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Medical appliance coating composition and medical appliance
ๅป็ๅจๆขฐ็จๆถๆ็ปๅ็ฉๅๅป็ๅจๆขฐ
EP1870117B1
European Patent Office
- Other languages
German French - Inventor
Shingo c/o Terumo Kabushiki Kaisha Ishii Makoto C/O Terumo Kabushiki Kaisha Onishi - Current Assignee
- Terumo Corp
- ๅ ถไป่ฏญ่จ
- ๅพท่ฏญ
- ๆณ่ฏญ
- ๅๆ่
- Shingo c/o Terumo Kabushiki Kaisha Ishii
- Makoto C/O Terumo Kabushiki Kaisha ๅคง่ฅฟ
- ๅฝๅๅ่ฎฉไบบ
- ๆณฐๅฐ่ๅ ฌๅธ
Worldwide applications ๅ
จ็ๅบ็จ
2006
JP
2007
DE
EP
AT
US
2006 ๅคชๅนณ็ป ๅฃซ2007 ๅพทEPAT ็ณ่ฏทๅท๏ผAT07011661T ็ณ่ฏทๆฅ๏ผ2007-06-14 ๆณๅพ็ถๆ ๏ผ
2006 ๅคชๅนณ็ป ๅฃซ2007 ๅพทEPAT ็ณ่ฏทๅท๏ผAT07011661T ็ณ่ฏทๆฅ๏ผ2007-06-14 ๆณๅพ็ถๆ ๏ผ
Application EP07011661A events
ๅบ็จ EP07011661A ไบไปถ
ๅบ็จ EP07011661A ไบไปถ
2010-11-10
Application granted ็ณ่ฏท่ทๆนๅ
Status ๅฐไฝ
Not-in-force ๆ ๆ
2027-06-14
Anticipated expiration ้ข่ฎกๅฐๆ
- Info
- Patent citations (18)
- Cited by (59)
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- ่ฎจ่ฎบ
Description ๆ่ฟฐ
translated from
-
[0001] The present invention relates to a medical appliance-coating composition capable of imparting a stable slidableness to a medical appliance. The present invention also relates to provide a medical appliance on which a slidable coating film having a stable slidableness is formed.
ๆฌๅๆๆถๅไธ็ง่ฝๅค่ตไบๅป็ๅจๆขฐไปฅ็จณๅฎ็ๆปๅจๆง็ๅป็ๅจๆขฐ็จๆถๆ็ปๅ็ฉ๏ผไปฅๅๆไพไธ็งๅฝขๆๆๅ ทๆ็จณๅฎ็ๆปๅจๆง็ๆปๅจๆถ่็ๅป็ๅจๆขฐใ -
[0002] It is necessary to apply silicone oil or the like such as polysiloxane to a sliding portion or the like of a gasket for use in a pre-filled syringe as a lubricant to enhance the slidableness of the gasket and securely discharge a liquid medicine from the pre-filled syringe. But in dependence on a liquid medicine, it is difficult to pre-fill the liquid medicine in a syringe owing to an interaction of the liquid medicine with the lubricant For example, there is a case in which monoammonium glycyrrhetate which is an injection contacts the silicone oil to generate a foreign matter which is insoluble in water.
ไธบไบๆ้ซ้ขๅ ๅผๆณจๅฐๅจๅซๅ็ๆปๅจๆง๏ผๅนถๅฎๅ จๅฐไป้ขๅ ๅผๆณจๅฐๅจไธญๆๅบ่ฏๆถฒ๏ผ้่ฆๅจ้ขๅ ๅผๆณจๅฐๅจๅซๅ็ๆปๅจ้จไฝ็ญๆถๆน่็ก ๆฐง็ท็ญ็ก ๆฒนไฝไธบๆถฆๆปๅใ็ถ่๏ผ็ฑไบ่ฏๆถฒไธๆถฆๆปๅไน้ดๅญๅจ็ธไบไฝ็จ๏ผๅ ๆญค้พไปฅๅฐ่ฏๆถฒ้ขๅ ๅฐๆณจๅฐๅจไธญใไพๅฆ๏ผๆณจๅฐๅ็่้ ธๅ้ต็ๆๆถไผไธ็ก ๆฒนๆฅ่งฆ๏ผไบง็ไธๆบถไบๆฐด็ๅผ็ฉใ -
[0003] The method of applying the lubricant to the sliding portion of the gasket to enhance the slidableness of the gasket is widely used in disposable injection syringes. But it is desired that the lubricant is not applied to the sliding portion or the like of the gasket for use in the pre-filled syringe accommodating a medicine for hours in consideration of influence of the lubricant on the medicine accommodated therein.
ๅจไธๆฌกๆงๆณจๅฐๅจไธญ๏ผไธบไบๆ้ซๅซๅ็ๆปๅจๆง๏ผๅจๅซๅ็ๆปๅจ้จๆถๆนๆถฆๆปๅ็ๆนๆณ่ขซๅนฟๆณไฝฟ็จใไฝ่่ๅฐๆถฆๆปๅๅฏนๆๅฎน็บณ็่ฏ็ฉ็ๅฝฑๅ๏ผๅฏนไบ้ฟๆถ้ดไฝฟ็จ็้ขๅ ๅผๆณจๅฐๅจ๏ผๆๅฅฝไธ่ฆๅจๅซๅ็ๆปๅจ้จ็ญ้จไฝๆถๆนๆถฆๆปๅใ -
[0004] The gasket for solving the above-described problem is disclosed in
็จไบ่งฃๅณไธ่ฟฐ้ฎ้ข็ๅซ็ๅทฒๅจ ไธญๅ ฌๅผใ็จไบ่งฃๅณไธ่ฟฐ้ฎ้ข็ๅซ็็ฑๆฌ็ณ่ฏทไบบๆๅบ๏ผๅนถๅทฒๅจ ไธญๅ ฌๅผใ ๅจ่ฏฅๅซๅไธญ๏ผ่ณๅฐๅซๅไธปไฝ็ๅจๅด่ฆ็ๆ็ฑๆฉๆฆ็ณปๆฐไฝไบๅซๅไธปไฝ็ๆฐๆ ่ๅถๆ็่่ใๅ่ฎพๅค็ฎกไพงๆ ่่่็่กจ้ข็ฒ็ณๅบฆๅฎไนไธบ Ra 1 ๏ผๅซๅไธปไฝไพงๆ ่่่็่กจ้ข็ฒ็ณๅบฆๅฎไนไธบ Ra 2 ๏ผๅๆปก่ถณ 1.5Ra 1 โฆRa 2 ็ๅ ณ็ณปใ่ฏดๆไนฆไธญ่ฎฐ่ฝฝไบ่กจ้ข็ฒ็ณๅบฆ Ra 1 ็ไผ้่ๅดไธบ 0.1 ่ณ 1.5ฮผmใ -
[0005] In the medical appliance disclosed in
ๅจ๏ผB๏ผๆๅ ฌๅผ็ๅป็ๅจๆขฐไธญ๏ผๅพ ๅค็็ๅบๆ็ๅ ่กจ้ขๅ/ๆ่กจ้ขๆถ่ฆๆๅซๆ็ขณ็บณ็ฑณ็ฎก็่ๅ็ฉๆๆ๏ผๆ่ ๏ผB๏ผๅฐ็ฑๅซๆ็ขณ็บณ็ฑณ็ฎก็่ๅ็ฉๆๆๅฝขๆ็่่็ปๅๅฐๅพ ๅค็็ๅบๆ็ๅ ่กจ้ขๅ/ๆ่กจ้ขไธใ -
[0006] The gasket disclosed in
ๅไธญๅ ฌๅผ็ๅซ็ ๆ นๆฎไฝฟ็จๆกไปถ๏ผๅซ็่ฝๅคๅๆฅ่ถณๅค้ซ็ๆๆใไฝๆฅ็ๅข้ฟ็้ๆฑๆฏ๏ผๅผๅไธ็งๅซ็๏ผๅ ถๅบๆฌๅ่ฝๆฏ้ฒๆญขๅจไธฅ่ๆกไปถไธ๏ผไพๅฆ๏ผๅฝ้ขๅ ๅผๆณจๅฐๅจไธญ่ฃ ๆๅซๆ่กจ้ขๆดปๆงๅ็ๆณจๅฐๆถฒๆถ๏ผไปฅๅๅจ้ซๅไธๆณจๅฐ่ฏ็ฉๆถ๏ผๅ็ๆถฒไฝๆณๆผใๆญคๅค๏ผ่ฟ็งๅซโโ็่ฟ่ฆๆฑๅจไธไฝฟ็จ็ก ๆฒน็ญๆถฆๆปๅ็ๆ ๅตไธๅ ทๆ่พ้ซ็ๆปๅจๆงใ -
[0007] There is a growing demand for the development of a medical appliance which has a high degree of slidableness and very accurate and stable medicine-discharge performance. When a liquid medicine is discharged from a pre-filled syringe by operating a syringe pump at a speed so low (for example, moving speed is about 2mm/hour when liquid medicine is discharged at 1mL/hour from syringe having diameter of 24mm) that the movement of the pump is unvisible, there may occur a discharge state called pulsation. In this case, there is a fear that the liquid medicine is prevented from being accurately administered.
