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Medical appliance coating composition and medical appliance
ๅŒป็–—ๅ™จๆขฐ็”จๆถ‚ๆ–™็ป„ๅˆ็‰ฉๅŠๅŒป็–—ๅ™จๆขฐ

Abstract  ๆŠฝ่ฑก็š„

A medical appliance-coating composition contains a solvent-based silicone rubber, and in addition, carbon nanotubes, and fine particles of silicone resin. A medical appliance (1) having a slidable coating film (3) formed thereon moves in contact with an inner surface of a medical member or an inner surface of a lumen. The slidable coating film (3) is disposed at a portion, of the medical appliance, which contacts the medical member or the lumen. The slidable coating film (3) is comprised of silicone rubber, the carbon nanotubes and the fine particles of the silicone resin.
ไธ€็งๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉ๏ผŒๅ…ถๅŒ…ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถใ€็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚ไธ€็งๅŒป็–—ๅ™จๆขฐ๏ผˆ1๏ผ‰ไธŠๅฝขๆˆๆœ‰ๆป‘ๅŠจๆถ‚ๅฑ‚่†œ๏ผˆ3๏ผ‰๏ผŒ่ฏฅๆป‘ๅŠจๆถ‚ๅฑ‚่†œไธŽๅŒป็–—ๆž„ไปถ็š„ๅ†…่กจ้ขๆˆ–็ฎก่…”็š„ๅ†…่กจ้ขๆŽฅ่งฆๅนถ็งปๅŠจใ€‚ๆป‘ๅŠจๆถ‚ๅฑ‚่†œ๏ผˆ3๏ผ‰่ฎพ็ฝฎไบŽๅŒป็–—ๅ™จๆขฐไธŽๅŒป็–—ๆž„ไปถๆˆ–็ฎก่…”ๆŽฅ่งฆ็š„้ƒจๅˆ†ใ€‚ๆป‘ๅŠจๆถ‚ๅฑ‚่†œ๏ผˆ3๏ผ‰็”ฑ็ก…ๆฉก่ƒถใ€็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ๆž„ๆˆใ€‚

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Classifications  ๅˆ†็ฑป

A61L29/085 Macromolecular materials
A61L29/085 ้ซ˜ๅˆ†ๅญๆๆ–™
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ๆŸฅ็œ‹ๅฆๅค– 10 ไธชๅˆ†็ฑป

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EP1870117B1

European Patent Office

Other languages
German
French
Inventor
Shingo c/o Terumo Kabushiki Kaisha Ishii
Makoto C/O Terumo Kabushiki Kaisha Onishi
Current Assignee
Terumo Corp

ๅ…ถไป–่ฏญ่จ€
ๅพท่ฏญ
ๆณ•่ฏญ
ๅ‘ๆ˜Ž่€…
Shingo c/o Terumo Kabushiki Kaisha Ishii
Makoto C/O Terumo Kabushiki Kaisha ๅคง่ฅฟ
ๅฝ“ๅ‰ๅ—่ฎฉไบบ
ๅˆ—ๅ‡บ็š„ๅ—่ฎฉไบบๅฏ่ƒฝไธๅ‡†็กฎใ€‚
Google ๅฐšๆœช่ฟ›่กŒๆณ•ๅพ‹ๅˆ†ๆž๏ผŒไนŸไธๅฏน่ฏฅๅˆ—่กจ็š„ๅ‡†็กฎๆ€งไฝœๅ‡บไปปไฝ•้™ˆ่ฟฐๆˆ–ไฟ่ฏใ€‚
ๆณฐๅฐ”่Œ‚ๅ…ฌๅธ

Worldwide applications  ๅ…จ็ƒๅบ”็”จ
2006 JP 2007 DE EP AT US
2006 ๅคชๅนณ็ป…ๅฃซ
็”ณ่ฏทๅท๏ผšJP2006171955A
็”ณ่ฏทๆ—ฅ๏ผš2006-06-21
ๆณ•ๅพ‹็Šถๆ€๏ผšๅพ…ๅฎก
2007 ๅพท
็”ณ่ฏทๅท๏ผšDE602007010379T
็”ณ่ฏทๆ—ฅ๏ผš2007-06-14
ๆณ•ๅพ‹็Šถๆ€๏ผšๆœ‰ๆ•ˆ
EP
็”ณ่ฏทๅท๏ผšEP07011661A
็”ณ่ฏทๆ—ฅ๏ผš2007-06-14
ๆณ•ๅพ‹็Šถๆ€๏ผšๆ— ๆ•ˆ
AT ็”ณ่ฏทๅท๏ผšAT07011661T ็”ณ่ฏทๆ—ฅ๏ผš2007-06-14 ๆณ•ๅพ‹็Šถๆ€ ๏ผš
็พŽๅ›ฝ
็Ÿฅ่ฏ†ไบงๆƒ
็ปˆๆญข
็”ณ่ฏทๅท๏ผšUS11/812,448
็”ณ่ฏทๆ—ฅ๏ผš2007-06-19
ๆณ•ๅพ‹็Šถๆ€๏ผšๆ”พๅผƒ

Application EP07011661A events
ๅบ”็”จ EP07011661A ไบ‹ไปถ
2010-11-10
Application granted  ็”ณ่ฏท่Žทๆ‰นๅ‡†
Not-in-force  ๆ— ๆ•ˆ
Anticipated expiration  ้ข„่ฎกๅˆฐๆœŸ

