Free PMC article. Review.

AMD 的进展初期以视网膜色素上皮的萎缩性改变为特征,同时伴有溶酶体脂氟辛和细胞外沉积物的形成。慢性氧化应激、蛋白质聚集和炎症导致的损害……
The progression of AMD is initially characterized by atrophic alterations in the retinal pigment epithelium, as well as the formation of lys …

LAMP2A, LAMP2B 和 LAMP2C:相似的结构,不同的作用。
AutophagySCU 生物学CSCI升级版 生物学1区SCI基础版 生物1区IF 14.6
Qiao L, Hu J, Qiu X, Wang C, Peng J, Zhang C, Zhang M, Lu H, Chen W. Qiao L, et al. Autophagy. 2023 Nov;19(11):2837-2852. doi: 10.1080/15548627.2023.2235196. Epub 2023 Jul 21. Autophagy. 2023. PMID: 37469132 Free PMC article. Review.

LAMP2B 对于心肌细胞中的自噬体-溶酶体融合是必需的,是外泌体膜的成分之一。LAMP2C 主要与一种新型的自噬作用有关,该作用涉及核酸被摄入溶酶体进行降解。...功能方面的进展……
LAMP2B is required for autophagosome-lysosome fusion in cardiomyocytes and is one of the components of exosome membranes. LAMP2C is p …

AIM2 和 NLRP3 炎症复合体在放疗期间触发由 IL-1 介导的抗肿瘤效应。
Science ImmunologySCU 医学A-SCI升级版 医学1区SCI基础版 医学1区IF 17.6
Han C, Godfrey V, Liu Z, Han Y, Liu L, Peng H, Weichselbaum RR, Zaki H, Fu YX. Han C, et al. Sci Immunol. 2021 May 7;6(59):eabc6998. doi: 10.1126/sciimmunol.abc6998. Sci Immunol. 2021. PMID: 33963060

为了确定炎症小体途径中的哪个分子导致了这种抗性,我们研究了几种炎症小体缺陷小鼠的放射治疗抗肿瘤效果。在 Aim2(-/-)或 Nlrp3(-/-)小鼠中生长的肿瘤对放射仍然敏感,就像野生型小鼠一样……
To map out which molecule in the inflammasome pathway contributed to this resistant, we investigated the antitumor effect of radiation in se …

蜗牛调节的外泌体 microRNA-21 抑制 NLRP3 炎症小体活性以增强顺铂抵抗性。
Journal For Immunotherapy of CancerSCU 医学CSCI升级版 医学1区SCI基础版 医学1区IF 10.3
Cheng HY, Hsieh CH, Lin PH, Chen YT, Hsu DS, Tai SK, Chu PY, Yang MH. Cheng HY, et al. J Immunother Cancer. 2022 Aug;10(8):e004832. doi: 10.1136/jitc-2022-004832. J Immunother Cancer. 2022. PMID: 36002186 Free PMC article.

临近连接检测和 IL-1β(IL-1beta)水平用于检测 NLRP3 炎症小体的激活。RNA 测序用于分析外泌体 RNA。使用 MIR21 敲除的人单核细胞 THP 细胞和 mir21 敲除的小鼠口腔癌...
A proximity ligation assay and interleukin-1beta (IL-1beta) level were used for detecting activation of NLRP3 inflammasomes. RNA sequ …

癌症衍生的外泌体 TRIM59 调节巨噬细胞 NLRP3 炎症小体的激活,促进肺癌进展。
Journal of Experimental & Clinical Cancer ResearchSCU 医学CSCI升级版 医学1区SCI基础版 医学1区IF 11.4
Liang M, Chen X, Wang L, Qin L, Wang H, Sun Z, Zhao W, Geng B. Liang M, et al. J Exp Clin Cancer Res. 2020 Aug 31;39(1):176. doi: 10.1186/s13046-020-01688-7. J Exp Clin Cancer Res. 2020. PMID: 32867817 Free PMC article.

肿瘤衍生外泌体与巨噬细胞之间的通讯在促进肿瘤进展中起着关键作用。然而,外泌体如何调节肺癌的发展机制尚未完全理解。...结果:我们证明了...
The communication between tumor-derived exosomes and macrophages has a critical role in facilitating tumor progression. However, the …

人脐带间充质干细胞衍生的外泌体通过促进 FOXO3a 依赖性线粒体自噬减轻氧糖剥夺/再灌注诱导的巨噬细胞焦亡。
Oxidative Medicine And Cellular LongevitySCU 生物学DEI检索SCI基础版 生物2区
Hu Z, Yuan Y, Zhang X, Lu Y, Dong N, Jiang X, Xu J, Zheng D. Hu Z, et al. Oxid Med Cell Longev. 2021 Nov 2;2021:6219715. doi: 10.1155/2021/6219715. eCollection 2021. Oxid Med Cell Longev. 2021. PMID: 34765084 Free PMC article.