ไบบไปฌๅฏนๅผๅไธ็งๅ ทๆ้ซๅบฆๆปๅจๆงๅ้ซๅบฆ็ฒพ็กฎ็จณๅฎ็่ฏ็ฉๆๅบๆง่ฝ็ๅป็ๅจๆขฐ็้ๆฑๆฅ็ๅข้ฟใๅฝไฝฟ็จๆณจๅฐๆณตไปฅๆไฝ็้ๅบฆ๏ผไพๅฆ๏ผๅฝ่ฏๆถฒไปฅ1ๆฏซๅ/ๅฐๆถ็้ๅบฆไป็ดๅพ24ๆฏซ็ฑณ็ๆณจๅฐๅจไธญๆๅบๆถ๏ผๅ ถ็งปๅจ้ๅบฆ็บฆไธบ2ๆฏซ็ฑณ/ๅฐๆถ๏ผไป้ขๅ ๅผๆณจๅฐๅจไธญๆๅบ่ฏๆถฒๆถ๏ผๅฏ่ฝไผๅบ็ฐไธ็ง็งฐไธบ่ๅจ็ๆๅบ็ถๆใๅจ่ฟ็งๆ ๅตไธ๏ผไบบไปฌๆ ๅฟ่ฏๆถฒ็็ป่ฏ็ฒพๅบฆไผๅๅฐๅฝฑๅใ -
[0008] The thin film disclosed in
ๆๅ ฌๅผ็่่ๅจ็็ฉ็ธๅฎนๆงใๆ้งๆงๅๆๆญ็ปๆงๆน้ขๅ ทๆไธๅฎ็จๅบฆ็ๆๆๆง๏ผไฝๅ ถๆปๅจๆงๅนถไธ็ๆณใ -
[0009] The present invention has been made to solve the above-described problem. Therefore it is an object of the present invention to provide a medical appliance-coating composition capable of imparting a stable slidableness to a medical appliance without imparting a lubricant to the surface thereof. It is another object of the present invention to provide a medical appliance on which a slidable coating film having a stable slidable surface is formed.
ๆฌๅๆๆญฃๆฏไธบไบ่งฃๅณไธ่ฟฐ้ฎ้ข่ๅๅบ็ใๆฌๅๆ็็ฎ็ๅจไบๆไพไธ็งๅป็ๅจๆขฐ็จๆถๆ็ปๅ็ฉ๏ผ่ฏฅ็ปๅ็ฉๆ ้ๅจๅป็ๅจๆขฐ่กจ้ขๆทปๅ ๆถฆๆปๅ๏ผๅณๅฏ่ตไบๅป็ๅจๆขฐ็จณๅฎ็ๆปๅจๆงใๆฌๅๆ็ๅฆไธ็ฎ็ๅจไบๆไพไธ็งๅป็ๅจๆขฐ๏ผ่ฏฅๅป็ๅจๆขฐไธๅฝขๆไบๅ ทๆ็จณๅฎๆปๅจ่กจ้ข็ๆปๅจๆถ่ใ -
[0010] The object described above is attained by the following a medical appliance-coating composition.
ไธ่ฟฐ็ฎ็้่ฟไปฅไธๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉๅฎ็ฐใ -
[0011] A medical appliance-coating composition, for imparting slidableness to said medical appliance, which contains a solvent-based silicone rubber, carbon nanotubes, and fine particles of silicone resin.
ไธ็งๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉ๏ผ็จไบ่ตไบๆ่ฟฐๅป็ๅจๆขฐๆปๅจๆง๏ผๅ ถๅ ๅซๆบถๅๅ็ก ๆฉก่ถใ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่็ป้ข็ฒใ -
[0012] A medical appliance, having a slidable coating film formed thereon, which moves in contact with an inner surface of a medical member or an inner surface of a body lumen, wherein said slidable coating film is disposed at a portion, of said medical appliance, which contacts said medical member or said body lumen; and said slidable coating film is comprised of silicone rubber, carbon nanotubes and fine particles of silicone resin.
ไธ็งๅป็ๅจๆขฐ๏ผๅ ถไธๅฝขๆๆๅฏๆปๅจ็ๆถ่๏ผ่ฏฅๆถ่ไธๅป็ๆไปถ็ๅ ่กจ้ขๆไฝ่ ็ๅ ่กจ้ขๆฅ่งฆๅนถ็งปๅจ๏ผๅ ถไธญๆ่ฟฐๅฏๆปๅจ็ๆถ่่ฎพ็ฝฎๅจๆ่ฟฐๅป็ๅจๆขฐไธๆ่ฟฐๅป็ๆไปถๆๆ่ฟฐไฝ่ ๆฅ่งฆ็้จๅ๏ผๅนถไธๆ่ฟฐๅฏๆปๅจ็ๆถ่็ฑ็ก ๆฉก่ถใ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่็็ป้ข็ฒๆๆใ -
Fig.1 is a front view showing a gasket for use in a syringe, of an embodiment of a medical appliance of the present invention.
ๅพ1ๆฏ็คบๅบๆฌๅๆ็ๅป็ๅจๆขฐ็ไธไธชๅฎๆฝๆนๅผ็ๆณจๅฐๅจ็จๅซๅ็ไธป่งๅพใ -
Fig. 2 is a sectional view showing the gasket shown inFig.1 .
ๅพ2ๆฏๅพ1ๆ็คบๅซๅ็ๅ้ขๅพใ -
Fig. 3 is a top view showing the gasket shown inFig.1 .
ๅพ3ๆฏๅพ1ๆ็คบๅซๅ็ไฟฏ่งๅพใ -
Fig. 4 is a bottom view showing the gasket shown inFig.1 .
ๅพ4ๆฏๅพ1ๆ็คบๅซๅ็ไปฐ่งๅพใ -
Fig. 5 is a sectional view showing a pre-filled syringe of an embodiment of the present invention.
ๅพ5ไธบ่กจ็คบๆฌๅๆไธๅฎๆฝไพ็้ขๅ ๅผๆณจๅฐๅจ็ๅ้ขๅพใ -
Fig. 6 is a sectional view showing a guide wire of an embodiment of the medical appliance of the present invention.
ๅพ6ไธบ่กจ็คบๆฌๅๆ็ๅป็ๅจๆขฐ็ไธไธชๅฎๆฝไพ็ๅฏผไธ็ๅ้ขๅพใ -
Fig. 7 is a table 1a showing components of medical appliance-coating compositions of examples of the present invention and compounding ratio thereof.
ๅพ 7 ไธบ่กจ็คบๆฌๅๆ็ๅฎๆฝไพ็ๅป็ๅจๆขฐๆถๆ็ปๅ็ฉ็ๆๅๅๅ ถ้ ๅๆฏ็่กจ 1aใ -
Fig. 8 is a table 1b showing components of medical appliance-coating compositions of comparison examples and compounding ratio thereof.
ๅพ 8 ไธบ่กจ็คบๆฏ่พไพ็ๅป็ๅจๆขฐๆถๆ็ปๅ็ฉ็ๆๅๅๅ ถ้ ๅๆฏ็่กจ 1bใ -
Fig. 9 shows the surface of a slidable coating film which is formed by applying a medical appliance-coating composition of an example 1 to a substrate and is photographed by an electron microscope.
ๅพ9ๆฏๅฐๅฎๆฝไพ1็ๅป็ๅจๆขฐๆถๆ็ปๅ็ฉๆถๅธไบๅบๆไธ่ๅฝขๆ็ๆปๅจๆงๆถ่็่กจ้ข็็ตๅญๆพๅพฎ้็ ง็ใ -
Fig. 10 shows the surface of a guide wire of an example 18 photographed by an electron microscope.
ๅพ10็คบๅบไบ้่ฟ็ตๅญๆพๅพฎ้ๆๆ็ๅฎๆฝไพ18็ๅฏผไธ่กจ้ขใ -
[0013] The medical appliance-coating composition (hereinafter often referred to as merely composition or slidable composition) of the present invention and the medical appliance of the present invention having a slidable coating film formed thereon will be described below. The medical appliance-coating composition of the present invention is a medical appliance-coating slidable composition
ไปฅไธ๏ผๅฏนๆฌๅๆ็ๅป็ๅจๆขฐ็จๆถๅฑ็ปๅ็ฉ๏ผไปฅไธ๏ผๆๆถ็ฎ็งฐไธบ็ปๅ็ฉๆๆปๅจๆง็ปๅ็ฉ๏ผไปฅๅๅฝขๆๆๆปๅจๆงๆถ่็ๆฌๅๆ็ๅป็ๅจๆขฐ่ฟ่ก่ฏดๆใๆฌๅๆ็ๅป็ๅจๆขฐ็จๆถๅฑ็ปๅ็ฉไธบๅป็ๅจๆขฐ็จๆปๅจๆง็ปๅ็ฉใ -
[0014] Initially the composition of the present invention is described below.