Description  ๆ่ฟฐ

  • [0001]
    The present invention relates to a medical appliance-coating composition capable of imparting a stable slidableness to a medical appliance. The present invention also relates to provide a medical appliance on which a slidable coating film having a stable slidableness is formed.
    ๆœฌๅ‘ๆ˜Žๆถ‰ๅŠไธ€็ง่ƒฝๅคŸ่ต‹ไบˆๅŒป็–—ๅ™จๆขฐไปฅ็จณๅฎš็š„ๆป‘ๅŠจๆ€ง็š„ๅŒป็–—ๅ™จๆขฐ็”จๆถ‚ๆ–™็ป„ๅˆ็‰ฉ๏ผŒไปฅๅŠๆไพ›ไธ€็งๅฝขๆˆๆœ‰ๅ…ทๆœ‰็จณๅฎš็š„ๆป‘ๅŠจๆ€ง็š„ๆป‘ๅŠจๆถ‚่†œ็š„ๅŒป็–—ๅ™จๆขฐใ€‚
  • [0002]
    It is necessary to apply silicone oil or the like such as polysiloxane to a sliding portion or the like of a gasket for use in a pre-filled syringe as a lubricant to enhance the slidableness of the gasket and securely discharge a liquid medicine from the pre-filled syringe. But in dependence on a liquid medicine, it is difficult to pre-fill the liquid medicine in a syringe owing to an interaction of the liquid medicine with the lubricant For example, there is a case in which monoammonium glycyrrhetate which is an injection contacts the silicone oil to generate a foreign matter which is insoluble in water.
    ไธบไบ†ๆ้ซ˜้ข„ๅ……ๅผๆณจๅฐ„ๅ™จๅžซๅœˆ็š„ๆป‘ๅŠจๆ€ง๏ผŒๅนถๅฎ‰ๅ…จๅœฐไปŽ้ข„ๅ……ๅผๆณจๅฐ„ๅ™จไธญๆŽ’ๅ‡บ่ฏๆถฒ๏ผŒ้œ€่ฆๅœจ้ข„ๅ……ๅผๆณจๅฐ„ๅ™จๅžซๅœˆ็š„ๆป‘ๅŠจ้ƒจไฝ็ญ‰ๆถ‚ๆŠน่š็ก…ๆฐง็ƒท็ญ‰็ก…ๆฒนไฝœไธบๆถฆๆป‘ๅ‰‚ใ€‚็„ถ่€Œ๏ผŒ็”ฑไบŽ่ฏๆถฒไธŽๆถฆๆป‘ๅ‰‚ไน‹้—ดๅญ˜ๅœจ็›ธไบ’ไฝœ็”จ๏ผŒๅ› ๆญค้šพไปฅๅฐ†่ฏๆถฒ้ข„ๅ……ๅˆฐๆณจๅฐ„ๅ™จไธญใ€‚ไพ‹ๅฆ‚๏ผŒๆณจๅฐ„ๅ‰‚็”˜่‰้…ธๅ•้“ต็›ๆœ‰ๆ—ถไผšไธŽ็ก…ๆฒนๆŽฅ่งฆ๏ผŒไบง็”ŸไธๆบถไบŽๆฐด็š„ๅผ‚็‰ฉใ€‚
  • [0003]
    The method of applying the lubricant to the sliding portion of the gasket to enhance the slidableness of the gasket is widely used in disposable injection syringes. But it is desired that the lubricant is not applied to the sliding portion or the like of the gasket for use in the pre-filled syringe accommodating a medicine for hours in consideration of influence of the lubricant on the medicine accommodated therein.
    ๅœจไธ€ๆฌกๆ€งๆณจๅฐ„ๅ™จไธญ๏ผŒไธบไบ†ๆ้ซ˜ๅžซๅœˆ็š„ๆป‘ๅŠจๆ€ง๏ผŒๅœจๅžซๅœˆ็š„ๆป‘ๅŠจ้ƒจๆถ‚ๆŠนๆถฆๆป‘ๅ‰‚็š„ๆ–นๆณ•่ขซๅนฟๆณ›ไฝฟ็”จใ€‚ไฝ†่€ƒ่™‘ๅˆฐๆถฆๆป‘ๅ‰‚ๅฏนๆ‰€ๅฎน็บณ็š„่ฏ็‰ฉ็š„ๅฝฑๅ“๏ผŒๅฏนไบŽ้•ฟๆ—ถ้—ดไฝฟ็”จ็š„้ข„ๅ……ๅผๆณจๅฐ„ๅ™จ๏ผŒๆœ€ๅฅฝไธ่ฆๅœจๅžซๅœˆ็š„ๆป‘ๅŠจ้ƒจ็ญ‰้ƒจไฝๆถ‚ๆŠนๆถฆๆป‘ๅ‰‚ใ€‚
  • [0004]
    The gasket for solving the above-described problem is disclosed in . The gasket for solving the above-described problem is proposed by the present applicant as disclosed in . In this gasket, at least the periphery of the gasket body is covered with the film formed of fluororesin having a lower coefficient of friction than the gasket body. Supposing that the surface roughness of the resin film on the outer tube side thereof is defined as Ra1 and that the surface roughness of the resin film on the gasket body side thereof is defined as Ra2, the relationship of 1.5Ra1 โ‰ฆ Ra2 is satisfied. That the surface roughness Ra1 is preferably in the range of 0.1 to 1.5ยตm is described in the specification.
    ็”จไบŽ่งฃๅ†ณไธŠ่ฟฐ้—ฎ้ข˜็š„ๅžซ็‰‡ๅทฒๅœจ ไธญๅ…ฌๅผ€ใ€‚็”จไบŽ่งฃๅ†ณไธŠ่ฟฐ้—ฎ้ข˜็š„ๅžซ็‰‡็”ฑๆœฌ็”ณ่ฏทไบบๆๅ‡บ๏ผŒๅนถๅทฒๅœจ ไธญๅ…ฌๅผ€ใ€‚ ๅœจ่ฏฅๅžซๅœˆไธญ๏ผŒ่‡ณๅฐ‘ๅžซๅœˆไธปไฝ“็š„ๅ‘จๅ›ด่ฆ†็›–ๆœ‰็”ฑๆ‘ฉๆ“ฆ็ณปๆ•ฐไฝŽไบŽๅžซๅœˆไธปไฝ“็š„ๆฐŸๆ ‘่„‚ๅˆถๆˆ็š„่–„่†œใ€‚ๅ‡่ฎพๅค–็ฎกไพงๆ ‘่„‚่–„่†œ็š„่กจ้ข็ฒ—็ณ™ๅบฆๅฎšไน‰ไธบ Ra 1 ๏ผŒๅžซๅœˆไธปไฝ“ไพงๆ ‘่„‚่–„่†œ็š„่กจ้ข็ฒ—็ณ™ๅบฆๅฎšไน‰ไธบ Ra 2 ๏ผŒๅˆ™ๆปก่ถณ 1.5Ra 1 โ‰ฆRa 2 ็š„ๅ…ณ็ณปใ€‚่ฏดๆ˜Žไนฆไธญ่ฎฐ่ฝฝไบ†่กจ้ข็ฒ—็ณ™ๅบฆ Ra 1 ็š„ไผ˜้€‰่Œƒๅ›ดไธบ 0.1 ่‡ณ 1.5ฮผmใ€‚
  • [0005]
    In the medical appliance disclosed in ) the inner surface and/or the surface of the base material to be treated is coated with the polymeric material containing carbon nanotube or (B) the thin film formed of the polymeric material containing the carbon nanotube is bonded to the inner surface and/or the surface of the base material to be treated.
    ๅœจ๏ผˆB๏ผ‰ๆ‰€ๅ…ฌๅผ€็š„ๅŒป็–—ๅ™จๆขฐไธญ๏ผŒๅพ…ๅค„็†็š„ๅŸบๆ็š„ๅ†…่กจ้ขๅ’Œ/ๆˆ–่กจ้ขๆถ‚่ฆ†ๆœ‰ๅซๆœ‰็ขณ็บณ็ฑณ็ฎก็š„่šๅˆ็‰ฉๆๆ–™๏ผŒๆˆ–่€…๏ผˆB๏ผ‰ๅฐ†็”ฑๅซๆœ‰็ขณ็บณ็ฑณ็ฎก็š„่šๅˆ็‰ฉๆๆ–™ๅฝขๆˆ็š„่–„่†œ็ป“ๅˆๅˆฐๅพ…ๅค„็†็š„ๅŸบๆ็š„ๅ†…่กจ้ขๅ’Œ/ๆˆ–่กจ้ขไธŠใ€‚
  • [0006]
    The gasket disclosed in and in works on a sufficiently high effect in dependence on a use condition. But there is a growing demand for the development of a gasket which has a basic function of preventing leak of a liquid when the gasket is subjected to a strict condition, for example, when an injection liquid containing a surface active agent is accommodated in the pre-filled syringe and when a medicine is administered under a high pressure. In addition this gasket is demanded to have a high degree of slidableness without using the lubricant such as the silicone oil.
    ๅ’Œไธญๅ…ฌๅผ€็š„ๅžซ็‰‡ ๆ นๆฎไฝฟ็”จๆกไปถ๏ผŒๅžซ็‰‡่ƒฝๅคŸๅ‘ๆŒฅ่ถณๅคŸ้ซ˜็š„ๆ•ˆๆžœใ€‚ไฝ†ๆ—ฅ็›Šๅขž้•ฟ็š„้œ€ๆฑ‚ๆ˜ฏ๏ผŒๅผ€ๅ‘ไธ€็งๅžซ็‰‡๏ผŒๅ…ถๅŸบๆœฌๅŠŸ่ƒฝๆ˜ฏ้˜ฒๆญขๅœจไธฅ่‹›ๆกไปถไธ‹๏ผˆไพ‹ๅฆ‚๏ผŒๅฝ“้ข„ๅ……ๅผๆณจๅฐ„ๅ™จไธญ่ฃ…ๆœ‰ๅซๆœ‰่กจ้ขๆดปๆ€งๅ‰‚็š„ๆณจๅฐ„ๆถฒๆ—ถ๏ผŒไปฅๅŠๅœจ้ซ˜ๅŽ‹ไธ‹ๆณจๅฐ„่ฏ็‰ฉๆ—ถ๏ผ‰ๅ‘็”Ÿๆถฒไฝ“ๆณ„ๆผใ€‚ๆญคๅค–๏ผŒ่ฟ™็งๅžซโ€‹โ€‹็‰‡่ฟ˜่ฆๆฑ‚ๅœจไธไฝฟ็”จ็ก…ๆฒน็ญ‰ๆถฆๆป‘ๅ‰‚็š„ๆƒ…ๅ†ตไธ‹ๅ…ทๆœ‰่พƒ้ซ˜็š„ๆป‘ๅŠจๆ€งใ€‚
  • [0007]
    There is a growing demand for the development of a medical appliance which has a high degree of slidableness and very accurate and stable medicine-discharge performance. When a liquid medicine is discharged from a pre-filled syringe by operating a syringe pump at a speed so low (for example, moving speed is about 2mm/hour when liquid medicine is discharged at 1mL/hour from syringe having diameter of 24mm) that the movement of the pump is unvisible, there may occur a discharge state called pulsation. In this case, there is a fear that the liquid medicine is prevented from being accurately administered.
    ไบบไปฌๅฏนๅผ€ๅ‘ไธ€็งๅ…ทๆœ‰้ซ˜ๅบฆๆป‘ๅŠจๆ€งๅ’Œ้ซ˜ๅบฆ็ฒพ็กฎ็จณๅฎš็š„่ฏ็‰ฉๆŽ’ๅ‡บๆ€ง่ƒฝ็š„ๅŒป็–—ๅ™จๆขฐ็š„้œ€ๆฑ‚ๆ—ฅ็›Šๅขž้•ฟใ€‚ๅฝ“ไฝฟ็”จๆณจๅฐ„ๆณตไปฅๆžไฝŽ็š„้€Ÿๅบฆ๏ผˆไพ‹ๅฆ‚๏ผŒๅฝ“่ฏๆถฒไปฅ1ๆฏซๅ‡/ๅฐๆ—ถ็š„้€ŸๅบฆไปŽ็›ดๅพ„24ๆฏซ็ฑณ็š„ๆณจๅฐ„ๅ™จไธญๆŽ’ๅ‡บๆ—ถ๏ผŒๅ…ถ็งปๅŠจ้€Ÿๅบฆ็บฆไธบ2ๆฏซ็ฑณ/ๅฐๆ—ถ๏ผ‰ไปŽ้ข„ๅ……ๅผๆณจๅฐ„ๅ™จไธญๆŽ’ๅ‡บ่ฏๆถฒๆ—ถ๏ผŒๅฏ่ƒฝไผšๅ‡บ็Žฐไธ€็ง็งฐไธบ่„‰ๅŠจ็š„ๆŽ’ๅ‡บ็Šถๆ€ใ€‚ๅœจ่ฟ™็งๆƒ…ๅ†ตไธ‹๏ผŒไบบไปฌๆ‹…ๅฟƒ่ฏๆถฒ็š„็ป™่ฏ็ฒพๅบฆไผšๅ—ๅˆฐๅฝฑๅ“ใ€‚
  • [0008]
    The thin film disclosed in is effective to some extent in that the thin film is biocompatible, flexible, and resistant to kink, but is unpreferable in its slidableness.
    ๆ‰€ๅ…ฌๅผ€็š„่–„่†œๅœจ็”Ÿ็‰ฉ็›ธๅฎนๆ€งใ€ๆŸ”้Ÿงๆ€งๅ’ŒๆŠ—ๆ‰ญ็ป“ๆ€งๆ–น้ขๅ…ทๆœ‰ไธ€ๅฎš็จ‹ๅบฆ็š„ๆœ‰ๆ•ˆๆ€ง๏ผŒไฝ†ๅ…ถๆป‘ๅŠจๆ€งๅนถไธ็†ๆƒณใ€‚
  • [0009]
    The present invention has been made to solve the above-described problem. Therefore it is an object of the present invention to provide a medical appliance-coating composition capable of imparting a stable slidableness to a medical appliance without imparting a lubricant to the surface thereof. It is another object of the present invention to provide a medical appliance on which a slidable coating film having a stable slidable surface is formed.
    ๆœฌๅ‘ๆ˜Žๆญฃๆ˜ฏไธบไบ†่งฃๅ†ณไธŠ่ฟฐ้—ฎ้ข˜่€Œๅšๅ‡บ็š„ใ€‚ๆœฌๅ‘ๆ˜Ž็š„็›ฎ็š„ๅœจไบŽๆไพ›ไธ€็งๅŒป็–—ๅ™จๆขฐ็”จๆถ‚ๆ–™็ป„ๅˆ็‰ฉ๏ผŒ่ฏฅ็ป„ๅˆ็‰ฉๆ— ้œ€ๅœจๅŒป็–—ๅ™จๆขฐ่กจ้ขๆทปๅŠ ๆถฆๆป‘ๅ‰‚๏ผŒๅณๅฏ่ต‹ไบˆๅŒป็–—ๅ™จๆขฐ็จณๅฎš็š„ๆป‘ๅŠจๆ€งใ€‚ๆœฌๅ‘ๆ˜Ž็š„ๅฆไธ€็›ฎ็š„ๅœจไบŽๆไพ›ไธ€็งๅŒป็–—ๅ™จๆขฐ๏ผŒ่ฏฅๅŒป็–—ๅ™จๆขฐไธŠๅฝขๆˆไบ†ๅ…ทๆœ‰็จณๅฎšๆป‘ๅŠจ่กจ้ข็š„ๆป‘ๅŠจๆถ‚่†œใ€‚
  • [0010]
    The object described above is attained by the following a medical appliance-coating composition.
    ไธŠ่ฟฐ็›ฎ็š„้€š่ฟ‡ไปฅไธ‹ๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉๅฎž็Žฐใ€‚
  • [0011]
    A medical appliance-coating composition, for imparting slidableness to said medical appliance, which contains a solvent-based silicone rubber, carbon nanotubes, and fine particles of silicone resin.
    ไธ€็งๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉ๏ผŒ็”จไบŽ่ต‹ไบˆๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐๆป‘ๅŠจๆ€ง๏ผŒๅ…ถๅŒ…ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถใ€็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚็ป†้ข—็ฒ’ใ€‚
  • [0012]
    A medical appliance, having a slidable coating film formed thereon, which moves in contact with an inner surface of a medical member or an inner surface of a body lumen, wherein said slidable coating film is disposed at a portion, of said medical appliance, which contacts said medical member or said body lumen; and said slidable coating film is comprised of silicone rubber, carbon nanotubes and fine particles of silicone resin.
    ไธ€็งๅŒป็–—ๅ™จๆขฐ๏ผŒๅ…ถไธŠๅฝขๆˆๆœ‰ๅฏๆป‘ๅŠจ็š„ๆถ‚่†œ๏ผŒ่ฏฅๆถ‚่†œไธŽๅŒป็–—ๆž„ไปถ็š„ๅ†…่กจ้ขๆˆ–ไฝ“่…”็š„ๅ†…่กจ้ขๆŽฅ่งฆๅนถ็งปๅŠจ๏ผŒๅ…ถไธญๆ‰€่ฟฐๅฏๆป‘ๅŠจ็š„ๆถ‚่†œ่ฎพ็ฝฎๅœจๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐไธŽๆ‰€่ฟฐๅŒป็–—ๆž„ไปถๆˆ–ๆ‰€่ฟฐไฝ“่…”ๆŽฅ่งฆ็š„้ƒจๅˆ†๏ผ›ๅนถไธ”ๆ‰€่ฟฐๅฏๆป‘ๅŠจ็š„ๆถ‚่†œ็”ฑ็ก…ๆฉก่ƒถใ€็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚็š„็ป†้ข—็ฒ’ๆž„ๆˆใ€‚
    • Fig.1 is a front view showing a gasket for use in a syringe, of an embodiment of a medical appliance of the present invention.
      ๅ›พ1ๆ˜ฏ็คบๅ‡บๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐ็š„ไธ€ไธชๅฎžๆ–ฝๆ–นๅผ็š„ๆณจๅฐ„ๅ™จ็”จๅžซๅœˆ็š„ไธป่ง†ๅ›พใ€‚
    • Fig. 2 is a sectional view showing the gasket shown in Fig.1.
      ๅ›พ2ๆ˜ฏๅ›พ1ๆ‰€็คบๅžซๅœˆ็š„ๅ‰–้ขๅ›พใ€‚
    • Fig. 3 is a top view showing the gasket shown in Fig.1.
      ๅ›พ3ๆ˜ฏๅ›พ1ๆ‰€็คบๅžซๅœˆ็š„ไฟฏ่ง†ๅ›พใ€‚
    • Fig. 4 is a bottom view showing the gasket shown in Fig.1.
      ๅ›พ4ๆ˜ฏๅ›พ1ๆ‰€็คบๅžซๅœˆ็š„ไปฐ่ง†ๅ›พใ€‚
    • Fig. 5 is a sectional view showing a pre-filled syringe of an embodiment of the present invention.
      ๅ›พ5ไธบ่กจ็คบๆœฌๅ‘ๆ˜Žไธ€ๅฎžๆ–ฝไพ‹็š„้ข„ๅ……ๅผๆณจๅฐ„ๅ™จ็š„ๅ‰–้ขๅ›พใ€‚
    • Fig. 6 is a sectional view showing a guide wire of an embodiment of the medical appliance of the present invention.
      ๅ›พ6ไธบ่กจ็คบๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐ็š„ไธ€ไธชๅฎžๆ–ฝไพ‹็š„ๅฏผไธ็š„ๅ‰–้ขๅ›พใ€‚
    • Fig. 7 is a table 1a showing components of medical appliance-coating compositions of examples of the present invention and compounding ratio thereof.
      ๅ›พ 7 ไธบ่กจ็คบๆœฌๅ‘ๆ˜Ž็š„ๅฎžๆ–ฝไพ‹็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉ็š„ๆˆๅˆ†ๅŠๅ…ถ้…ๅˆๆฏ”็š„่กจ 1aใ€‚
    • Fig. 8 is a table 1b showing components of medical appliance-coating compositions of comparison examples and compounding ratio thereof.
      ๅ›พ 8 ไธบ่กจ็คบๆฏ”่พƒไพ‹็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉ็š„ๆˆๅˆ†ๅŠๅ…ถ้…ๅˆๆฏ”็š„่กจ 1bใ€‚
    • Fig. 9 shows the surface of a slidable coating film which is formed by applying a medical appliance-coating composition of an example 1 to a substrate and is photographed by an electron microscope.
      ๅ›พ9ๆ˜ฏๅฐ†ๅฎžๆ–ฝไพ‹1็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉๆถ‚ๅธƒไบŽๅŸบๆไธŠ่€Œๅฝขๆˆ็š„ๆป‘ๅŠจๆ€งๆถ‚่†œ็š„่กจ้ข็š„็”ตๅญๆ˜พๅพฎ้•œ็…ง็‰‡ใ€‚
    • Fig. 10 shows the surface of a guide wire of an example 18 photographed by an electron microscope.
      ๅ›พ10็คบๅ‡บไบ†้€š่ฟ‡็”ตๅญๆ˜พๅพฎ้•œๆ‹ๆ‘„็š„ๅฎžๆ–ฝไพ‹18็š„ๅฏผไธ่กจ้ขใ€‚
  • [0013]
    The medical appliance-coating composition (hereinafter often referred to as merely composition or slidable composition) of the present invention and the medical appliance of the present invention having a slidable coating film formed thereon will be described below. The medical appliance-coating composition of the present invention is a medical appliance-coating slidable composition
    ไปฅไธ‹๏ผŒๅฏนๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐ็”จๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉ๏ผˆไปฅไธ‹๏ผŒๆœ‰ๆ—ถ็ฎ€็งฐไธบ็ป„ๅˆ็‰ฉๆˆ–ๆป‘ๅŠจๆ€ง็ป„ๅˆ็‰ฉ๏ผ‰ไปฅๅŠๅฝขๆˆๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œ็š„ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐ่ฟ›่กŒ่ฏดๆ˜Žใ€‚ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐ็”จๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉไธบๅŒป็–—ๅ™จๆขฐ็”จๆป‘ๅŠจๆ€ง็ป„ๅˆ็‰ฉใ€‚
  • [0014]
    Initially the composition of the present invention is described below.
    ไธ‹้ข้ฆ–ๅ…ˆๅฏนๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉ่ฟ›่กŒ่ฏดๆ˜Žใ€‚
  • [0015]
    The composition of the present invention imparts slidableness to the medical appliance and contains solvent-based silicone rubber and in addition, carbon nanotubes and fine particles of silicone resin.
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉ่ต‹ไบˆๅŒป็–—ๅ™จๆขฐๆป‘ๅŠจๆ€ง๏ผŒๅนถไธ”ๅŒ…ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถไปฅๅŠ็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚็ป†้ข—็ฒ’ใ€‚
  • [0016]
    The composition of the present invention contains solvent-based silicone rubber as its main component and in addition, carbon nanotubes and fine particles of silicone resin.
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉไปฅๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถไธบไธป่ฆๆˆๅˆ†๏ผŒๅฆๅค–่ฟ˜ๅซๆœ‰็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚
  • [0017]
    A liquid organic polysiloxane compound is used as the solvent-based silicone rubber used for the composition of the present invention.
    ๆœฌๅ‘ๆ˜Ž็ป„ๅˆ็‰ฉไธญไฝฟ็”จ็š„ๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ้‡‡็”จๆถฒๆ€ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉใ€‚
  • [0018]
    The organic polysiloxane compound which is used in the present invention is a polymer containing a repeated structural unit of an organic silicone compound indicated by R1(R2)-Si-O in the backbone thereof. R1 and R2 denote lower alkyl groups having 1 to 8 carbons. As the organic polysiloxane compound, it is possible to use polyalkylsiloxanes (more specifically, polydimethylsiloxane, polyethylsiloxane, polymethylphenylsiloxane, and polydiphenylsiloxane), polyalkyl hydrogen siloxane, and substances having epoxy group, hydroxyl group, carboxylic group, vinyl group, amino group, alkoxy group or fluorine group introduced into ends or molecular chains of the above-described polymers.
    ๆœฌๅ‘ๆ˜Žไธญไฝฟ็”จ็š„ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉ๏ผŒๆ˜ฏๆŒ‡ๅœจไธป้“พไธŠๅซๆœ‰ไปฅ R1(R2)-Si-O ่กจ็คบ็š„ๆœ‰ๆœบ็ก…ๅŒ–ๅˆ็‰ฉ้‡ๅค็ป“ๆž„ๅ•ๅ…ƒ็š„่šๅˆ็‰ฉใ€‚R1 ๅ’Œ R2 ่กจ็คบ็ขณๅŽŸๅญๆ•ฐไธบ 1 ่‡ณ 8 ็š„ไฝŽ็บง็ƒทๅŸบใ€‚ไฝœไธบๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉ๏ผŒๅฏไปฅไฝฟ็”จ่š็ƒทๅŸบ็ก…ๆฐง็ƒท๏ผˆๆ›ดๅ…ทไฝ“ๅœฐ๏ผŒ่šไบŒ็”ฒๅŸบ็ก…ๆฐง็ƒทใ€่šไน™ๅŸบ็ก…ๆฐง็ƒทใ€่š็”ฒๅŸบ่‹ฏๅŸบ็ก…ๆฐง็ƒทๅ’Œ่šไบŒ่‹ฏๅŸบ็ก…ๆฐง็ƒท๏ผ‰ใ€่š็ƒทๅŸบๆฐข็ก…ๆฐง็ƒท๏ผŒไปฅๅŠๅœจไธŠ่ฟฐ่šๅˆ็‰ฉ็š„ๆœซ็ซฏๆˆ–ๅˆ†ๅญ้“พไธญๅผ•ๅ…ฅ็ŽฏๆฐงๅŸบใ€็พŸๅŸบใ€็พงๅŸบใ€ไน™็ƒฏๅŸบใ€ๆฐจๅŸบใ€็ƒทๆฐงๅŸบๆˆ–ๆฐŸๅŸบ็š„็‰ฉ่ดจใ€‚
  • [0019]
    As the organic polysiloxane compound, it is possible to use both homopolymer-type organic polysiloxane composed of one kind of a repeated structural unit and random-type, block-type or graft-type organic polysiloxane composed of a combination of not less than two kinds of repeated structural units.
    ไฝœไธบๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉ๏ผŒๅฏไปฅไฝฟ็”จ็”ฑไธ€็ง้‡ๅค็ป“ๆž„ๅ•ๅ…ƒๆž„ๆˆ็š„ๅ‡่š็‰ฉๅž‹ๆœ‰ๆœบ่š็ก…ๆฐง็ƒท๏ผŒไปฅๅŠ็”ฑไธค็งไปฅไธŠ้‡ๅค็ป“ๆž„ๅ•ๅ…ƒ็š„็ป„ๅˆๆž„ๆˆ็š„ๆ— ่ง„ๅž‹ใ€ๅตŒๆฎตๅž‹ๆˆ–ๆŽฅๆžๅž‹ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทใ€‚
  • [0020]
    As the organic silicone compound constituting the repeated structural unit, it is possible to list methyltrimethoxysilane, methyltriethoxysilane, methyltriisopropoxysilane, methyltri-t-butoxysilane, methyltrichlorosilane, methyltribromosilane; ethyltrimethoxysilane, ethyltriethoxysilane, ethyltriisopropoxysilane, ethyltri-t-butoxysilane, ethytrichlorosilane, ethyltribromosilane; n-propyltrimethoxysilane, n-propyltriethoxysilane, n-propyltriisopropoxysilane, n-propyltri-t-butoxysilane, n-propyltrichlorosilane, n-propyltribromosilane; n-hexyltrimethoxysilane, n-hexyltriethoxysilane, n-hexyltriisopropoxysilane, n-hexyltri-t-butoxysilane, n-hexyltrichlorosilane, n-hexyltribromosilane; n-decyltrimethoxysilane, n-decyltriethoxysilane, n-decyltriisopropoxysilane, n-decyltri-t-butoxysilane, n-decyltrichlorosilane, n-decyltribromosilane; n-octadecyltrimethoxysilane, n-octadecyltriethoxysilane, n-octadecyltriisopropoxysilane, n-octadecyltri-t-butoxysilane, n-octadecyltrichlorosilane, n-octadecyltribromosilane, tetramethoxysilane, tetraethoxysilane, tetrabutoxysilane, dimethoxydiethoxysilane; dimethyldimethoxysilane, dimethyldiethoxysilane, ฮณ-glycydoxypropylmethyldimethoxysilane, ฮณ-glycydoxypropylmethyldiethoxysilane, ฮณ -glycydoxypropyltrimethoxysilane, ฮณ -glycydoxypropyltriethoxysilane, ฮณ -glycydoxypropyltriisopropoxysilane, and ฮณ -glycydoxypropyltri-t-butoxysilane.
    ไฝœไธบๆž„ๆˆ้‡ๅค็ป“ๆž„ๅ•ๅ…ƒ็š„ๆœ‰ๆœบ็ก…ๅŒ–ๅˆ็‰ฉ๏ผŒๅฏไปฅๅˆ—ไธพ็”ฒๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€็”ฒๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€็”ฒๅŸบไธ‰ๅผ‚ไธ™ๆฐงๅŸบ็ก…็ƒทใ€็”ฒๅŸบไธ‰ๅ”ไธๆฐงๅŸบ็ก…็ƒทใ€็”ฒๅŸบไธ‰ๆฐฏ็ก…็ƒทใ€็”ฒๅŸบไธ‰ๆบด็ก…็ƒท๏ผ›ไน™ๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€ไน™ๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€ไน™ๅŸบไธ‰ๅผ‚ไธ™ๆฐงๅŸบ็ก…็ƒทใ€ไน™ๅŸบไธ‰ๅ”ไธๆฐงๅŸบ็ก…็ƒทใ€ไน™ๅŸบไธ‰ๆฐฏ็ก…็ƒทใ€ไน™ๅŸบไธ‰ๆบด็ก…็ƒท๏ผ›ๆญฃไธ™ๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€ๆญฃไธ™ๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€ๆญฃไธ™ๅŸบไธ‰ๅผ‚ไธ™ๆฐงๅŸบ็ก…็ƒทใ€ๆญฃไธ™ๅŸบไธ‰ๅ”ไธๆฐงๅŸบ็ก…็ƒทใ€ๆญฃไธ™ๅŸบไธ‰ๆฐฏ็ก…็ƒทใ€ๆญฃไธ™ๅŸบไธ‰ๆบด็ก…็ƒท๏ผ›ๆญฃๅทฑๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€ๆญฃๅทฑๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€ๆญฃๅทฑๅŸบไธ‰ๅผ‚ไธ™ๆฐงๅŸบ็ก…็ƒทใ€ๆญฃๅทฑๅŸบไธ‰ๅ”ไธๆฐงๅŸบ็ก…็ƒทใ€ๆญฃๅทฑๅŸบไธ‰ๆฐฏ็ก…็ƒทใ€ๆญฃๅทฑๅŸบไธ‰ๆบด็ก…็ƒท๏ผ›ๆญฃ็™ธๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€ๆญฃ็™ธๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€ๆญฃ็™ธๅŸบไธ‰ๅผ‚ไธ™ๆฐงๅŸบ็ก…็ƒทใ€ๆญฃ็™ธๅŸบไธ‰ๅ”ไธๆฐงๅŸบ็ก…็ƒทใ€ๆญฃ็™ธๅŸบไธ‰ๆฐฏ็ก…็ƒทใ€ๆญฃ็™ธๅŸบไธ‰ๆบด็ก…็ƒท๏ผ›ๆญฃๅๅ…ซ็ƒทๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€ๆญฃๅๅ…ซ็ƒทๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€ๆญฃๅๅ…ซ็ƒทๅŸบไธ‰ๅผ‚ไธ™ๆฐงๅŸบ็ก…็ƒทใ€ๆญฃๅๅ…ซ็ƒทๅŸบไธ‰ๅ”ไธๆฐงๅŸบ็ก…็ƒทใ€ๆญฃๅๅ…ซ็ƒทๅŸบไธ‰ๆฐฏ็ก…็ƒทใ€ๆญฃๅๅ…ซ็ƒทๅŸบไธ‰ๆบด็ก…็ƒทใ€ๅ››็”ฒๆฐงๅŸบ็ก…็ƒทใ€ๅ››ไน™ๆฐงๅŸบ็ก…็ƒทใ€ๅ››ไธๆฐงๅŸบ็ก…็ƒทใ€ไบŒ็”ฒๆฐงๅŸบไบŒไน™ๆฐงๅŸบ็ก…็ƒท๏ผ›ไบŒ็”ฒๅŸบไบŒ็”ฒๆฐงๅŸบ็ก…็ƒทใ€ไบŒ็”ฒๅŸบไบŒไน™ๆฐงๅŸบ็ก…็ƒทใ€ฮณ-็ผฉๆฐด็”˜ๆฒนๆฐงไธ™ๅŸบ็”ฒๅŸบไบŒ็”ฒๆฐงๅŸบ็ก…็ƒทใ€ฮณ-็ผฉๆฐด็”˜ๆฒนๆฐงไธ™ๅŸบ็”ฒๅŸบไบŒไน™ๆฐงๅŸบ็ก…็ƒทใ€ฮณ-็ผฉๆฐด็”˜ๆฒนๆฐงไธ™ๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€ฮณ-็ผฉๆฐด็”˜ๆฒนๆฐงไธ™ๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€ฮณ-็ผฉๆฐด็”˜ๆฒนๆฐงไธ™ๅŸบไธ‰ๅผ‚ไธ™ๆฐงๅŸบ็ก…็ƒทใ€ฮณ-็ผฉๆฐด็”˜ๆฒนๆฐงไธ™ๅŸบไธ‰ๅ”ไธๆฐงๅŸบ็ก…็ƒทใ€‚
  • [0021]
    An organic solvent is used for the composition of the present invention. Toluene, xylene, and the like are used as the organic solvent Although the content of the solvent-based silicone rubber is different according to the content of a nonvolatile content thereof, it is preferable that the solvent-based silicone rubber is contained at 5 to 40 wt% in the composition containing the organic solvent The content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the medical appliance-coating composition containing the organic solvent is set favorably to the range of 0.5 to 20 wt% and more favorably to the range of 10 to 70 wt%.
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉไธญไฝฟ็”จๆœ‰ๆœบๆบถๅ‰‚ใ€‚ไฝœไธบๆœ‰ๆœบๆบถๅ‰‚๏ผŒๅฏไฝฟ็”จ็”ฒ่‹ฏใ€ไบŒ็”ฒ่‹ฏ็ญ‰ใ€‚ๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„ๅซ้‡ๆ นๆฎๅ…ถไธๆŒฅๅ‘ๆˆๅˆ†็š„ๅซ้‡่€ŒไธๅŒ๏ผŒไผ˜้€‰ๅœจๅซๆœ‰ๆœ‰ๆœบๆบถๅ‰‚็š„็ป„ๅˆ็‰ฉไธญ๏ผŒๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„ๅซ้‡ไธบ5่‡ณ40้‡้‡๏ผ…ใ€‚ๅซๆœ‰ๆœ‰ๆœบๆบถๅ‰‚็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉไธญ๏ผŒไฝœไธบๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถไธๆŒฅๅ‘ๆˆๅˆ†็š„ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉ็š„ๅซ้‡ไผ˜้€‰ไธบ0.5่‡ณ20้‡้‡๏ผ…๏ผŒๆ›ดไผ˜้€‰ไธบ10่‡ณ70้‡้‡๏ผ…ใ€‚
  • [0022]
    Carbon nanotubes are contained in the composition of the present invention.
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉๅซๆœ‰็ขณ็บณ็ฑณ็ฎกใ€‚
  • [0023]
    The carbon nanotube is cylindrically formed of a network (graphene sheet) of six-membered rings made of carbon. The carbon nanotube is classified into a single-layer carbon nanotube and a multi-layer carbon nanotube.
    ็ขณ็บณ็ฑณ็ฎกๆ˜ฏ็”ฑ็ขณๆž„ๆˆ็š„ๅ…ญๅ…ƒ็Žฏ็ฝ‘็ปœ๏ผˆ็Ÿณๅขจ็ƒฏ็‰‡๏ผ‰ๆž„ๆˆ็š„ๅœ†ๆŸฑ็Šถ็ป“ๆž„ใ€‚็ขณ็บณ็ฑณ็ฎกๅˆ†ไธบๅ•ๅฑ‚็ขณ็บณ็ฑณ็ฎกๅ’Œๅคšๅฑ‚็ขณ็บณ็ฑณ็ฎกใ€‚
  • [0024]
    In the present invention, it is possible to use the single-layer carbon nanotube or/and the multi-layer carbon nanotube. The carbon nanotube which is used in the present invention is the multi-layer carbon nanotube having an average diameter less than 800nm and preferably 10 to 250nm and an average fiber length less than 2mm and preferably in the range of 0.001 to 1mm. The carbon nanotube is contained in the composition in the range of 0.01 to 2 wt% and preferably in the range of 0.01 to 1 wt%. The content of the carbon nanotube contained in the composition is favorably 1/3000 to 1/16 and more favorably 1/1000 to 1/30 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
    ๆœฌๅ‘ๆ˜Žไธญ๏ผŒๅฏไปฅไฝฟ็”จๅ•ๅฑ‚็ขณ็บณ็ฑณ็ฎกๆˆ–/ๅ’Œๅคšๅฑ‚็ขณ็บณ็ฑณ็ฎกใ€‚ๆœฌๅ‘ๆ˜Žไธญไฝฟ็”จ็š„็ขณ็บณ็ฑณ็ฎกไธบๅคšๅฑ‚็ขณ็บณ็ฑณ็ฎก๏ผŒๅ…ถๅนณๅ‡็›ดๅพ„ๅฐไบŽ800็บณ็ฑณ๏ผŒไผ˜้€‰ไธบ10่‡ณ250็บณ็ฑณ๏ผŒๅนณๅ‡็บค็ปด้•ฟๅบฆๅฐไบŽ2ๆฏซ็ฑณ๏ผŒไผ˜้€‰ไธบ0.001่‡ณ1ๆฏซ็ฑณใ€‚็ขณ็บณ็ฑณ็ฎกๅœจ็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไธบ0.01่‡ณ2้‡้‡๏ผ…๏ผŒไผ˜้€‰ไธบ0.01่‡ณ1้‡้‡๏ผ…ใ€‚็ป„ๅˆ็‰ฉไธญ็ขณ็บณ็ฑณ็ฎก็š„ๅซ้‡ไผ˜้€‰ไธบๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉๅซ้‡็š„1/3000่‡ณ1/16๏ผŒๆ›ดไผ˜้€‰ไธบ1/1000่‡ณ1/30๏ผŒๆ‰€่ฟฐๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉๆ˜ฏ็ป„ๅˆ็‰ฉไธญๆ‰€ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„้žๆŒฅๅ‘ๆ€งๆˆๅˆ†ใ€‚
  • [0025]
    The slidable composition of the present invention contains fine particles of silicone resin. The size of the fine particle of the silicone resin is in the range of 0.5 to 30ยตm, favorably in the range of 1 to 10ยตm, and more favorably in the range of 2 to 8ยตm. The fine particle of the silicone resin is adhesive to the component of the solvent-based silicone rubber. Fine particles of the silicone resin called organopolysiloxane containing dimethylpolysiloxane therein as its main component is preferable. The fine particle of the silicone resin may contain functional groups such as a vinyl group, an epoxy group, an amino group, and the like. The fine particles of the silicone resin having a structure in which a siloxane bond is crosslinked in a three-dimensional network, namely, the structure of polymethyl silsesquioxane is especially favorable. The silicone resin may consist of fine particles of one kind thereof or in combination of two or more kinds thereof.
    ๆœฌๅ‘ๆ˜Ž็š„ๆป‘ๅŠจๆ€ง็ป„ๅˆ็‰ฉๅซๆœ‰็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„ๅฐบๅฏธๅœจ 0.5 ่‡ณ 30ฮผm ่Œƒๅ›ดๅ†…๏ผŒไผ˜้€‰ๅœจ 1 ่‡ณ 10ฮผm ่Œƒๅ›ดๅ†…๏ผŒๆ›ดไผ˜้€‰ๅœจ 2 ่‡ณ 8ฮผm ่Œƒๅ›ดๅ†…ใ€‚็ก…ๆ ‘่„‚ๅพฎ็ฒ’ไธŽๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถๆˆๅˆ†ๅ…ทๆœ‰็ฒ˜ๅˆๆ€งใ€‚ไผ˜้€‰ไปฅไบŒ็”ฒๅŸบ่š็ก…ๆฐง็ƒทไธบไธป่ฆๆˆๅˆ†็š„ๆœ‰ๆœบ่š็ก…ๆฐง็ƒท็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚็ก…ๆ ‘่„‚ๅพฎ็ฒ’ๅฏไปฅๅซๆœ‰ไน™็ƒฏๅŸบใ€็ŽฏๆฐงๅŸบใ€ๆฐจๅŸบ็ญ‰ๅฎ˜่ƒฝๅ›ขใ€‚ๅฐคๅ…ถไผ˜้€‰ๅ…ทๆœ‰็ก…ๆฐง็ƒท้”ฎไบค่”ๆˆไธ‰็ปด็ฝ‘็ปœ็ป“ๆž„๏ผˆๅณ่š็”ฒๅŸบๅ€ๅŠ็ก…ๆฐง็ƒท็ป“ๆž„๏ผ‰็š„็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚็ก…ๆ ‘่„‚ๅฏไปฅ็”ฑไธ€็งๆˆ–ไธค็งไปฅไธŠๅพฎ็ฒ’็ป„ๅˆ่€Œๆˆใ€‚
  • [0026]
    It is preferable that the fine particles of the silicone resin are contained at 0.2 to 50 wt% and favorably 1 to 20 wt% in the composition. The fine particles of the silicone resin are contained in the composition at favorably 1/150 to 1/1 and more favorably 1/30 to 1/1.5 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
    ไผ˜้€‰็ป„ๅˆ็‰ฉไธญ็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„ๅซ้‡ไธบ0.2่‡ณ50้‡้‡๏ผ…๏ผŒๆ›ดไผ˜้€‰ไธบ1่‡ณ20้‡้‡๏ผ…ใ€‚ไผ˜้€‰็ป„ๅˆ็‰ฉไธญ็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„ๅซ้‡ไธบ็ป„ๅˆ็‰ฉไธญๆ‰€ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„ไธๆŒฅๅ‘ๆˆๅˆ†โ€”โ€”ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉๅซ้‡็š„1/150่‡ณ1/1๏ผŒๆ›ดไผ˜้€‰ไธบ1/30่‡ณ1/1.5ใ€‚
  • [0027]
    It is preferable that the composition of the present invention contains a surface active agent (in other words, surfactant).
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉไผ˜้€‰ๅซๆœ‰่กจ้ขๆดปๆ€งๅ‰‚(ๆข่จ€ไน‹๏ผŒ่กจ้ขๆดปๆ€งๅ‰‚)ใ€‚
  • [0028]
    As the surface active agent, a nonionic surface active agent is preferable. As the nonionic surface active agent, it is possible to use polyoxyethylenealkylphenyl ethers having alkyl groups such as octyl, nonyl, dodecyl; polyoxyethylenealkyl ethers having alkyl groups such as octyl, lauryl, cetyl, stearyl, and oleyl; polyethylene glycol fatty esters such as monooleate, monostearate, distearate, monolaurate of polyethylene glycol; polyoxyethylenealkylamines having the alkyl group such as the lauryl, the stearyl, and the oleyl; sorbitan fatty esters such as sorbitan sesquioleate, sorbitan sesquiisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan distearate, sorbitan tristearate, sorbitan monooleate, sorbitan trioleate; polyoxyethylene sorbitan fatty esters such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan trioleate, and polyoxyethylene sorbitan of fatty ester of coconut oil; polyethylene glycol ethers, fatty diethanolamides such as diethanolamide laurate; sucrose fatty esters; fatty monoglycerides such as monoglyceride laurate, monoglyceride stearate, monoglyceride oleate; polyoxyethylene fatty amides such as polyoxyethylene lauramide, polyoxyethylene stearamide, polyoxyethylene oleamide; and polyoxyethylene castor oil, polyoxyethylene hardened castor oil.
    ไฝœไธบ่กจ้ขๆดปๆ€งๅ‰‚๏ผŒไผ˜้€‰้ž็ฆปๅญๅž‹่กจ้ขๆดปๆ€งๅ‰‚ใ€‚ไฝœไธบ้ž็ฆปๅญๅž‹่กจ้ขๆดปๆ€งๅ‰‚๏ผŒๅฏไปฅไฝฟ็”จๅ…ทๆœ‰่พ›ๅŸบใ€ๅฃฌๅŸบใ€ๅไบŒ็ƒทๅŸบ็ญ‰็ƒทๅŸบ็š„่šๆฐงไน™็ƒฏ็ƒทๅŸบ่‹ฏๅŸบ้†š๏ผ›ๅ…ทๆœ‰่พ›ๅŸบใ€ๆœˆๆก‚ๅŸบใ€้ฒธ่œกๅŸบใ€็กฌ่„‚ๅŸบใ€ๆฒนๅŸบ็ญ‰็ƒทๅŸบ็š„่šๆฐงไน™็ƒฏ็ƒทๅŸบ้†š๏ผ›่šไน™ไบŒ้†‡ๅ•ๆฒน้…ธ้…ฏใ€ๅ•็กฌ่„‚้…ธ้…ฏใ€ไบŒ็กฌ่„‚้…ธ้…ฏใ€ๅ•ๆœˆๆก‚้…ธ้…ฏ็ญ‰่šไน™ไบŒ้†‡่„‚่‚ช้…ธ้…ฏ๏ผ›ๅ…ทๆœ‰ๆœˆๆก‚ๅŸบใ€็กฌ่„‚ๅŸบใ€ๆฒนๅŸบ็ญ‰็ƒทๅŸบ็š„่šๆฐงไน™็ƒฏ็ƒทๅŸบ่ƒบ๏ผ›่„ฑๆฐดๅฑฑๆขจ้†‡ๅ€ๅŠๆฒน้…ธ้…ฏใ€่„ฑๆฐดๅฑฑๆขจ้†‡ๅ€ๅŠๅผ‚็กฌ่„‚้…ธ้…ฏใ€่„ฑๆฐดๅฑฑๆขจ้†‡ๅ•ๆœˆๆก‚้…ธ้…ฏใ€่„ฑๆฐดๅฑฑๆขจ้†‡ๅ•ๆฃ•ๆฆˆ้…ธ้…ฏใ€่„ฑๆฐดๅฑฑๆขจ้†‡ๅ•็กฌ่„‚้…ธ้…ฏใ€่„ฑๆฐดๅฑฑๆขจ้†‡ไบŒ็กฌ่„‚้…ธ้…ฏใ€่„ฑๆฐดๅฑฑๆขจ้†‡ไธ‰็กฌ่„‚้…ธ้…ฏใ€่„ฑๆฐดๅฑฑๆขจ้†‡ๅ•ๆฒน้…ธ้…ฏใ€่„ฑๆฐดๅฑฑๆขจ้†‡ไธ‰ๆฒน้…ธ้…ฏ็ญ‰่„ฑๆฐดๅฑฑๆขจ้†‡่„‚่‚ช้…ธ้…ฏ๏ผ›่šๆฐงไน™็ƒฏ่„ฑๆฐดๅฑฑๆขจ้†‡่„‚่‚ช้…ธ้…ฏ๏ผŒไพ‹ๅฆ‚่šๆฐงไน™็ƒฏ่„ฑๆฐดๅฑฑๆขจ้†‡ๅ•ๆœˆๆก‚้…ธ้…ฏใ€่šๆฐงไน™็ƒฏ่„ฑๆฐดๅฑฑๆขจ้†‡ๅ•ๆฃ•ๆฆˆ้…ธ้…ฏใ€่šๆฐงไน™็ƒฏ่„ฑๆฐดๅฑฑๆขจ้†‡ๅ•็กฌ่„‚้…ธ้…ฏใ€่šๆฐงไน™็ƒฏ่„ฑๆฐดๅฑฑๆขจ้†‡ไธ‰็กฌ่„‚้…ธ้…ฏใ€่šๆฐงไน™็ƒฏ่„ฑๆฐดๅฑฑๆขจ้†‡ๅ•ๆฒน้…ธ้…ฏใ€่šๆฐงไน™็ƒฏ่„ฑๆฐดๅฑฑๆขจ้†‡ไธ‰ๆฒน้…ธ้…ฏๅ’Œๆคฐๅญๆฒน่„‚่‚ช้…ธ้…ฏ็š„่šๆฐงไน™็ƒฏ่„ฑๆฐดๅฑฑๆขจ้†‡๏ผ›่šไน™ไบŒ้†‡้†š๏ผŒ่„‚่‚ช้…ธไบŒไน™้†‡้…ฐ่ƒบ๏ผŒไพ‹ๅฆ‚ไบŒไน™้†‡้…ฐ่ƒบๆœˆๆก‚้…ธ้…ฏ๏ผ›่”—็ณ–่„‚่‚ช้…ธ้…ฏ๏ผ›่„‚่‚ช้…ธๅ•็”˜ๆฒน้…ฏ๏ผŒไพ‹ๅฆ‚ๅ•็”˜ๆฒนๆœˆๆก‚้…ธ้…ฏใ€ๅ•็”˜ๆฒน็กฌ่„‚้…ธ้…ฏใ€ๅ•็”˜ๆฒนๆฒน้…ธ้…ฏ๏ผ›่šๆฐงไน™็ƒฏ่„‚่‚ช้…ฐ่ƒบ๏ผŒไพ‹ๅฆ‚่šๆฐงไน™็ƒฏๆœˆๆก‚้…ฐ่ƒบใ€่šๆฐงไน™็ƒฏ็กฌ่„‚้…ฐ่ƒบใ€่šๆฐงไน™็ƒฏๆฒน้…ฐ่ƒบ๏ผ›ไปฅๅŠ่šๆฐงไน™็ƒฏ่“–้บปๆฒนใ€่šๆฐงไน™็ƒฏ็กฌๅŒ–่“–้บปๆฒนใ€‚
  • [0029]
    The surface active agent is contained at 0.05 to 5 wt% and preferably 0.5 to 3 wt% in the composition. The surface active agent is contained in the composition at favorably 1/600 to 1/6 and more favorably 1/60 to 1/10 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
    ่กจ้ขๆดปๆ€งๅ‰‚ๅœจ็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไธบ0.05่‡ณ5้‡้‡๏ผ…๏ผŒไผ˜้€‰ไธบ0.5่‡ณ3้‡้‡๏ผ…ใ€‚่กจ้ขๆดปๆ€งๅ‰‚ๅœจ็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไผ˜้€‰ไธบ็ป„ๅˆ็‰ฉไธญๆ‰€ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„ไธๆŒฅๅ‘ๆˆๅˆ†โ€”โ€”ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉๅซ้‡็š„1/600่‡ณ1/6๏ผŒๆ›ดไผ˜้€‰ไธบ1/60่‡ณ1/10ใ€‚
  • [0030]
    It is preferable that the composition of the present invention contains an adhesion-improving agent A silane coupling agent is preferable as the adhesion-improving agent As the silane coupling agent it is possible to use an acrylic (methacrylic) functional silane coupling agent, an epoxy functional silane coupling agent, and an amino (imino) functional silane coupling agent
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉไผ˜้€‰ๅซๆœ‰็ฒ˜ๅˆๆ”น่ฟ›ๅ‰‚ใ€‚ไผ˜้€‰็ก…็ƒทๅถ่”ๅ‰‚ไฝœไธบ็ฒ˜ๅˆๆ”น่ฟ›ๅ‰‚ใ€‚ไฝœไธบ็ก…็ƒทๅถ่”ๅ‰‚๏ผŒๅฏไปฅไฝฟ็”จไธ™็ƒฏ้…ธ๏ผˆ็”ฒๅŸบไธ™็ƒฏ้…ธ๏ผ‰ๅฎ˜่ƒฝ็ก…็ƒทๅถ่”ๅ‰‚ใ€็Žฏๆฐงๅฎ˜่ƒฝ็ก…็ƒทๅถ่”ๅ‰‚ๅ’ŒๆฐจๅŸบ๏ผˆไบšๆฐจๅŸบ๏ผ‰ๅฎ˜่ƒฝ็ก…็ƒทๅถ่”ๅ‰‚ใ€‚
  • [0031]
    As the acrylic (methacrylic) functional silane coupling agent, it is possible to list 3-methacryloxypropyl trimethoxy silane, 3-methacryloxypropyl triethoxy silane, 3-acryloxypropyl trimethoxy silane, 3-acryloxypropyl triethoxy silane, methacryloxymethyl trimethoxy silane, methacryloxymethyl triethoxy silane, acryloxymethyl trimethoxy silane, and acryloxymethyl triethoxy silane.
    ไฝœไธบไธ™็ƒฏ้…ธ๏ผˆ็”ฒๅŸบไธ™็ƒฏ้…ธ๏ผ‰ๅฎ˜่ƒฝ็ก…็ƒทๅถ่”ๅ‰‚๏ผŒๅฏไปฅๅˆ—ไธพ3-็”ฒๅŸบไธ™็ƒฏ้…ฐๆฐงๅŸบไธ™ๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€3-็”ฒๅŸบไธ™็ƒฏ้…ฐๆฐงๅŸบไธ™ๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€3-ไธ™็ƒฏ้…ฐๆฐงๅŸบไธ™ๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€3-ไธ™็ƒฏ้…ฐๆฐงๅŸบไธ™ๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€็”ฒๅŸบไธ™็ƒฏ้…ฐๆฐงๅŸบ็”ฒๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€็”ฒๅŸบไธ™็ƒฏ้…ฐๆฐงๅŸบ็”ฒๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€ไธ™็ƒฏ้…ฐๆฐงๅŸบ็”ฒๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€ไธ™็ƒฏ้…ฐๆฐงๅŸบ็”ฒๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€‚
  • [0032]
    As the epoxy functional silane coupling agent, it is possible to list 3-glycidoxypropyltrimethoxysilane, 3-glycidoxypropyltriethoxysilane, 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane, and 2-(3,4-epoxycyclohexyl)ethyltriethoxysilane.
    ไฝœไธบ็Žฏๆฐงๅฎ˜่ƒฝ็ก…็ƒทๅถ่”ๅ‰‚๏ผŒๅฏไปฅๅˆ—ไธพ3-็Žฏๆฐงไธ™ๆฐงๅŸบไธ™ๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€3-็Žฏๆฐงไธ™ๆฐงๅŸบไธ™ๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€2-(3๏ผŒ4-็Žฏๆฐง็ŽฏๅทฑๅŸบ)ไน™ๅŸบไธ‰็”ฒๆฐงๅŸบ็ก…็ƒทใ€2-(3๏ผŒ4-็Žฏๆฐง็ŽฏๅทฑๅŸบ)ไน™ๅŸบไธ‰ไน™ๆฐงๅŸบ็ก…็ƒทใ€‚
  • [0033]
    As examples of the amino (imino) functional silane coupling agent it is possible to list alkoxysilane, containing an amino group and (or) an imino group, such as H2NCH2 CH2CH2Si(OCH3)3, H2NCH2CH2NHCH2CH2CH2Si(OCH3)3, H2NCH2CH2NHCH2CH2CH2Si(CH3)(OCH3)2, and (C2H5O)3Si(CH2)3NH(CH2)2NH(CH2)3Si(OC2H5)3 and products formed by reaction between the alkoxysilane containing the amino group and (or) the imino group and methacryloxy silane compounds such as CH2=C(CH3)COOCH2CH2CH2Si(OCH3)3, and CH2=C(CH3)COOCH2CH2CH2Si(OCH2CH2OCH3)3.
    ไฝœไธบๆฐจๅŸบ๏ผˆไบšๆฐจๅŸบ๏ผ‰ๅฎ˜่ƒฝ็ก…็ƒทๅถ่”ๅ‰‚็š„ไพ‹ๅญ๏ผŒๅฏไปฅๅˆ—ไธพๅซๆœ‰ๆฐจๅŸบๅ’Œ๏ผˆๆˆ–๏ผ‰ไบšๆฐจๅŸบ็š„็ƒทๆฐงๅŸบ็ก…็ƒท๏ผŒไพ‹ๅฆ‚ H 2 NCH 2 CH 2 CH 2 Si(OCH 3 ) 3 ใ€H 2 NCH 2 CH 2 NHCH 2 CH 2 CH 2 Si (OCH 3 ) 3 ใ€H 2 NCH 2 CH 2 NHCH 2 CH 2 CH 2 Si(CH 3 )(OCH 3 ) 2 ๅ’Œ (C 2 H 5 O) 3 Si(CH 2 ) 3 NH(CH 2 ) 2 NH(CH 2 ) 3 Si(OC 2 H 5 ) 3 ๏ผŒไปฅๅŠ็”ฑๅซๆœ‰ๆฐจๅŸบๅ’Œ๏ผˆๆˆ–๏ผ‰ไบšๆฐจๅŸบ็š„็ƒทๆฐงๅŸบ็ก…็ƒทไธŽ็”ฒๅŸบไธ™็ƒฏ้…ฐๆฐงๅŸบ็ก…็ƒทๅŒ–ๅˆ็‰ฉๅๅบ”ๅฝขๆˆ็š„ไบง็‰ฉ๏ผŒไพ‹ๅฆ‚ CH 2 =C(CH 3 )COOCH 2 CH 2 CH 2 Si(OCH 3 ) 3 ใ€CH 2 =C(CH 3 )COOCH 2 CH 2 CH 2 Si(OCH 2 CH 2 OCH 3 ) 3 ใ€‚
  • [0034]
    The silane coupling agent is contained in the composition favorably at 1/100 to 1/5 and more favorably at 3/100 to 1/10 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
    ็ก…็ƒทๅถ่”ๅ‰‚ๅœจ็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไผ˜้€‰ไธบๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉๅซ้‡็š„1/100่‡ณ1/5๏ผŒๆ›ดไผ˜้€‰ไธบ3/100่‡ณ1/10๏ผŒๆ‰€่ฟฐๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉๆ˜ฏ็ป„ๅˆ็‰ฉไธญๆ‰€ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„้žๆŒฅๅ‘ๆ€งๆˆๅˆ†ใ€‚
  • [0035]
    It is preferable that the composition of the present invention contains powder of the resin of the polyolefin family.
    ไผ˜้€‰ๅœฐ๏ผŒๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉๅซๆœ‰่š็ƒฏ็ƒƒๆ—ๆ ‘่„‚็š„็ฒ‰ๆœซใ€‚
  • [0036]
    As the fine particle of the resin of the polyolefin family, fine particles of polyethylene, polypropylene, and the like can be used. Fine particles of only one kind of the above-described synthetic resins or mixtures thereof may be used.
    ไฝœไธบ่š็ƒฏ็ƒƒ็ฑปๆ ‘่„‚ๅพฎ็ฒ’๏ผŒๅฏไปฅไฝฟ็”จ่šไน™็ƒฏใ€่šไธ™็ƒฏ็ญ‰ๅพฎ็ฒ’ใ€‚ไนŸๅฏไปฅไฝฟ็”จไธŠ่ฟฐๅˆๆˆๆ ‘่„‚ไธญ็š„ไธ€็งๆˆ–ๅฎƒไปฌ็š„ๆททๅˆ็‰ฉ็š„ๅพฎ็ฒ’ใ€‚
  • [0037]
    The size of the fine particle of the resin of the polyolefin family is set to the range of 0.5 to 10ยตm and favorably to the range of 2 to 8ยตm.
    ่š็ƒฏ็ƒƒ็ฑปๆ ‘่„‚็š„ๅพฎ็ฒ’ๅฐบๅฏธ่ฎพๅฎšไธบ 0.5๏ฝž10ฮผm ็š„่Œƒๅ›ด๏ผŒไผ˜้€‰ไธบ 2๏ฝž8ฮผm ็š„่Œƒๅ›ดใ€‚
  • [0038]
    The fine particles of the resin of the polyolefin family are contained in the composition at 0.1 to 50 wt% and favorably at 1 to 20 wt%. The fine particles of the resin of the polyolefin family is contained in the composition at favorably 1/150 to 1/1 and more favorably 1/30 to 1/1.5 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
    ่š็ƒฏ็ƒƒ็ฑปๆ ‘่„‚ๅพฎ็ฒ’ๅœจ็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไธบ0.1่‡ณ50้‡้‡๏ผ…๏ผŒไผ˜้€‰ไธบ1่‡ณ20้‡้‡๏ผ…ใ€‚่š็ƒฏ็ƒƒ็ฑปๆ ‘่„‚ๅพฎ็ฒ’ๅœจ็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไผ˜้€‰ไธบๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉ๏ผˆๅณ็ป„ๅˆ็‰ฉไธญๆ‰€ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„้žๆŒฅๅ‘ๆ€งๆˆๅˆ†๏ผ‰ๅซ้‡็š„1/150่‡ณ1/1๏ผŒๆ›ดไผ˜้€‰ไธบ1/30่‡ณ1/1.5ใ€‚
  • [0039]
    It is preferable that the composition of the present invention contains powder of mica.
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉไผ˜้€‰ๅซๆœ‰ไบ‘ๆฏ็ฒ‰ๆœซใ€‚
  • [0040]
    As the powder of the mica, natural mica powder or synthetic mica powder can be used. The synthetic mica powder is classified into an unswelling-type mica (for example, fluorine phlogopite, potassium tetrasilisic mica) and swelling-type mica (for example, sodium tetrasilisic mica, sodium hectorite). Although both can be used, the unswelling-type mica is favorable.
    ไบ‘ๆฏ็ฒ‰ๅฏไปฅไฝฟ็”จๅคฉ็„ถไบ‘ๆฏ็ฒ‰ๆˆ–ๅˆๆˆไบ‘ๆฏ็ฒ‰ใ€‚ๅˆๆˆไบ‘ๆฏ็ฒ‰ๅˆ†ไธบ้ž่†จ่ƒ€ๅž‹ไบ‘ๆฏ๏ผˆไพ‹ๅฆ‚ๆฐŸ้‡‘ไบ‘ๆฏใ€้’พๅ››็ก…ไบ‘ๆฏ๏ผ‰ๅ’Œ่†จ่ƒ€ๅž‹ไบ‘ๆฏ๏ผˆไพ‹ๅฆ‚้’ ๅ››็ก…ไบ‘ๆฏใ€้’ ้”‚่’™่„ฑ็Ÿณ๏ผ‰ใ€‚ไธค็งไบ‘ๆฏ้ƒฝๅฏไปฅไฝฟ็”จ๏ผŒไฝ†้ž่†จ่ƒ€ๅž‹ไบ‘ๆฏๆ›ดไฝณใ€‚
  • [0041]
    The size of the mica powder is set to the range of 0.5 to 10ยตm and favorably the range of 2 to 8ยตm.
    ไบ‘ๆฏ็ฒ‰็š„ๅฐบๅฏธ่ฎพๅฎšไธบ 0.5 ่‡ณ 10ฮผm ็š„่Œƒๅ›ด๏ผŒไผ˜้€‰ไธบ 2 ่‡ณ 8ฮผm ็š„่Œƒๅ›ดใ€‚
  • [0042]
    The powder of the mica is contained in the composition at 0.1 to 50 wt% and favorably at 1 to 15 wt%. The powder of the mica is contained in the composition at favorably 1/300 to 1/1.5 and more favorably 1/30 to 1/2 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
    ๆ‰€่ฟฐไบ‘ๆฏ็ฒ‰ๅœจๆ‰€่ฟฐ็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไธบ0.1่‡ณ50้‡้‡๏ผ…๏ผŒไผ˜้€‰ไธบ1่‡ณ15้‡้‡๏ผ…ใ€‚ ๆ‰€่ฟฐไบ‘ๆฏ็ฒ‰ๅœจๆ‰€่ฟฐ็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไผ˜้€‰ไธบๆ‰€่ฟฐ็ป„ๅˆ็‰ฉไธญๆ‰€ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„ไธๆŒฅๅ‘ๆˆๅˆ†โ€”โ€”ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉๅซ้‡็š„1/300่‡ณ1/1.5๏ผŒๆ›ดไผ˜้€‰ไธบ1/30่‡ณ1/2ใ€‚
  • [0043]
    The composition of the present invention may contain a catalyst for obtaining silicone rubber of condensation type by means of a crosslinking reaction. The catalyst may be added to the solvent-based silicone rubber when the composition is used. For example, as the catalyst, it is possible to use organic carboxylate or the ester of metals such as titanium, tin, zinc, cobalt, lead, calcium, manganese. More specifically, it is possible to use dialkyl tin compounds, titanium dipropoxide bisacetylacetonate, dibutyl tin laurate, cobalt naphthenate, and platinic chloride.
