In a double-blind, randomized, placebo-controlled crossover study, 40 healthy adults were evaluated on the acute (single-dose) response to 1000 mg of lion’s mane, examining its effects on mental acuity and mood. The study introduces MycoThrive™ Lion’s Mane, a premium organic lion’s mane extract and the newest addition to a series of innovative functional ingredients developed by Applied Food Sciences (AFS), a Texas-based company.
在一项双盲、随机、安慰剂对照交叉研究中，评估了 40 名健康成年人对 1000 毫克狮鬃精的急性（单剂量）反应，检查其对精神敏锐度和情绪的影响。研究介绍MycoThrive™ 狮子鬃毛是一种优质有机狮鬃精提取物，是德克萨斯州 Applied Food Sciences (AFS) 公司开发的一系列创新功能成分的最新成员。
Consumers are increasingly drawn to natural supplements that can enhance cognitive function and support emotional well-being. Among these supplements, lion’s mane mushroom is notable for its impressive nootropic properties. However, for this emerging ingredient to succeed, the industry must support it with more high-quality scientific research to better determine its proper usage levels and unique functional properties, ensuring consistent, noticeable benefits for consumers. This study is a significant addition to the numerous clinical research projects published by AFS in recent years, marking a notable milestone for modern research on lion’s mane mushrooms.
消费者越来越被能够增强认知功能和支持情绪健康的天然补充剂所吸引。在这些补充剂中，狮鬃菇以其令人印象深刻的促智特性而闻名。然而，为了使这种新兴成分取得成功，该行业必须提供更多高质量的科学研究支持，以更好地确定其适当的使用水平和独特的功能特性，确保为消费者带来一致、显着的好处。这项研究是 AFS 近年来发表的众多临床研究项目的重要补充，标志着狮鬃菇现代研究的一个显着里程碑。
Understanding Lion’s Mane
了解狮子鬃毛
Lion’s mane (Hericium Erinaceus) is a unique mushroom with a long history of traditional use in Eastern medicine. Often referred to as the “Mountain Priest” or “Smart Mushroom,” it has garnered attention for its ability to support cognitive function and overall well-being. The primary bioactive compounds found in lion’s mane include β-glucan polysaccharides, proteins, hericenones, and erinacines, which all affect how the ingredient functions in the body. Evidence suggests that the primary mechanism of action for cognitive support is through the stimulation of Nerve Growth Factor (NGF) synthesis. NGF is essential for brain cell growth, neuroprotection, and cognitive processes such as memory, attention, and spatial navigation.[i] AFS is proud to partner with award-winning mushroom biotechnologists in Finland to responsibly source its high-quality, nordic-grown lion’s mane.
狮子的鬃毛（猴头菇）是一种独特的蘑菇，在东方医学中具有悠久的传统使用历史。它通常被称为“山祭司”或“智能蘑菇”，因其支持认知功能和整体健康的能力而受到关注。狮子鬃毛中发现的主要生物活性化合物包括 β-葡聚糖多糖、蛋白质、猴头菇酮和猴头菇素，这些都会影响该成分在体内的功能。有证据表明，认知支持的主要作用机制是通过刺激神经生长因子 (NGF) 的合成。 NGF 对于脑细胞生长、神经保护和记忆、注意力和空间导航等认知过程至关重要。 [我] AFS 很荣幸能与芬兰屡获殊荣的蘑菇生物技术专家合作，以负责任的方式采购北欧种植的高品质狮子鬃毛。
Study Methodology 研究方法
The placebo-controlled crossover study was designed to evaluate attention, working memory, mental processing speed, and mood in healthy adults. The study examined a single dose of 1000 mg of MycoThrive™ Lion’s Mane (formally known as “Nordic Lion’s Mane”) vs. 650 mg of guayusa extract (AmaTea® Max) vs. the placebo. Testing occurred at three intervals: baseline pre-ingestion, as well as 60 and 120 minutes post-ingestion.
这项安慰剂对照交叉研究旨在评估健康成年人的注意力、工作记忆、心理处理速度和情绪。该研究比较了单剂量 1000 毫克的 MycoThrive™ 狮鬃精（正式名称为“北欧狮鬃精”）与 650 毫克的番石榴提取物 (AmaTea® Max) 以及安慰剂。测试分三个时间间隔进行：摄入前的基线以及摄入后 60 和 120 分钟。
The study measured cognitive function through comprehensive neuropsychological assessments, including the Go/No-Go, Serial-Sevens, and N-Back tasks. Participants were also given subject assessments for cognitive perception based on a visual analog scale (VAS) and for mood based on a subjective happiness scale (SHS). All tasks used in this study are clinically validated testing methods. While this article focuses on the results of the lion’s mane, the complete study can be viewed in the MDPI Nutrients Journal.