ไธ้ข้ฆๅ ๅฏนๆฌๅๆ็็ปๅ็ฉ่ฟ่ก่ฏดๆใ -
[0015] The composition of the present invention imparts slidableness to the medical appliance and contains solvent-based silicone rubber and in addition, carbon nanotubes and fine particles of silicone resin.
ๆฌๅๆ็็ปๅ็ฉ่ตไบๅป็ๅจๆขฐๆปๅจๆง๏ผๅนถไธๅ ๅซๆบถๅๅ็ก ๆฉก่ถไปฅๅ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่็ป้ข็ฒใ -
[0016] The composition of the present invention contains solvent-based silicone rubber as its main component and in addition, carbon nanotubes and fine particles of silicone resin.
ๆฌๅๆ็็ปๅ็ฉไปฅๆบถๅๅ็ก ๆฉก่ถไธบไธป่ฆๆๅ๏ผๅฆๅค่ฟๅซๆ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่ๅพฎ็ฒใ -
[0017] A liquid organic polysiloxane compound is used as the solvent-based silicone rubber used for the composition of the present invention.
ๆฌๅๆ็ปๅ็ฉไธญไฝฟ็จ็ๆบถๅๅ็ก ๆฉก่ถ้็จๆถฒๆๆๆบ่็ก ๆฐง็ทๅๅ็ฉใ -
[0018] The organic polysiloxane compound which is used in the present invention is a polymer containing a repeated structural unit of an organic silicone compound indicated by R1(R2)-Si-O in the backbone thereof. R1 and R2 denote lower alkyl groups having 1 to 8 carbons. As the organic polysiloxane compound, it is possible to use polyalkylsiloxanes (more specifically, polydimethylsiloxane, polyethylsiloxane, polymethylphenylsiloxane, and polydiphenylsiloxane), polyalkyl hydrogen siloxane, and substances having epoxy group, hydroxyl group, carboxylic group, vinyl group, amino group, alkoxy group or fluorine group introduced into ends or molecular chains of the above-described polymers.
ๆฌๅๆไธญไฝฟ็จ็ๆๆบ่็ก ๆฐง็ทๅๅ็ฉ๏ผๆฏๆๅจไธป้พไธๅซๆไปฅ R1(R2)-Si-O ่กจ็คบ็ๆๆบ็ก ๅๅ็ฉ้ๅค็ปๆๅๅ ็่ๅ็ฉใR1 ๅ R2 ่กจ็คบ็ขณๅๅญๆฐไธบ 1 ่ณ 8 ็ไฝ็บง็ทๅบใไฝไธบๆๆบ่็ก ๆฐง็ทๅๅ็ฉ๏ผๅฏไปฅไฝฟ็จ่็ทๅบ็ก ๆฐง็ท๏ผๆดๅ ทไฝๅฐ๏ผ่ไบ็ฒๅบ็ก ๆฐง็ทใ่ไนๅบ็ก ๆฐง็ทใ่็ฒๅบ่ฏๅบ็ก ๆฐง็ทๅ่ไบ่ฏๅบ็ก ๆฐง็ท๏ผใ่็ทๅบๆฐข็ก ๆฐง็ท๏ผไปฅๅๅจไธ่ฟฐ่ๅ็ฉ็ๆซ็ซฏๆๅๅญ้พไธญๅผๅ ฅ็ฏๆฐงๅบใ็พๅบใ็พงๅบใไน็ฏๅบใๆฐจๅบใ็ทๆฐงๅบๆๆฐๅบ็็ฉ่ดจใ -
[0019] As the organic polysiloxane compound, it is possible to use both homopolymer-type organic polysiloxane composed of one kind of a repeated structural unit and random-type, block-type or graft-type organic polysiloxane composed of a combination of not less than two kinds of repeated structural units.
ไฝไธบๆๆบ่็ก ๆฐง็ทๅๅ็ฉ๏ผๅฏไปฅไฝฟ็จ็ฑไธ็ง้ๅค็ปๆๅๅ ๆๆ็ๅ่็ฉๅๆๆบ่็ก ๆฐง็ท๏ผไปฅๅ็ฑไธค็งไปฅไธ้ๅค็ปๆๅๅ ็็ปๅๆๆ็ๆ ่งๅใๅตๆฎตๅๆๆฅๆๅๆๆบ่็ก ๆฐง็ทใ -
[0020] As the organic silicone compound constituting the repeated structural unit, it is possible to list methyltrimethoxysilane, methyltriethoxysilane, methyltriisopropoxysilane, methyltri-t-butoxysilane, methyltrichlorosilane, methyltribromosilane; ethyltrimethoxysilane, ethyltriethoxysilane, ethyltriisopropoxysilane, ethyltri-t-butoxysilane, ethytrichlorosilane, ethyltribromosilane; n-propyltrimethoxysilane, n-propyltriethoxysilane, n-propyltriisopropoxysilane, n-propyltri-t-butoxysilane, n-propyltrichlorosilane, n-propyltribromosilane; n-hexyltrimethoxysilane, n-hexyltriethoxysilane, n-hexyltriisopropoxysilane, n-hexyltri-t-butoxysilane, n-hexyltrichlorosilane, n-hexyltribromosilane; n-decyltrimethoxysilane, n-decyltriethoxysilane, n-decyltriisopropoxysilane, n-decyltri-t-butoxysilane, n-decyltrichlorosilane, n-decyltribromosilane; n-octadecyltrimethoxysilane, n-octadecyltriethoxysilane, n-octadecyltriisopropoxysilane, n-octadecyltri-t-butoxysilane, n-octadecyltrichlorosilane, n-octadecyltribromosilane, tetramethoxysilane, tetraethoxysilane, tetrabutoxysilane, dimethoxydiethoxysilane; dimethyldimethoxysilane, dimethyldiethoxysilane, ฮณ-glycydoxypropylmethyldimethoxysilane, ฮณ-glycydoxypropylmethyldiethoxysilane, ฮณ -glycydoxypropyltrimethoxysilane, ฮณ -glycydoxypropyltriethoxysilane, ฮณ -glycydoxypropyltriisopropoxysilane, and ฮณ -glycydoxypropyltri-t-butoxysilane.
ไฝไธบๆๆ้ๅค็ปๆๅๅ ็ๆๆบ็ก ๅๅ็ฉ๏ผๅฏไปฅๅไธพ็ฒๅบไธ็ฒๆฐงๅบ็ก ็ทใ็ฒๅบไธไนๆฐงๅบ็ก ็ทใ็ฒๅบไธๅผไธๆฐงๅบ็ก ็ทใ็ฒๅบไธๅไธๆฐงๅบ็ก ็ทใ็ฒๅบไธๆฐฏ็ก ็ทใ็ฒๅบไธๆบด็ก ็ท๏ผไนๅบไธ็ฒๆฐงๅบ็ก ็ทใไนๅบไธไนๆฐงๅบ็ก ็ทใไนๅบไธๅผไธๆฐงๅบ็ก ็ทใไนๅบไธๅไธๆฐงๅบ็ก ็ทใไนๅบไธๆฐฏ็ก ็ทใไนๅบไธๆบด็ก ็ท๏ผๆญฃไธๅบไธ็ฒๆฐงๅบ็ก ็ทใๆญฃไธๅบไธไนๆฐงๅบ็ก ็ทใๆญฃไธๅบไธๅผไธๆฐงๅบ็ก ็ทใๆญฃไธๅบไธๅไธๆฐงๅบ็ก ็ทใๆญฃไธๅบไธๆฐฏ็ก ็ทใๆญฃไธๅบไธๆบด็ก ็ท๏ผๆญฃๅทฑๅบไธ็ฒๆฐงๅบ็ก ็ทใๆญฃๅทฑๅบไธไนๆฐงๅบ็ก ็ทใๆญฃๅทฑๅบไธๅผไธๆฐงๅบ็ก ็ทใๆญฃๅทฑๅบไธๅไธๆฐงๅบ็ก ็ทใๆญฃๅทฑๅบไธๆฐฏ็ก ็ทใๆญฃๅทฑๅบไธๆบด็ก ็ท๏ผๆญฃ็ธๅบไธ็ฒๆฐงๅบ็ก ็ทใๆญฃ็ธๅบไธไนๆฐงๅบ็ก ็ทใๆญฃ็ธๅบไธๅผไธๆฐงๅบ็ก ็ทใๆญฃ็ธๅบไธๅไธๆฐงๅบ็ก ็ทใๆญฃ็ธๅบไธๆฐฏ็ก ็ทใๆญฃ็ธๅบไธๆบด็ก ็ท๏ผๆญฃๅๅ ซ็ทๅบไธ็ฒๆฐงๅบ็ก ็ทใๆญฃๅๅ ซ็ทๅบไธไนๆฐงๅบ็ก ็ทใๆญฃๅๅ ซ็ทๅบไธๅผไธๆฐงๅบ็ก ็ทใๆญฃๅๅ ซ็ทๅบไธๅไธๆฐงๅบ็ก ็ทใๆญฃๅๅ ซ็ทๅบไธๆฐฏ็ก ็ทใๆญฃๅๅ ซ็ทๅบไธๆบด็ก ็ทใๅ็ฒๆฐงๅบ็ก ็ทใๅไนๆฐงๅบ็ก ็ทใๅไธๆฐงๅบ็ก ็ทใไบ็ฒๆฐงๅบไบไนๆฐงๅบ็ก ็ท๏ผไบ็ฒๅบไบ็ฒๆฐงๅบ็ก ็ทใไบ็ฒๅบไบไนๆฐงๅบ็ก ็ทใฮณ-็ผฉๆฐด็ๆฒนๆฐงไธๅบ็ฒๅบไบ็ฒๆฐงๅบ็ก ็ทใฮณ-็ผฉๆฐด็ๆฒนๆฐงไธๅบ็ฒๅบไบไนๆฐงๅบ็ก ็ทใฮณ-็ผฉๆฐด็ๆฒนๆฐงไธๅบไธ็ฒๆฐงๅบ็ก ็ทใฮณ-็ผฉๆฐด็ๆฒนๆฐงไธๅบไธไนๆฐงๅบ็ก ็ทใฮณ-็ผฉๆฐด็ๆฒนๆฐงไธๅบไธๅผไธๆฐงๅบ็ก ็ทใฮณ-็ผฉๆฐด็ๆฒนๆฐงไธๅบไธๅไธๆฐงๅบ็ก ็ทใ -
[0021] An organic solvent is used for the composition of the present invention. Toluene, xylene, and the like are used as the organic solvent Although the content of the solvent-based silicone rubber is different according to the content of a nonvolatile content thereof, it is preferable that the solvent-based silicone rubber is contained at 5 to 40 wt% in the composition containing the organic solvent The content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the medical appliance-coating composition containing the organic solvent is set favorably to the range of 0.5 to 20 wt% and more favorably to the range of 10 to 70 wt%.