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉๅฏๅซๆœ‰็”จไบŽ้€š่ฟ‡ไบค่”ๅๅบ”่Žทๅพ—็ผฉๅˆๅž‹็ก…ๆฉก่ƒถ็š„ๅ‚ฌๅŒ–ๅ‰‚ใ€‚่ฏฅๅ‚ฌๅŒ–ๅ‰‚ๅฏๅœจไฝฟ็”จๆ—ถๆทปๅŠ ๅˆฐๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถไธญใ€‚ไพ‹ๅฆ‚๏ผŒๅฏไปฅไฝฟ็”จๆœ‰ๆœบ็พง้…ธ็›ๆˆ–้’›ใ€้”กใ€้”Œใ€้’ดใ€้“…ใ€้’™ใ€้”ฐ็ญ‰้‡‘ๅฑž็š„้…ฏไฝœไธบๅ‚ฌๅŒ–ๅ‰‚ใ€‚ๆ›ดๅ…ทไฝ“ๅœฐ๏ผŒๅฏไปฅไฝฟ็”จไบŒ็ƒทๅŸบ้”กๅŒ–ๅˆ็‰ฉใ€ๅŒไน™้…ฐไธ™้…ฎไบŒไธ™ๆฐงๅŸบ้’›ใ€ๆœˆๆก‚้…ธไบŒไธๅŸบ้”กใ€็Žฏ็ƒท้…ธ้’ดๅ’ŒๆฐฏๅŒ–้“‚ใ€‚
  • [0044]
    The composition of the present invention is prepared as follows:
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉๅˆถๅค‡ๅฆ‚ไธ‹๏ผš
  • [0045]
    Initially a surface active agent is added to a solvent (for example, organic solvent). Carbon nanotubes are added to the solvent to which the surface active agent has been added. The solution is stirred to prepare a liquid in which the carbon nanotubes are preferably dispersed. Thereafter the solvent-based silicone rubber is added to the liquid in which the carbon nanotubes have been dispersed. Thereby the composition is prepared. Therefore in the composition, the solvent-based silicone rubber is dispersed or dissolved in the solvent in which the carbon nanotubes are dispersed owing to the presence of the added surface active agent
    ้ฆ–ๅ…ˆๅฐ†่กจ้ขๆดปๆ€งๅ‰‚ๆทปๅŠ ๅˆฐๆบถๅ‰‚๏ผˆไพ‹ๅฆ‚ๆœ‰ๆœบๆบถๅ‰‚๏ผ‰ไธญใ€‚ๅฐ†็ขณ็บณ็ฑณ็ฎกๆทปๅŠ ๅˆฐๅทฒๆทปๅŠ ่กจ้ขๆดปๆ€งๅ‰‚็š„ๆบถๅ‰‚ไธญใ€‚ๆ…ๆ‹Œๆบถๆถฒ๏ผŒๅˆถๅค‡็ขณ็บณ็ฑณ็ฎกๅˆ†ๆ•ฃ็š„ๆถฒไฝ“ใ€‚็„ถๅŽๅฐ†ๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถๆทปๅŠ ๅˆฐ็ขณ็บณ็ฑณ็ฎกๅˆ†ๆ•ฃ็š„ๆถฒไฝ“ไธญใ€‚็”ฑๆญคๅˆถๅค‡ๅ‡บ็ป„ๅˆ็‰ฉใ€‚ๅ› ๆญค๏ผŒๅœจ่ฏฅ็ป„ๅˆ็‰ฉไธญ๏ผŒ็”ฑไบŽๆทปๅŠ ็š„่กจ้ขๆดปๆ€งๅ‰‚็š„ๅญ˜ๅœจ๏ผŒๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถๅˆ†ๆ•ฃๆˆ–ๆบถ่งฃๅœจ็ขณ็บณ็ฑณ็ฎกๅˆ†ๆ•ฃ็š„ๆบถๅ‰‚ไธญใ€‚
  • [0046]
    Thereafter the adhesion-improving agent and the catalyst are used as necessary.
    ๆญคๅŽๆ นๆฎ้œ€่ฆไฝฟ็”จ็ฒ˜ๅˆๆ”น่ฟ›ๅ‰‚ๅ’Œๅ‚ฌๅŒ–ๅ‰‚ใ€‚
  • [0047]
    It is possible to use the composition of the present invention of a two component type. In this case, to form the composition, the surface active agent, the carbon nanotube, the solvent-based silicone rubber, and the adhesion-improving agent which is used as necessary are added to the organic solvent to from the main agent whereas the auxiliary agent consisting of the catalyst is added to the main agent at the time of use. Alternatively it is possible to compose the main agent of a mixture of the organic solvent, the surface active agent, the carbon nanotube, and the solvent-based silicone rubber and compose the auxiliary agent of the adhesion-improving agent and the catalyst both of which are added to the main agent at the time of use.
    ๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉไนŸๅฏไปฅ้‡‡็”จๅŒ็ป„ๅˆ†ๅž‹ใ€‚ๆญคๆ—ถ๏ผŒๅฐ†่กจ้ขๆดปๆ€งๅ‰‚ใ€็ขณ็บณ็ฑณ็ฎกใ€ๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถไปฅๅŠๆ นๆฎ้œ€่ฆไฝฟ็”จ็š„็ฒ˜ๅˆๆ”นๅ–„ๅ‰‚ๆทปๅŠ ๅˆฐๆœ‰ๆœบๆบถๅ‰‚ไธญ๏ผŒๅฝขๆˆไธปๅ‰‚๏ผŒๅนถๅœจไฝฟ็”จๆ—ถๅฐ†็”ฑๅ‚ฌๅŒ–ๅ‰‚็ป„ๆˆ็š„ๅŠฉๅ‰‚ๆทปๅŠ ๅˆฐไธปๅ‰‚ไธญใ€‚ๆˆ–่€…๏ผŒไนŸๅฏไปฅๅฐ†ๆœ‰ๆœบๆบถๅ‰‚ใ€่กจ้ขๆดปๆ€งๅ‰‚ใ€็ขณ็บณ็ฑณ็ฎกๅ’Œๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถๆททๅˆ๏ผŒๅฝขๆˆไธปๅ‰‚๏ผŒๅนถๅฐ†็ฒ˜ๅˆๆ”นๅ–„ๅ‰‚ๅ’Œๅ‚ฌๅŒ–ๅ‰‚ไฝœไธบๅŠฉๅ‰‚๏ผŒๅนถๅœจไฝฟ็”จๆ—ถๅฐ†ไบŒ่€…ๆทปๅŠ ๅˆฐไธปๅ‰‚ไธญใ€‚
  • [0048]
    The details of the solvent the surface active agent the carbon nanotube, the solvent-based silicone rubber, the adhesion-improving agent and the catalyst are as described above. The addition amount of each of these components is as described above.
    ๆบถๅ‰‚ใ€่กจ้ขๆดปๆ€งๅ‰‚ใ€็ขณ็บณ็ฑณ็ฎกใ€ๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถใ€็ฒ˜ๅˆๆ€งๆ”น่‰ฏๅ‰‚ใ€ๅ‚ฌๅŒ–ๅ‰‚็š„่ฏฆๆƒ…ๅฆ‚ไธŠๆ‰€่ฟฐใ€‚ๅ„ๆˆๅˆ†็š„ๆทปๅŠ ้‡ๅฆ‚ไธŠๆ‰€่ฟฐใ€‚
  • [0049]
    The coefficient of dynamic friction of the slidable coating film made of the composition of the present invention is set favorably to not more than 0.15 and more favorably to not more than 0.13, when the coefficient of dynamic friction thereof is measured in accordance with the method of JIS K 7125.
    ๅฝ“ๆŒ‰็…ง JIS K 7125 ็š„ๆ–นๆณ•ๆต‹้‡ๅ…ถๅŠจๆ‘ฉๆ“ฆ็ณปๆ•ฐๆ—ถ๏ผŒ็”ฑๆœฌๅ‘ๆ˜Ž็š„็ป„ๅˆ็‰ฉๅˆถๆˆ็š„ๆป‘ๅŠจๆถ‚่†œ็š„ๅŠจๆ‘ฉๆ“ฆ็ณปๆ•ฐไผ˜้€‰่ฎพๅฎšไธบไธๅคงไบŽ 0.15๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšไธบไธๅคงไบŽ 0.13ใ€‚
  • [0050]
    The medical appliance having the slidable coating film (in other words, slidable coating layer) of the present invention formed thereon is described below.
    ไปฅไธ‹ๅฏนๅฝขๆˆๆœ‰ๆœฌๅ‘ๆ˜Ž็š„ๆป‘ๅŠจๆ€งๆถ‚่†œ(ๆข่จ€ไน‹๏ผŒๆป‘ๅŠจๆ€งๆถ‚ๅฑ‚)็š„ๅŒป็–—ๅ™จๆขฐ่ฟ›่กŒ่ฏดๆ˜Žใ€‚
  • [0051]
    The medical appliance 1 of the present invention having the slidable coating film formed thereon moves in contact with an inner surface of a medical member or an inner surface of a body lumen (for example, blood vessel, alimentary canal, abdominal cavity) and has a slidable coating film 3 formed at a portion thereof which contacts the medical member or the body lumen. The slidable coating film 3 is comprised of silicone rubber, carbon nanotubes and fine particles of silicone resin.
    ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐ 1 ๅฝขๆˆๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œ๏ผŒ่ฏฅๆป‘ๅŠจๆ€งๆถ‚่†œไธŽๅŒป็–—้ƒจไปถ็š„ๅ†…่กจ้ขๆˆ–ไฝ“่…”๏ผˆไพ‹ๅฆ‚๏ผŒ่ก€็ฎกใ€ๆถˆๅŒ–้“ใ€่…น่…”๏ผ‰็š„ๅ†…่กจ้ขๆŽฅ่งฆ๏ผŒๅนถๅœจไธŽๅŒป็–—้ƒจไปถๆˆ–ไฝ“่…”ๆŽฅ่งฆ็š„้ƒจๅˆ†ๅฝขๆˆๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œ 3ใ€‚่ฏฅๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ็”ฑ็ก…ๆฉก่ƒถใ€็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ๆž„ๆˆใ€‚
  • [0052]
    In the medical appliance 1 of the present example, the slidable coating film 3 is composed of the silicone rubber and contains the carbon nanotubes and the fine particles of the silicone resin.
    ๅœจๆœฌๅฎžๆ–ฝไพ‹็š„ๅŒป็–—ๅ™จๆขฐ 1 ไธญ๏ผŒ ๆป‘ๅŠจๆถ‚่†œ 3 ็”ฑ็ก…ๆฉก่ƒถๆž„ๆˆ๏ผŒๅนถๅซๆœ‰็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚็š„ๅพฎ็ฒ’ใ€‚
  • [0053]
    The slidable coating film 3 is formed as a rough surface. The rough surface is formed mainly of the fine particles of the silicone resin. The slidable coating film 3 is reinforced with the carbon nanotube. A part of the rough surface is formed of the carbon nanotube.
    ๆป‘ๅŠจๆถ‚่†œ 3 ๅฝขๆˆไธบ็ฒ—็ณ™่กจ้ขใ€‚่ฏฅ็ฒ—็ณ™่กจ้ขไธป่ฆ็”ฑ็ก…ๆ ‘่„‚็š„ๅพฎ็ฒ’ๆž„ๆˆใ€‚ ๆป‘ๅŠจๆถ‚่†œ 3 ็”ฑ็ขณ็บณ็ฑณ็ฎกๅขžๅผบใ€‚่ฏฅ็ฒ—็ณ™่กจ้ข็š„ไธ€้ƒจๅˆ†็”ฑ็ขณ็บณ็ฑณ็ฎกๆž„ๆˆใ€‚
  • [0054]
    The medical appliance of the present invention having the slidable coating film formed thereon is described below by using an embodiment in which the medical appliance is used as a gasket for use in a syringe and incorporated in the syringe.
    ไปฅไธ‹๏ผŒไปฅๅฝขๆˆๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œ็š„ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐไฝœไธบๆณจๅฐ„ๅ™จ็”จๅžซๅœˆๅนถ็ป„่ฃ…ๅˆฐๆณจๅฐ„ๅ™จไธญ็š„ๅฎžๆ–ฝๆ–นๅผ่ฟ›่กŒ่ฏดๆ˜Žใ€‚
  • [0055]
    Fig.1 is a front view showing a gasket, for use in a syringe, of an embodiment of a medical appliance of the present invention. Fig. 2 is a sectional view showing the gasket shown in Fig. 1. Fig. 3 is a top view showing the gasket shown in Fig. 1. Fig. 4 is bottom view showing the gasket shown in Fig.1.
    ๅ›พ1ๆ˜ฏๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐ็š„ไธ€ไธชๅฎžๆ–ฝๆ–นๅผ็š„ๆณจๅฐ„ๅ™จ็”จๅžซ็‰‡็š„ไธป่ง†ๅ›พใ€‚ๅ›พ2ๆ˜ฏๅ›พ1ๆ‰€็คบๅžซ็‰‡็š„ๅ‰–้ขๅ›พใ€‚ๅ›พ3ๆ˜ฏๅ›พ1ๆ‰€็คบๅžซ็‰‡็š„ไฟฏ่ง†ๅ›พใ€‚ๅ›พ4ๆ˜ฏๅ›พ1ๆ‰€็คบๅžซ็‰‡็š„ไปฐ่ง†ๅ›พใ€‚
  • [0056]
    The medical appliance of this embodiment having the slidable coating film formed thereon is a gasket 1 for use in a syringe and accommodated liquid-tightly and slidably inside an outer cylinder 11, for use in the syringe, which is a medical member. The gasket 1 has the slidable coating film 3 disposed at a portion thereof which contacts the outer cylinder 11. The slidable coating film 3 has a rough surface attributed to the presence of the fine particle of the silicone resin contained therein. The gasket 1 has a core part 2 and the slidable coating film 3 formed on a portion, of an outer surface of the core part 2, which contacts an inner surface of the outer cylinder 11. The slidable coating film 3 may be formed on the entire outer surface of the core part 2.
    ๆœฌๅฎžๆ–ฝไพ‹ไธญ๏ผŒๅฝขๆˆๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œ็š„ๅŒป็–—ๅ™จๆขฐไธบๆณจๅฐ„ๅ™จ็”จๅžซ็‰‡ 1๏ผŒ่ฏฅๅžซ็‰‡ 1 ๆถฒๅฏ†ๅœฐไธ”ๅฏๆป‘ๅŠจๅœฐๅฎน็บณไบŽไฝœไธบๅŒป็–—้ƒจไปถ็š„ๆณจๅฐ„ๅ™จๅค–็ญ’ 11 ๅ†…ใ€‚ ๅžซ็‰‡ 1 ๅœจๅ…ถไธŽๅค–็ญ’ 11 ๆŽฅ่งฆ็š„้ƒจๅˆ†่ฎพ็ฝฎๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œ 3ใ€‚็”ฑไบŽๅ…ถไธญๅซๆœ‰็š„็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„ๅญ˜ๅœจ ๏ผŒๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ็š„่กจ้ข็ฒ—็ณ™ใ€‚ ๅžซ็‰‡ 1 ๅ…ทๆœ‰่Šฏ้ƒจ 2 ๅ’ŒๅฝขๆˆไบŽ่Šฏ้ƒจ 2 ๅค–่กจ้ขไธŠไธŽๅค–็ญ’ 11 ๅ†…่กจ้ขๆŽฅ่งฆ็š„้ƒจๅˆ†็š„ๆป‘ๅŠจๆ€งๆถ‚่†œ 3ใ€‚ ๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ๅฏไปฅๅฝขๆˆไบŽ่Šฏ้ƒจ 2 ็š„ๆ•ดไธชๅค–่กจ้ขไธŠใ€‚
  • [0057]
    A medical appliance of this embodiment is a syringe 10. The syringe 10 has a gasket 1, for use in the syringe, which is a first medical member; and an outer cylinder 11, for use in the syringe, which is a second medical member and accommodates the gasket 1 therein liquid-tightly and slidably. The slidable coating film 3 is provided at a portion, of the gasket 1, which contacts the outer cylinder 11. In forming the slidable coating film 3 on the gasket 1, the slidable coating film 3 is disposed on a portion, of the outer surface of the core part 2, which contacts the inner surface of the outer cylinder 11. The slidable coating film 3 may be formed on the entire outer surface of the core part 2. When the slidable coating film 3 is formed on the inner surface of the outer cylinder 11, the slidable coating film 3 is formed on the inner surface of a region, of the outer cylinder 11, in which the gasket 1 slidably moves.
    ๆœฌๅฎžๆ–ฝไพ‹็š„ๅŒป็–—ๅ™จๆขฐไธบๆณจๅฐ„ๅ™จ 10ใ€‚ ๆณจๅฐ„ๅ™จ 10 ๅ…ทๆœ‰๏ผš็”จไบŽไฝœไธบ็ฌฌไธ€ๅŒป็–—้ƒจไปถ็š„ๆณจๅฐ„ๅ™จ็š„ๅžซๅœˆ 1๏ผ›ไปฅๅŠ็”จไบŽไฝœไธบ็ฌฌไบŒๅŒป็–—้ƒจไปถ็š„ๆณจๅฐ„ๅ™จ็š„ๅค–็ญ’ 11๏ผŒ่ฏฅๅค–็ญ’ 11 ไปฅๆถฒๅฏ†ไธ”ๆป‘ๅŠจ่‡ชๅฆ‚็š„ๆ–นๅผๅฎน็บณๅžซๅœˆ 1ใ€‚ ๆป‘ๅŠจๆถ‚่†œ 3 ่ฎพ็ฝฎๅœจๅžซ็‰‡ 1 ไธŽๅค–็ญ’ 11 ๆŽฅ่งฆ็š„้ƒจๅˆ†ใ€‚ๅœจๅžซ็‰‡ 1 ไธŠๅฝขๆˆๆป‘ๅŠจๆถ‚่†œ 3 ๆ—ถ๏ผŒ ๆป‘ๅŠจๆถ‚่†œ 3 ่ฎพ็ฝฎๅœจ่Šฏ้ƒจ 2 ๅค–่กจ้ขไธŠไธŽๅค–็ญ’ 11 ๅ†…่กจ้ขๆŽฅ่งฆ็š„้ƒจๅˆ†ใ€‚ ๆป‘ๅŠจๆถ‚่†œ 3 ๅฏไปฅๅฝขๆˆๅœจ่Šฏ้ƒจ 2 ็š„ๆ•ดไธชๅค–่กจ้ขไธŠใ€‚ๅฝ“ๆป‘ๅŠจๆถ‚่†œ 3 ๅฝขๆˆๅœจๅค–็ญ’ 11 ็š„ๅ†…่กจ้ขไธŠๆ—ถ๏ผŒ ๆป‘ๅŠจๆถ‚่†œ 3 ๅฝขๆˆๅœจๅค–็ญ’ 11 ไธญๅžซ็‰‡ 1 ๆป‘ๅŠจๅŒบๅŸŸ็š„ๅ†…่กจ้ขไธŠใ€‚
  • [0058]
    The gasket and the syringe which are an embodiment of the medical appliance of the present invention are described below.
    ไปฅไธ‹ๅฏนไฝœไธบๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐ็š„ไธ€ไธชๅฎžๆ–ฝๆ–นๅผ็š„ๅžซๅœˆๅŠๆณจๅฐ„ๅ™จ่ฟ›่กŒ่ฏดๆ˜Žใ€‚
  • [0059]
    As shown in Figs. 1, 2, and 5, the core part 2 of the gasket 1 for use in the syringe has a main body 5 extending in an almost equal diameter; a tapered portion 6, disposed at a distal side of the main body 5, whose diameter decreases taperingly to the distal end thereof; a plunger-mounting portion 4 provided inside the main body 5 from a proximal end thereof toward a distal side thereof; a distal-side annular rib 7a provided on a side surface of the distal portion of the main body 5, and a proximal-side annular rib 7b provided on a side surface of the proximal portion of the main body 5.
    ๅฆ‚ๅ›พ 1ใ€ๅ›พ 2 ๅ’Œๅ›พ 5 ๆ‰€็คบ๏ผŒๆณจๅฐ„ๅ™จ็”จๅžซๅœˆ 1 ็š„ๆ ธๅฟƒ้ƒจๅˆ† 2 ๅ…ทๆœ‰ไธ€ไธชๅ‡ ไนŽ็ญ‰็›ดๅพ„ๅปถไผธ็š„ไธปไฝ“ 5๏ผ›ไธ€ไธช่ฎพ็ฝฎๅœจไธปไฝ“ 5 ่ฟœ็ซฏไพง็š„้”ฅๅฝข้ƒจๅˆ† 6๏ผŒๅ…ถ็›ดๅพ„ๅ‘่ฟœ็ซฏๅ‘ˆ้”ฅๅฝขๅ‡ๅฐ๏ผ›ไธ€ไธช่ฎพ็ฝฎๅœจไธปไฝ“ 5 ๅ†…้ƒจใ€ไปŽ่ฟ‘็ซฏๅ‘่ฟœ็ซฏไพง็š„ๆŸฑๅกžๅฎ‰่ฃ…้ƒจๅˆ† 4๏ผ›ไธ€ไธช่ฎพ็ฝฎๅœจไธปไฝ“ 5 ่ฟœ็ซฏ้ƒจๅˆ†ไพง้ข็š„่ฟœ็ซฏไพง็Žฏๅฝข่‚‹ 7a๏ผŒไปฅๅŠไธ€ไธช่ฎพ็ฝฎๅœจไธปไฝ“ 5 ่ฟ‘็ซฏ้ƒจๅˆ†ไพง้ข็š„่ฟ‘็ซฏไพง็Žฏๅฝข่‚‹ 7bใ€‚
  • [0060]
    As shown in Figs. 2 and 4, the plunger-mounting portion 4 is formed as a concave portion, approximately columnar, which is disposed inside the main body 5 and extends from the proximal end of the main body 5 to a position in the vicinity of the distal end thereof. A screwing portion 8 capable of engaging a screwing portion formed at a distal end of a plunger is formed on a side surface of the concave portion. A distal-end surface of the concave portion is formed almost flatly. The plunger-mounting portion 4 does not necessarily have to be formed as the screwing portion, but may be formed as an engaging portion which engages the distal portion of the plunger.
    ๅฆ‚ๅ›พ 2 ๅ’Œๅ›พ 4 ๆ‰€็คบ๏ผŒๆŸฑๅกžๅฎ‰่ฃ…้ƒจ 4 ๅ‘ˆ่ฟ‘ไผผๅœ†ๆŸฑๅฝข็š„ๅ‡น้™ท้ƒจๅˆ†๏ผŒไฝไบŽไธปไฝ“ 5 ๅ†…้ƒจ๏ผŒๅนถไปŽไธปไฝ“ 5 ็š„่ฟ‘็ซฏๅปถไผธ่‡ณๅ…ถ่ฟœ็ซฏ้™„่ฟ‘ใ€‚ๅ‡น้™ท้ƒจๅˆ†็š„ไพง้ขๅฝขๆˆๆœ‰่žบ็บน้ƒจๅˆ† 8๏ผŒ่ฏฅ่žบ็บน้ƒจๅˆ†ๅฏไธŽๆŸฑๅกž่ฟœ็ซฏ็š„่žบ็บน้ƒจๅˆ†ๅ•ฎๅˆใ€‚ๅ‡น้™ท้ƒจๅˆ†็š„่ฟœ็ซฏ่กจ้ขๅ‡ ไนŽๅนณๅฆใ€‚ๆŸฑๅกžๅฎ‰่ฃ…้ƒจ 4 ๅนถ้žๅฟ…้กปๅฝขๆˆไธบ่žบ็บน้ƒจๅˆ†๏ผŒไนŸๅฏไปฅๅฝขๆˆไธบไธŽๆŸฑๅกž่ฟœ็ซฏ้ƒจๅˆ†ๅ•ฎๅˆ็š„ๅ•ฎๅˆ้ƒจๅˆ†ใ€‚
  • [0061]
    The outer diameters of the annular ribs 7a and 7b are formed a little larger than the inner diameter of the outer cylinder 11 for use in the syringe. Therefore the annular ribs 7a and 7b compressively deform inside the outer cylinder 11. In the embodiment, two annular ribs are formed, but three or more annular ribs may be formed.
    ๅค–ๅพ„ ็Žฏๅฝข่‚‹ๆก 7a ๅ’Œ 7b ๅฝขๆˆๅพ—ๆฏ”ๆณจๅฐ„ๅ™จไฝฟ็”จ็š„ๅค–็ญ’ 11 ็š„ๅ†…ๅพ„็จๅคงใ€‚ๅ› ๆญค ็Žฏ็Šถ่‚‹ 7aใ€7b ๅœจๅค–็ญ’ 11 ๅ†…ๅŽ‹็ผฉๅ˜ๅฝขใ€‚ๅœจๆœฌๅฎžๆ–ฝไพ‹ไธญ๏ผŒๅฝขๆˆๆœ‰ไธคไธช็Žฏ็Šถ่‚‹๏ผŒไฝ†ไนŸๅฏไปฅๅฝขๆˆไธ‰ไธชไปฅไธŠ็š„็Žฏ็Šถ่‚‹ใ€‚
  • [0062]
    It is preferable that an elastic material is used to compose the core part 2. As the elastic material, it is possible to list rubber materials (vulcanized rubber materials are preferable) such as natural rubber, isoprene rubber, butyl rubber, chloroprene rubber, nitrile-butadiene rubber, styrene-butadiene rubber, silicone rubber; styrene elastomer and hydrogenated styrene elastomer; and mixtures of the styrene elastomer and polyolefins such as polyethylene, polypropylene, polybutene, and ฮฑ-olefin copolymers; mixtures of the styrene elastomer and oil such as liquid paraffin, process oil; and mixtures of the styrene elastomer and powdery inorganic substances such as talc, cast, mica, and the like. Further it is possible to use polyvinyl chloride elastomer, olefin elastomer, polyester elastomer, polyamide elastomer, polyurethane elastomer, and mixtures of these elastomers as the materials for the core part 2. As the elastic material, the diene rubbers and the styrene elastomer are especially preferable because these rubbers or elastomers are favorable in elastic properties and resistant to sterilization by steam.
    ไผ˜้€‰ไฝฟ็”จๅผนๆ€งๆๆ–™ๆฅๆž„ๆˆ่Šฏ้ƒจ 2ใ€‚ไฝœไธบๅผนๆ€งๆๆ–™๏ผŒๅฏไปฅๅˆ—ไธพ๏ผšๅคฉ็„ถๆฉก่ƒถใ€ๅผ‚ๆˆŠไบŒ็ƒฏๆฉก่ƒถใ€ไธๅŸบๆฉก่ƒถใ€ๆฐฏไธๆฉก่ƒถใ€ไธ่…ˆๆฉก่ƒถใ€ไธ่‹ฏๆฉก่ƒถใ€็ก…ๆฉก่ƒถ็ญ‰ๆฉก่ƒถๆๆ–™๏ผˆไผ˜้€‰็กซๅŒ–ๆฉก่ƒถๆๆ–™๏ผ‰๏ผ›่‹ฏไน™็ƒฏๅผนๆ€งไฝ“ใ€ๆฐขๅŒ–่‹ฏไน™็ƒฏๅผนๆ€งไฝ“๏ผ›่‹ฏไน™็ƒฏๅผนๆ€งไฝ“ไธŽ่šไน™็ƒฏใ€่šไธ™็ƒฏใ€่šไธ็ƒฏใ€ฮฑ-็ƒฏ็ƒƒๅ…ฑ่š็‰ฉ็ญ‰่š็ƒฏ็ƒƒ็š„ๆททๅˆ็‰ฉ๏ผ›่‹ฏไน™็ƒฏๅผนๆ€งไฝ“ไธŽๆถฒไฝ“็Ÿณ่œกใ€ๅŠ ๅทฅๆฒน็ญ‰ๆฒน็š„ๆททๅˆ็‰ฉ๏ผ›่‹ฏไน™็ƒฏๅผนๆ€งไฝ“ไธŽๆป‘็Ÿณ็ฒ‰ใ€้“ธ้“ใ€ไบ‘ๆฏ็ญ‰็ฒ‰ๆœซ็Šถๆ— ๆœบ็‰ฉ็š„ๆททๅˆ็‰ฉใ€‚ๅฆๅค–๏ผŒๅฏไปฅไฝฟ็”จ่šๆฐฏไน™็ƒฏๅผนๆ€งไฝ“ใ€็ƒฏ็ƒƒๅผนๆ€งไฝ“ใ€่š้…ฏๅผนๆ€งไฝ“ใ€่š้…ฐ่ƒบๅผนๆ€งไฝ“ใ€่šๆฐจ้…ฏๅผนๆ€งไฝ“ไปฅๅŠ่ฟ™ไบ›ๅผนๆ€งไฝ“็š„ๆททๅˆ็‰ฉไฝœไธบ่Šฏ้ƒจ 2 ็š„ๆๆ–™ใ€‚ไฝœไธบๅผนๆ€งๆๆ–™๏ผŒ็‰นๅˆซไผ˜้€‰ไบŒ็ƒฏๆฉก่ƒถๅ’Œ่‹ฏไน™็ƒฏๅผนๆ€งไฝ“๏ผŒๅ› ไธบ่ฟ™ไบ›ๆฉก่ƒถๆˆ–ๅผนๆ€งไฝ“ๅ…ทๆœ‰่‰ฏๅฅฝ็š„ๅผนๆ€ง๏ผŒๅนถไธ”่€่’ธๆฑฝ็ญ่Œใ€‚
  • [0063]
    It is essential that the slidable coating film 3 is formed at the annular ribs. More specifically, it is essential that the slidable coating film is formed at the distal-side annular rib 7a and the proximal-side annular rib 7b.
    ๅฟ…้กปๅœจ็Žฏ็Šถ่‚‹ไธŠๅฝขๆˆๆป‘ๅŠจๆ€งๆถ‚่†œ 3ใ€‚ๅ…ทไฝ“่€Œ่จ€๏ผŒๅฟ…้กปๅœจ่ฟœไฝไพง็Žฏ็Šถ่‚‹ 7a ๅ’Œ่ฟ‘ไฝไพง็Žฏ็Šถ่‚‹ 7b ไธŠๅฝขๆˆๆป‘ๅŠจๆ€งๆถ‚่†œใ€‚
  • [0064]
    The thickness of the slidable coating film 3 is set favorably to the range of 1 to 20ยตm and more favorably to the range of 3 to 10ยตm. When the thickness of the slidable coating film 3 is not less than 1ยตm, the slidable coating film 3 works on a sufficiently high slidable performance. When the thickness of the slidable coating film 3 is not more than 10ยตm, the slidable coating film 3 can be securely formed as the rough surface attributed to the presence of the fine particle of the silicone resin contained therein without adversely affecting the elasticity of the gasket
    ๆป‘ๅŠจๆถ‚่†œ 3 ็š„ๅŽšๅบฆไผ˜้€‰่ฎพๅฎšๅœจ 1 ่‡ณ 20ฮผm ็š„่Œƒๅ›ดๅ†…๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšๅœจ 3 ่‡ณ 10ฮผm ็š„่Œƒๅ›ดๅ†…ใ€‚ๅฝ“ๆป‘ๅŠจๆถ‚่†œ 3 ็š„ๅŽšๅบฆไธๅฐไบŽ 1ฮผm ๆ—ถ๏ผŒ ๆป‘ๅŠจๆถ‚่†œ 3 ๅฏๅ‘ๆŒฅ่ถณๅคŸ้ซ˜็š„ๆป‘ๅŠจๆ€ง่ƒฝใ€‚ๅฝ“ๆป‘ๅŠจๆถ‚่†œ 3 ็š„ๅŽšๅบฆไธๅคงไบŽ 10ฮผm ๆ—ถ๏ผŒ็”ฑไบŽๅ…ถไธญๅซๆœ‰็š„็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„ๅญ˜ๅœจ๏ผŒ ๆป‘ๅŠจๆถ‚่†œ 3 ๅฏไปฅๅฏ้ ๅœฐๅฝขๆˆ็ฒ—็ณ™่กจ้ข๏ผŒ่€Œไธไผšๅฏนๅžซๅœˆ็š„ๅผนๆ€งไบง็”Ÿไธๅˆฉๅฝฑๅ“ใ€‚
  • [0065]
    The slidable coating film 3 is composed of the silicone rubber as its main component and contains the carbon nanotubes and the fine particles of the silicone resin. In other words, the slidable coating film 3 is composed of the coating film made of the silicone rubber, the carbon nanotubes and the fine particles of the silicone resin both held by the coating film. The coating film disposed on the surface of the slidable coating film is flexible. Further the slidable coating film is highly slidable owing to the rough surface thereof formed of the fine particles of the silicone resin contained therein. Furthermore, the carbon nanotubes contained in the slidable coating film impart a strength thereto to such an extent that the slidable coating film stands up a resistance force generated when the slidable coating film 3 slides in contact with the inner surface of the outer cylinder 11. The slidable coating film can be formed by applying the (slidable) composition on the core part of the gasket and hardening it
    ๆป‘ๅŠจๆถ‚่†œ 3 ไปฅ็ก…ๆฉก่ƒถไธบไธป่ฆๆˆๅˆ†๏ผŒๅนถๅซๆœ‰็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚ๆขๅฅ่ฏ่ฏด๏ผŒ ๆป‘ๅŠจๆถ‚่†œ 3 ็”ฑ็ก…ๆฉก่ƒถๆถ‚ๅฑ‚ใ€็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ๆž„ๆˆ๏ผŒ็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ๅ‡่ขซๆถ‚ๅฑ‚ๆ‰€ไฟๆŒใ€‚ๆป‘ๅŠจๆถ‚่†œ่กจ้ข็š„ๆถ‚ๅฑ‚ๅ…ทๆœ‰ๆŸ”้Ÿงๆ€งใ€‚ๆญคๅค–๏ผŒ็”ฑไบŽๆป‘ๅŠจๆถ‚่†œ่กจ้ข็”ฑ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ๆž„ๆˆ๏ผŒไฝฟๅ…ถๅ…ทๆœ‰่‰ฏๅฅฝ็š„ๆป‘ๅŠจๆ€งใ€‚ๆญคๅค–๏ผŒๆป‘ๅŠจๆถ‚่†œไธญๅซๆœ‰็š„็ขณ็บณ็ฑณ็ฎก่ต‹ไบˆๅ…ถไธ€ๅฎš็š„ๅผบๅบฆ๏ผŒไฝฟๅ…ถ่ƒฝๅคŸๆ‰ฟๅ—ๆป‘ๅŠจๆถ‚่†œ 3 ไธŽๅค–็ญ’ 11 ๅ†…่กจ้ขๆป‘ๅŠจๆŽฅ่งฆๆ—ถไบง็”Ÿ็š„้˜ปๅŠ›ใ€‚ๆป‘ๅŠจๆถ‚่†œๅฏไปฅ้€š่ฟ‡ๅฐ†๏ผˆๆป‘ๅŠจ๏ผ‰็ป„ๅˆ็‰ฉๆถ‚่ฆ†ๅœจๅžซ็‰‡็š„่Šฏ้ƒจๅนถไฝฟๅ…ถ็กฌๅŒ–ๆฅๅฝขๆˆใ€‚
  • [0066]
    The coefficient of dynamic friction of the slidable coating film to be formed on the gasket is favorably not more than 0.15 and more favorably not more than 0.13, when the coefficient of dynamic friction thereof is measured in accordance with the method of JIS K 7125.
    ๅฝ“ๆŒ‰็…ง JIS K 7125 ็š„ๆ–นๆณ•ๆต‹้‡ๅ…ถๅŠจๆ‘ฉๆ“ฆ็ณปๆ•ฐๆ—ถ๏ผŒๅฝขๆˆๅœจๅžซๅœˆไธŠ็š„ๅฏๆป‘ๅŠจๆถ‚่†œ็š„ๅŠจๆ‘ฉๆ“ฆ็ณปๆ•ฐไผ˜้€‰ไธบไธ่ถ…่ฟ‡ 0.15๏ผŒๆ›ดไผ˜้€‰ไธบไธ่ถ…่ฟ‡ 0.13ใ€‚
  • [0067]
    As the silicone rubber which is used as the main component of the slidable coating film 3, it is preferable to use the hardened solvent-based silicone rubber. A liquid organic polysiloxane compound is used as the solvent-based silicone rubber. Therefore the hardened liquid organic polysiloxane compound is preferable as the silicone rubber. The above-described organic polysiloxane compounds can be preferably used. More specifically, the hardened liquid organic polysiloxane compound is preferably the crosslinked organic polysiloxane compound. The Young's modulus of the silicone rubber is favorably not more than 3,000 MPa and more favorably not more than 1,000 MPa.
    ไฝœไธบๆป‘ๅŠจๆถ‚่†œ 3 ไธป่ฆๆˆๅˆ†็š„็ก…ๆฉก่ƒถ๏ผŒไผ˜้€‰ไฝฟ็”จๅ›บๅŒ–็š„ๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถใ€‚็”ฑไบŽๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถไฝฟ็”จๆถฒๆ€ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉ๏ผŒๅ› ๆญคไผ˜้€‰ไฝฟ็”จๅ›บๅŒ–็š„ๆถฒๆ€ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉใ€‚ไผ˜้€‰ไฝฟ็”จไธŠ่ฟฐๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉใ€‚ๆ›ดๅ…ทไฝ“ๅœฐ๏ผŒไผ˜้€‰ไฝฟ็”จๅ›บๅŒ–็š„ๆถฒๆ€ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉไบค่”ๆœ‰ๆœบ่š็ก…ๆฐง็ƒทๅŒ–ๅˆ็‰ฉใ€‚็ก…ๆฉก่ƒถ็š„ๆจๆฐๆจก้‡ไผ˜้€‰ไธบ 3000MPa ไปฅไธ‹๏ผŒๆ›ดไผ˜้€‰ไธบ 1000MPa ไปฅไธ‹ใ€‚
  • [0068]
    The slidable coating film 3 contains a large number of fine particles of the silicone resin held by the coating film of the silicone rubber. The slidable coating film 3 has the rough surface attributed to the presence of the fine particles of the silicone resin contained therein. Owing to the rough surface, the slidable coating film 3 has a stable slidableness.
    ๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ไธญ๏ผŒ็ก…ๆฉก่ƒถๆถ‚่†œไธŠ้™„็€ๆœ‰ๅคง้‡็š„็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚็”ฑไบŽ็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„ๅญ˜ๅœจ๏ผŒ ๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ่กจ้ขๅ‘ˆ็Žฐ็ฒ—็ณ™ๅบฆใ€‚ๆญฃๆ˜ฏ็”ฑไบŽ่ฏฅ็ฒ—็ณ™ๅบฆ๏ผŒ ๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ๆ‰ๅ…ทๆœ‰็จณๅฎš็š„ๆป‘ๅŠจๆ€งใ€‚
  • [0069]
    The surface roughness (Ra, measuring method: JIS B 0601: 1994) of the slidable coating film 3 is favorably in the range of 1.7 to 4.5ยตm and more favorably in the range of 2.0 to 3.0ยตm. The surface roughness Ra1 described in is sufficiently higher than the surface roughness of 0.1 to 1.5ยตm. The detail of the fine particle of the silicone resin is as described previously. The size of the fine particle of the silicone resin is set to the range of 0.5 to 10ยตm and favorably to the range of 2 to 8ยตm. The ratio of the average diameter of the fine particle of the silicone resin to the average film thickness (average film thickness including fine particles) of the slidable coating film 3 is set favorably to 0.2 to 1.5, more favorably to 0.3 to 1.2, and most favorably to 0.4 to 1.0. When the above-described ratio is below 1.5, the rough surface does not cause a decrease in the air-tightness of the slidable coating film 3. When the ratio is above 0.2, the surface of the slidable coating film 3 can be roughened to a sufficiently hight extent The fine particles of the silicone resin are adhesive to the coating film of the silicone rubber. The content of the fine particles of the silicone resin is 3 to 60% of the weight (weight after slidable coating film hardens) of the slidable coating film and 2 to 60% in a volume ratio. The above-described fine particles of the silicone resin are used in the present invention.
    ๆป‘ๅŠจๆถ‚่†œ 3 ็š„่กจ้ข็ฒ—็ณ™ๅบฆ(Ra๏ผŒๆต‹ๅฎšๆ–นๆณ•๏ผšJIS B 0601:1994)ไผ˜้€‰ไธบ 1.7๏ฝž4.5ฮผm๏ผŒๆ›ดไผ˜้€‰ไธบ 2.0๏ฝž3.0ฮผmใ€‚ ่ฟœ้ซ˜ไบŽ 0.1 ่‡ณ 1.5ฮผm ็š„่กจ้ข็ฒ—็ณ™ๅบฆใ€‚็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„่ฏฆ็ป†ๆƒ…ๅ†ตๅฆ‚ไธŠๆ‰€่ฟฐใ€‚็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„ๅฐบๅฏธ่ฎพๅฎšไธบ 0.5 ่‡ณ 10ฮผm ็š„่Œƒๅ›ด๏ผŒไผ˜้€‰ไธบ 2 ่‡ณ 8ฮผm ็š„่Œƒๅ›ดใ€‚็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„ๅนณๅ‡็ฒ’ๅพ„ไธŽๆป‘ๅŠจๆถ‚่†œ 3 ็š„ๅนณๅ‡่†œๅŽš๏ผˆๅŒ…ๅซๅพฎ็ฒ’็š„ๅนณๅ‡่†œๅŽš๏ผ‰็š„ๆฏ”ๅ€ผไผ˜้€‰ไธบ 0.2 ่‡ณ 1.5๏ผŒๆ›ดไผ˜้€‰ไธบ 0.3 ่‡ณ 1.2๏ผŒๆœ€ไผ˜้€‰ไธบ 0.4 ่‡ณ 1.0ใ€‚ๅฝ“ไธŠ่ฟฐๆฏ”ไพ‹ไฝŽไบŽ 1.5 ๆ—ถ๏ผŒ็ฒ—็ณ™่กจ้ขไธไผšๅฏผ่‡ดๆป‘ๅŠจๆถ‚่†œ 3 ็š„ๆฐ”ๅฏ†ๆ€งไธ‹้™ใ€‚ๅฝ“่ฏฅๆฏ”ไพ‹้ซ˜ไบŽ 0.2 ๆ—ถ๏ผŒ ๆป‘ๅŠจๆถ‚่†œ 3 ็š„่กจ้ขๅฏไปฅ่พพๅˆฐ่ถณๅคŸ้ซ˜็š„็ฒ—็ณ™ๅบฆใ€‚็ก…ๆ ‘่„‚ๅพฎ็ฒ’ไธŽ็ก…ๆฉก่ƒถๆถ‚่†œๅ…ทๆœ‰่‰ฏๅฅฝ็š„็ฒ˜ๅˆๆ€งใ€‚็ก…ๆ ‘่„‚ๅพฎ็ฒ’็š„ๅซ้‡ไธบๆป‘ๅŠจๆถ‚่†œ้‡้‡๏ผˆๆป‘ๅŠจๆถ‚่†œๅ›บๅŒ–ๅŽ็š„้‡้‡๏ผ‰็š„ 3%่‡ณ 60%๏ผŒไฝ“็งฏๆฏ”ไธบ 2%่‡ณ 60%ใ€‚ๆœฌๅ‘ๆ˜Žไธญไฝฟ็”จไธŠ่ฟฐ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚
  • [0070]
    Because the gasket 1 of the present invention has the above-described slidable coating film 3 formed thereon, the gasket 1 has a stable slidableness without applying a lubricant to the sliding surface thereof and is capable of maintaining sealing performance of a space for accommodating a medicine. Because the slidable coating film 3 contains the fine particles, it has the rough surface as shown in Fig. 9.
    ๆœฌๅ‘ๆ˜Ž็š„ๅžซ็‰‡ 1๏ผŒ็”ฑไบŽๅ…ถ่กจ้ขๅฝขๆˆๆœ‰ไธŠ่ฟฐๆป‘ๅŠจๆ€งๆถ‚่†œ 3๏ผŒๅ› ๆญคๅณไฝฟๆป‘ๅŠจ้ขๆœชๆถ‚ๆ•ทๆถฆๆป‘ๅ‰‚๏ผŒไนŸๅ…ทๆœ‰็จณๅฎš็š„ๆป‘ๅŠจๆ€ง๏ผŒ่ƒฝๅคŸ็ปดๆŒ่ฏๅ“ๆ”ถ็บณ็ฉบ้—ด็š„ๅฏ†ๅฐๆ€งใ€‚็”ฑไบŽๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ๅซๆœ‰ๅพฎ็ฒ’๏ผŒๅ› ๆญคๅ…ถ่กจ้ขๅ‘ˆ็Žฐๅฆ‚ๅ›พ 9 ๆ‰€็คบ็š„็ฒ—็ณ™็Šถๆ€ใ€‚
  • [0071]
    The slidable coating film 3 contains a large number of the carbon nanotubes held by the coating film of the silicone rubber. The above-described carbon nanotubes are used. It is preferable that the content of the carbon nanotube is 0.01 to 3% of the weight (weight of fine particle after it hardens) of the slidable coating film and 0.004 to 5% thereof in a volume ratio.
    ๆป‘ๅŠจๆถ‚่†œ 3 ๅซๆœ‰ๅคง้‡็š„็ขณ็บณ็ฑณ็ฎก๏ผŒ่ฟ™ไบ›็ขณ็บณ็ฑณ็ฎก่ขซ็ก…ๆฉก่ƒถๆถ‚่†œๆ‰€ไฟๆŒใ€‚็ขณ็บณ็ฑณ็ฎก็š„ไฝฟ็”จๆ–นๆณ•ๅฆ‚ไธŠๆ‰€่ฟฐใ€‚็ขณ็บณ็ฑณ็ฎก็š„ๅซ้‡ไผ˜้€‰ไธบๆป‘ๅŠจๆถ‚่†œ้‡้‡๏ผˆๅ›บๅŒ–ๅŽๅพฎ็ฒ’็š„้‡้‡๏ผ‰็š„ 0.01๏ผ…่‡ณ 3๏ผ…๏ผŒไฝ“็งฏๆฏ”ไธบ 0.004๏ผ…่‡ณ 5๏ผ…ใ€‚
  • [0072]
    It is preferable that the slidable coating film 3 contains the powder of the resin of the polyolefin family. The kind of the fine particles of the resin of the olefin family to be used in the present invention is previously described. It is preferable that the content of the powder of the resin of the polyolefin family is set to the range of 3 to 60% of the weight (weight of fine particle after it hardens) of the slidable coating film and to the range of 4 to 65% thereof in a volume ratio.
    ๆป‘ๅŠจๆถ‚่†œ 3 ไผ˜้€‰ๅซๆœ‰่š็ƒฏ็ƒƒ็ฑปๆ ‘่„‚็ฒ‰ๆœซใ€‚ๆœฌๅ‘ๆ˜Žไธญไฝฟ็”จ็š„็ƒฏ็ƒƒ็ฑปๆ ‘่„‚ๅพฎ็ฒ’็š„็ง็ฑปๅทฒๅœจไธŠๆ–‡่ฟฐๅŠใ€‚่š็ƒฏ็ƒƒ็ฑปๆ ‘่„‚็ฒ‰ๆœซ็š„ๅซ้‡ไผ˜้€‰ไธบๆป‘ๅŠจๆถ‚่†œ้‡้‡๏ผˆๅพฎ็ฒ’ๅ›บๅŒ–ๅŽ็š„้‡้‡๏ผ‰็š„ 3%่‡ณ 60%๏ผŒไฝ“็งฏๆฏ”ไผ˜้€‰ไธบ 4%่‡ณ 65%ใ€‚
  • [0073]
    It is preferable that the slidable coating film 3 contains the powder of the mica. The kind of the mica to be used in the present invention is previously described. It is preferable that the content of the powder of the mica is set to the range of 1 to 40% of the weight (weight of fine particle after it hardens) of the slidable coating film and 0.4 to 15% thereof in a volume ratio.
    ๆป‘ๅŠจๆถ‚่†œ 3 ไผ˜้€‰ๅซๆœ‰ไบ‘ๆฏ็ฒ‰ใ€‚ๆœฌๅ‘ๆ˜Žไธญไฝฟ็”จ็š„ไบ‘ๆฏ็ง็ฑปๅทฒๅœจไธŠๆ–‡่ฟฐๅŠใ€‚ไบ‘ๆฏ็ฒ‰็š„ๅซ้‡ไผ˜้€‰่ฎพๅฎšไธบๆป‘ๅŠจๆถ‚่†œ้‡้‡๏ผˆๅ›บๅŒ–ๅŽๅพฎ็ฒ’็š„้‡้‡๏ผ‰็š„ 1%่‡ณ 40%็š„่Œƒๅ›ด๏ผŒไฝ“็งฏๆฏ”ไธบ 0.4%่‡ณ 15%ใ€‚
  • [0074]
    The slidable coating film 3 may contain the surface active agent The kind of the surface active agents to be used in the present invention is previously described. It is preferable that the content of the surface active agent is set to the range of 0.05 to 5% of the weight of (weight of fine particle after it hardens) of the slidable coating film.
    ๆป‘ๅŠจๆถ‚่†œ 3 ๅฏๅซๆœ‰่กจ้ขๆดปๆ€งๅ‰‚ใ€‚ๆœฌๅ‘ๆ˜Žไธญไฝฟ็”จ็š„่กจ้ขๆดปๆ€งๅ‰‚็š„็ง็ฑปๅทฒๅœจไธŠๆ–‡่ฟฐๅŠใ€‚่กจ้ขๆดปๆ€งๅ‰‚็š„ๅซ้‡ไผ˜้€‰ไธบๆป‘ๅŠจๆถ‚่†œ้‡้‡๏ผˆๅ›บๅŒ–ๅŽ็š„ๅพฎ็ฒ’้‡้‡๏ผ‰็š„ 0.05๏ฝž5๏ผ…็š„่Œƒๅ›ดใ€‚
  • [0075]
    The slidable coating film 3 may contain the adhesion-improving agent The kind of the adhesion-improving agent to be used in the present invention is previously described. It is preferable that the content of the adhesion-improving agent is set to the range of 10 to 50% of the weight of (weight of fine particle after it hardens) the slidable coating film.
    ๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ๅฏๅซๆœ‰้™„็€ๅŠ›ๆ”นๅ–„ๅ‰‚ใ€‚ๆœฌๅ‘ๆ˜Žไธญไฝฟ็”จ็š„้™„็€ๅŠ›ๆ”นๅ–„ๅ‰‚็š„็ง็ฑปๅทฒๅœจไธŠๆ–‡่ฟฐๅŠใ€‚้™„็€ๅŠ›ๆ”นๅ–„ๅ‰‚็š„ๅซ้‡ไผ˜้€‰ไธบๆป‘ๅŠจๆ€งๆถ‚่†œ้‡้‡๏ผˆๅ›บๅŒ–ๅŽ็š„ๅพฎ็ฒ’้‡้‡๏ผ‰็š„ 10๏ผ…่‡ณ 5โ€‹โ€‹0๏ผ…ใ€‚
  • [0076]
    The slidable coating film 3 may contain the catalyst for obtaining the silicone rubber of a condensation type by means of a crosslinking reaction. The kind of the catalyst to be used in the present invention is previously described.
    ๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ไธญๅฏไปฅๅซๆœ‰็”จไบŽ้€š่ฟ‡ไบค่”ๅๅบ”ๅพ—ๅˆฐ็ผฉๅˆๅž‹็ก…ๆฉก่ƒถ็š„ๅ‚ฌๅŒ–ๅ‰‚ใ€‚ๆœฌๅ‘ๆ˜Žไธญไฝฟ็”จ็š„ๅ‚ฌๅŒ–ๅ‰‚็š„็ง็ฑปๅทฒๅœจไธŠๆ–‡ไธญๆ่ฟฐใ€‚
  • [0077]
    The method of forming the slidable coating film 3 is described below.
    ไปฅไธ‹ๅฏนๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ็š„ๅฝขๆˆๆ–นๆณ•่ฟ›่กŒ่ฏดๆ˜Žใ€‚
  • [0078]
    Initially the above-described composition is prepared.
    ้ฆ–ๅ…ˆๅˆถๅค‡ไธŠ่ฟฐ็ป„ๅˆ็‰ฉใ€‚
  • [0079]
    The slidable coating film is obtained by applying the composition to the clean surface of the gasket and hardening it At this time, the composition can be applied to the surface of the gasket by carrying out a known method such as a dip coating method, a spraying method, and the like. It is preferable that a coating solution is sprayed to the surface of the object to be coated with the object being rotated (at 100 to 600 rpm). It is preferable to heat a portion of the gasket to be coated to 50 to 100ยฐC before the coating solution is sprayed thereto. Thereby the composition can be rapidly fixed to the surface of the portion of the gasket to be coated. Therefore it is easy to carry out this method.
    ๅฐ†็ป„ๅˆ็‰ฉๆถ‚่ฆ†ไบŽๅžซ็‰‡็š„ๆธ…ๆด่กจ้ขๅนถไฝฟๅ…ถๅ›บๅŒ–๏ผŒๅณๅฏ่Žทๅพ—ๆป‘ๅŠจๆ€งๆถ‚่†œใ€‚ๆญคๆ—ถ๏ผŒๅฏไปฅ้€š่ฟ‡ๆตธๆถ‚ๆณ•ใ€ๅ–ทๆถ‚ๆณ•็ญ‰ๅทฒ็Ÿฅๆ–นๆณ•ๅฐ†็ป„ๅˆ็‰ฉๆถ‚่ฆ†ไบŽๅžซ็‰‡่กจ้ขใ€‚ไผ˜้€‰ๅœจๆ—‹่ฝฌ๏ผˆ100 ่‡ณ 600 rpm๏ผ‰็š„็Šถๆ€ไธ‹๏ผŒๅฐ†ๆถ‚ๆ–™ๆบถๆถฒๅ–ทๆถ‚ไบŽๅพ…ๆถ‚่ฆ†็‰ฉไฝ“่กจ้ขใ€‚ๅ–ทๆถ‚ๆถ‚ๆ–™ๆบถๆถฒไน‹ๅ‰๏ผŒไผ˜้€‰ๅฐ†ๅพ…ๆถ‚่ฆ†็š„ๅžซ็‰‡้ƒจๅˆ†ๅŠ ็ƒญ่‡ณ 50 ่‡ณ 100ยฐCใ€‚่ฟ™ๆ ท๏ผŒ็ป„ๅˆ็‰ฉๅฏไปฅๅฟซ้€Ÿๅ›บๅŒ–ไบŽๅพ…ๆถ‚่ฆ†ๅžซ็‰‡้ƒจๅˆ†็š„่กจ้ขไธŠใ€‚ๅ› ๆญค๏ผŒ่ฏฅๆ–นๆณ•ๆ˜“ไบŽๆ“ไฝœใ€‚
  • [0080]
    As the method of hardening the composition, it may be left at a normal temperature, but it is preferable to heat it The method of thermally hardening the composition is not limited to a specific method, provided that the base material of the gasket is not modified or deformed. It is possible to adopt conventional methods of drying the composition by hot air, drying the composition by an oven utilizing infrared rays or by a drier which is used under a reduced pressure. The composition can be hardened in a short period of time by using the coating solution containing the silane coupling agent In forming the slidable coating film on the gasket, the concentration of the mixed solution is appropriately controlled and the dipping method, the spraying method or the like is carried out
    ๅ›บๅŒ–็ป„ๅˆ็‰ฉ็š„ๆ–นๆณ•๏ผŒๅฏไปฅ็ฝฎไบŽๅธธๆธฉไธ‹๏ผŒไฝ†ๆœ€ๅฅฝๅŠ ็ƒญใ€‚็ƒญๅ›บๅŒ–็ป„ๅˆ็‰ฉ็š„ๆ–นๆณ•ไธๅฑ€้™ไบŽ็‰นๅฎšๆ–นๆณ•๏ผŒๅช่ฆๅžซ็‰‡็š„ๅŸบๆไธๅ‘็”Ÿๆ”นๆ€งๆˆ–ๅ˜ๅฝขๅณๅฏใ€‚ๅฏไปฅ้‡‡็”จๅธธ่ง„ๆ–นๆณ•๏ผŒไพ‹ๅฆ‚็”จ็ƒญ้ฃŽๅนฒ็‡ฅ็ป„ๅˆ็‰ฉใ€็”จ็บขๅค–็บฟ็ƒค็ฎฑๅนฒ็‡ฅ็ป„ๅˆ็‰ฉๆˆ–ๅœจๅ‡ๅŽ‹ไธ‹ไฝฟ็”จ็š„ๅนฒ็‡ฅๅ™จๅนฒ็‡ฅ็ป„ๅˆ็‰ฉใ€‚ไฝฟ็”จๅซๆœ‰็ก…็ƒทๅถ่”ๅ‰‚็š„ๆถ‚ๅฑ‚ๆบถๆถฒ๏ผŒๅฏไปฅๅœจ็Ÿญๆ—ถ้—ดๅ†…ไฝฟ็ป„ๅˆ็‰ฉๅ›บๅŒ–ใ€‚ๅœจๅžซ็‰‡ไธŠๅฝขๆˆๆป‘ๅŠจๆถ‚่†œๆ—ถ๏ผŒๅบ”้€‚ๅฝ“ๆŽงๅˆถๆททๅˆๆบถๆถฒ็š„ๆต“ๅบฆ๏ผŒๅนถ้‡‡็”จๆตธๆธๆณ•ใ€ๅ–ทๆถ‚ๆณ•็ญ‰ๆ–นๆณ•ใ€‚
  • [0081]
    As shown in Fig. 5, the syringe 10 which is an embodiment of the medical appliance of the present invention includes an outer cylinder 11, for use in the syringe, which has a needle-mounting portion 15 disposed at a distal side thereof and a flange 16 disposed at a proximal end thereof; a gasket 1, for use in the syringe, which is capable of liquid-tightly and airtightly sliding on an inner surface 12 of the outer cylinder 11; a plunger 17 which is or can be mounted on the gasket 1; a sealing member 18 for sealing the needle-mounting portion 15 of the outer cylinder 11; and a medicine-accommodating portion 19, for accommodating a medicine 26, which is surround with the sealing member 18, the inner surface 12 of the outer cylinder 11 (and the inner surface of the slidable coating film 3), and the gasket 1. Instead of the sealing member 18, a needle may be mounted on the needle-mounting portion 15. As shown in Fig. 5, the sealing member 18 into which a double ended needle can be directly inserted is preferable.
    ๅฆ‚ๅ›พ 5 ๆ‰€็คบ๏ผŒไฝœไธบๆœฌๅ‘ๆ˜ŽๅŒป็–—ๅ™จๆขฐ็š„ไธ€ไธชๅฎžๆ–ฝไพ‹็š„ๆณจๅฐ„ๅ™จ 10 ๅŒ…ๆ‹ฌ๏ผš็”จไบŽๆณจๅฐ„ๅ™จ็š„ๅค–็ญ’ 11๏ผŒๅ…ถ่ฟœ็ซฏไพง่ฎพๆœ‰้’ˆๅฎ‰่ฃ…้ƒจๅˆ† 15๏ผŒ่ฟ‘็ซฏ่ฎพๆœ‰ๅ‡ธ็ผ˜ 16๏ผ›็”จไบŽๆณจๅฐ„ๅ™จ็š„ๅžซๅœˆ 1๏ผŒๅ…ถ่ƒฝๅคŸๅœจๅค–็ญ’ 11 ็š„ๅ†…่กจ้ข 12 ไธŠๆถฒๅฏ†ไธ”ๆฐ”ๅฏ†ๅœฐๆป‘ๅŠจ๏ผ› ๆŸฑๅกž 17๏ผŒๅ…ถๅฎ‰่ฃ…ๅœจๆˆ–ๅฏๅฎ‰่ฃ…ๅœจๅžซๅœˆ 1 ไธŠ๏ผ›ๅฏ†ๅฐไปถ 18๏ผŒ็”จไบŽๅฏ†ๅฐๅค–็ญ’ 11 ็š„้’ˆๅฎ‰่ฃ…้ƒจๅˆ† 15๏ผ›ไปฅๅŠ็”จไบŽๅฎน็บณ่ฏ็‰ฉ 26 ็š„่ฏ็‰ฉๅฎน็บณ้ƒจ 19๏ผŒ่ฏฅ่ฏ็‰ฉๅฎน็บณ้ƒจ 19 ่ขซๅฏ†ๅฐไปถ 18ใ€ๅค–็ญ’ 11 ็š„ๅ†…่กจ้ข 12๏ผˆไปฅๅŠๆป‘ๅŠจๆถ‚่†œ 3 ็š„ๅ†…่กจ้ข๏ผ‰ๅ’Œๅžซๅœˆ 1 ๅŒ…ๅ›ดใ€‚้™คไบ†ๅฏ†ๅฐไปถ 18 ไน‹ๅค–๏ผŒ่ฟ˜ๅฏไปฅๅฐ†้’ˆๅคดๅฎ‰่ฃ…ๅœจ้’ˆๅฎ‰่ฃ…้ƒจ 15 ไธŠใ€‚ๅฆ‚ๅ›พ 5 ๆ‰€็คบ๏ผŒๅฏ็›ดๆŽฅๆ’ๅ…ฅๅŒๅคด้’ˆ็š„ๅฏ†ๅฐไปถ 18 ๆ˜ฏไผ˜้€‰็š„ใ€‚
  • [0082]
    As shown in Fig. 5, the above-described medical appliance is a pre-filled syringe 25 including the syringe 10 and the medicine 26.
    ๅฆ‚ๅ›พ 5 ๆ‰€็คบ๏ผŒไธŠ่ฟฐๅŒป็–—ๅ™จๆขฐไธบๅŒ…ๆ‹ฌๆณจๅฐ„ๅ™จ 10 ๅ’Œ่ฏ็‰ฉ 26 ็š„้ข„ๅ……ๅผๆณจๅฐ„ๅ™จ 25ใ€‚
  • [0083]
    The outer cylinder 11 for use in the syringe has the needle-mounting portion 15 disposed at the distal portion thereof and the flange 16 disposed at the proximal end thereof. The outer cylinder 11 is made of a material transparent or semitransparent It is preferable that the outer cylinder 11 is made of a material having low oxygen permeability or vapor permeability. It is preferable that the material of the outer cylinder 11 has glass transition point or a melting point not less than 110ยฐC.
    ๆณจๅฐ„ๅ™จ็”จ็š„ๅค–็ญ’ 11 ๅœจๅ…ถ่ฟœ็ซฏ่ฎพๆœ‰้’ˆๅฎ‰่ฃ…้ƒจ 15๏ผŒๅœจๅ…ถ่ฟ‘็ซฏ่ฎพๆœ‰ๅ‡ธ็ผ˜ 16ใ€‚ ๅค–็ญ’ 11 ็”ฑ้€ๆ˜Žๆˆ–ๅŠ้€ๆ˜Žๆๆ–™ๅˆถๆˆใ€‚ ๅค–็ญ’ 11 ไผ˜้€‰็”ฑ้€ๆฐงๆ€งๆˆ–้€ๆนฟๆ€งไฝŽ็š„ๆๆ–™ๅˆถๆˆใ€‚ๅค–็ญ’ 11 ็š„ๆๆ–™ไผ˜้€‰็Žป็’ƒๅŒ–่ฝฌๅ˜็‚นๆˆ–็†”็‚นไธไฝŽไบŽ 110ยฐCใ€‚
  • [0084]
    As the material to form the outer cylinder 11, the following resins are preferable: polyolefin such as polypropylene, polyethylene, poly (4-methylpentene-1), and cyclic polyolefin; polyesters such as polyethylene terephthalate, polyethylene naphthalate, and non-crystalline polyarylate; polystyrene; polyamide; polycarbonate, polyvinyl chloride; acrylic resin; acrylonitrile-butadiene-styrene copolymer, and non-crystalline polyetherimide. The polypropylene, the poly (4-methylpentene-1), the cyclic polyolefin, the polyethylene naphthalate, and the non-crystalline polyetherimide are especially preferable because these resins are transparent and resistant to steam sterilization under pressure. These resins can be used as a material to form not only the outer cylinder but also containers capable of accommodating medicines.
    ไฝœไธบๅค–็ญ’ 11 ็š„ๆž„ๆˆๆๆ–™๏ผŒไผ˜้€‰ไปฅไธ‹ๆ ‘่„‚๏ผš่šไธ™็ƒฏใ€่šไน™็ƒฏใ€่š๏ผˆ4-็”ฒๅŸบๆˆŠ็ƒฏ-1๏ผ‰ใ€็Žฏ็Šถ่š็ƒฏ็ƒƒ็ญ‰่š็ƒฏ็ƒƒ๏ผ›่šๅฏน่‹ฏไบŒ็”ฒ้…ธไน™ไบŒ้†‡้…ฏใ€่š่˜ไบŒ็”ฒ้…ธไน™ไบŒ้†‡้…ฏใ€้žๆ™ถๆ€่š่Šณ้…ฏ็ญ‰่š้…ฏ๏ผ›่š่‹ฏไน™็ƒฏ๏ผ›่š้…ฐ่ƒบ๏ผ›่š็ขณ้…ธ้…ฏใ€่šๆฐฏไน™็ƒฏ๏ผ›ไธ™็ƒฏ้…ธๆ ‘่„‚๏ผ›ไธ™็ƒฏ่…ˆ-ไธไบŒ็ƒฏ-่‹ฏไน™็ƒฏๅ…ฑ่š็‰ฉใ€้žๆ™ถๆ€่š้†š้…ฐไบš่ƒบใ€‚่šไธ™็ƒฏใ€่š๏ผˆ4-็”ฒๅŸบๆˆŠ็ƒฏ-1๏ผ‰ใ€็Žฏ็Šถ่š็ƒฏ็ƒƒใ€่š่˜ไบŒ็”ฒ้…ธไน™ไบŒ้†‡้…ฏใ€้žๆ™ถๆ€่š้†š้…ฐไบš่ƒบ็ญ‰ๆ ‘่„‚็”ฑไบŽ้€ๆ˜Žๆ€งๅฅฝไธ”่€้ซ˜ๅŽ‹่’ธๆฑฝ็ญ่Œ๏ผŒๅ› ๆญคๅฐคไธบไผ˜้€‰ใ€‚่ฟ™ไบ›ๆ ‘่„‚ไธไป…ๅฏ็”จไฝœๅค–็ญ’็š„ๆž„ๆˆๆๆ–™๏ผŒ่ฟ˜ๅฏ็”จไฝœๅฎน็บณ่ฏ็‰ฉ็š„ๅฎนๅ™จ็š„ๆž„ๆˆๆๆ–™ใ€‚
  • [0085]
    The gasket 1, for use in the syringe, having the slidable coating film 3 is used in the embodiment of the present invention. The construction of the gasket 1, for use in the syringe, having the slidable coating film 3 is as described above.
    ๆœฌๅ‘ๆ˜Žๅฎžๆ–ฝไพ‹ไธญ๏ผŒ้‡‡็”จๅ…ทๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ็š„ๆณจๅฐ„ๅ™จ็”จๅžซ็‰‡ 1ใ€‚ๅ…ทๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œ 3 ็š„ๆณจๅฐ„ๅ™จ็”จๅžซ็‰‡ 1 ็š„็ป“ๆž„ๅฆ‚ไธŠๆ‰€่ฟฐใ€‚