背景:间充质干细胞衍生的外泌体(MSC-exos)已被确认为治疗新生儿缺血性脑损伤(HIBD)的有前景的治疗策略。...最后,使用 FOXO3a siRNA 来探讨 FOXO3a 在 MSC-exo 诱导的自噬中的作用。
BACKGROUND: Mesenchymal stem cell-derived exosomes (MSC-exos) have been recognized as a promising therapeutic strategy for neonatal h …

CD44 靶向的外泌体载药系统装载枫香脂素通过调节 NLRP3 介导的焦亡对抗肝纤维化。
Advanced Healthcare MaterialsSCU 工程技术CEI检索SCI升级版 医学2区SCI基础版 工程技术1区IF 10.0
Gong L, Zhou H, Zhang S, Wang C, Fu K, Ma C, Zhang Y, Peng C, Li Y. Gong L, et al. Adv Healthc Mater. 2023 Apr;12(11):e2202228. doi: 10.1002/adhm.202202228. Epub 2023 Jan 15. Adv Healthc Mater. 2023. PMID: 36603210

在这项研究中,开发了一种基于 CD44 特异性配体、透明质酸(HA)修饰的乳制品来源的外泌体(mExo)的纳米载体,命名为 HA-mExo-FA,用于装载药物。结果表明,HA 修饰能够将载药外泌体递送到靶细胞,并形成特定的...
In this study, the nanocarrier of CD44-specific ligand Hyaluronic acid (HA)-modified milk-derived exosomes (mExo) encapsulated with F …

人脐带间充质干细胞衍生的外泌体通过 NRF2/NF-κB/NLRP3 途径减轻神经炎症和氧化应激。
Cns Neuroscience & TherapeuticsSCU 医学CSCI升级版 医学1区SCI基础版 医学2区IF 4.8
Che J, Wang H, Dong J, Wu Y, Zhang H, Fu L, Zhang J. Che J, et al. CNS Neurosci Ther. 2024 Mar;30(3):e14454. doi: 10.1111/cns.14454. Epub 2023 Sep 12. CNS Neurosci Ther. 2024. PMID: 37697971 Free PMC article.

机制上,外泌体增加了 NRF2 水平,并抑制了 LPS 诱导的 NF-kappaB p65 磷酸化和 NLRP3 炎症小体激活。...结论:人脐带间充质干细胞来源的外泌体减轻了 LPS/H(2)O(2)诱导的神经炎症和氧化损伤。
Mechanistically, the exosomes increased the NRF2 levels and inhibited the LPS-induced NF-kappaB p65 phosphorylation and NLRP3

外泌体相关 microRNA-138-5p 通过调整 GPR124 来调节胚胎着床和早期妊娠。
PharmaceuticsSCU 医学DSCI升级版 医学3区SCI基础版 医学2区IF 4.9
Wu HM, Lo TC, Tsai CL, Chen LH, Huang HY, Wang HS, Yu J. Wu HM, et al. Pharmaceutics. 2022 May 30;14(6):1172. doi: 10.3390/pharmaceutics14061172. Pharmaceutics. 2022. PMID: 35745744 Free PMC article.

我们还展示了自发性流产与正常妊娠相比,NLRP3 炎性小体过度激活的现象。在这里,我们新发现 miR-138-5p 和 GPR124 调整后的 NLRP3 炎性小体在细胞外囊泡中表达。
We also showed the excessive activation of the NLRP3 inflammasome in spontaneous miscarriage compared to normal pregnancy. Here, we n …
 第 2 页

癌症衍生的 exosomal Alu RNA 促进结肠癌进展。
Experimental And Molecular MedicineSCU 医学DSCI升级版 医学2区SCI基础版 医学2区IF 9.5
Magliacane Trotta S, Adinolfi A, D'Orsi L, Panico S, Mercadante G, Mehlen P, Ambati J, De Falco S, Tarallo V. Magliacane Trotta S, et al. Exp Mol Med. 2024 Mar;56(3):700-710. doi: 10.1038/s12276-024-01166-6. Epub 2024 Mar 14. Exp Mol Med. 2024. PMID: 38486106 Free PMC article.