ๆฌๅๆ็็ปๅ็ฉไธญไฝฟ็จๆๆบๆบถๅใไฝไธบๆๆบๆบถๅ๏ผๅฏไฝฟ็จ็ฒ่ฏใไบ็ฒ่ฏ็ญใๆบถๅๅ็ก ๆฉก่ถ็ๅซ้ๆ นๆฎๅ ถไธๆฅๅๆๅ็ๅซ้่ไธๅ๏ผไผ้ๅจๅซๆๆๆบๆบถๅ็็ปๅ็ฉไธญ๏ผๆบถๅๅ็ก ๆฉก่ถ็ๅซ้ไธบ5่ณ40้้๏ผ ใๅซๆๆๆบๆบถๅ็ๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉไธญ๏ผไฝไธบๆบถๅๅ็ก ๆฉก่ถไธๆฅๅๆๅ็ๆๆบ่็ก ๆฐง็ทๅๅ็ฉ็ๅซ้ไผ้ไธบ0.5่ณ20้้๏ผ ๏ผๆดไผ้ไธบ10่ณ70้้๏ผ ใ -
[0022] Carbon nanotubes are contained in the composition of the present invention.
ๆฌๅๆ็็ปๅ็ฉๅซๆ็ขณ็บณ็ฑณ็ฎกใ -
[0023] The carbon nanotube is cylindrically formed of a network (graphene sheet) of six-membered rings made of carbon. The carbon nanotube is classified into a single-layer carbon nanotube and a multi-layer carbon nanotube.
็ขณ็บณ็ฑณ็ฎกๆฏ็ฑ็ขณๆๆ็ๅ ญๅ ็ฏ็ฝ็ป๏ผ็ณๅขจ็ฏ็๏ผๆๆ็ๅๆฑ็ถ็ปๆใ็ขณ็บณ็ฑณ็ฎกๅไธบๅๅฑ็ขณ็บณ็ฑณ็ฎกๅๅคๅฑ็ขณ็บณ็ฑณ็ฎกใ -
[0024] In the present invention, it is possible to use the single-layer carbon nanotube or/and the multi-layer carbon nanotube. The carbon nanotube which is used in the present invention is the multi-layer carbon nanotube having an average diameter less than 800nm and preferably 10 to 250nm and an average fiber length less than 2mm and preferably in the range of 0.001 to 1mm. The carbon nanotube is contained in the composition in the range of 0.01 to 2 wt% and preferably in the range of 0.01 to 1 wt%. The content of the carbon nanotube contained in the composition is favorably 1/3000 to 1/16 and more favorably 1/1000 to 1/30 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
ๆฌๅๆไธญ๏ผๅฏไปฅไฝฟ็จๅๅฑ็ขณ็บณ็ฑณ็ฎกๆ/ๅๅคๅฑ็ขณ็บณ็ฑณ็ฎกใๆฌๅๆไธญไฝฟ็จ็็ขณ็บณ็ฑณ็ฎกไธบๅคๅฑ็ขณ็บณ็ฑณ็ฎก๏ผๅ ถๅนณๅ็ดๅพๅฐไบ800็บณ็ฑณ๏ผไผ้ไธบ10่ณ250็บณ็ฑณ๏ผๅนณๅ็บค็ปด้ฟๅบฆๅฐไบ2ๆฏซ็ฑณ๏ผไผ้ไธบ0.001่ณ1ๆฏซ็ฑณใ็ขณ็บณ็ฑณ็ฎกๅจ็ปๅ็ฉไธญ็ๅซ้ไธบ0.01่ณ2้้๏ผ ๏ผไผ้ไธบ0.01่ณ1้้๏ผ ใ็ปๅ็ฉไธญ็ขณ็บณ็ฑณ็ฎก็ๅซ้ไผ้ไธบๆๆบ่็ก ๆฐง็ทๅๅ็ฉๅซ้็1/3000่ณ1/16๏ผๆดไผ้ไธบ1/1000่ณ1/30๏ผๆ่ฟฐๆๆบ่็ก ๆฐง็ทๅๅ็ฉๆฏ็ปๅ็ฉไธญๆๅซๆบถๅๅ็ก ๆฉก่ถ็้ๆฅๅๆงๆๅใ -
[0025] The slidable composition of the present invention contains fine particles of silicone resin. The size of the fine particle of the silicone resin is in the range of 0.5 to 30ยตm, favorably in the range of 1 to 10ยตm, and more favorably in the range of 2 to 8ยตm. The fine particle of the silicone resin is adhesive to the component of the solvent-based silicone rubber. Fine particles of the silicone resin called organopolysiloxane containing dimethylpolysiloxane therein as its main component is preferable. The fine particle of the silicone resin may contain functional groups such as a vinyl group, an epoxy group, an amino group, and the like. The fine particles of the silicone resin having a structure in which a siloxane bond is crosslinked in a three-dimensional network, namely, the structure of polymethyl silsesquioxane is especially favorable. The silicone resin may consist of fine particles of one kind thereof or in combination of two or more kinds thereof.
ๆฌๅๆ็ๆปๅจๆง็ปๅ็ฉๅซๆ็ก ๆ ่ๅพฎ็ฒใ็ก ๆ ่ๅพฎ็ฒ็ๅฐบๅฏธๅจ 0.5 ่ณ 30ฮผm ่ๅดๅ ๏ผไผ้ๅจ 1 ่ณ 10ฮผm ่ๅดๅ ๏ผๆดไผ้ๅจ 2 ่ณ 8ฮผm ่ๅดๅ ใ็ก ๆ ่ๅพฎ็ฒไธๆบถๅๅ็ก ๆฉก่ถๆๅๅ ทๆ็ฒๅๆงใไผ้ไปฅไบ็ฒๅบ่็ก ๆฐง็ทไธบไธป่ฆๆๅ็ๆๆบ่็ก ๆฐง็ท็ก ๆ ่ๅพฎ็ฒใ็ก ๆ ่ๅพฎ็ฒๅฏไปฅๅซๆไน็ฏๅบใ็ฏๆฐงๅบใๆฐจๅบ็ญๅฎ่ฝๅขใๅฐคๅ ถไผ้ๅ ทๆ็ก ๆฐง็ท้ฎไบค่ๆไธ็ปด็ฝ็ป็ปๆ๏ผๅณ่็ฒๅบๅๅ็ก ๆฐง็ท็ปๆ๏ผ็็ก ๆ ่ๅพฎ็ฒใ็ก ๆ ่ๅฏไปฅ็ฑไธ็งๆไธค็งไปฅไธๅพฎ็ฒ็ปๅ่ๆใ -
[0026] It is preferable that the fine particles of the silicone resin are contained at 0.2 to 50 wt% and favorably 1 to 20 wt% in the composition. The fine particles of the silicone resin are contained in the composition at favorably 1/150 to 1/1 and more favorably 1/30 to 1/1.5 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
ไผ้็ปๅ็ฉไธญ็ก ๆ ่ๅพฎ็ฒ็ๅซ้ไธบ0.2่ณ50้้๏ผ ๏ผๆดไผ้ไธบ1่ณ20้้๏ผ ใไผ้็ปๅ็ฉไธญ็ก ๆ ่ๅพฎ็ฒ็ๅซ้ไธบ็ปๅ็ฉไธญๆๅซๆบถๅๅ็ก ๆฉก่ถ็ไธๆฅๅๆๅโโๆๆบ่็ก ๆฐง็ทๅๅ็ฉๅซ้็1/150่ณ1/1๏ผๆดไผ้ไธบ1/30่ณ1/1.5ใ -
[0027] It is preferable that the composition of the present invention contains a surface active agent (in other words, surfactant).