  • [0086]
    As shown in Fig. 5, the plunger 17 has a sectionally cross-shaped main body 20 extended axially; a plunger-side screwing portion 21, provided at a distal portion thereof, which engages the plunger-mounting portion 4; a disk portion 22, for pressing use, which is disposed at a proximal end of the main body 20; and a rib formed midway on the main body 20.
    ๅฆ‚ๅ›พ 5 ๆ‰€็คบ๏ผŒ ๆŸฑๅกž 17 ๅ…ทๆœ‰่ฝดๅ‘ๅปถไผธ็š„ๆˆช้ขๅ‘ˆๅๅญ—ๅฝข็š„ไธปไฝ“ 20๏ผ›่ฎพ็ฝฎๅœจๅ…ถ่ฟœ็ซฏ้ƒจ็š„ๆŸฑๅกžไพง่žบ็บน้ƒจ 21๏ผŒๅ…ถไธŽๆŸฑๅกžๅฎ‰่ฃ…้ƒจ 4 ๆŽฅๅˆ๏ผ›่ฎพ็ฝฎๅœจไธปไฝ“ 20 ่ฟ‘็ซฏ็š„็”จไบŽๆŒ‰ๅŽ‹็š„็›˜็Šถ้ƒจ 22๏ผ›ไปฅๅŠๅœจไธปไฝ“ 20 ไธญ้ƒจๅฝขๆˆ็š„่‚‹ๆกใ€‚
  • [0087]
    The medicine 26 is contained in the syringe 10 of this embodiment As the medicine 26, it is possible to use a liquid medicine insoluble in water, a liquid medicine having a high adsorbability, a liquid medicine containing a surface active agent and having a low viscosity and a high degree of penetration, and liquid medicines containing an electrolytic substance, vitamins, minerals, and antibiotics. It is also possible to use powdery medicine such as protein preparation, a freeze-drying agent A liquid drug is also used as the medicine 26.
    ๆœฌๅฎžๆ–ฝไพ‹็š„ๆณจๅฐ„ๅ™จ 10 ๅ†…่ฃ…ๆœ‰่ฏ็‰ฉ 26ใ€‚ไฝœไธบ่ฏ็‰ฉ 26๏ผŒๅฏไปฅไฝฟ็”จไธๆบถไบŽๆฐด็š„่ฏๆถฒใ€ๅธ้™„ๆ€ง้ซ˜็š„่ฏๆถฒใ€ๅซๆœ‰่กจ้ขๆดปๆ€งๅ‰‚็š„ไฝŽ็ฒ˜ๅบฆใ€้ซ˜ๆธ—้€ๆ€ง็š„่ฏๆถฒใ€ไปฅๅŠๅซๆœ‰็”ต่งฃ่ดจใ€็ปด็”Ÿ็ด ใ€็Ÿฟ็‰ฉ่ดจใ€ๆŠ—็”Ÿ็ด ็ญ‰็š„่ฏๆถฒใ€‚ๆญคๅค–๏ผŒ่ฟ˜ๅฏไปฅไฝฟ็”จ่›‹็™ฝ่ดจๅˆถๅ‰‚ใ€ๅ†ปๅนฒๅ‰‚็ญ‰็ฒ‰็Šถ่ฏ็‰ฉไฝœไธบ่ฏ็‰ฉ 26ใ€‚
  • [0088]
    As the material composing the plunger 17 and the sealing member 18, it is preferable to use hard resin or semi-hard resin such as high-density polyethylene, polypropylene, polystyrene, polyethylene terephthalate, and the like.
    ไฝœไธบๆž„ๆˆๆŸฑๅกž 17 ๅ’Œๅฏ†ๅฐไปถ 18 ็š„ๆๆ–™๏ผŒไผ˜้€‰ไฝฟ็”จ็กฌ่ดจๆ ‘่„‚ๆˆ–ๅŠ็กฌ่ดจๆ ‘่„‚๏ผŒไพ‹ๅฆ‚้ซ˜ๅฏ†ๅบฆ่šไน™็ƒฏใ€่šไธ™็ƒฏใ€่š่‹ฏไน™็ƒฏใ€่šๅฏน่‹ฏไบŒ็”ฒ้…ธไน™ไบŒ้†‡้…ฏ็ญ‰ใ€‚
  • [0089]
    The above-described syringe is an example of medical appliances which move in contact with the inner surface of a medical member. The medical appliances of any types can be used, provided that they slidably contact the inner surface of the medical member. For example, the medical appliance may be a rubber stopper-provided vial, a transfusion bag, a blood collection tube, a decompression blood collection tube. The medical appliance of the present invention may be an O-ring, a plug, a lid, and the like, provided that these medical appliances slidably contact the medical member. For example, the medical appliance may be a rubber stopper of the vial, the lid of the transfusion bag, and the like.
    ไธŠ่ฟฐๆณจๅฐ„ๅ™จๆ˜ฏไธŽๅŒป็–—้ƒจไปถๅ†…่กจ้ขๆŽฅ่งฆๅนถ็งปๅŠจ็š„ๅŒป็–—ๅ™จๆขฐ็š„ไธ€ไธชไพ‹ๅญใ€‚ไปปไฝ•็ฑปๅž‹็š„ๅŒป็–—ๅ™จๆขฐๅ‡ๅฏไฝฟ็”จ๏ผŒๅช่ฆๅฎƒไปฌ่ƒฝๅคŸๆป‘ๅŠจๅœฐๆŽฅ่งฆๅŒป็–—้ƒจไปถ็š„ๅ†…่กจ้ขๅณๅฏใ€‚ไพ‹ๅฆ‚๏ผŒๅŒป็–—ๅ™จๆขฐๅฏไปฅๆ˜ฏๅธฆๆฉก่ƒถๅกž็š„่ฏ็“ถใ€่พ“ๆถฒ่ข‹ใ€้‡‡่ก€็ฎกใ€ๅ‡ๅŽ‹้‡‡่ก€็ฎกใ€‚ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐๅฏไปฅๆ˜ฏ O ๅฝข็Žฏใ€ๅกžๅญใ€็›–ๅญ็ญ‰๏ผŒๅช่ฆ่ฟ™ไบ›ๅŒป็–—ๅ™จๆขฐ่ƒฝๅคŸๆป‘ๅŠจๅœฐๆŽฅ่งฆๅŒป็–—้ƒจไปถๅณๅฏใ€‚ไพ‹ๅฆ‚๏ผŒๅŒป็–—ๅ™จๆขฐๅฏไปฅๆ˜ฏ่ฏ็“ถ็š„ๆฉก่ƒถๅกžใ€่พ“ๆถฒ่ข‹็š„็›–ๅญ็ญ‰ใ€‚
  • [0090]
    The medical appliance of the present invention may move in contact with the inner surface of a body lumen. The medical appliance which moves in contact with the inner surface of the body lumen includes a catheter, a guide wire, a vasodilating device, and the like. The medical appliance of the present invention may move in contact with the inner surface of the medical member and that of the lumen. The medical appliance which moves in contact with the inner surface of the lumen includes the catheter which is inserted into another catheter (for example, guiding catheter), the guide wire, the vasodilating device, and the like, the distal ends of which are guided to a desired portion of the lumen.
    ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐๅฏไปฅไธŽไฝ“่…”ๅ†…่กจ้ขๆŽฅ่งฆๅนถ็งปๅŠจใ€‚ไธŽไฝ“่…”ๅ†…่กจ้ขๆŽฅ่งฆๅนถ็งปๅŠจ็š„ๅŒป็–—ๅ™จๆขฐๅŒ…ๆ‹ฌๅฏผ็ฎกใ€ๅฏผไธใ€่ก€็ฎกๆ‰ฉๅผ ่ฃ…็ฝฎ็ญ‰ใ€‚ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐๅฏไปฅไธŽๅŒป็–—ๆž„ไปถ็š„ๅ†…่กจ้ขๅ’Œไฝ“่…”ๅ†…่กจ้ขๆŽฅ่งฆๅนถ็งปๅŠจใ€‚ไธŽไฝ“่…”ๅ†…่กจ้ขๆŽฅ่งฆๅนถ็งปๅŠจ็š„ๅŒป็–—ๅ™จๆขฐๅŒ…ๆ‹ฌๆ’ๅ…ฅๅ…ถไป–ๅฏผ็ฎก๏ผˆไพ‹ๅฆ‚ๅฏผๅผ•ๅฏผ็ฎก๏ผ‰็š„ๅฏผ็ฎกใ€ๅฏผไธใ€่ก€็ฎกๆ‰ฉๅผ ่ฃ…็ฝฎ็ญ‰๏ผŒๅ…ถ่ฟœ็ซฏ่ขซๅผ•ๅฏผ่‡ณไฝ“่…”็š„ๆ‰€้œ€้ƒจไฝใ€‚
  • [0091]
    An embodiment in which the medical appliance of the present invention is applied to the guide wire is described below with reference to Fig. 6.
    ไธ‹้ข๏ผŒๅ‚็…งๅ›พ6ๅฏนๅฐ†ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐๅบ”็”จไบŽๅฏผไธ็š„ๅฎžๆ–ฝๆ–นๅผ่ฟ›่กŒ่ฏดๆ˜Žใ€‚
  • [0092]
    Fig. 6 is a sectional view an embodiment of the guide wire of the present invention.
    ๅ›พ6ๆ˜ฏๆœฌๅ‘ๆ˜Ž็š„ๅฏผไธ็š„ไธ€ไธชๅฎžๆ–ฝไพ‹็š„ๅ‰–้ขๅ›พใ€‚
  • [0093]
    A guide wire 50 of this embodiment has an inner core 52 and a slidable coating film 53 covering the inner core 52. The slidable coating film 53 is comprised of the silicone rubber, the carbon nanotube, and the fine particle of the silicone resin. In this embodiment, the slidable coating film 53 is composed of silicone rubber, and contains carbon nanotubes and fine particles of silicone resin.
    ๆœฌๅฎžๆ–ฝไพ‹็š„ๅฏผไธ 50 ๅ…ทๆœ‰ๅ†…่Šฏ 52 ๅ’ŒๅŒ…่ฆ†ๅ†…่Šฏ 52 ็š„ๆป‘ๅŠจๆถ‚่†œ 53ใ€‚ ๆป‘ๅŠจๆถ‚่†œ 53 ็”ฑ็ก…ๆฉก่ƒถใ€็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ๆž„ๆˆใ€‚ๅœจๆœฌๅฎžๆ–ฝไพ‹ไธญ๏ผŒ ๆป‘ๅŠจๆถ‚่†œ 53 ็”ฑ็ก…ๆฉก่ƒถๆž„ๆˆ๏ผŒๅนถๅŒ…ๅซ็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚
  • [0094]
    The guide wire of the embodiment shown in Fig. 6 has the inner core 52 including a main body 52a having a higher rigidity and a distal portion 52b, formed integrally with the main body 52a, which has a smaller diameter than the main body 52a and a lower rigidity; a high X-ray opaque portion 54 disposed at a distal end of the inner core 52; and a slidable coating film 53 coating the entire inner core 52 having the high X-ray opaque portion 54 provided at the distal end thereof. Because the slidable coating film 53 contains fine particles, the slidable coating film 53 has a rough surface as shown in Fig. 10.
    ๅ›พ 6 ๆ‰€็คบๅฎžๆ–ฝไพ‹็š„ๅฏผไธๅ…ทๆœ‰ๅ†…่Šฏ 52๏ผŒๅ†…่Šฏ 52 ๅŒ…ๆ‹ฌๅˆšๆ€ง่พƒ้ซ˜็š„ไธปไฝ“ 52a ๅ’ŒไธŽไธปไฝ“ 52a ไธ€ไฝ“ๆˆๅž‹็š„่ฟœ็ซฏ้ƒจ 52b๏ผŒ่ฟœ็ซฏ้ƒจ 52b ็š„็›ดๅพ„ๅฐไบŽไธปไฝ“ 52a๏ผŒไธ”ๅˆšๆ€ง่พƒไฝŽ๏ผ› ๅ†…่Šฏ 52 ็š„่ฟœ็ซฏ่ฎพ็ฝฎๆœ‰้ซ˜ X ๅฐ„็บฟไธ้€ๅฐ„้ƒจ 54๏ผ›ไปฅๅŠ่ฆ†็›–ๆ•ดไธชๅ†…่Šฏ 52 ็š„ๅฏๆป‘ๅŠจๆถ‚ๅฑ‚ 53๏ผŒๅ…ถไธญ้ซ˜ X ๅฐ„็บฟไธ้€ๅฐ„้ƒจ 54 ่ฎพ็ฝฎๅœจๅ†…่Šฏ 52 ็š„่ฟœ็ซฏใ€‚็”ฑไบŽๅฏๆป‘ๅŠจๆถ‚ๅฑ‚ 53 ไธญๅซๆœ‰็ป†ๅฐ้ข—็ฒ’๏ผŒๅ› ๆญคๅ…ถ่กจ้ขๅฆ‚ๅ›พ 10 ๆ‰€็คบ่พƒไธบ็ฒ—็ณ™ใ€‚
  • [0095]
    The inner core 52 of the guide wire 50 has the main body 52a and the distal portion 52b both made of an elastic material and integrally with each other. The diameter of the distal portion 52b is set smaller than that of the distal end of the main body 52a. Therefore the distal portion 52b has a lower rigidity than the main body 52a. The distal portion 52b may be so formed that the diameter thereof becomes gradually smaller from the distal end of the main body 52a. Thereby when a force is applied to the distal end of the distal portion 52b, the distal portion 52b is gradually bent, which allows the operability of the guide wire to be improved.
    ๅฏผไธ 50 ็š„ๅ†…่Šฏ 52 ็”ฑไธปไฝ“ 52a ๅ’Œ่ฟœ็ซฏ 52b ็ป„ๆˆ๏ผŒไธค่€…ๅ‡็”ฑๅผนๆ€งๆๆ–™ๅˆถๆˆ๏ผŒๅนถไธ€ไฝ“ๆˆๅž‹ใ€‚่ฟœ็ซฏ 52b ็š„็›ดๅพ„ๅฐไบŽไธปไฝ“ 52a ่ฟœ็ซฏ็š„็›ดๅพ„ใ€‚ๅ› ๆญค๏ผŒ่ฟœ็ซฏ 52b ็š„ๅˆšๅบฆไฝŽไบŽไธปไฝ“ 52aใ€‚่ฟœ็ซฏ 52b ็š„็›ดๅพ„ๅฏไปฅ่ฎพ่ฎกๆˆไปŽไธปไฝ“ 52a ่ฟœ็ซฏๅผ€ๅง‹้€ๆธๅ‡ๅฐใ€‚่ฟ™ๆ ท๏ผŒๅฝ“ๅฏน่ฟœ็ซฏ 52b ็š„่ฟœ็ซฏๆ–ฝๅŠ ๅŠ›ๆ—ถ๏ผŒ่ฟœ็ซฏ 52b ไผš้€ๆธๅผฏๆ›ฒ๏ผŒไปŽ่€Œๆ้ซ˜ๅฏผไธ็š„ๆ“ไฝœๆ€งใ€‚
  • [0096]
    It is preferable that the inner core 52 is made of super-elastic metals or stainless steel. As the super-elastic metals, it is preferable to use a Ti-Ni alloy of 49 - 58 atomic percent of Ni, a Cu-Zn alloy of 38.5 - 41.5 wt% of Zn, a Cu-Zn-X alloy of 1 - 10 wt% of X (X = Be, Si, Sn, Al, Ga), and a Ni-Al alloy of 36 - 38 atomic percent of Al. The Ti-Ni alloy is especially favorable.
    ๅ†…่Šฏ 52 ไผ˜้€‰็”ฑ่ถ…ๅผนๆ€ง้‡‘ๅฑžๆˆ–ไธ้”ˆ้’ขๅˆถๆˆใ€‚ไฝœไธบ่ถ…ๅผนๆ€ง้‡‘ๅฑž๏ผŒไผ˜้€‰ไฝฟ็”จ Ni ๅซ้‡ไธบ 49 - 58 ๅŽŸๅญ็™พๅˆ†ๆฏ”็š„ Ti-Ni ๅˆ้‡‘ใ€Zn ๅซ้‡ไธบ 38.5 - 41.5 ้‡้‡็™พๅˆ†ๆฏ”็š„ Cu-Zn ๅˆ้‡‘ใ€X ๅซ้‡ไธบ 1 - 10 ้‡้‡็™พๅˆ†ๆฏ”็š„ Cu-Zn-X ๅˆ้‡‘๏ผˆX = Beใ€Siใ€Snใ€Alใ€Ga๏ผ‰ไปฅๅŠ Al ๅซ้‡ไธบ 36 - 38 ๅŽŸๅญ็™พๅˆ†ๆฏ”็š„ Ni-Al ๅˆ้‡‘ใ€‚Ti-Ni ๅˆ้‡‘ๅฐคไธบ็†ๆƒณใ€‚
  • [0097]
    The outer diameter of the main body 52a of the inner core 52 is set favorably to the range of 0.10 to 1.00mm and more favorably to 0.15 to 0.40mm. The length of the main body 52a thereof is set favorably to the range of 1000 to 4000mm and more favorably to the range of 1500 to 3000mm. The buckling strength (yield stress at load-applied time) of the main body 52a thereof is set favorably to the range of 30 to 100 Kg/mm2 (22 degree C) and more favorably to the range of 40 to 55 Kg/mm2. The restoring stress (yield stress at load-removed time) of the main body 52a thereof is set favorably to the range of 20 to 80 Kg/mm2 (22 degree C) and more favorably to the range of 30 to 35 Kg/mm2.
    ๅ†…่Šฏ 52 ็š„ไธปไฝ“ 52a ็š„ๅค–ๅพ„ไผ˜้€‰่ฎพๅฎšไธบ 0.10 ่‡ณ 1.00mm๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšไธบ 0.15 ่‡ณ 0.40mmใ€‚ ไธปไฝ“ 52a ็š„้•ฟๅบฆไผ˜้€‰่ฎพๅฎšไธบ 1000 ่‡ณ 4000mm๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšไธบ 1500 ่‡ณ 3000mmใ€‚ ไธปไฝ“ 52a ็š„ๆŠ—ๅผฏๅผบๅบฆ๏ผˆๆ–ฝๅŠ ่ฝฝ่ทๆ—ถ็š„ๅฑˆๆœๅบ”ๅŠ›๏ผ‰ไผ˜้€‰่ฎพๅฎšไธบ 30 ่‡ณ 100Kg/ mmยฒ ๏ผˆ22โ„ƒ๏ผ‰็š„่Œƒๅ›ด๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšไธบ 40 ่‡ณ 55Kg/ mmยฒ ็š„่Œƒๅ›ดใ€‚ๅ…ถไธปไฝ“ 52a ็š„ๆขๅคๅบ”ๅŠ›(ๅธ่ฝฝๆ—ถ็š„ๅฑˆๆœๅบ”ๅŠ›)ไผ˜้€‰่ฎพๅฎšไธบ 20๏ฝž80Kg/mm 2 (22โ„ƒ)็š„่Œƒๅ›ด๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšไธบ 30๏ฝž35Kg/mm 2 ็š„่Œƒๅ›ดใ€‚
  • [0098]
    The outer diameter of the distal portion 52b of the inner core 52 is set favorably to the range of 0.03 to 0.15mm and more favorably to the range of 0.05 to 0.10mm. The length of the distal portion 52b thereof is set favorably to the range of 10 to 300mm and more favorably to the range of 50 to 150mm. The bending load of the distal portion 52b thereof is set favorably to the range of 0.1 to 10g and more favorably to the range of 0.3 to 6.0g. The restoring stress of the distal portion 52b thereof is set favorably to the range of 0.1 to 10g and more favorably to the range of 0.3 to 6.0g.
    ๅ†…่Šฏ 52 ็š„่ฟœ็ซฏ้ƒจ 52b ็š„ๅค–ๅพ„ไผ˜้€‰่ฎพๅฎšๅœจ 0.03 ่‡ณ 0.15mm ็š„่Œƒๅ›ดๅ†…๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšๅœจ 0.05 ่‡ณ 0.10mm ็š„่Œƒๅ›ดๅ†…ใ€‚ๅ…ถ่ฟœ็ซฏ้ƒจ 52b ็š„้•ฟๅบฆไผ˜้€‰่ฎพๅฎšๅœจ 10 ่‡ณ 300mm ็š„่Œƒๅ›ดๅ†…๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšๅœจ 50 ่‡ณ 150mm ็š„่Œƒๅ›ดๅ†…ใ€‚ๅ…ถ่ฟœ็ซฏ้ƒจ 52b ็š„ๅผฏๆ›ฒ่ฝฝ่ทไผ˜้€‰่ฎพๅฎšๅœจ 0.1 ่‡ณ 10g ็š„่Œƒๅ›ดๅ†…๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšๅœจ 0.3 ่‡ณ 6.0g ็š„่Œƒๅ›ดๅ†…ใ€‚ๅ…ถ่ฟœ็ซฏ้ƒจ 52b ็š„ๆขๅคๅบ”ๅŠ›ไผ˜้€‰่ฎพๅฎšๅœจ 0.1 ่‡ณ 10g ็š„่Œƒๅ›ดๅ†…๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšๅœจ 0.3 ่‡ณ 6.0g ็š„่Œƒๅ›ดๅ†…ใ€‚
  • [0099]
    The above-described outer diameter of the distal portion of the inner core does not necessarily have to be entirely set to the above-described range, but may be partly set to the above-described range. The restoring stress of the main body of the inner core and that of the distal portion thereof do not necessarily have to be set to an equal value, but it is preferable to devise a method of allowing the main body of the inner core and the distal portion thereof to obtain a suitable property at a proper diameter by changing the restoring stress thereof in various thermal treatment conditions. That is, it is preferable to separately thermally treat the main body of the inner core and the distal portion thereof in such a way that the main body thereof has a larger restoring stress and that the distal portion thereof is flexible. The inner core does not necessarily have to be made of one wire, but the inner core may be composed of a plurality of parallel or twisted wires so that the above-described function of the inner core, namely, the property thereof changes stepwise or successively.
    ไธŠ่ฟฐๅ†…่Šฏ่ฟœ็ซฏ้ƒจๅˆ†็š„ๅค–ๅพ„ไธๅฟ…ๅฎŒๅ…จ่ฎพๅฎšๅœจไธŠ่ฟฐ่Œƒๅ›ดๅ†…๏ผŒไนŸๅฏไปฅ้ƒจๅˆ†่ฎพๅฎšๅœจไธŠ่ฟฐ่Œƒๅ›ดๅ†…ใ€‚ๅ†…่Šฏไธปไฝ“็š„ๆขๅคๅบ”ๅŠ›ๅ’Œ่ฟœ็ซฏ้ƒจๅˆ†็š„ๆขๅคๅบ”ๅŠ›ไธๅฟ…่ฎพๅฎšไธบ็›ธ็ญ‰ๅ€ผ๏ผŒไฝ†ไผ˜้€‰่ฎพ่ฎกไธ€็งๆ–นๆณ•๏ผŒ้€š่ฟ‡ๅœจไธๅŒ็š„็ƒญๅค„็†ๆกไปถไธ‹ๆ”นๅ˜ๅ†…่Šฏไธปไฝ“ๅŠๅ…ถ่ฟœ็ซฏ้ƒจๅˆ†็š„ๆขๅคๅบ”ๅŠ›๏ผŒไฝฟๅ†…่Šฏไธปไฝ“ๅŠๅ…ถ่ฟœ็ซฏ้ƒจๅˆ†ๅœจๅˆ้€‚็š„็›ดๅพ„ไธ‹่Žทๅพ—ๅˆ้€‚็š„ๆ€ง่ƒฝใ€‚ไนŸๅฐฑๆ˜ฏ่ฏด๏ผŒไผ˜้€‰ๅˆ†ๅˆซๅฏนๅ†…่Šฏไธปไฝ“ๅŠๅ…ถ่ฟœ็ซฏ้ƒจๅˆ†่ฟ›่กŒ็ƒญๅค„็†๏ผŒไฝฟๅพ—ไธปไฝ“้ƒจๅˆ†ๅ…ทๆœ‰่พƒๅคง็š„ๆขๅคๅบ”ๅŠ›๏ผŒ่€Œ่ฟœ็ซฏ้ƒจๅˆ†ๅ…ทๆœ‰ๆŸ”้Ÿงๆ€งใ€‚ๅ†…่Šฏไธๅฟ…็”ฑไธ€ๆ น้‡‘ๅฑžไธๅˆถๆˆ๏ผŒไนŸๅฏไปฅ็”ฑๅคšๆ นๅนณ่กŒๆˆ–็ปžๅˆ็š„้‡‘ๅฑžไธ็ป„ๆˆ๏ผŒไปŽ่€Œไฝฟๅ†…่Šฏ็š„ไธŠ่ฟฐๅŠŸ่ƒฝ๏ผˆๅณๅ…ถๆ€ง่ƒฝ๏ผ‰้€ๆญฅๆˆ–่ฟž็ปญๅœฐๅ˜ๅŒ–ใ€‚
  • [0100]
    In the embodiment shown in Fig. 6, the high X-ray opaque portion 54 fixed to the distal end of the inner core 52 is made of the annular metal member having high radiographic visualization. More specifically, the high X-ray opaque portion 54 is formed of a pipe-shaped metal member. As metals having the high radiographic visualization, gold, platinum, lead, silver, bismuth, and tungsten are favorable. Gold is especially favorable.
    ๅœจๅ›พ 6 ๆ‰€็คบ็š„ๅฎžๆ–ฝไพ‹ไธญ๏ผŒๅ›บๅฎšๅœจๅ†…่Šฏ 52 ่ฟœ็ซฏ็š„้ซ˜ X ๅฐ„็บฟไธ้€ๆ€ง้ƒจๅˆ† 54 ็”ฑๅ…ทๆœ‰้ซ˜ X ๅฐ„็บฟๆ˜พๅฝฑๆ€ง็š„็Žฏๅฝข้‡‘ๅฑžๆž„ไปถๅˆถๆˆใ€‚ๆ›ดๅ…ทไฝ“ๅœฐ่ฏด๏ผŒ้ซ˜ X ๅฐ„็บฟไธ้€ๆ€ง้ƒจๅˆ† 54 ็”ฑ็ฎก็Šถ้‡‘ๅฑžๆž„ไปถๅˆถๆˆใ€‚ไฝœไธบๅ…ทๆœ‰้ซ˜ X ๅฐ„็บฟๆ˜พๅฝฑๆ€ง็š„้‡‘ๅฑž๏ผŒไผ˜้€‰้‡‘ใ€้“‚ใ€้“…ใ€้“ถใ€้“‹ๅ’Œ้’จใ€‚ๅฐคๅ…ถไผ˜้€‰้‡‘ใ€‚
  • [0101]
    The high X-ray opaque portion 54 is fixed to the distal end of the inner core 52 by means of mechanical crimping, plating or soldered to an evaporated metal.
    ้ซ˜ X ๅฐ„็บฟไธ้€ๆ˜Žๅบฆ้ƒจๅˆ† 54 ้€š่ฟ‡ๆœบๆขฐๅŽ‹ๆŽฅใ€็”ต้•€ๆˆ–็„ŠๆŽฅๅˆฐ่’ธๅ‘้‡‘ๅฑž็š„ๆ–นๅผๅ›บๅฎšๅˆฐๅ†…ๆ ธ 52 ็š„่ฟœ็ซฏใ€‚
  • [0102]
    The outer diameter of the high X-ray opaque portion 54 is set favorably to the range of 0.20 to 0.90mm and more favorably to the range of 0.25 to 0.40mm. The inner diameter of the high X-ray opaque portion 54 is set favorably to the range of 0.04 to 0.16mm and more favorably to the range of 0.06 to 0.11mm. The length of the high X-ray opaque portion 54 is set favorably to the range of 1.00 to 10.00mm and more favorably to the range of 1.5 to 4.0mm.
    ้ซ˜ X ๅฐ„็บฟไธ้€ๆ˜Žๅบฆ้ƒจๅˆ† 54 ็š„ๅค–ๅพ„ไผ˜้€‰่ฎพๅฎšๅœจ 0.20 ่‡ณ 0.90 ๆฏซ็ฑณ็š„่Œƒๅ›ดๅ†…๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšๅœจ 0.25 ่‡ณ 0.40 ๆฏซ็ฑณ็š„่Œƒๅ›ดๅ†…ใ€‚้ซ˜ X ๅฐ„็บฟไธ้€ๆ˜Žๅบฆ้ƒจๅˆ† 54 ็š„ๅ†…ๅพ„ไผ˜้€‰่ฎพๅฎšๅœจ 0.04 ่‡ณ 0.16 ๆฏซ็ฑณ็š„่Œƒๅ›ดๅ†…๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšๅœจ 0.06 ่‡ณ 0.11 ๆฏซ็ฑณ็š„่Œƒๅ›ดๅ†…ใ€‚้ซ˜ X ๅฐ„็บฟไธ้€ๆ˜Žๅบฆ้ƒจๅˆ† 54 ็š„้•ฟๅบฆไผ˜้€‰่ฎพๅฎšๅœจ 1.00 ่‡ณ 10.00 ๆฏซ็ฑณ็š„่Œƒๅ›ดๅ†…๏ผŒๆ›ดไผ˜้€‰่ฎพๅฎšๅœจ 1.5 ่‡ณ 4.0 ๆฏซ็ฑณ็š„่Œƒๅ›ดๅ†…ใ€‚
  • [0103]
    The high X-ray opaque portion 54 may be composed of a coiled narrow wire made of the above-described metal having a high radiographic visualization. The narrow wire having a diameter of 0.02 to 0.10mm can be preferably used. The length of the high X-ray opaque portion 54 wound around the inner core 52 in the range from the distal end thereof is set to the range of 1.0 to 10.0mm and favorably to the range of 1.5 to 4.0mm.
    ้ซ˜ X ๅฐ„็บฟไธ้€ๆ€ง้ƒจๅˆ† 54 ๅฏ็”ฑไธŠ่ฟฐๅ…ทๆœ‰้ซ˜ X ๅฐ„็บฟๆ˜พๅฝฑๆ€ง็š„้‡‘ๅฑžๅˆถๆˆ็š„่žบๆ—‹็Šถ็ป†ไธๆž„ๆˆใ€‚ไผ˜้€‰ไฝฟ็”จ็›ดๅพ„ไธบ 0.02 ่‡ณ 0.10 ๆฏซ็ฑณ็š„็ป†ไธใ€‚้ซ˜ X ๅฐ„็บฟไธ้€ๆ€ง้ƒจๅˆ† 54 ไปŽๅ…ถ่ฟœ็ซฏ่ตท็ผ ็ป•ๅœจๅ†…่Šฏ 52 ไธŠ็š„้•ฟๅบฆ่ฎพๅฎšไธบ 1.0 ่‡ณ 10.0 ๆฏซ็ฑณ๏ผŒไผ˜้€‰่ฎพๅฎšไธบ 1.5 ่‡ณ 4.0 ๆฏซ็ฑณใ€‚
  • [0104]
    It is preferable that as shown in Fig. 6, the slidable coating film 53 coating the entire inner core 52 has an almost uniform outer diameter, including the distal portion thereof. The outer diameter of the slidable coating film 53 is set almost uniformly over the whole length thereof by adjusting the thickness thereof in such a way that a stepped portion of the high X-ray opaque portion 54 formed at the distal end of the inner core 52 does not adversely affect the outer configuration of the guide wire 50.
    ๅฆ‚ๅ›พ 6 ๆ‰€็คบ๏ผŒ่ฆ†็›–ๆ•ดไธชๅ†…่Šฏ 52 ็š„ๆป‘ๅŠจๆถ‚ๅฑ‚ 53๏ผŒๅŒ…ๆ‹ฌๅ…ถ่ฟœ็ซฏ้ƒจๅˆ†๏ผŒไผ˜้€‰ๅ…ทๆœ‰ๅ‡ ไนŽๅ‡ๅŒ€็š„ๅค–ๅพ„ใ€‚ ๆป‘ๅŠจๆถ‚ๅฑ‚ 53 ็š„ๅค–ๅพ„้€š่ฟ‡่ฐƒ่Š‚ๅ…ถๅŽšๅบฆ๏ผŒไฝฟๅ…ถๅœจๆ•ดไธช้•ฟๅบฆไธŠๅ‡ ไนŽๅ‡ๅŒ€ๅœฐ่ฎพ็ฝฎ๏ผŒไฝฟๅพ—ๅœจๅ†…่Šฏ 52 ่ฟœ็ซฏๅฝขๆˆ็š„้ซ˜ X ๅฐ„็บฟไธ้€ๅฐ„้ƒจๅˆ† 54 ็š„ๅฐ้˜ถ้ƒจๅˆ†ไธไผšๅฏนๅฏผไธ 50 ็š„ๅค–ๅฝขไบง็”Ÿไธๅˆฉๅฝฑๅ“ใ€‚
  • [0105]
    As the slidable coating film 53, it is possible to preferably use the same slidable coating film as the slidable coating film 3 formed on the above-described gasket
    ไฝœไธบๆป‘ๅŠจๆถ‚่†œ 53๏ผŒไผ˜้€‰ไฝฟ็”จไธŽไธŠ่ฟฐๅžซ็‰‡ไธŠๅฝขๆˆ็š„ๆป‘ๅŠจๆถ‚่†œ 3 ็›ธๅŒ็š„ๆป‘ๅŠจๆถ‚่†œใ€‚
  • [0106]
    The outer diameter of the slidable coating film 53 is set to the range of 0.25 to 1.04mm and favorably to the range of 0.30 to 0.64mm. The thickness of the inner core 52 disposed around the main body 52a is set to the range of 0.25 to 1.04mm and favorably to the range of 0.30 to 0.64mm.
    ๆป‘ๅŠจๆถ‚่†œ 53 ็š„ๅค–ๅพ„่ฎพๅฎšไธบ 0.25๏ฝž1.04mm ็š„่Œƒๅ›ด๏ผŒไผ˜้€‰ไธบ 0.30๏ฝž0.64mm ็š„่Œƒๅ›ดใ€‚้…็ฝฎๅœจไธปไฝ“ 52a ๅ‘จๅ›ด็š„ๅ†…่Šฏ 52 ็š„ๅŽšๅบฆ่ฎพๅฎšไธบ 0.25๏ฝž1.04mm ็š„่Œƒๅ›ด๏ผŒไผ˜้€‰ไธบ 0.30๏ฝž0.64mm ็š„่Œƒๅ›ดใ€‚
  • [0107]
    It is preferable that the distal end of the guide wire 50 (distal end of slidable coating film 53) is curved, namely, hemispherical as shown in Fig. 6 to prevent walls of blood vessels from being damaged and improve the operability of the guide wire 50.
    ๅฏผไธ 50 ็š„่ฟœ็ซฏ๏ผˆๅฏๆป‘ๅŠจๆถ‚่†œ 53 ็š„่ฟœ็ซฏ๏ผ‰ไผ˜้€‰ไธบๅผฏๆ›ฒ็š„๏ผŒๅณๅฆ‚ๅ›พ 6 ๆ‰€็คบ็š„ๅŠ็ƒๅฝข๏ผŒไปฅ้˜ฒๆญข่ก€็ฎกๅฃๅ—ๆŸๅนถๆ้ซ˜ๅฏผไธ 50 ็š„ๅฏๆ“ไฝœๆ€งใ€‚
  • [0108]
    In the guide wire 50 of this embodiment, the entire inner core 52 is covered with the slidable coating film 53. But the mode of the guide wire 50 is not limited to this mode. A part of the inner core 52 may be covered with the slidable coating film 53. For example, only the distal portion or only the main body of the inner core 52 may be covered with the slidable coating film 53.
    ๅœจๆœฌๅฎžๆ–ฝไพ‹็š„ๅฏผไธ 50 ไธญ๏ผŒๆ•ดไธชๅ†…่Šฏ 52 ๅ‡่ขซๅฏๆป‘ๅŠจ็š„ๆถ‚ๅฑ‚ 53 ่ฆ†็›–ใ€‚ไฝ†ๅฏผไธ 50 ็š„ๅฝขๆ€ไธ้™ไบŽๆญคใ€‚ ๅ†…่Šฏ 52 ็š„ไธ€้ƒจๅˆ†ไนŸๅฏไปฅ่ขซๅฏๆป‘ๅŠจ็š„ๆถ‚ๅฑ‚ 53 ่ฆ†็›–ใ€‚ไพ‹ๅฆ‚๏ผŒไนŸๅฏไปฅไป…ๅ†…่Šฏ 52 ็š„่ฟœ็ซฏ้ƒจๅˆ†ๆˆ–ไธปไฝ“้ƒจๅˆ†่ขซๅฏๆป‘ๅŠจ็š„ๆถ‚ๅฑ‚ 53 ่ฆ†็›–ใ€‚
  • โ€ข EXAMPLES  โ€ข ็คบไพ‹
  • [0109]
    The examples of the present invention are described below.
    ไธ‹้ขๅฏนๆœฌๅ‘ๆ˜Ž็š„ๅฎžๆ–ฝไพ‹่ฟ›่กŒ่ฏดๆ˜Žใ€‚
  • โ€ข Examples 1 through 16 and Comparison Examples 1 through 13
    โ€ข ็คบไพ‹ 1 ่‡ณ 16 ๅ’Œๆฏ”่พƒ็คบไพ‹ 1 ่‡ณ 13
  • [0110]
    A surface active agent (nonionic surface active agent, commercial name: "Reodoll AO-15V" produced by Kao Co., Ltd.) was added to a solvent (toluene). After the carbon nanotubes were added to the solvent, the solution was stirred to prepare a liquid in which the carbon nanotubes were preferably dispersed. The solvent-based silicone rubber (commercial name: "YSR 3022" containing 30 wt% of silicone rubber component such as polyalkylsiloxane or the like produced by GE Toshiba Silicone Co., Ltd.) was added to the liquid in which the carbon nanotubes had been dispersed. Thereafter a filler (fine particle of silicone resin, powder of mica, powdery resin of polyolefin family), an adhesion-improving agent (commercial name "XC9603", containing silane coupling agent, which was produced by GE Toshiba Silicone Co., Ltd.), a catalyst (commercial name "YC6831", containing dialkyl tin compounds, which was produced by GE Toshiba Silicone Co., Ltd.) were added to the liquid. Thereby the (slidable) composition of each of the examples of the present invention and the comparison examples was prepared.
    ๅฐ†่กจ้ขๆดปๆ€งๅ‰‚๏ผˆ้ž็ฆปๅญ่กจ้ขๆดปๆ€งๅ‰‚๏ผŒๅ•†ๅ“ๅ๏ผšโ€œReodoll AO-15Vโ€๏ผŒ่Šฑ็Ž‹ๆ ชๅผไผš็คพ็”Ÿไบง๏ผ‰ๅŠ ๅ…ฅๆบถๅ‰‚๏ผˆ็”ฒ่‹ฏ๏ผ‰ไธญใ€‚ๅฐ†็ขณ็บณ็ฑณ็ฎกๅŠ ๅ…ฅๆบถๅ‰‚ๅŽ๏ผŒๆ…ๆ‹Œๆบถๆถฒ๏ผŒไฝฟๅ…ถ่พพๅˆฐ็ขณ็บณ็ฑณ็ฎก่‰ฏๅฅฝๅˆ†ๆ•ฃ็š„ๆบถๆถฒ็Šถๆ€ใ€‚ๅฐ†ๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ๏ผˆๅ•†ๅ“ๅ๏ผšโ€œYSR 3022โ€๏ผŒๅซๆœ‰ 30 wt%็š„็ก…ๆฉก่ƒถๆˆๅˆ†๏ผŒไพ‹ๅฆ‚่š็ƒทๅŸบ็ก…ๆฐง็ƒท็ญ‰๏ผŒGE ไธœ่Šๆœ‰ๆœบ็ก…ๆ ชๅผไผš็คพ็”Ÿไบง๏ผ‰ๅŠ ๅ…ฅๅˆฐ็ขณ็บณ็ฑณ็ฎกๅˆ†ๆ•ฃ็š„ๆบถๆถฒไธญใ€‚้šๅŽ๏ผŒๅฐ†ๅกซๆ–™๏ผˆ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€ไบ‘ๆฏ็ฒ‰ใ€่š็ƒฏ็ƒƒ็ฑป็ฒ‰ๆœซๆ ‘่„‚๏ผ‰ใ€้™„็€ๅŠ›ๆ”นๅ–„ๅ‰‚๏ผˆๅ•†ๅ“ๅโ€œXC9603โ€๏ผŒๅซ็ก…็ƒทๅถ่”ๅ‰‚๏ผŒGE ไธœ่Šๆœ‰ๆœบ็ก…ๆ ชๅผไผš็คพ็”Ÿไบง๏ผ‰ๅ’Œๅ‚ฌๅŒ–ๅ‰‚๏ผˆๅ•†ๅ“ๅโ€œYC6831โ€๏ผŒๅซไบŒ็ƒทๅŸบ้”กๅŒ–ๅˆ็‰ฉ๏ผŒGE ไธœ่Šๆœ‰ๆœบ็ก…ๆ ชๅผไผš็คพ็”Ÿไบง๏ผ‰ๅŠ ๅ…ฅๅˆฐไธŠ่ฟฐๆถฒไฝ“ไธญ๏ผŒๅˆถๅค‡ๅ‡บๆœฌๅ‘ๆ˜Žๅฎžๆ–ฝไพ‹ๅ’Œๆฏ”่พƒไพ‹็š„๏ผˆๅฏๆป‘ๅŠจ๏ผ‰็ป„ๅˆ็‰ฉใ€‚
  • [0111]
    As the fine particle of the silicone resin, "Tospearl 145" ((commercial name) produced by GE Toshiba Silicone Co., Ltd.) was used. The "Tospearl 145" consisted of polymethyl silsesquioxane having an average diameter of 4.5ยตm and true specific gravity of 1.32 (25ยฐC). As the powdery mica, the unswelling-type mica (commercial name: "PDM-5B" consisting of fluorine phlogopite produced by Topy Kogyo Co., Ltd., average diameter: 6ยตm) was used. As the powdery resin of the polyolefin family, powder of polyethylene (spherical, average diameter 5ยตm) was used.
    ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ไฝฟ็”จไบ†โ€œTospearl 145โ€๏ผˆๅ•†ๅ“ๅ๏ผŒGE ไธœ่Šๆœ‰ๆœบ็ก…ๆ ชๅผไผš็คพ็”Ÿไบง๏ผ‰ใ€‚โ€œTospearl 145โ€็”ฑ่š็”ฒๅŸบๅ€ๅŠ็ก…ๆฐง็ƒทๆž„ๆˆ๏ผŒๅนณๅ‡็ฒ’ๅพ„ 4.5ฮผm๏ผŒ็œŸๆฏ”้‡ 1.32๏ผˆ25โ„ƒ๏ผ‰ใ€‚ไบ‘ๆฏ็ฒ‰ไฝฟ็”จไบ†้ž่†จ่ƒ€ๅž‹ไบ‘ๆฏ๏ผˆๅ•†ๅ“ๅโ€œPDM-5Bโ€๏ผŒ็”ฑไธœ่Šๅทฅไธšๆ ชๅผไผš็คพ็”Ÿไบง๏ผŒ็”ฑๆฐŸ้‡‘ไบ‘ๆฏๆž„ๆˆ๏ผŒๅนณๅ‡็ฒ’ๅพ„ 6ฮผm๏ผ‰ใ€‚่š็ƒฏ็ƒƒ็ฑป็ฒ‰ๆœซๆ ‘่„‚ไฝฟ็”จไบ†่šไน™็ƒฏ็ฒ‰ๆœซ๏ผˆ็ƒๅฝข๏ผŒๅนณๅ‡็ฒ’ๅพ„ 5ฮผm๏ผ‰ใ€‚
  • [0112]
    In all the examples and the comparison examples, the amount of the toluene was adjusted so that the content of the solvent-based silicone rubber contained in the composition was 10 wt%. The components of the compositions of examples and comparison examples and compounding rates thereof are as shown in table 1a and 1b of Fig. 7 and Fig. 8.
    ๆ‰€ๆœ‰ๅฎžๆ–ฝไพ‹ๅ’Œๆฏ”่พƒไพ‹ไธญ๏ผŒๅ‡่ฐƒๆ•ด็”ฒ่‹ฏ็š„็”จ้‡๏ผŒไฝฟ็ป„ๅˆ็‰ฉไธญๆ‰€ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„ๅซ้‡ไธบ 10wt๏ผ…ใ€‚ๅฎžๆ–ฝไพ‹ๅ’Œๆฏ”่พƒไพ‹็š„็ป„ๅˆ็‰ฉ็š„็ป„ๅˆ†ๅŠๅ…ถ้…ๅˆๆฏ”ไพ‹ๅˆ†ๅˆซๅฆ‚ๅ›พ 7 ๅ’Œๅ›พ 8 ็š„่กจ 1a ๅ’Œ 1b ๆ‰€็คบใ€‚
  • [0113]
    The following three kinds of carbon nanotubes were used: Type A (used in only example 15) having an average diameter of about 70nm (about ฯ† 20 to 120nm) and an average length of about 0.1mm; Type B (used in only example 16) having an average diameter of about 350nm (about ฯ† 200 to 500nm) and an average length of about 0.1mm; and Type C (used in all of examples and comparison examples other than 15 and 16) having an average diameter of about 150nm (about ฯ† 100 to 200nm) and an average length of about 0.1mm.
    ๆ‰€็”จ็š„็ขณ็บณ็ฑณ็ฎกๆœ‰ไปฅไธ‹ไธ‰็ง๏ผšA ๅž‹๏ผˆๅช็”จไบŽๅฎžๆ–ฝไพ‹ 15๏ผ‰๏ผŒๅนณๅ‡็›ดๅพ„็บฆไธบ 70nm๏ผˆ็บฆ ฯ†20 ่‡ณ 120nm๏ผ‰๏ผŒๅนณๅ‡้•ฟๅบฆ็บฆไธบ 0.1mm๏ผ›B ๅž‹๏ผˆๅช็”จไบŽๅฎžๆ–ฝไพ‹ 16๏ผ‰๏ผŒๅนณๅ‡็›ดๅพ„็บฆไธบ 350nm๏ผˆ็บฆ ฯ†200 ่‡ณ 500nm๏ผ‰๏ผŒๅนณๅ‡้•ฟๅบฆ็บฆไธบ 0.1mm๏ผ›C ๅž‹๏ผˆ็”จไบŽ้™คๅฎžๆ–ฝไพ‹ 15 ๅ’Œ 16 ไน‹ๅค–็š„ๆ‰€ๆœ‰ๅฎžๆ–ฝไพ‹ๅ’Œๆฏ”่พƒไพ‹๏ผ‰๏ผŒๅนณๅ‡็›ดๅพ„็บฆไธบ 150nm๏ผˆ็บฆ ฯ†100 ่‡ณ 200nm๏ผ‰๏ผŒๅนณๅ‡้•ฟๅบฆ็บฆไธบ 0.1mmใ€‚
  • โ€ข Experiment 1
    โ€ข ๅฎž้ชŒ 1
  • [0114]
    The coefficient of dynamic friction of each composition was measured in accordance with the method of JIS K 7125 by using a tribo-gear (Tribo-gear TYPE-14DR manufactured by HEIDON).
    ๆ นๆฎ JIS K 7125 ็š„ๆ–นๆณ•๏ผŒไฝฟ็”จๆ‘ฉๆ“ฆ้ฝฟ่ฝฎ(HEIDON ๅˆถ้€ ็š„ Tribo-gear TYPE-14DR)ๆต‹้‡ๆฏ็ง็ป„ๅˆ็‰ฉ็š„ๅŠจๆ‘ฉๆ“ฆ็ณปๆ•ฐใ€‚
  • [0115]
    More specifically, the composition of each of the examples 1 through 16 and the comparison examples 1 through 13 was sprayed to a substrate consisting of butyl rubber (hardness: A70, Raโ‰’0.4ยตm). The components and compounding rates of each composition are as shown in table 1a and 1b. The prepared sample of each composition was brought into contact with a stainless steel terminal (ฯ† 10mm, Raโ‰’ 0.4ยตm) for measuring the coefficient of friction of each composition. The coefficient of friction of each sample was measured when the sample was slid 10mm at a speed of 100mm/minute, with a load of 200g being vertically applied to the terminal. After the terminal was slid, the surface state of the coating film was visually checked. The coefficient of dynamic friction of the substrate made of butyl rubber was 1.42, when the coating agent was not applied thereto.
    ๅ…ทไฝ“่€Œ่จ€๏ผŒๅฐ†ๅฎžๆ–ฝไพ‹ 1 ่‡ณ 16 ๅ’Œๆฏ”่พƒไพ‹ 1 ่‡ณ 13 ็š„็ป„ๅˆ็‰ฉๅ–ทๆถ‚ๅˆฐ็”ฑไธๅŸบๆฉก่ƒถ๏ผˆ็กฌๅบฆ๏ผšA70๏ผŒRaโ‰’0.4ฮผm๏ผ‰ๅˆถๆˆ็š„ๅŸบๆไธŠใ€‚ๅ„็ป„ๅˆ็‰ฉ็š„ๆˆๅˆ†ๅ’Œ้…ๆฏ”ๅฆ‚่กจ 1a ๅ’Œ 1b ๆ‰€็คบใ€‚ๅฐ†ๅˆถๅค‡ๅฅฝ็š„ๅ„็ป„ๅˆ็‰ฉ็š„ๆ ทๅ“ไธŽไธ้”ˆ้’ข็ซฏๅญ๏ผˆ ฯ†10mm ๏ผŒRaโ‰’0.4ฮผm๏ผ‰ๆŽฅ่งฆ๏ผŒๆต‹้‡ๅ„็ป„ๅˆ็‰ฉ็š„ๆ‘ฉๆ“ฆ็ณปๆ•ฐใ€‚ไปฅ 100mm/ๅˆ†้’Ÿ็š„้€Ÿๅบฆๅฐ†ๆ ทๅ“ๆป‘ๅŠจ 10mm๏ผŒๅนถๅœจ็ซฏๅญไธŠๅž‚็›ดๆ–ฝๅŠ  200g ็š„่ดŸ่ฝฝ๏ผŒๆต‹้‡ๅ„ๆ ทๅ“็š„ๆ‘ฉๆ“ฆ็ณปๆ•ฐใ€‚ๆป‘ๅŠจ็ซฏๅญๅŽ๏ผŒ็›ฎ่ง†ๆฃ€ๆŸฅๆถ‚่†œ็š„่กจ้ข็Šถๆ€ใ€‚ๆœชๆถ‚่ฆ†ๆถ‚ๅฑ‚ๅ‰‚ๆ—ถ๏ผŒไธๅŸบๆฉก่ƒถๅŸบๆ็š„ๅŠจๆ‘ฉๆ“ฆ็ณปๆ•ฐไธบ 1.42ใ€‚
  • [0116]
    Fig. 9 shows the image of the coating film, made of the composition of the example 1, which was formed on the substrate of the butyl rubber. The image was obtained by using an electron microscope.
    ๅ›พ9ไธบๅฎžๆ–ฝไพ‹1็š„็ป„ๅˆ็‰ฉๅœจไธๅŸบๆฉก่ƒถๅŸบๆไธŠๅฝขๆˆ็š„ๆถ‚่†œ็š„ๅ›พๅƒ๏ผŒ่ฏฅๅ›พๅƒๆ˜ฏ้€š่ฟ‡็”ตๅญๆ˜พๅพฎ้•œ่Žทๅพ—็š„ใ€‚
  • [0117]
    From the comparison between the composition of the examples 1, 7 through 14 and that of the comparison example 7; between the composition of the example 2 and that of the comparison example 8; between the composition of the example 3 and that of the comparison example 9; between the composition of the example 4 and that of the comparison example 10; between the composition of the example 5 and that of the comparison example 12; and between the composition of the example 6 and that of the comparison example 13, it was confirmed that the coefficient of dynamic friction decreased owing to the addition of the carbon nanotube to the rubber component (solvent-based silicone rubber). It could be also confirmed that the slidableness-improving effect can be favorably obtained when the mixing amount of the carbon nanotube for 100 parts by weight of the solvent-based silicone rubber is in the range of 0.01 to 2 parts by weight It could be confirmed from the results of the composition of the examples 1 through 6 that the compositions show a low coefficient of dynamic friction owing to the addition of the carbon nanotube to the rubber component, even though the compositions of the powder of the silicone resin, polyethylene, and mica changed to some extent
    ้€š่ฟ‡ๆฏ”่พƒๅฎžๆ–ฝไพ‹1ใ€7่‡ณ14็š„็ป„ๅˆ็‰ฉไธŽๆฏ”่พƒไพ‹7็š„็ป„ๅˆ็‰ฉใ€ๅฎžๆ–ฝไพ‹2็š„็ป„ๅˆ็‰ฉไธŽๆฏ”่พƒไพ‹8็š„็ป„ๅˆ็‰ฉใ€ๅฎžๆ–ฝไพ‹3็š„็ป„ๅˆ็‰ฉไธŽๆฏ”่พƒไพ‹9็š„็ป„ๅˆ็‰ฉใ€ๅฎžๆ–ฝไพ‹4็š„็ป„ๅˆ็‰ฉไธŽๆฏ”่พƒไพ‹10็š„็ป„ๅˆ็‰ฉใ€ๅฎžๆ–ฝไพ‹5็š„็ป„ๅˆ็‰ฉไธŽๆฏ”่พƒไพ‹12็š„็ป„ๅˆ็‰ฉใ€ๅฎžๆ–ฝไพ‹6็š„็ป„ๅˆ็‰ฉไธŽๆฏ”่พƒไพ‹13็š„็ป„ๅˆ็‰ฉ๏ผŒๅฏไปฅ็กฎ่ฎค๏ผŒ็”ฑไบŽๅœจๆฉก่ƒถ็ป„ๅˆ†๏ผˆๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ๏ผ‰ไธญๆทปๅŠ ไบ†็ขณ็บณ็ฑณ็ฎก๏ผŒๅ› ๆญคๅŠจๆ‘ฉๆ“ฆ็ณปๆ•ฐ้™ไฝŽไบ†ใ€‚่ฟ˜ๅฏไปฅ่ฏๅฎž๏ผŒๅฝ“็ขณ็บณ็ฑณ็ฎก็š„ๆททๅˆ้‡ไธบ100้‡้‡ไปฝๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ็š„0.01่‡ณ2้‡้‡ไปฝๆ—ถ๏ผŒๅฏไปฅ่‰ฏๅฅฝๅœฐ่Žทๅพ—ๆ”นๅ–„ๆป‘ๅŠจๆ€ง็š„ๆ•ˆๆžœใ€‚ไปŽๅฎžๆ–ฝไพ‹1่‡ณ6็š„็ป„ๅˆ็‰ฉ็š„็ป“ๆžœๅฏไปฅ่ฏๅฎž๏ผŒ็”ฑไบŽๅœจๆฉก่ƒถ็ป„ๅˆ†ไธญๆทปๅŠ ไบ†็ขณ็บณ็ฑณ็ฎก๏ผŒๅณไฝฟ็ก…ๆ ‘่„‚็ฒ‰ๆœซใ€่šไน™็ƒฏๅ’Œไบ‘ๆฏ็š„ๆˆๅˆ†ๅ‘็”Ÿไธ€ๅฎš็จ‹ๅบฆ็š„ๅ˜ๅŒ–๏ผŒ็ป„ๅˆ็‰ฉไป่กจ็Žฐๅ‡บ่พƒไฝŽ็š„ๅŠจๆ€ๆ‘ฉๆ“ฆ็ณปๆ•ฐใ€‚
  • [0118]
    From the comparison between the composition of the example 2 and that of the comparison example 8, it was confirmed that the addition of the carbon nanotube to the rubber component caused the coefficient of dynamic friction to decrease to a higher extent than the extent of the effect which can be brought about by the addition of PTFE to the rubber component
    ้€š่ฟ‡ๅฎžๆ–ฝไพ‹ 2 ๅ’Œๆฏ”่พƒไพ‹ 8 ็š„็ป„ๅˆ็‰ฉ็š„ๆฏ”่พƒ๏ผŒๅฏไปฅ็กฎ่ฎค๏ผŒๅœจๆฉก่ƒถ็ป„ๅˆ†ไธญๆทปๅŠ ็ขณ็บณ็ฑณ็ฎกๅฏไฝฟๅŠจๆ‘ฉๆ“ฆ็ณปๆ•ฐ้™ไฝŽๅˆฐๆฏ”ๅœจๆฉก่ƒถ็ป„ๅˆ†ไธญๆทปๅŠ  PTFE ๆ›ดๆœ‰ๆ•ˆ็š„็จ‹ๅบฆใ€‚
  • [0119]
    From the experimental result of the composition of the comparison example 11, it was confirmed that when the amount of the filler added to 100 parts by weight of the solvent-based silicone rubber is not less than 100 parts by weight, peel-off (decrease of wear resistance) of the coating film occurred. From the comparison of the compositions of the example 1, 15, 16, it could be confirmed that the slidableness of the composition could be improved by the addition of the carbon nanotube to the rubber component although the diameters of the carbon nanotubes were different from one another.
    ไปŽๆฏ”่พƒไพ‹11็š„็ป„ๅˆ็‰ฉ็š„ๅฎž้ชŒ็ป“ๆžœๅฏ็กฎ่ฎค๏ผŒๅฝ“็›ธๅฏนไบŽ100้‡้‡ไปฝๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถ๏ผŒๅกซๆ–™็š„ๆทปๅŠ ้‡ไธไฝŽไบŽ100้‡้‡ไปฝๆ—ถ๏ผŒไผšๅ‘็”Ÿๆถ‚่†œๅ‰ฅ็ฆป๏ผˆ่€็ฃจๆ€งไธ‹้™๏ผ‰ใ€‚ไปŽๅฎžๆ–ฝไพ‹1ใ€15ใ€16็š„็ป„ๅˆ็‰ฉ็š„ๆฏ”่พƒๅฏ็กฎ่ฎค๏ผŒๅฐฝ็ฎก็ขณ็บณ็ฑณ็ฎก็š„็›ดๅพ„ๅ„ไธ็›ธๅŒ๏ผŒไฝ†้€š่ฟ‡ๅœจๆฉก่ƒถ็ป„ๅˆ†ไธญๆทปๅŠ ็ขณ็บณ็ฑณ็ฎกๅฏไปฅๆ”นๅ–„็ป„ๅˆ็‰ฉ็š„ๆป‘ๅŠจๆ€งใ€‚
  • โ€ข Example 17  โ€ข ็คบไพ‹ 17
  • [0120]
    The core part of a gasket for use in a syringe having the configuration shown in Figs. 1 and 2 was formed by using butyl rubber. The core part was formed by press-molding a vulcanizing rubber composition composed of the butyl rubber and additives added thereto. As the configuration of the obtained core part, it had a length of 20mm, an outer diameter of 23.7mm at distal-side and proximal-side annular ribs, a length of 10mm between the center of the distal-side annular rib and the center of the proximal-side annular rib, an outer diameter of 21.5mm at a same diameter portion of the core part which extend from the distal-side annular rib to the proximal-side annular rib, a length (depth) of 8mm in the plunger-mounting concave portion having a female screw at an inner side thereof, an inner diameter of 14.5mm at the distal side of the plunger-mounting concave portion, and an inner diameter of 15mm at the rear side of the plunger-mounting concave portion.
    ๅ›พ 1ใ€ๅ›พ 2 ๆ‰€็คบ็ป“ๆž„็š„ๆณจๅฐ„ๅ™จ็”จๅžซๅœˆ็š„่Šฏ้ƒจ้‡‡็”จไธๅŸบๆฉก่ƒถๅˆถๆˆใ€‚่ฏฅ่Šฏ้ƒจ็”ฑไธๅŸบๆฉก่ƒถๅŠๅ…ถๆทปๅŠ ็š„ๆทปๅŠ ๅ‰‚ๆž„ๆˆ็š„็กซๅŒ–ๆฉก่ƒถ็ป„ๅˆ็‰ฉๅŽ‹ๅˆถๆˆๅž‹่€Œๆˆใ€‚ๆ‰€่Žทๅพ—็š„ๆ ธๅฟƒ้ƒจๅˆ†็š„็ป“ๆž„ไธบ๏ผš้•ฟๅบฆไธบ 20mm๏ผŒ่ฟœ็ซฏไพงๅ’Œ่ฟ‘็ซฏไพง็Žฏๅฝข่‚‹็š„ๅค–ๅพ„ไธบ 23.7mm๏ผŒ่ฟœ็ซฏไพง็Žฏๅฝข่‚‹็š„ไธญๅฟƒไธŽ่ฟ‘็ซฏไพง็Žฏๅฝข่‚‹็š„ไธญๅฟƒไน‹้—ด็š„้•ฟๅบฆไธบ 10mm๏ผŒไปŽ่ฟœ็ซฏไพง็Žฏๅฝข่‚‹ๅปถไผธ่‡ณ่ฟ‘็ซฏไพง็Žฏๅฝข่‚‹็š„ๆ ธๅฟƒ้ƒจๅˆ†็š„็›ธๅŒ็›ดๅพ„้ƒจๅˆ†็š„ๅค–ๅพ„ไธบ 21.5mm๏ผŒๆŸฑๅกžๅฎ‰่ฃ…ๅ‡น้ƒจ็š„้•ฟๅบฆ๏ผˆๆทฑๅบฆ๏ผ‰ไธบ 8mm๏ผŒๆŸฑๅกžๅฎ‰่ฃ…ๅ‡น้ƒจ็š„่ฟœ็ซฏไพงๅ†…ๅพ„ไธบ 14.5mm๏ผŒๆŸฑๅกžๅฎ‰่ฃ…ๅ‡น้ƒจๅŽไพงๅ†…ๅพ„ไธบ 15mmใ€‚
  • [0121]
    At a room temperature and a normal pressure, the composition of the example 1 was sprayed to the core part of the gasket formed as described above. Thereafter the composition was dried at 110ยฐC for 10 minutes. Thereby the gasket for use in the syringe was formed.
    ๅœจๅฎคๆธฉๅธธๅŽ‹ไธ‹๏ผŒๅฐ†ๅฎžๆ–ฝไพ‹1็š„็ป„ๅˆ็‰ฉๅ–ทๆถ‚ๅˆฐไธŠ่ฟฐๅฝขๆˆ็š„ๅžซ็‰‡็š„่Šฏ้ƒจใ€‚ไน‹ๅŽ๏ผŒๅœจ110โ„ƒไธ‹ๅนฒ็‡ฅ10ๅˆ†้’Ÿใ€‚็”ฑๆญค๏ผŒๅฝขๆˆๆณจๅฐ„ๅ™จ็”จๅžซ็‰‡ใ€‚
  • [0122]
    The average thickness of the slidable coating film formed on the core member was about 7ยตm. The ratio of the diameter of the fine particle to the average film thickness of the slidable coating film was about 0.7.
    ๅฝขๆˆไบŽ่ŠฏๆไธŠ็š„ๆป‘ๅŠจๆ€งๆถ‚่†œ็š„ๅนณๅ‡ๅŽšๅบฆ็บฆไธบ 7ฮผm๏ผŒๅพฎ็ฒ’็›ดๅพ„ไธŽๆป‘ๅŠจๆ€งๆถ‚่†œๅนณๅ‡่†œๅŽšไน‹ๆฏ”็บฆไธบ 0.7ใ€‚
  • โ€ข Comparison Example 14  ยทๆฏ”่พƒไพ‹14
  • [0123]
    A gasket for use in a syringe of the comparison example 14 was formed in a manner similar to that used in the example 17 except that the composition of the comparison example 7 was used. The average thickness of the slidable coating film formed on the core member was about 7ยตm.
    ้™ค้‡‡็”จๆฏ”่พƒไพ‹ 7 ็š„็ป„ๅˆ็‰ฉๅค–๏ผŒๅ…ถไป–ไธŽๅฎžๆ–ฝไพ‹ 17 ๅŒๆ ทๅœฐๅฝขๆˆๆฏ”่พƒไพ‹ 14 ็š„ๆณจๅฐ„ๅ™จ็”จๅžซๅœˆใ€‚ๅœจ่ŠฏๆไธŠๅฝขๆˆ็š„ๆป‘ๅŠจๆ€งๆถ‚่†œ็š„ๅนณๅ‡ๅŽšๅบฆ็บฆไธบ 7ฮผmใ€‚
  • โ€ข Comparison Example 15  ยทๆฏ”่พƒไพ‹15
  • [0124]
    A syringe (30ml, silicone oil was applied to syringe manufactured by Terumo Kabushiki Kaisha) in which a gasket made of SEBS thermoplastic elastomer was mounted was used in the comparison example 15.
    ๆฏ”่พƒไพ‹ 15 ไธญไฝฟ็”จไบ†ๅฎ‰่ฃ…ไบ† SEBS ็ƒญๅก‘ๆ€งๅผนๆ€งไฝ“ๅˆถๅžซๅœˆ็š„ๆณจๅฐ„ๅ™จ(Terumo Kabushiki Kaisha ๅˆถ๏ผŒ30ml๏ผŒๆถ‚ๆœ‰็ก…ๆฒน็š„ๆณจๅฐ„ๅ™จ)ใ€‚
  • โ€ข Comparison Example 16  ยทๆฏ”่พƒไพ‹16
  • [0125]
    Except that the composition was not applied to the core member, a gasket made of butyl rubber formed in a manner similar to that used in the example 17 was used in the comparison example 16.
    ้™คไบ†ๆœชๅฐ†็ป„ๅˆ็‰ฉๆถ‚่ฆ†ๅˆฐ่ŠฏไปถไธŠไน‹ๅค–๏ผŒๅœจๅฏนๆฏ”ไพ‹ 16 ไธญไฝฟ็”จไบ†ไปฅไธŽๅฎžๆ–ฝไพ‹ 17 ไธญๆ‰€ไฝฟ็”จ็š„ๆ–นๅผ็ฑปไผผ็š„ๆ–นๅผๅฝขๆˆ็š„็”ฑไธๅŸบๆฉก่ƒถๅˆถๆˆ็š„ๅžซๅœˆใ€‚
  • โ€ข Experiment 2
    โ€ข ๅฎž้ชŒ 2
  • [0126]
    Polypropylene (produced by Nippon Polychem Co., Ltd.) was injection-molded to form outer cylinders, for use in a syringe, which had a configuration shown in Fig. 5. The cylindrical portion of the outer cylinder for use in the syringe had an inner diameter of 23.5mm and a length of 95mm. Polypropylene (produced by Nippon Polychem Co., Ltd.) was injection-molded to form plungers shown in Fig. 5.
    ๅฐ†่šไธ™็ƒฏ๏ผˆๆ—ฅๆœฌ Polychem ๆ ชๅผไผš็คพๅˆถ้€ ๏ผ‰ๆณจๅก‘ๆˆๅž‹๏ผŒๅˆถๆˆๅฆ‚ๅ›พ 5 ๆ‰€็คบๅฝข็Šถ็š„ๆณจๅฐ„ๅ™จๅค–็ญ’ใ€‚ๆณจๅฐ„ๅ™จๅค–็ญ’็š„ๅœ†ๆŸฑ้ƒจๅˆ†ๅ†…ๅพ„ไธบ 23.5mm๏ผŒ้•ฟๅบฆไธบ 95mmใ€‚ๅฐ†่šไธ™็ƒฏ๏ผˆๆ—ฅๆœฌ Polychem ๆ ชๅผไผš็คพๅˆถ้€ ๏ผ‰ๆณจๅก‘ๆˆๅž‹๏ผŒๅˆถๆˆๅฆ‚ๅ›พ 5 ๆ‰€็คบ็š„ๆŸฑๅกžใ€‚
  • [0127]
    The gaskets of the example 17 and the comparison examples 14 through 16 and the plungers were mounted on the outer cylinders to form some syringes. Silicone oil was applied to the inner surface of the outer cylinder of the comparison example 15. Except the syringe of the comparison example 5, the syringes were sterilized by autoclaving. Thereafter the following evaluations were made.
    ๅฐ†ๅฎžๆ–ฝไพ‹17ใ€ๆฏ”่พƒไพ‹14่‡ณ16็š„ๅžซๅœˆๅŠๆŽจๆ†ๅฎ‰่ฃ…ๅˆฐๅค–็ญ’ไธŠ๏ผŒๅˆถๆˆๆณจๅฐ„ๅ™จใ€‚ๆฏ”่พƒไพ‹15็š„ๅค–็ญ’ๅ†…่กจ้ขๆถ‚ๆŠนไบ†็ก…ๆฒนใ€‚้™คๆฏ”่พƒไพ‹5็š„ๆณจๅฐ„ๅ™จๅค–๏ผŒๅ…ถไฝ™ๆณจๅฐ„ๅ™จๅ‡้‡‡็”จ้ซ˜ๅŽ‹็ญ่Œๅ™จ่ฟ›่กŒ็ญ่Œใ€‚ไน‹ๅŽ๏ผŒ่ฟ›่กŒไบ†ไปฅไธ‹่ฏ„ไผฐใ€‚
  • [0128]
    The sliding resistance value in each syringe was measured by an autograph (AG-IS manufactured by Shimazu Seisakusho Co., Ltd.). More specifically, with the distal end of each syringe and the proximal end of the plunger fixed to a fixing portion of the autograph to which an object to be measured is fixed, the plunger was moved downward 30mm at a speed of 50mm/minute to measure a maximum sliding resistance value (maximum stress [N] required in section of 0 to 30mm) and an average sliding resistance value (average sliding resistance value [N] in section of 25 to 50mm). Table 2 shows the results. Table 2
    Example 17  ็คบไพ‹ 17 Comparison Example 14  ๆฏ”่พƒไพ‹14 Comparison Example 15  ๆฏ”่พƒไพ‹15 Comparison Example 16  ๆฏ”่พƒไพ‹16
    Maximum sliding resistance value (N)
    ๆœ€ๅคงๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผˆN๏ผ‰
    5.8 11.5 20 93.7
    Average sliding resistance value (N)
    ๅนณๅ‡ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผˆN๏ผ‰
    4.9 10.2 0.7 90.5