该研究通过全面的神经心理学评估来测量认知功能，包括 Go/No-Go、Serial-Sevens 和 N-Back 任务。参与者还接受了基于视觉模拟量表（VAS）的认知感知和基于主观幸福量表（SHS）的情绪评估。本研究中使用的所有任务都是经过临床验证的测试方法。虽然本文重点关注狮子鬃毛的结果，但完整的研究可以在MDPI 营养杂志。
Results of MycoThrive™ Organic Lion’s Mane
MycoThrive™ 有机狮鬃精的结果
Participants taking MycoThrive™ Lion’s Mane demonstrated acute improvements in working memory, attention, concentration, and reaction time that were statistically significant compared to the placebo. Additionally, MycoThrive™ Lion’s Mane helped improve the participants’ mood and sense of happiness compared to their peers, reflecting a significant impact on contentment and emotional well-being.[ii]
服用 MycoThrive™ Lion's Mane 的参与者表现出工作记忆、注意力、注意力和反应时间的显着改善，与安慰剂相比，具有统计学显着性。此外，与同龄人相比，MycoThrive™ Lion's Mane 有助于改善参与者的情绪和幸福感，反映出对满足感和情绪健康的重大影响。 [二]
基于 N-Back 任务平均值的数据。每分时间，一种测试工作记忆反应时间的有效方法。 [二]
The Importance of this Study
这项研究的重要性
For lion’s mane, this study marks an important milestone in understanding its acute cognitive benefits in healthy adults. Until now, most lion’s mane studies have examined its impact on people with known health conditions.[iii] Only a few studies have explored the effects of lion's mane in healthy adults [iv, v], and fewer have examined its acute (i.e., single-dose) cognitive effects. Therefore, this research challenges the prevailing belief that lion's mane can only provide more long-term, chronic benefits (i.e., 30-60 days use). Instead, the study takes a significant step towards understanding lion's mane's more immediate cognitive advantages for healthy adults in as little as 60 minutes post-ingestion. Moreover, it helps address the pressing need for transparency and alleviates confusion by providing more consistent structure-function claims, reducing skepticism and increasing confidence in the market.
对于狮鬃毛来说，这项研究标志着了解其对健康成年人的急性认知益处的一个重要里程碑。到目前为止，大多数狮子鬃毛研究都考察了它对已知健康状况的人的影响。 [三]只有少数研究探讨了狮子鬃毛对健康成年人的影响[四、五] ，并且很少有人检查其急性（即单剂量）认知效应。因此，这项研究挑战了人们普遍认为狮鬃精只能提供更长期、慢性益处（即使用 30-60 天）的观点。相反，这项研究朝着了解健康成年人在摄入狮鬃毛后短短 60 分钟内所具有的更直接的认知优势迈出了重要一步。此外，它通过提供更一致的结构功能声明、减少怀疑并增强市场信心，有助于解决对透明度的迫切需求并减少混乱。
Conclusion 结论
For over 20 years, Applied Food Sciences (AFS) has supported the natural products industry with innovative functional ingredients. The company is excited to announce its collaboration with some of the world's leading mycologists to extend its expertise into functional fungi with the launch of MycoThrive™ Lion’s Mane, a clinically studied extract for mood and focus. This new and exciting ingredient is part of the MycoThrive™ premium line of functional mushrooms that also includes cordyceps, chaga, reishi, maitake, and shiitake. To see the entire AFS ingredient portfolio or inquire about MycoThrive™ Lion’s Mane, click here.
20 多年来，应用食品科学 (AFS) 一直通过创新的功能成分为天然产品行业提供支持。该公司很高兴地宣布与一些世界领先的真菌学家合作，推出 MycoThrive™ 狮鬃精，这是一种针对情绪和注意力的临床研究提取物，将其专业知识扩展到功能性真菌领域。这种令人兴奋的新成分是 MycoThrive™ 优质功能性蘑菇系列的一部分，该系列还包括冬虫夏草、白桦茸、灵芝、舞茸和香菇。要查看整个 AFS 成分组合或询问有关 MycoThrive™ 狮鬃菇的信息，点击这里。
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