ๆฌๅๆ็็ปๅ็ฉไผ้ๅซๆ่กจ้ขๆดปๆงๅ(ๆข่จไน๏ผ่กจ้ขๆดปๆงๅ)ใ -
[0028] As the surface active agent, a nonionic surface active agent is preferable. As the nonionic surface active agent, it is possible to use polyoxyethylenealkylphenyl ethers having alkyl groups such as octyl, nonyl, dodecyl; polyoxyethylenealkyl ethers having alkyl groups such as octyl, lauryl, cetyl, stearyl, and oleyl; polyethylene glycol fatty esters such as monooleate, monostearate, distearate, monolaurate of polyethylene glycol; polyoxyethylenealkylamines having the alkyl group such as the lauryl, the stearyl, and the oleyl; sorbitan fatty esters such as sorbitan sesquioleate, sorbitan sesquiisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan distearate, sorbitan tristearate, sorbitan monooleate, sorbitan trioleate; polyoxyethylene sorbitan fatty esters such as polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan tristearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan trioleate, and polyoxyethylene sorbitan of fatty ester of coconut oil; polyethylene glycol ethers, fatty diethanolamides such as diethanolamide laurate; sucrose fatty esters; fatty monoglycerides such as monoglyceride laurate, monoglyceride stearate, monoglyceride oleate; polyoxyethylene fatty amides such as polyoxyethylene lauramide, polyoxyethylene stearamide, polyoxyethylene oleamide; and polyoxyethylene castor oil, polyoxyethylene hardened castor oil.
ไฝไธบ่กจ้ขๆดปๆงๅ๏ผไผ้้็ฆปๅญๅ่กจ้ขๆดปๆงๅใไฝไธบ้็ฆปๅญๅ่กจ้ขๆดปๆงๅ๏ผๅฏไปฅไฝฟ็จๅ ทๆ่พๅบใๅฃฌๅบใๅไบ็ทๅบ็ญ็ทๅบ็่ๆฐงไน็ฏ็ทๅบ่ฏๅบ้๏ผๅ ทๆ่พๅบใๆๆกๅบใ้ฒธ่กๅบใ็กฌ่ๅบใๆฒนๅบ็ญ็ทๅบ็่ๆฐงไน็ฏ็ทๅบ้๏ผ่ไนไบ้ๅๆฒน้ ธ้ ฏใๅ็กฌ่้ ธ้ ฏใไบ็กฌ่้ ธ้ ฏใๅๆๆก้ ธ้ ฏ็ญ่ไนไบ้่่ช้ ธ้ ฏ๏ผๅ ทๆๆๆกๅบใ็กฌ่ๅบใๆฒนๅบ็ญ็ทๅบ็่ๆฐงไน็ฏ็ทๅบ่บ๏ผ่ฑๆฐดๅฑฑๆขจ้ๅๅๆฒน้ ธ้ ฏใ่ฑๆฐดๅฑฑๆขจ้ๅๅๅผ็กฌ่้ ธ้ ฏใ่ฑๆฐดๅฑฑๆขจ้ๅๆๆก้ ธ้ ฏใ่ฑๆฐดๅฑฑๆขจ้ๅๆฃๆฆ้ ธ้ ฏใ่ฑๆฐดๅฑฑๆขจ้ๅ็กฌ่้ ธ้ ฏใ่ฑๆฐดๅฑฑๆขจ้ไบ็กฌ่้ ธ้ ฏใ่ฑๆฐดๅฑฑๆขจ้ไธ็กฌ่้ ธ้ ฏใ่ฑๆฐดๅฑฑๆขจ้ๅๆฒน้ ธ้ ฏใ่ฑๆฐดๅฑฑๆขจ้ไธๆฒน้ ธ้ ฏ็ญ่ฑๆฐดๅฑฑๆขจ้่่ช้ ธ้ ฏ๏ผ่ๆฐงไน็ฏ่ฑๆฐดๅฑฑๆขจ้่่ช้ ธ้ ฏ๏ผไพๅฆ่ๆฐงไน็ฏ่ฑๆฐดๅฑฑๆขจ้ๅๆๆก้ ธ้ ฏใ่ๆฐงไน็ฏ่ฑๆฐดๅฑฑๆขจ้ๅๆฃๆฆ้ ธ้ ฏใ่ๆฐงไน็ฏ่ฑๆฐดๅฑฑๆขจ้ๅ็กฌ่้ ธ้ ฏใ่ๆฐงไน็ฏ่ฑๆฐดๅฑฑๆขจ้ไธ็กฌ่้ ธ้ ฏใ่ๆฐงไน็ฏ่ฑๆฐดๅฑฑๆขจ้ๅๆฒน้ ธ้ ฏใ่ๆฐงไน็ฏ่ฑๆฐดๅฑฑๆขจ้ไธๆฒน้ ธ้ ฏๅๆคฐๅญๆฒน่่ช้ ธ้ ฏ็่ๆฐงไน็ฏ่ฑๆฐดๅฑฑๆขจ้๏ผ่ไนไบ้้๏ผ่่ช้ ธไบไน้้ ฐ่บ๏ผไพๅฆไบไน้้ ฐ่บๆๆก้ ธ้ ฏ๏ผ่็ณ่่ช้ ธ้ ฏ๏ผ่่ช้ ธๅ็ๆฒน้ ฏ๏ผไพๅฆๅ็ๆฒนๆๆก้ ธ้ ฏใๅ็ๆฒน็กฌ่้ ธ้ ฏใๅ็ๆฒนๆฒน้ ธ้ ฏ๏ผ่ๆฐงไน็ฏ่่ช้ ฐ่บ๏ผไพๅฆ่ๆฐงไน็ฏๆๆก้ ฐ่บใ่ๆฐงไน็ฏ็กฌ่้ ฐ่บใ่ๆฐงไน็ฏๆฒน้ ฐ่บ๏ผไปฅๅ่ๆฐงไน็ฏ่้บปๆฒนใ่ๆฐงไน็ฏ็กฌๅ่้บปๆฒนใ -
[0029] The surface active agent is contained at 0.05 to 5 wt% and preferably 0.5 to 3 wt% in the composition. The surface active agent is contained in the composition at favorably 1/600 to 1/6 and more favorably 1/60 to 1/10 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
่กจ้ขๆดปๆงๅๅจ็ปๅ็ฉไธญ็ๅซ้ไธบ0.05่ณ5้้๏ผ ๏ผไผ้ไธบ0.5่ณ3้้๏ผ ใ่กจ้ขๆดปๆงๅๅจ็ปๅ็ฉไธญ็ๅซ้ไผ้ไธบ็ปๅ็ฉไธญๆๅซๆบถๅๅ็ก ๆฉก่ถ็ไธๆฅๅๆๅโโๆๆบ่็ก ๆฐง็ทๅๅ็ฉๅซ้็1/600่ณ1/6๏ผๆดไผ้ไธบ1/60่ณ1/10ใ -
[0030] It is preferable that the composition of the present invention contains an adhesion-improving agent A silane coupling agent is preferable as the adhesion-improving agent As the silane coupling agent it is possible to use an acrylic (methacrylic) functional silane coupling agent, an epoxy functional silane coupling agent, and an amino (imino) functional silane coupling agent
ๆฌๅๆ็็ปๅ็ฉไผ้ๅซๆ็ฒๅๆน่ฟๅใไผ้็ก ็ทๅถ่ๅไฝไธบ็ฒๅๆน่ฟๅใไฝไธบ็ก ็ทๅถ่ๅ๏ผๅฏไปฅไฝฟ็จไธ็ฏ้ ธ๏ผ็ฒๅบไธ็ฏ้ ธ๏ผๅฎ่ฝ็ก ็ทๅถ่ๅใ็ฏๆฐงๅฎ่ฝ็ก ็ทๅถ่ๅๅๆฐจๅบ๏ผไบๆฐจๅบ๏ผๅฎ่ฝ็ก ็ทๅถ่ๅใ -
[0031] As the acrylic (methacrylic) functional silane coupling agent, it is possible to list 3-methacryloxypropyl trimethoxy silane, 3-methacryloxypropyl triethoxy silane, 3-acryloxypropyl trimethoxy silane, 3-acryloxypropyl triethoxy silane, methacryloxymethyl trimethoxy silane, methacryloxymethyl triethoxy silane, acryloxymethyl trimethoxy silane, and acryloxymethyl triethoxy silane.