    ไฝฟ็”จ่‡ชๅŠจ็ป˜ๅ›พไปช๏ผˆๅฒ›ๆดฅๅˆถไฝœๆ‰€ๆ ชๅผไผš็คพๅˆถ้€ ๏ผŒAG-IS๏ผ‰ๆต‹้‡ๅ„ๆณจๅฐ„ๅ™จ็š„ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผใ€‚ๅ…ทไฝ“่€Œ่จ€๏ผŒๅฐ†ๅ„ๆณจๅฐ„ๅ™จ็š„ๅ‰็ซฏๅ’ŒๆŸฑๅกž็š„่ฟ‘็ซฏๅ›บๅฎšๅœจ่‡ชๅŠจ็ป˜ๅ›พไปช็š„ๅ›บๅฎš้ƒจไธŠ๏ผŒๅนถๅฐ†ๅพ…ๆต‹็‰ฉๅ›บๅฎšๅœจๅ›บๅฎš้ƒจไธŠ๏ผŒไปฅ 50mm/ๅˆ†้’Ÿ็š„้€ŸๅบฆไฝฟๆŸฑๅกžๅ‘ไธ‹็งปๅŠจ 30mm๏ผŒๆต‹้‡ๆœ€ๅคงๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผˆ0 ่‡ณ 30mm ๆˆช้ขๆ‰€้œ€็š„ๆœ€ๅคงๅบ”ๅŠ›[N]๏ผ‰ๅ’Œๅนณๅ‡ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผˆ25 ่‡ณ 50mm ๆˆช้ข็š„ๅนณๅ‡ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ[N]๏ผ‰ใ€‚็ป“ๆžœๅˆ—ไบŽ่กจ 2ใ€‚ ่กจ 2
  • [0129]
    As shown in table 2, the syringe using the gasket of the example 17 had smaller maximum and average sliding resistance values than the syringes using the gaskets of the comparison examples. In addition, the syringe of the example 17 had a small difference between the maximum sliding resistance value and the average sliding resistance value. Thus there is little fear that a liquid medicine was discharged from the syringe when an operation of pressing the plunger starts, which allowed the liquid medicine to be discharged safely and easily.
    ๅฆ‚่กจ2ๆ‰€็คบ๏ผŒไฝฟ็”จๅฎžๆ–ฝไพ‹17็š„ๅžซ็‰‡็š„ๆณจๅฐ„ๅ™จ๏ผŒๅ…ถๆœ€ๅคงๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผๅ’Œๅนณๅ‡ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผๅ‡ๅฐไบŽไฝฟ็”จๆฏ”่พƒไพ‹็š„ๅžซ็‰‡็š„ๆณจๅฐ„ๅ™จใ€‚ๆญคๅค–๏ผŒๅฎžๆ–ฝไพ‹17็š„ๆณจๅฐ„ๅ™จ็š„ๆœ€ๅคงๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผไธŽๅนณๅ‡ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผไน‹ๅทฎ่พƒๅฐใ€‚ๅ› ๆญค๏ผŒๅœจๅผ€ๅง‹ๆŽจๅŽ‹ๆŸฑๅกž็š„ๆ“ไฝœๆ—ถ๏ผŒๅ‡ ไนŽไธ็”จๆ‹…ๅฟƒ่ฏๆถฒไผšไปŽๆณจๅฐ„ๅ™จไธญๅ–ทๅ‡บ๏ผŒไปŽ่€Œๅฏไปฅๅฎ‰ๅ…จ่ฝปๆพๅœฐๅ–ทๅ‡บ่ฏๆถฒใ€‚
  • โ€ข Experiment 3
    โ€ข ๅฎž้ชŒ 3
  • [0130]
    As a material to form an outer cylinder for use in a syringe, annular polypropylene (ZEONEX: registered trademark produced by Zeon Corporation) was injection-molded to form the outer cylinder for use in the syringe having a configuration shown in Fig. 5. Except that the outer cylinder for use in the syringe was used, the sliding resistance values of the gaskets for syringes of the example 17 and the comparison examples 14 through 16 were measured in a manner similar to that used in the experiment 1. Table 3 shows the results. Table 3
    Example 17  ็คบไพ‹ 17 Comparison Example 14  ๆฏ”่พƒไพ‹14 Comparison Example 15  ๆฏ”่พƒไพ‹15 Comparison Example 16  ๆฏ”่พƒไพ‹16
    Maximum sliding resistance value (N)
    ๆœ€ๅคงๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผˆN๏ผ‰
    3.6 4.8 2.1 23.1
    Average sliding resistance value (N)
    ๅนณๅ‡ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผˆN๏ผ‰
    2.0 3.6 0.6 17.0