在这里,我们展示了 Alu RNA 可以通过激活 NLRP3 炎症小体和释放 IL-1β来诱导结直肠癌(CRC)细胞的上皮-间质转化(EMT)。Alu RNA 通过外泌体存储、运输并传递给 CRC 细胞。外泌体……
Here, we showed that Alu RNA can induce epithelial-to-mesenchymal transition (EMT) through NLRP3 inflammasome activation and IL-1beta …

miR-223-3p 在癌症发展和癌症药物耐药性中的作用:同一枚硬币,不同的面。
International Journal of Molecular SciencesSCU 生物学DSCI升级版 生物学2区SCI基础版 生物2区IF 4.9
Barbagallo D, Ponti D, Bassani B, Bruno A, Pulze L, Akkihal SA, George-William JN, Gundamaraju R, Campomenosi P. Barbagallo D, et al. Int J Mol Sci. 2024 Jul 26;25(15):8191. doi: 10.3390/ijms25158191. Int J Mol Sci. 2024. PMID: 39125761 Free PMC article. Review.

有趣的是,当 miRNA 作为抑癌基因或癌基因在不同癌症中起作用时,NLRP3 和 FBXW7 始终被识别为 miR-223 的目标。我们的综述还描述了 miR-223 在生物流体或其细胞外环境中增加的情况。
Intriguingly, NLRP3 and FBXW7 are consistently identified as miR-223 targets when the miRNA acts as an oncosuppressor or an oncogene, …

CD11c+ 粒细胞外泌体在结肠炎期间降低肠道炎症。
Jci InsightSCU 医学BSCI升级版 医学1区SCI基础版 医学2区IF 6.3
Bauer KM, Nelson MC, Tang WW, Chiaro TR, Brown DG, Ghazaryan A, Lee SH, Weis AM, Hill JH, Klag KA, Tran VB, Thompson JW, Ramstead AG, Monts JK, Marvin JE, Alexander M, Voth WP, Stephens WZ, Ward DM, Petrey AC, Round JL, O'Connell RM. Bauer KM, et al. JCI Insight. 2022 Oct 10;7(19):e159469. doi: 10.1172/jci.insight.159469. JCI Insight. 2022. PMID: 36214220 Free PMC article.

细胞间通讯对于哺乳动物系统,包括消化道(GI)系统的稳态至关重要。外泌体是纳米级的脂质胞外囊泡,它们在多种细胞类型之间进行通讯。...在抗炎外泌体……
Intercellular communication is critical for homeostasis in mammalian systems, including the gastrointestinal (GI) tract. Exosomes are …

脂多糖使人类巨噬细胞为非经典炎性小体诱导的外泌体分泌做好准备。
Journal of ImmunologySCU 医学CSCI升级版 医学3区SCI基础版 医学2区IF 3.6
Cypryk W, Czernek L, Horodecka K, Chrzanowski J, Stańczak M, Nurmi K, Bilicka M, Gadzinowski M, Walczak-Drzewiecka A, Stensland M, Eklund K, Fendler W, Nyman TA, Matikainen S. Cypryk W, et al. J Immunol. 2023 Feb 1;210(3):322-334. doi: 10.4049/jimmunol.2200444. J Immunol. 2023. PMID: 36525001

人类巨噬细胞分泌载有大量免疫调节蛋白的胞外囊泡(EVs)。囊泡介导的巨噬细胞蛋白分泌受不明确机制的调控;然而,现在已知炎症条件显著……
Human macrophages secrete extracellular vesicles (EVs) loaded with numerous immunoregulatory proteins. Vesicle-mediated …

尿苷转移酶 TUT7 介导的外泌体 miR-1246 积累重新编程 TAMs 以支持 CRC 进展。
Advanced ScienceSCU 材料科学BEI检索SCI升级版 材料科学1区IF 14.3
Feng Y, Jin C, Wang T, Chen Z, Ji D, Zhang Y, Zhang C, Zhang D, Peng W, Sun Y. Feng Y, et al. Adv Sci (Weinh). 2024 Apr;11(15):e2304222. doi: 10.1002/advs.202304222. Epub 2024 Feb 11. Adv Sci (Weinh). 2024. PMID: 38342611 Free PMC article.