ไฝไธบไธ็ฏ้ ธ๏ผ็ฒๅบไธ็ฏ้ ธ๏ผๅฎ่ฝ็ก ็ทๅถ่ๅ๏ผๅฏไปฅๅไธพ3-็ฒๅบไธ็ฏ้ ฐๆฐงๅบไธๅบไธ็ฒๆฐงๅบ็ก ็ทใ3-็ฒๅบไธ็ฏ้ ฐๆฐงๅบไธๅบไธไนๆฐงๅบ็ก ็ทใ3-ไธ็ฏ้ ฐๆฐงๅบไธๅบไธ็ฒๆฐงๅบ็ก ็ทใ3-ไธ็ฏ้ ฐๆฐงๅบไธๅบไธไนๆฐงๅบ็ก ็ทใ็ฒๅบไธ็ฏ้ ฐๆฐงๅบ็ฒๅบไธ็ฒๆฐงๅบ็ก ็ทใ็ฒๅบไธ็ฏ้ ฐๆฐงๅบ็ฒๅบไธไนๆฐงๅบ็ก ็ทใไธ็ฏ้ ฐๆฐงๅบ็ฒๅบไธ็ฒๆฐงๅบ็ก ็ทใไธ็ฏ้ ฐๆฐงๅบ็ฒๅบไธไนๆฐงๅบ็ก ็ทใ -
[0032] As the epoxy functional silane coupling agent, it is possible to list 3-glycidoxypropyltrimethoxysilane, 3-glycidoxypropyltriethoxysilane, 2-(3,4-epoxycyclohexyl)ethyltrimethoxysilane, and 2-(3,4-epoxycyclohexyl)ethyltriethoxysilane.
ไฝไธบ็ฏๆฐงๅฎ่ฝ็ก ็ทๅถ่ๅ๏ผๅฏไปฅๅไธพ3-็ฏๆฐงไธๆฐงๅบไธๅบไธ็ฒๆฐงๅบ็ก ็ทใ3-็ฏๆฐงไธๆฐงๅบไธๅบไธไนๆฐงๅบ็ก ็ทใ2-(3๏ผ4-็ฏๆฐง็ฏๅทฑๅบ)ไนๅบไธ็ฒๆฐงๅบ็ก ็ทใ2-(3๏ผ4-็ฏๆฐง็ฏๅทฑๅบ)ไนๅบไธไนๆฐงๅบ็ก ็ทใ -
[0033] As examples of the amino (imino) functional silane coupling agent it is possible to list alkoxysilane, containing an amino group and (or) an imino group, such as H2NCH2 CH2CH2Si(OCH3)3, H2NCH2CH2NHCH2CH2CH2Si(OCH3)3, H2NCH2CH2NHCH2CH2CH2Si(CH3)(OCH3)2, and (C2H5O)3Si(CH2)3NH(CH2)2NH(CH2)3Si(OC2H5)3 and products formed by reaction between the alkoxysilane containing the amino group and (or) the imino group and methacryloxy silane compounds such as CH2=C(CH3)COOCH2CH2CH2Si(OCH3)3, and CH2=C(CH3)COOCH2CH2CH2Si(OCH2CH2OCH3)3.
ไฝไธบๆฐจๅบ๏ผไบๆฐจๅบ๏ผๅฎ่ฝ็ก ็ทๅถ่ๅ็ไพๅญ๏ผๅฏไปฅๅไธพๅซๆๆฐจๅบๅ๏ผๆ๏ผไบๆฐจๅบ็็ทๆฐงๅบ็ก ็ท๏ผไพๅฆ H 2 NCH 2 CH 2 CH 2 Si(OCH 3 ) 3 ใH 2 NCH 2 CH 2 NHCH 2 CH 2 CH 2 Si (OCH 3 ) 3 ใH 2 NCH 2 CH 2 NHCH 2 CH 2 CH 2 Si(CH 3 )(OCH 3 ) 2 ๅ (C 2 H 5 O) 3 Si(CH 2 ) 3 NH(CH 2 ) 2 NH(CH 2 ) 3 Si(OC 2 H 5 ) 3 ๏ผไปฅๅ็ฑๅซๆๆฐจๅบๅ๏ผๆ๏ผไบๆฐจๅบ็็ทๆฐงๅบ็ก ็ทไธ็ฒๅบไธ็ฏ้ ฐๆฐงๅบ็ก ็ทๅๅ็ฉๅๅบๅฝขๆ็ไบง็ฉ๏ผไพๅฆ CH 2 =C(CH 3 )COOCH 2 CH 2 CH 2 Si(OCH 3 ) 3 ใCH 2 =C(CH 3 )COOCH 2 CH 2 CH 2 Si(OCH 2 CH 2 OCH 3 ) 3 ใ -
[0034] The silane coupling agent is contained in the composition favorably at 1/100 to 1/5 and more favorably at 3/100 to 1/10 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
็ก ็ทๅถ่ๅๅจ็ปๅ็ฉไธญ็ๅซ้ไผ้ไธบๆๆบ่็ก ๆฐง็ทๅๅ็ฉๅซ้็1/100่ณ1/5๏ผๆดไผ้ไธบ3/100่ณ1/10๏ผๆ่ฟฐๆๆบ่็ก ๆฐง็ทๅๅ็ฉๆฏ็ปๅ็ฉไธญๆๅซๆบถๅๅ็ก ๆฉก่ถ็้ๆฅๅๆงๆๅใ -
[0035] It is preferable that the composition of the present invention contains powder of the resin of the polyolefin family.
ไผ้ๅฐ๏ผๆฌๅๆ็็ปๅ็ฉๅซๆ่็ฏ็ๆๆ ่็็ฒๆซใ -
[0036] As the fine particle of the resin of the polyolefin family, fine particles of polyethylene, polypropylene, and the like can be used. Fine particles of only one kind of the above-described synthetic resins or mixtures thereof may be used.
ไฝไธบ่็ฏ็็ฑปๆ ่ๅพฎ็ฒ๏ผๅฏไปฅไฝฟ็จ่ไน็ฏใ่ไธ็ฏ็ญๅพฎ็ฒใไนๅฏไปฅไฝฟ็จไธ่ฟฐๅๆๆ ่ไธญ็ไธ็งๆๅฎไปฌ็ๆททๅ็ฉ็ๅพฎ็ฒใ -
[0037] The size of the fine particle of the resin of the polyolefin family is set to the range of 0.5 to 10ยตm and favorably to the range of 2 to 8ยตm.
่็ฏ็็ฑปๆ ่็ๅพฎ็ฒๅฐบๅฏธ่ฎพๅฎไธบ 0.5๏ฝ10ฮผm ็่ๅด๏ผไผ้ไธบ 2๏ฝ8ฮผm ็่ๅดใ -
[0038] The fine particles of the resin of the polyolefin family are contained in the composition at 0.1 to 50 wt% and favorably at 1 to 20 wt%. The fine particles of the resin of the polyolefin family is contained in the composition at favorably 1/150 to 1/1 and more favorably 1/30 to 1/1.5 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
่็ฏ็็ฑปๆ ่ๅพฎ็ฒๅจ็ปๅ็ฉไธญ็ๅซ้ไธบ0.1่ณ50้้๏ผ ๏ผไผ้ไธบ1่ณ20้้๏ผ ใ่็ฏ็็ฑปๆ ่ๅพฎ็ฒๅจ็ปๅ็ฉไธญ็ๅซ้ไผ้ไธบๆๆบ่็ก ๆฐง็ทๅๅ็ฉ๏ผๅณ็ปๅ็ฉไธญๆๅซๆบถๅๅ็ก ๆฉก่ถ็้ๆฅๅๆงๆๅ๏ผๅซ้็1/150่ณ1/1๏ผๆดไผ้ไธบ1/30่ณ1/1.5ใ -
[0039] It is preferable that the composition of the present invention contains powder of mica.
ๆฌๅๆ็็ปๅ็ฉไผ้ๅซๆไบๆฏ็ฒๆซใ -
[0040] As the powder of the mica, natural mica powder or synthetic mica powder can be used. The synthetic mica powder is classified into an unswelling-type mica (for example, fluorine phlogopite, potassium tetrasilisic mica) and swelling-type mica (for example, sodium tetrasilisic mica, sodium hectorite). Although both can be used, the unswelling-type mica is favorable.
ไบๆฏ็ฒๅฏไปฅไฝฟ็จๅคฉ็ถไบๆฏ็ฒๆๅๆไบๆฏ็ฒใๅๆไบๆฏ็ฒๅไธบ้่จ่ๅไบๆฏ๏ผไพๅฆๆฐ้ไบๆฏใ้พๅ็ก ไบๆฏ๏ผๅ่จ่ๅไบๆฏ๏ผไพๅฆ้ ๅ็ก ไบๆฏใ้ ้่่ฑ็ณ๏ผใไธค็งไบๆฏ้ฝๅฏไปฅไฝฟ็จ๏ผไฝ้่จ่ๅไบๆฏๆดไฝณใ -
[0041] The size of the mica powder is set to the range of 0.5 to 10ยตm and favorably the range of 2 to 8ยตm.