    ไฝœไธบๆณจๅฐ„ๅ™จๅค–็ญ’็š„ๅฝขๆˆๆๆ–™๏ผŒ้‡‡็”จ็Žฏ็Šถ่šไธ™็ƒฏ๏ผˆZEONEX๏ผšๆ—ฅๆœฌ็‘ž็ฟๆ ชๅผไผš็คพ็”Ÿไบง็š„ๆณจๅ†Œๅ•†ๆ ‡๏ผ‰ๆณจๅก‘ๆˆๅž‹๏ผŒๅฝขๆˆๅฆ‚ๅ›พ 5 ๆ‰€็คบๅฝข็Šถ็š„ๆณจๅฐ„ๅ™จๅค–็ญ’ใ€‚้™คไบ†ไฝฟ็”จ่ฏฅๆณจๅฐ„ๅ™จๅค–็ญ’ไน‹ๅค–๏ผŒไธŽๅฎž้ชŒ 1 ๅŒๆ ทๅœฐๆต‹ๅฎšไบ†ๅฎžๆ–ฝไพ‹ 17 ๅ’Œๆฏ”่พƒไพ‹ 14๏ฝž16 ็š„ๆณจๅฐ„ๅ™จ็”จๅžซๅœˆ็š„ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผŒ็ป“ๆžœ็คบไบŽ่กจ 3ใ€‚ ่กจ 3
  • โ€ข Example 18  โ€ข ็คบไพ‹ 18
  • [0131]
    A base material of a guide wire including an inner core made of Ni-Ti having an outer diameter of 0,889 mm (0.035 inches) and a length of 450mm and a polyurethane coating film formed on the surface of the inner core was prepared. After the composition of the example 1 was applied to the entire outer surface of the base material of the guide wire by using a dip coating method at a room temperature and a normal pressure, the composition was dried at 110ยฐC for 10 minutes to obtain a guide wire of the present invention.
    ๅˆถๅค‡ๅฏผไธๅŸบๆ๏ผŒๅ…ถๅŒ…ๆ‹ฌๅค–ๅพ„ไธบ 0.889 ๆฏซ็ฑณ๏ผˆ0.035 ่‹ฑๅฏธ๏ผ‰ใ€้•ฟๅบฆไธบ 450 ๆฏซ็ฑณ็š„้•้’›ๅˆ้‡‘ๅ†…่Šฏ๏ผŒๅนถๅœจๅ†…่Šฏ่กจ้ขๅฝขๆˆ่šๆฐจ้…ฏๆถ‚่†œใ€‚ๅœจๅฎคๆธฉๅธธๅŽ‹ไธ‹๏ผŒ้‡‡็”จๆตธๆถ‚ๆณ•ๅฐ†ๅฎžๆ–ฝไพ‹ 1 ็š„็ป„ๅˆ็‰ฉๆถ‚่ฆ†ๅˆฐๅฏผไธๅŸบๆ็š„ๆ•ดไธชๅค–่กจ้ขไธŠ๏ผŒ็„ถๅŽๅœจ 110ยฐC ไธ‹ๅนฒ็‡ฅ 10 ๅˆ†้’Ÿ๏ผŒๅณๅพ—ๅˆฐๆœฌๅ‘ๆ˜Ž็š„ๅฏผไธใ€‚
  • [0132]
    The average thickness of the slidable coating film formed on the surface of the inner core was about 5ยตm. The ratio of the diameter of the fine particle to the average film thickness of the slidable coating film was 1. Fig. 10 shows the image of the guide wire of this embodiment obtained by using an electron microscope.
    ๅ†…่Šฏ่กจ้ขๅฝขๆˆ็š„ๆป‘ๅŠจๆถ‚่†œๅนณๅ‡ๅŽšๅบฆ็บฆไธบ 5ฮผm๏ผŒๅพฎ็ฒ’็›ดๅพ„ไธŽๆป‘ๅŠจๆถ‚่†œๅนณๅ‡่†œๅŽšไน‹ๆฏ”ไธบ 1ใ€‚ๅ›พ 10 ไธบๆœฌๅฎžๆ–ฝไพ‹ๅฏผไธ็š„็”ตๅญๆ˜พๅพฎ้•œ็…ง็‰‡ใ€‚
  • โ€ข Comparison Example 17  ยท ๆฏ”่พƒไพ‹ 17
  • [0133]
    A guide wire of the comparison example 17 was formed in a manner similar to that used in the example 18 except that the composition of the comparison example 7 was used. The average thickness of the slidable coating film formed on the core member was about 7ยตm.
    ๆฏ”่พƒไพ‹ 17 ็š„ๅฏผไธ๏ผŒ้™ค้‡‡็”จๆฏ”่พƒไพ‹ 7 ็š„็ป„ๆˆๅค–๏ผŒๅ…ถไฝ™ไธŽๅฎžๆ–ฝไพ‹ 18 ็›ธๅŒ๏ผŒๅˆถๆˆๆฏ”่พƒไพ‹ 17 ็š„ๅฏผไธใ€‚ๅœจ่ŠฏๆไธŠๅฝขๆˆ็š„ๆป‘ๅŠจๆ€งๆถ‚่†œ็š„ๅนณๅ‡ๅŽšๅบฆ็บฆไธบ 7ฮผmใ€‚
  • โ€ข Comparison Example 18  ยทๆฏ”่พƒไพ‹18
  • [0134]
    A guide wire of the comparison example 18 was formed in a manner similar to that used in the example 18 except that reactive silicone oil was applied to the core member instead of coating the core member with the composition.
    ๆฏ”่พƒไพ‹ 18 ็š„ๅฏผไธไปฅไธŽๅฎžๆ–ฝไพ‹ 18 ไธญ็›ธไผผ็š„ๆ–นๅผๅฝขๆˆ๏ผŒไธๅŒไน‹ๅค„ๅœจไบŽๅฐ†ๅๅบ”ๆ€ง็ก…ๆฒนๆ–ฝๅŠ ๅˆฐ่Šฏๆž„ไปถไธŠ๏ผŒ่€Œไธๆ˜ฏ็”จ็ป„ๅˆ็‰ฉๆถ‚่ฆ†่Šฏๆž„ไปถใ€‚
  • โ€ข Comparison Example 19  ยทๆฏ”่พƒไพ‹19
  • [0135]
    A guide wire (only inner core) of the comparison example 19 was formed in a manner similar to that used in the example 18 except that the composition was not applied to the core member of the guide wire.
    ๆฏ”่พƒไพ‹ 19 ็š„ๅฏผไธ ( ไป…ๆœ‰ๅ†…่Šฏ ) ไปฅไธŽๅฎžๆ–ฝไพ‹ 18 ไธญๆ‰€ไฝฟ็”จ็š„ๆ–นๅผ็ฑปไผผ็š„ๆ–นๅผๅฝขๆˆ๏ผŒๅชๆ˜ฏๆœชๅฐ†็ป„ๅˆ็‰ฉๆถ‚่ฆ†ๅˆฐๅฏผไธ็š„่Šฏๆž„ไปถไธŠใ€‚
  • โ€ข Experiment 4
    โ€ข ๅฎž้ชŒ 4
  • [0136]
    The sliding resistance value of each of guide wires of the example 18 and the comparison examples 17 through 19 was measured by the autograph (Autograph AG-IS manufactured by Shimazu Seisakusho Co., Ltd.) by sliding the guide wires on the inner surface of a dilator (made of polypropylene) which is used when the guide wire is inserted into a human body.
    ไฝฟ็”จ่‡ชๅŠจ็ป˜ๅ›พไปช๏ผˆๅฒ›ๆดฅๅˆถไฝœๆ‰€ๅˆถ้€ ็š„่‡ชๅŠจ็ป˜ๅ›พไปช AG-IS๏ผ‰ๆต‹้‡ๅฎžๆ–ฝไพ‹ 18 ๅ’Œๆฏ”่พƒไพ‹ 17 ่‡ณ 19 ็š„ๅ„ๅฏผไธ็š„ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผŒๆ–นๆณ•ๆ˜ฏๅฐ†ๅฏผไธๅœจๆ’ๅ…ฅไบบไฝ“ๆ—ถไฝฟ็”จ็š„ๆ‰ฉๅผ ๅ™จ๏ผˆ่šไธ™็ƒฏๅˆถๆˆ๏ผ‰็š„ๅ†…่กจ้ขไธŠๆป‘ๅŠจใ€‚
  • [0137]
    More specifically, the dilator was fixed to a jig (jig for curving the central portion of the body thereof into a circle having a radius of 25mm). After the guide wire was inserted into the dilator, the distal end of the guide wire was fixed to the fixing portion of the autograph to which an object to be measured is fixed. In this state, the guide wire was pulled upward 100mm at a speed of 100mm/minute to measure a maximum sliding resistance value (maximum stress [gf] required in section of 0 to 100mm) and an average sliding resistance value (average sliding resistance value [gf] in section of 5 to 100mm). Table 4 shows the results. Table 4
    Example 18  ็คบไพ‹ 18 Comparison Example 17  ๆฏ”่พƒไพ‹17 Comparison Example 18  ๆฏ”่พƒไพ‹18 Comparison Example 19  ๆฏ”่พƒไพ‹19
    Maximum sliding resistance value(gf)
    ๆœ€ๅคงๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ(gf)
    5.8 10.2 19.9 50.9
    Average sliding resistance value (gf)
    ๅนณๅ‡ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผˆgf๏ผ‰
    5.0 9.0 17.3 39.4