此外,exosomal miR-1246 序列中存在 Exo-模式,使其能够与 exosomal 分选蛋白 hnRNPA2B1 结合。RNA-seq 分析表明,外源性 miR-1246 在转录后水平上调节 TAMs 的极化,强调了……
Moreover, an Exo-motif is present in the exosomal miR-1246 sequence, enabling it to bind with the exosomal sorting protein hnR …

程序性细胞死亡,肿瘤免疫的新桥梁。
Cancer ScienceSCU 医学CSCI升级版 医学2区SCI基础版 医学2区IF 4.5
Li L, Jiang M, Qi L, Wu Y, Song D, Gan J, Li Y, Bai Y. Li L, et al. Cancer Sci. 2021 Oct;112(10):3979-3994. doi: 10.1111/cas.15059. Epub 2021 Aug 10. Cancer Sci. 2021. PMID: 34252266 Free PMC article. Review.

我们的理解已经超越了细胞,我们知道细胞焦亡涉及到细胞外反应。最近,由于细胞焦亡在激活免疫系统方面新兴的作用,人们对细胞焦亡的兴趣日益增加。同时,细胞焦亡介导的疗法……
Our understanding of pyroptosis has expanded beyond cells and is known to involve extracellular responses. Recently, there has been a …
 第 3 页

低氧和 TNF-alpha 调节人类诱导多能干细胞衍生心肌细胞外分泌微粒的释放。
Journal of Extracellular VesiclesSCU 医学CSCI升级版 医学1区SCI基础版 医学1区IF 15.5
Viola M, Bebelman MP, Maas RGC, de Voogt WS, Verweij FJ, Seinen CS, de Jager SCA, Vader P, Pegtel DM, Petrus Gerardus Sluijter J. Viola M, et al. J Extracell Vesicles. 2024 Nov;13(11):e70000. doi: 10.1002/jev2.70000. J Extracell Vesicles. 2024. PMID: 39508403 Free PMC article.

外泌体(EVs)在心脏的稳态和病理条件下,如心肌梗死(MI)时,作为细胞间通讯的重要媒介已经崭露头角。...此外,炎性细胞因子 TNF-alpha 增加了 CM-EV 的分泌。
Extracellular vesicles (EVs) have emerged as important mediators of intercellular communication in the heart under homeostatic

大蒜衍生的类外泌体纳米颗粒作为肝保护剂,通过抑制 CCR2/CCR5 信号和炎症减轻急性肝衰竭。
Biomaterials AdvancesEI检索SCI升级版 医学2区IF 5.5
Zhao X, Yin F, Fu L, Ma Y, Ye L, Huang Y, Fan W, Gao W, Cai Y, Mou X. Zhao X, et al. Biomater Adv. 2023 Nov;154:213592. doi: 10.1016/j.bioadv.2023.213592. Epub 2023 Aug 22. Biomater Adv. 2023. PMID: 37717364

近年来,作为新型治疗辅助手段或递送载体,植物来源的类外泌体纳米囊泡(PELNVs)得到了广泛研究。本研究旨在开发大蒜来源的类外泌体纳米囊泡(GaELNVs),以减轻……的肝脏损伤。
As a novel therapeutic adjuvant or delivery vehicle, plant-derived exosome-like nanovesicles (PELNVs) have been extensively studied i …

间充质干细胞衍生的外泌体通过 NF-κB/NLRP3 信号通路减轻小鼠巨细胞病毒感染性肺炎。
Viruses-baselSCU 医学DSCI升级版 医学3区SCI基础版 医学2区IF 3.8
Chen F, Chen Z, Wu HT, Chen XX, Zhan P, Wei ZY, Ouyang Z, Jiang X, Shen A, Luo MH, Liu Q, Zhou YP, Qin A. Chen F, et al. Viruses. 2024 Apr 16;16(4):619. doi: 10.3390/v16040619. Viruses. 2024. PMID: 38675960 Free PMC article.

近期研究表明,间充质干细胞衍生的外泌体(MSC-exos)在急性肺损伤的预临床模型中,如肺炎、ARDS 和脓毒症,具有潜在的治疗益处。从机制上讲,mMSC-exos 治疗减少了...
Recent studies have demonstrated the potential therapeutic benefits of exosomes derived from mesenchymal stem cells (MSC-exos) in pre …

丙型肝炎病毒患者外泌体分离的血浆模式及其对人类血管内皮细胞的影响。
International Journal of Molecular SciencesSCU 生物学DSCI升级版 生物学2区SCI基础版 生物2区IF 4.9
Grossini E, Smirne C, Venkatesan S, Tonello S, D'Onghia D, Minisini R, Cantaluppi V, Sainaghi PP, Comi C, Tanzi A, Bussolati B, Pirisi M. Grossini E, et al. Int J Mol Sci. 2023 Jun 15;24(12):10197. doi: 10.3390/ijms241210197. Int J Mol Sci. 2023. PMID: 37373343 Free PMC article.