ไบๆฏ็ฒ็ๅฐบๅฏธ่ฎพๅฎไธบ 0.5 ่ณ 10ฮผm ็่ๅด๏ผไผ้ไธบ 2 ่ณ 8ฮผm ็่ๅดใ -
[0042] The powder of the mica is contained in the composition at 0.1 to 50 wt% and favorably at 1 to 15 wt%. The powder of the mica is contained in the composition at favorably 1/300 to 1/1.5 and more favorably 1/30 to 1/2 of the content of the organic polysiloxane compound which is the nonvolatile content of the solvent-based silicone rubber contained in the composition.
ๆ่ฟฐไบๆฏ็ฒๅจๆ่ฟฐ็ปๅ็ฉไธญ็ๅซ้ไธบ0.1่ณ50้้๏ผ ๏ผไผ้ไธบ1่ณ15้้๏ผ ใ ๆ่ฟฐไบๆฏ็ฒๅจๆ่ฟฐ็ปๅ็ฉไธญ็ๅซ้ไผ้ไธบๆ่ฟฐ็ปๅ็ฉไธญๆๅซๆบถๅๅ็ก ๆฉก่ถ็ไธๆฅๅๆๅโโๆๆบ่็ก ๆฐง็ทๅๅ็ฉๅซ้็1/300่ณ1/1.5๏ผๆดไผ้ไธบ1/30่ณ1/2ใ -
[0043] The composition of the present invention may contain a catalyst for obtaining silicone rubber of condensation type by means of a crosslinking reaction. The catalyst may be added to the solvent-based silicone rubber when the composition is used. For example, as the catalyst, it is possible to use organic carboxylate or the ester of metals such as titanium, tin, zinc, cobalt, lead, calcium, manganese. More specifically, it is possible to use dialkyl tin compounds, titanium dipropoxide bisacetylacetonate, dibutyl tin laurate, cobalt naphthenate, and platinic chloride.
ๆฌๅๆ็็ปๅ็ฉๅฏๅซๆ็จไบ้่ฟไบค่ๅๅบ่ทๅพ็ผฉๅๅ็ก ๆฉก่ถ็ๅฌๅๅใ่ฏฅๅฌๅๅๅฏๅจไฝฟ็จๆถๆทปๅ ๅฐๆบถๅๅ็ก ๆฉก่ถไธญใไพๅฆ๏ผๅฏไปฅไฝฟ็จๆๆบ็พง้ ธ็ๆ้ใ้กใ้ใ้ดใ้ ใ้ใ้ฐ็ญ้ๅฑ็้ ฏไฝไธบๅฌๅๅใๆดๅ ทไฝๅฐ๏ผๅฏไปฅไฝฟ็จไบ็ทๅบ้กๅๅ็ฉใๅไน้ ฐไธ้ ฎไบไธๆฐงๅบ้ใๆๆก้ ธไบไธๅบ้กใ็ฏ็ท้ ธ้ดๅๆฐฏๅ้ใ -
[0044] The composition of the present invention is prepared as follows:
ๆฌๅๆ็็ปๅ็ฉๅถๅคๅฆไธ๏ผ -
[0045] Initially a surface active agent is added to a solvent (for example, organic solvent). Carbon nanotubes are added to the solvent to which the surface active agent has been added. The solution is stirred to prepare a liquid in which the carbon nanotubes are preferably dispersed. Thereafter the solvent-based silicone rubber is added to the liquid in which the carbon nanotubes have been dispersed. Thereby the composition is prepared. Therefore in the composition, the solvent-based silicone rubber is dispersed or dissolved in the solvent in which the carbon nanotubes are dispersed owing to the presence of the added surface active agent
้ฆๅ ๅฐ่กจ้ขๆดปๆงๅๆทปๅ ๅฐๆบถๅ๏ผไพๅฆๆๆบๆบถๅ๏ผไธญใๅฐ็ขณ็บณ็ฑณ็ฎกๆทปๅ ๅฐๅทฒๆทปๅ ่กจ้ขๆดปๆงๅ็ๆบถๅไธญใๆ ๆๆบถๆถฒ๏ผๅถๅค็ขณ็บณ็ฑณ็ฎกๅๆฃ็ๆถฒไฝใ็ถๅๅฐๆบถๅๅ็ก ๆฉก่ถๆทปๅ ๅฐ็ขณ็บณ็ฑณ็ฎกๅๆฃ็ๆถฒไฝไธญใ็ฑๆญคๅถๅคๅบ็ปๅ็ฉใๅ ๆญค๏ผๅจ่ฏฅ็ปๅ็ฉไธญ๏ผ็ฑไบๆทปๅ ็่กจ้ขๆดปๆงๅ็ๅญๅจ๏ผๆบถๅๅ็ก ๆฉก่ถๅๆฃๆๆบถ่งฃๅจ็ขณ็บณ็ฑณ็ฎกๅๆฃ็ๆบถๅไธญใ -
[0046] Thereafter the adhesion-improving agent and the catalyst are used as necessary.
ๆญคๅๆ นๆฎ้่ฆไฝฟ็จ็ฒๅๆน่ฟๅๅๅฌๅๅใ -
[0047] It is possible to use the composition of the present invention of a two component type. In this case, to form the composition, the surface active agent, the carbon nanotube, the solvent-based silicone rubber, and the adhesion-improving agent which is used as necessary are added to the organic solvent to from the main agent whereas the auxiliary agent consisting of the catalyst is added to the main agent at the time of use. Alternatively it is possible to compose the main agent of a mixture of the organic solvent, the surface active agent, the carbon nanotube, and the solvent-based silicone rubber and compose the auxiliary agent of the adhesion-improving agent and the catalyst both of which are added to the main agent at the time of use.
ๆฌๅๆ็็ปๅ็ฉไนๅฏไปฅ้็จๅ็ปๅๅใๆญคๆถ๏ผๅฐ่กจ้ขๆดปๆงๅใ็ขณ็บณ็ฑณ็ฎกใๆบถๅๅ็ก ๆฉก่ถไปฅๅๆ นๆฎ้่ฆไฝฟ็จ็็ฒๅๆนๅๅๆทปๅ ๅฐๆๆบๆบถๅไธญ๏ผๅฝขๆไธปๅ๏ผๅนถๅจไฝฟ็จๆถๅฐ็ฑๅฌๅๅ็ปๆ็ๅฉๅๆทปๅ ๅฐไธปๅไธญใๆ่ ๏ผไนๅฏไปฅๅฐๆๆบๆบถๅใ่กจ้ขๆดปๆงๅใ็ขณ็บณ็ฑณ็ฎกๅๆบถๅๅ็ก ๆฉก่ถๆททๅ๏ผๅฝขๆไธปๅ๏ผๅนถๅฐ็ฒๅๆนๅๅๅๅฌๅๅไฝไธบๅฉๅ๏ผๅนถๅจไฝฟ็จๆถๅฐไบ่ ๆทปๅ ๅฐไธปๅไธญใ -
[0048] The details of the solvent the surface active agent the carbon nanotube, the solvent-based silicone rubber, the adhesion-improving agent and the catalyst are as described above. The addition amount of each of these components is as described above.
ๆบถๅใ่กจ้ขๆดปๆงๅใ็ขณ็บณ็ฑณ็ฎกใๆบถๅๅ็ก ๆฉก่ถใ็ฒๅๆงๆน่ฏๅใๅฌๅๅ็่ฏฆๆ ๅฆไธๆ่ฟฐใๅๆๅ็ๆทปๅ ้ๅฆไธๆ่ฟฐใ -
[0049] The coefficient of dynamic friction of the slidable coating film made of the composition of the present invention is set favorably to not more than 0.15 and more favorably to not more than 0.13, when the coefficient of dynamic friction thereof is measured in accordance with the method of JIS K 7125.
ๅฝๆ็ ง JIS K 7125 ็ๆนๆณๆต้ๅ ถๅจๆฉๆฆ็ณปๆฐๆถ๏ผ็ฑๆฌๅๆ็็ปๅ็ฉๅถๆ็ๆปๅจๆถ่็ๅจๆฉๆฆ็ณปๆฐไผ้่ฎพๅฎไธบไธๅคงไบ 0.15๏ผๆดไผ้่ฎพๅฎไธบไธๅคงไบ 0.13ใ -
[0050] The medical appliance having the slidable coating film (in other words, slidable coating layer) of the present invention formed thereon is described below.
ไปฅไธๅฏนๅฝขๆๆๆฌๅๆ็ๆปๅจๆงๆถ่(ๆข่จไน๏ผๆปๅจๆงๆถๅฑ)็ๅป็ๅจๆขฐ่ฟ่ก่ฏดๆใ -
[0051] Themedical appliance 1 of the present invention having the slidable coating film formed thereon moves in contact with an inner surface of a medical member or an inner surface of a body lumen (for example, blood vessel, alimentary canal, abdominal cavity) and has aslidable coating film 3 formed at a portion thereof which contacts the medical member or the body lumen. Theslidable coating film 3 is comprised of silicone rubber, carbon nanotubes and fine particles of silicone resin.