    ๅ…ทไฝ“ๆฅ่ฏด๏ผŒๅฐ†ๆ‰ฉๅผ ๅ™จๅ›บๅฎšๅœจๅคนๅ…ท๏ผˆ็”จไบŽๅฐ†ๅ…ถไธปไฝ“ไธญๅฟƒ้ƒจๅˆ†ๅผฏๆ›ฒๆˆๅŠๅพ„ไธบ 25mm ็š„ๅœ†ๅฝข็š„ๅคนๅ…ท๏ผ‰ไธŠใ€‚ๅฐ†ๅฏผไธๆ’ๅ…ฅๆ‰ฉๅผ ๅ™จๅŽ๏ผŒๅฐ†ๅฏผไธ่ฟœ็ซฏๅ›บๅฎšๅœจๅ›บๅฎšๆœ‰ๅพ…ๆต‹็‰ฉ็š„่‡ชๅŠจ็ป˜ๅ›พไปช็š„ๅ›บๅฎš้ƒจๅˆ†ไธŠใ€‚ๅœจๆญค็Šถๆ€ไธ‹๏ผŒไปฅ 100mm/ๅˆ†้’Ÿ็š„้€Ÿๅบฆๅฐ†ๅฏผไธๅ‘ไธŠๆ‹‰ๅŠจ 100mm๏ผŒๆต‹้‡ๆœ€ๅคงๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผˆ0 ่‡ณ 100mm ๆˆช้ขๆ‰€้œ€็š„ๆœ€ๅคงๅบ”ๅŠ›[gf]๏ผ‰ๅ’Œๅนณๅ‡ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ๏ผˆ5 ่‡ณ 100mm ๆˆช้ข็š„ๅนณๅ‡ๆป‘ๅŠจ้˜ปๅŠ›ๅ€ผ[gf]๏ผ‰ใ€‚็ป“ๆžœๅฆ‚่กจ 4 ๆ‰€็คบใ€‚ ่กจ 4
  • [0138]
    It was confirmed that the guide wire (guide wire coated with composition of example 1) had slidableness improved over that of the comparison example 17 (guide wire coated with composition of comparison example 7), the comparison example 18 (guide wire having reactive silicone oil applied to inner core thereof), and the comparison example 19 (non-coated guide wire). It was confirmed that the guide wire of the example 18 had improved slidableness owing to the addition of the carbon nanotube to the rubber component
    ็ป่ฏๅฎž๏ผŒๆœฌๅฏผไธ๏ผˆๅฎžๆ–ฝไพ‹1็ป„ๅˆ็‰ฉๆถ‚่ฆ†็š„ๅฏผไธ๏ผ‰็š„ๆป‘ๅŠจๆ€งไผ˜ไบŽๅฏนๆฏ”ไพ‹17๏ผˆๅฏนๆฏ”ไพ‹7็ป„ๅˆ็‰ฉๆถ‚่ฆ†็š„ๅฏผไธ๏ผ‰ใ€ๅฏนๆฏ”ไพ‹18๏ผˆๅ†…่Šฏๆถ‚่ฆ†ๅๅบ”ๆ€ง็ก…ๆฒน็š„ๅฏผไธ๏ผ‰ๅ’Œๅฏนๆฏ”ไพ‹19๏ผˆๆ— ๆถ‚ๅฑ‚ๅฏผไธ๏ผ‰ใ€‚็ป่ฏๅฎž๏ผŒๅฎžๆ–ฝไพ‹18็š„ๅฏผไธ็”ฑไบŽๅœจๆฉก่ƒถ็ป„ๅˆ†ไธญๆทปๅŠ ไบ†็ขณ็บณ็ฑณ็ฎก๏ผŒๆป‘ๅŠจๆ€งๆœ‰ๆ‰€ๆ้ซ˜ใ€‚
  • [0139]
    The medical appliance-coating composition of the present invention contains the solvent-based silicone rubber as its main component and in addition the carbon nanotubes and the fine particles of the silicone resin.
    ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉไปฅๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถไธบไธป่ฆๆˆๅˆ†๏ผŒ่ฟ˜ๅซๆœ‰็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚
  • [0140]
    Therefore the coating film made of the medical appliance-coating composition has a high degree of slidableness and strength and is capable of imparting a sufficiently high degree of slidableness to the medical appliance.
    ๅ› ๆญค๏ผŒ็”ฑ่ฏฅๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉๅฝขๆˆ็š„ๆถ‚่†œๅ…ทๆœ‰้ซ˜็š„ๆป‘ๅŠจๆ€งๅ’Œๅผบๅบฆ๏ผŒ่ƒฝๅคŸ่ต‹ไบˆๅŒป็–—ๅ™จๆขฐ่ถณๅคŸ้ซ˜็š„ๆป‘ๅŠจๆ€งใ€‚
  • [0141]
    The medical appliance of the present invention moves in contact with the inner surface of the medical member or the inner surface of the lumen and has the slidable coating film formed at the portion thereof which contacts the medical member or the lumen. The slidable coating film is composed of the silicone rubber and contains the carbon nanotubes and the fine particles of the silicone resin.
    ๆœฌๅ‘ๆ˜Ž็š„ๅŒป็–—ๅ™จๆขฐไธŽๅŒป็–—็”จ้ƒจไปถ็š„ๅ†…่กจ้ขๆˆ–็ฎก่…”็š„ๅ†…่กจ้ขๆŽฅ่งฆ็งปๅŠจ๏ผŒๅนถๅœจไธŽๅŒป็–—็”จ้ƒจไปถๆˆ–็ฎก่…”ๆŽฅ่งฆ็š„้ƒจๅˆ†ๅฝขๆˆๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œใ€‚่ฏฅๆป‘ๅŠจๆ€งๆถ‚่†œ็”ฑ็ก…ๆฉก่ƒถๆž„ๆˆ๏ผŒๅนถๅซๆœ‰็ขณ็บณ็ฑณ็ฎกๅ’Œ็ก…ๆ ‘่„‚ๅพฎ็ฒ’ใ€‚
  • [0142]
    Therefore the slidable coating film formed on the medical appliance has a high degree of slidableness and strength. Thus the medical appliance keeps a sufficient degree of slidableness for a long time.
    ๅ› ๆญค๏ผŒๅœจๅŒป็–—ๅ™จๆขฐไธŠๅฝขๆˆ็š„ๆป‘ๅŠจๆถ‚่†œๅ…ทๆœ‰่พƒ้ซ˜็š„ๆป‘ๅŠจๆ€งๅ’Œๅผบๅบฆ๏ผŒไฝฟๅŒป็–—ๅ™จๆขฐ่ƒฝๅคŸ้•ฟๆ—ถ้—ดไฟๆŒ่ถณๅคŸ็š„ๆป‘ๅŠจๆ€งใ€‚