在这项研究中,我们旨在评估外泌体(EVs)作为与 HCV 相关的内皮功能障碍发病机制的致病因素的作用。...通过预先用 NLR 家族 PYD 域含 3 处理 HUVEC,这些有害影响得到了减少。
In this study, we aimed to evaluate the role of extracellular vesicles (EVs) as pathogenic factors for the onset of HCV-relate …

生物仿生纳米载体指导细胞外 ATP 稳态重塑能量代谢,激活固有和适应性免疫系统。
Advanced ScienceSCU 材料科学BEI检索SCI升级版 材料科学1区IF 14.3
Wu L, Xie W, Li Y, Ni Q, Timashev P, Lyu M, Xia L, Zhang Y, Liu L, Yuan Y, Liang XJ, Zhang Q. Wu L, et al. Adv Sci (Weinh). 2022 Jun;9(17):e2105376. doi: 10.1002/advs.202105376. Epub 2022 Apr 9. Adv Sci (Weinh). 2022. PMID: 35396800 Free PMC article.
An ecto-enzyme (CD39) antagonist POM1 and AMP-activated protein kinase (AMPK) agonist metformin are both encapsulated into cancer cell-derived exosomes and used as nanocarriers for tumor targeting delivery. This method increases the level of pro-inflammatory extr
An ecto-enzyme (CD39) antagonist POM1 and AMP-activated protein kinase (AMPK) agonist metformin are both encapsulated into cancer cel …
The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity. Cell Death & DiseaseSCU 生物学CSCI升级版 生物学1区SCI基础版 生物2区IF 8.1
Santavanond JP, Chiu YH, Tixeira R, Liu Z, Yap JKY, Chen KW, Li CL, Lu YR, Roncero-Carol J, Hoijman E, Rutter SF, Shi B, Ryan GF, Hodge AL, Caruso S, Baxter AA, Ozkocak DC, Johnson C, Day ZI, Mayfosh AJ, Hulett MD, Phan TK, Atkin-Smith GK, Poon IKH. Santavanond JP, et al. Cell Death Dis. 2024 Feb 9;15(2):123. doi: 10.1038/s41419-024-06513-z. Cell Death Dis. 2024. PMID: 38336804 Free PMC article.
Discovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and for the development of novel therapeutics for pathological conditions such as cancer and infectious diseases. The small molecule rapt …
Discovery of new small molecules that can activate distinct programmed cell death pathway is of significant interest as a research tool and …
Co-Treatment with Phlorotannin and Extracellular Vesicles from Ecklonia cava Inhibits UV-Induced Melanogenesis. AntioxidantsSCU 医学DSCI升级版 医学2区SCI基础版 医学2区IF 6.0
Byun KA, Park Y, Oh S, Batsukh S, Son KH, Byun K. Byun KA, et al. Antioxidants (Basel). 2024 Mar 28;13(4):408. doi: 10.3390/antiox13040408. Antioxidants (Basel). 2024. PMID: 38671856 Free PMC article.
Hyperpigmentation due to ultraviolet (UV)-induced melanogenesis causes various esthetic problems. Phlorotannin (PT) and extracellular vesicles (EVs) derived from various plants suppress melanogenesis pathways. ...Thus, co-treatment with PT and EVE reduced melanogene …
Hyperpigmentation due to ultraviolet (UV)-induced melanogenesis causes various esthetic problems. Phlorotannin (PT) and extracellular
Anisodamine Suppressed the Growth of Hepatocellular Carcinoma Cells, Induced Apoptosis and Regulated the Levels of Inflammatory Factors by Inhibiting NLRP3 Inflammasome Activation. Drug Design Development And TherapySCU 医学DSCI升级版 医学2区SCI基础版 医学3区IF 4.7
Li P, Liu Y, He Q. Li P, et al. Drug Des Devel Ther. 2020 Apr 29;14:1609-1620. doi: 10.2147/DDDT.S243383. eCollection 2020. Drug Des Devel Ther. 2020. PMID: 32425506 Free PMC article.
INTRODUCTION: Hepatocellular carcinoma (HCC) is a primary liver cancer with a 5-year incidence of over 70%. Anisodamine (ANI), an alkaloid extracted from Anisodus, has a good therapeutic effect in septic shock and morphine addiction. ...Mice were randomly divided in …
INTRODUCTION: Hepatocellular carcinoma (HCC) is a primary liver cancer with a 5-year incidence of over 70%. Anisodamine (ANI), …
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