Claims (17)
ๆƒๅˆฉ่ฆๆฑ‚ ๏ผˆ17๏ผ‰
Hide Dependent   ้š่—ๅ—ๆŠšๅ…ปไบบ

  1. A medical appliance-coating composition for imparting slidableness to said medical appliance which contains a solvent-based silicone rubber, carbon nanotubes, and fine particles of silicone resin, having an average diameter of as to 30 ยตm.
    ไธ€็ง็”จไบŽ่ต‹ไบˆๅŒป็–—ๅ™จๆขฐๆป‘ๅŠจๆ€ง็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉ๏ผŒๅ…ถๅŒ…ๅซๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถใ€็ขณ็บณ็ฑณ็ฎกๅ’Œๅนณๅ‡็›ดๅพ„ไธบ็บฆ 30ฮผm ็š„็ก…ๆ ‘่„‚็ป†้ข—็ฒ’ใ€‚
  2. A medical appliance-coating composition according to claim t wherein said solvent-based silicone rubber is silicone resin having polysiloxane as a basic structure thereof; and a content of said silicone resin having said polysiloxane as said basic structure thereof is 10 to 70 wt% in said medical appliance-coating composition.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚ 1 ๆ‰€่ฟฐ็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉ๏ผŒๅ…ถไธญๆ‰€่ฟฐๆบถๅ‰‚ๅž‹็ก…ๆฉก่ƒถไธบๅ…ทๆœ‰่š็ก…ๆฐง็ƒทไฝœไธบๅŸบๆœฌ็ป“ๆž„็š„็ก…ๆ ‘่„‚๏ผ›ๅนถไธ”ๆ‰€่ฟฐๅ…ทๆœ‰่š็ก…ๆฐง็ƒทไฝœไธบๅŸบๆœฌ็ป“ๆž„็š„็ก…ๆ ‘่„‚ๅœจๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไธบ 10 ่‡ณ 70wt๏ผ…ใ€‚
  3. A medical appliance-coating composition according to claim 1 or 2, wherein said carbon nanotubes have an average diameter set to less than 800nm and an average fiber length set to less than 2mm and are contained at 0.01 to 2 wt% in said medical appliance-coating composition.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚ 1 ๆˆ– 2 ๆ‰€่ฟฐ็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉ๏ผŒๅ…ถไธญๆ‰€่ฟฐ็ขณ็บณ็ฑณ็ฎก็š„ๅนณๅ‡็›ดๅพ„่ฎพๅฎšไธบๅฐไบŽ 800nm๏ผŒๅนณๅ‡็บค็ปด้•ฟๅบฆ่ฎพๅฎšไธบๅฐไบŽ 2mm๏ผŒๅนถไธ”ๅœจๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐๆถ‚ๅฑ‚็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไธบ 0.01 ่‡ณ 2wt๏ผ…ใ€‚
  4. A medical appliance-coating composition according to any one of claims 1 through 3, wherein said fine particles of said silicone resin having an average diameter set to 0.5 to 30ยตm are contained at 0.2 to 50 wt% in said medical appliance-coating composition.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚ 1 ่‡ณ 3 ไธญไปปไธ€้กน็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉ๏ผŒๅ…ถไธญๅนณๅ‡็›ดๅพ„่ฎพๅฎšไธบ 0.5 ่‡ณ 30ฮผm ็š„ๆ‰€่ฟฐๆœ‰ๆœบ็ก…ๆ ‘่„‚็ป†้ข—็ฒ’ๅœจๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉไธญ็š„ๅซ้‡ไธบ 0.2 ่‡ณ 50wt๏ผ…ใ€‚
  5. A medical appliance-coating composition according to any one of claims 1 through 4, wherein said medical appliance-coating composition contains a surface active agent.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚1่‡ณ4ไธญไปปไธ€้กน็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉ๏ผŒๅ…ถไธญๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉๅซๆœ‰่กจ้ขๆดปๆ€งๅ‰‚ใ€‚
  6. A medical appliance-coating composition according to any one of claims 1 through 4, wherein said medical appliance-coating composition contains a nonionic surface active agent.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚1่‡ณ4ไธญไปปไธ€้กน็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉ๏ผŒๅ…ถไธญๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉๅซๆœ‰้ž็ฆปๅญ่กจ้ขๆดปๆ€งๅ‰‚ใ€‚
  7. A medical appliance-coating composition according to any one of claims 1 through 6, wherein said medical appliance-coating composition contains powder of polyolefin resin or/ and powder of mica.
    7.ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚1่‡ณ6ไธญไปปๆ„ไธ€้กนๆ‰€่ฟฐ็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉ๏ผŒๅ…ถไธญๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉๅซๆœ‰่š็ƒฏ็ƒƒๆ ‘่„‚็ฒ‰ๆœซๆˆ–/ๅ’Œไบ‘ๆฏ็ฒ‰ๆœซใ€‚
  8. A medical appliance-coating composition according to claim 7, wherein said medical appliance-coating composition contains 0.1 to 50 wt% of said powder of said polyolefin resin or said powder of said mica.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚ 7 ็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉ๏ผŒๅ…ถไธญๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉๅซๆœ‰ 0.1 ่‡ณ 50wt๏ผ…็š„ๆ‰€่ฟฐ่š็ƒฏ็ƒƒๆ ‘่„‚็ฒ‰ๆœซๆˆ–ๆ‰€่ฟฐไบ‘ๆฏ็ฒ‰ๆœซใ€‚
  9. A medical appliance-coating composition according to any one of claims 1 through 8, wherein said medical appliance-coating composition contains a silane coupling agent.
    9.ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚1่‡ณ8ไธญไปปไธ€้กนๆ‰€่ฟฐ็š„ๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉ๏ผŒๅ…ถไธญๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐๆถ‚ๆ–™็ป„ๅˆ็‰ฉๅซๆœ‰็ก…็ƒทๅถ่”ๅ‰‚ใ€‚
  10. A medical appliance, having a slidable coating film formed thereon, which moves in contact with an inner surface of a medical member or an inner surface of a body lumen,
    ไธ€็งๅŒป็–—ๅ™จๆขฐ๏ผŒๅ…ถๅฝขๆˆๆœ‰ๆป‘ๅŠจๆ€งๆถ‚่†œ๏ผŒ่ฏฅๆถ‚่†œไธŽๅŒป็–—ๆž„ไปถ็š„ๅ†…่กจ้ขๆˆ–ไฝ“่…”็š„ๅ†…่กจ้ขๆŽฅ่งฆๅนถ็งปๅŠจ๏ผŒ

    wherein said slidable coating film is disposed at a portion, of said medical appliance, which contacts said medical member or said body lumen; and said slidable coating film is comprised of a composition according to claim 1.
    ๅ…ถไธญๆ‰€่ฟฐๅฏๆป‘ๅŠจๆถ‚่†œ่ฎพ็ฝฎๅœจๆ‰€่ฟฐๅŒป็–—ๅ™จๆขฐ็š„ไธŽๆ‰€่ฟฐๅŒป็–—ๆž„ไปถๆˆ–ๆ‰€่ฟฐไฝ“่…”ๆŽฅ่งฆ็š„้ƒจๅˆ†๏ผ›ๅนถไธ”ๆ‰€่ฟฐๅฏๆป‘ๅŠจๆถ‚่†œ็”ฑๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚1็š„็ป„ๅˆ็‰ฉๆž„ๆˆใ€‚
  11. A medical appliance according to claim 10, wherein said silicone rubber has polysiloxane as a basic structure thereof.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚10็š„ๅŒป็–—ๅ™จๆขฐ๏ผŒๅ…ถไธญๆ‰€่ฟฐ็ก…ๆฉก่ƒถๅ…ทๆœ‰่š็ก…ๆฐง็ƒทไฝœไธบๅ…ถๅŸบๆœฌ็ป“ๆž„ใ€‚
  12. A medical appliance according to claim 10 or 11, wherein said carbon nanotubes have diameters set to less than 800nm and an average fiber length set to less than 2mm and are contained at 0.01 to 3 wt% in said slidable coating film.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚ 10 ๆˆ– 11 ็š„ๅŒป็–—ๅ™จๆขฐ๏ผŒๅ…ถไธญๆ‰€่ฟฐ็ขณ็บณ็ฑณ็ฎก็š„็›ดๅพ„่ฎพๅฎšไธบๅฐไบŽ 800nm๏ผŒๅนณๅ‡็บค็ปด้•ฟๅบฆ่ฎพๅฎšไธบๅฐไบŽ 2mm๏ผŒๅนถไธ”ๅœจๆ‰€่ฟฐๅฏๆป‘ๅŠจๆถ‚่†œไธญ็š„ๅซ้‡ไธบ 0.01 ่‡ณ 3wt๏ผ…ใ€‚
  13. A medical appliance according to any one of claims 10 through 12, wherein said fine particles of said silicone resin have an average diameter set to 1 to 30ยตm and are contained at 3 to 60 wt% in said slidable coating film.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚ 10 ่‡ณ 12 ไธญไปปไธ€้กน็š„ๅŒป็–—ๅ™จๆขฐ๏ผŒๅ…ถไธญๆ‰€่ฟฐๆœ‰ๆœบ็ก…ๆ ‘่„‚็š„ๆ‰€่ฟฐ็ป†้ข—็ฒ’ๅ…ทๆœ‰ๅนณๅ‡็›ดๅพ„่ฎพๅฎšไธบ 1 ่‡ณ 30ฮผm ๅนถไธ”ๅœจๆ‰€่ฟฐๅฏๆป‘ๅŠจๆถ‚่†œไธญ็š„ๅซ้‡ไธบ 3 ่‡ณ 60wt๏ผ…ใ€‚
  14. A medical appliance according to any one of claims 10 through 13, wherein said slidable coating film contains powder of polyolefin resin or/and powder of mica.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚10่‡ณ13ไธญไปปไธ€้กน็š„ๅŒป็–—ๅ™จๆขฐ๏ผŒๅ…ถไธญๆ‰€่ฟฐๅฏๆป‘ๅŠจๆถ‚่†œๅซๆœ‰่š็ƒฏ็ƒƒๆ ‘่„‚็ฒ‰ๆœซๆˆ–/ๅ’Œไบ‘ๆฏ็ฒ‰ๆœซใ€‚
  15. A medical appliance according to any one of claims 10 through 14, wherein said slidable coating film has a rough surface attributed to presence of said fine particle of said silicone resin and/or said carbon nanotubes contained therein.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚10่‡ณ14ไธญไปปไธ€้กน็š„ๅŒป็–—ๅ™จๆขฐ๏ผŒๅ…ถไธญๆ‰€่ฟฐๅฏๆป‘ๅŠจๆถ‚่†œ็”ฑไบŽๅ…ถไธญๅŒ…ๅซ็š„ๆ‰€่ฟฐ็ก…้…ฎๆ ‘่„‚็š„ๆ‰€่ฟฐ็ป†้ข—็ฒ’ๅ’Œ/ๆˆ–ๆ‰€่ฟฐ็ขณ็บณ็ฑณ็ฎก็š„ๅญ˜ๅœจ่€Œๅ…ทๆœ‰็ฒ—็ณ™่กจ้ขใ€‚
  16. A medical appliance according to any one of claims 10 through 15, wherein said medical member is an outer cylinder for use in a syringe; and said medical appliance is a gasket for use in said syringe.
    16.ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚10่‡ณ15ไธญไปปไธ€้กนๆ‰€่ฟฐ็š„ๅŒป็–—ๅ™จๅ…ท๏ผŒๅ…ถไธญ๏ผŒ ๆ‰€่ฟฐๅŒป็–—็”จๆž„ไปถๆ˜ฏๆณจๅฐ„ๅ™จ็”จๅค–็ญ’๏ผŒๆ‰€่ฟฐๅŒป็–—ๅ™จๅ…ทๆ˜ฏๆ‰€่ฟฐๆณจๅฐ„ๅ™จ็”จๅžซๅœˆใ€‚
  17. A medical appliance according to any one of claims 10 through 15, wherein said medical appliance is a guide wire or a catheter for inserting said body lumen.
    ๆ นๆฎๆƒๅˆฉ่ฆๆฑ‚10่‡ณ15ไธญไปปไธ€้กน็š„ๅŒป็–—ๅ™จๅ…ท๏ผŒๅ…ถไธญๆ‰€่ฟฐๅŒป็–—ๅ™จๅ…ทๆ˜ฏ็”จไบŽๆ’ๅ…ฅๆ‰€่ฟฐไฝ“็ฎก็š„ๅฏผไธๆˆ–ๅฏผ็ฎกใ€‚