ๆฌๅๆ็ๅป็ๅจๆขฐ 1 ๅฝขๆๆๆปๅจๆงๆถ่๏ผ่ฏฅๆปๅจๆงๆถ่ไธๅป็้จไปถ็ๅ ่กจ้ขๆไฝ่ ๏ผไพๅฆ๏ผ่ก็ฎกใๆถๅ้ใ่ น่ ๏ผ็ๅ ่กจ้ขๆฅ่งฆ๏ผๅนถๅจไธๅป็้จไปถๆไฝ่ ๆฅ่งฆ็้จๅๅฝขๆๆๆปๅจๆงๆถ่ 3ใ่ฏฅๆปๅจๆงๆถ่ 3 ็ฑ็ก ๆฉก่ถใ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่ๅพฎ็ฒๆๆใ -
[0052] In themedical appliance 1 of the present example, theslidable coating film 3 is composed of the silicone rubber and contains the carbon nanotubes and the fine particles of the silicone resin.
ๅจๆฌๅฎๆฝไพ็ๅป็ๅจๆขฐ 1 ไธญ๏ผ ๆปๅจๆถ่ 3 ็ฑ็ก ๆฉก่ถๆๆ๏ผๅนถๅซๆ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่็ๅพฎ็ฒใ -
[0053] Theslidable coating film 3 is formed as a rough surface. The rough surface is formed mainly of the fine particles of the silicone resin. Theslidable coating film 3 is reinforced with the carbon nanotube. A part of the rough surface is formed of the carbon nanotube.
ๆปๅจๆถ่ 3 ๅฝขๆไธบ็ฒ็ณ่กจ้ขใ่ฏฅ็ฒ็ณ่กจ้ขไธป่ฆ็ฑ็ก ๆ ่็ๅพฎ็ฒๆๆใ ๆปๅจๆถ่ 3 ็ฑ็ขณ็บณ็ฑณ็ฎกๅขๅผบใ่ฏฅ็ฒ็ณ่กจ้ข็ไธ้จๅ็ฑ็ขณ็บณ็ฑณ็ฎกๆๆใ -
[0054] The medical appliance of the present invention having the slidable coating film formed thereon is described below by using an embodiment in which the medical appliance is used as a gasket for use in a syringe and incorporated in the syringe.
ไปฅไธ๏ผไปฅๅฝขๆๆๆปๅจๆงๆถ่็ๆฌๅๆ็ๅป็ๅจๆขฐไฝไธบๆณจๅฐๅจ็จๅซๅๅนถ็ป่ฃ ๅฐๆณจๅฐๅจไธญ็ๅฎๆฝๆนๅผ่ฟ่ก่ฏดๆใ -
[0055] Fig.1 is a front view showing a gasket, for use in a syringe, of an embodiment of a medical appliance of the present invention.Fig. 2 is a sectional view showing the gasket shown inFig. 1 .Fig. 3 is a top view showing the gasket shown inFig. 1 .Fig. 4 is bottom view showing the gasket shown inFig.1 .
ๅพ1ๆฏๆฌๅๆ็ๅป็ๅจๆขฐ็ไธไธชๅฎๆฝๆนๅผ็ๆณจๅฐๅจ็จๅซ็็ไธป่งๅพใๅพ2ๆฏๅพ1ๆ็คบๅซ็็ๅ้ขๅพใๅพ3ๆฏๅพ1ๆ็คบๅซ็็ไฟฏ่งๅพใๅพ4ๆฏๅพ1ๆ็คบๅซ็็ไปฐ่งๅพใ -
[0056] The medical appliance of this embodiment having the slidable coating film formed thereon is agasket 1 for use in a syringe and accommodated liquid-tightly and slidably inside anouter cylinder 11, for use in the syringe, which is a medical member. Thegasket 1 has theslidable coating film 3 disposed at a portion thereof which contacts theouter cylinder 11. Theslidable coating film 3 has a rough surface attributed to the presence of the fine particle of the silicone resin contained therein. Thegasket 1 has acore part 2 and theslidable coating film 3 formed on a portion, of an outer surface of thecore part 2, which contacts an inner surface of theouter cylinder 11. Theslidable coating film 3 may be formed on the entire outer surface of thecore part 2.
ๆฌๅฎๆฝไพไธญ๏ผๅฝขๆๆๆปๅจๆงๆถ่็ๅป็ๅจๆขฐไธบๆณจๅฐๅจ็จๅซ็ 1๏ผ่ฏฅๅซ็ 1 ๆถฒๅฏๅฐไธๅฏๆปๅจๅฐๅฎน็บณไบไฝไธบๅป็้จไปถ็ๆณจๅฐๅจๅค็ญ 11 ๅ ใ ๅซ็ 1 ๅจๅ ถไธๅค็ญ 11 ๆฅ่งฆ็้จๅ่ฎพ็ฝฎๆๆปๅจๆงๆถ่ 3ใ็ฑไบๅ ถไธญๅซๆ็็ก ๆ ่ๅพฎ็ฒ็ๅญๅจ ๏ผๆปๅจๆงๆถ่ 3 ็่กจ้ข็ฒ็ณใ ๅซ็ 1 ๅ ทๆ่ฏ้จ 2 ๅๅฝขๆไบ่ฏ้จ 2 ๅค่กจ้ขไธไธๅค็ญ 11 ๅ ่กจ้ขๆฅ่งฆ็้จๅ็ๆปๅจๆงๆถ่ 3ใ ๆปๅจๆงๆถ่ 3 ๅฏไปฅๅฝขๆไบ่ฏ้จ 2 ็ๆดไธชๅค่กจ้ขไธใ -
[0057] A medical appliance of this embodiment is asyringe 10. Thesyringe 10 has agasket 1, for use in the syringe, which is a first medical member; and anouter cylinder 11, for use in the syringe, which is a second medical member and accommodates thegasket 1 therein liquid-tightly and slidably. Theslidable coating film 3 is provided at a portion, of thegasket 1, which contacts theouter cylinder 11. In forming theslidable coating film 3 on thegasket 1, theslidable coating film 3 is disposed on a portion, of the outer surface of thecore part 2, which contacts the inner surface of theouter cylinder 11. Theslidable coating film 3 may be formed on the entire outer surface of thecore part 2. When theslidable coating film 3 is formed on the inner surface of theouter cylinder 11, theslidable coating film 3 is formed on the inner surface of a region, of theouter cylinder 11, in which thegasket 1 slidably moves.
ๆฌๅฎๆฝไพ็ๅป็ๅจๆขฐไธบๆณจๅฐๅจ 10ใ ๆณจๅฐๅจ 10 ๅ ทๆ๏ผ็จไบไฝไธบ็ฌฌไธๅป็้จไปถ็ๆณจๅฐๅจ็ๅซๅ 1๏ผไปฅๅ็จไบไฝไธบ็ฌฌไบๅป็้จไปถ็ๆณจๅฐๅจ็ๅค็ญ 11๏ผ่ฏฅๅค็ญ 11 ไปฅๆถฒๅฏไธๆปๅจ่ชๅฆ็ๆนๅผๅฎน็บณๅซๅ 1ใ ๆปๅจๆถ่ 3 ่ฎพ็ฝฎๅจๅซ็ 1 ไธๅค็ญ 11 ๆฅ่งฆ็้จๅใๅจๅซ็ 1 ไธๅฝขๆๆปๅจๆถ่ 3 ๆถ๏ผ ๆปๅจๆถ่ 3 ่ฎพ็ฝฎๅจ่ฏ้จ 2 ๅค่กจ้ขไธไธๅค็ญ 11 ๅ ่กจ้ขๆฅ่งฆ็้จๅใ ๆปๅจๆถ่ 3 ๅฏไปฅๅฝขๆๅจ่ฏ้จ 2 ็ๆดไธชๅค่กจ้ขไธใๅฝๆปๅจๆถ่ 3 ๅฝขๆๅจๅค็ญ 11 ็ๅ ่กจ้ขไธๆถ๏ผ ๆปๅจๆถ่ 3 ๅฝขๆๅจๅค็ญ 11 ไธญๅซ็ 1 ๆปๅจๅบๅ็ๅ ่กจ้ขไธใ -
[0058] The gasket and the syringe which are an embodiment of the medical appliance of the present invention are described below.
ไปฅไธๅฏนไฝไธบๆฌๅๆ็ๅป็ๅจๆขฐ็ไธไธชๅฎๆฝๆนๅผ็ๅซๅๅๆณจๅฐๅจ่ฟ่ก่ฏดๆใ -
[0059] As shown inFigs. 1, 2 , and5 , thecore part 2 of thegasket 1 for use in the syringe has amain body 5 extending in an almost equal diameter; a taperedportion 6, disposed at a distal side of themain body 5, whose diameter decreases taperingly to the distal end thereof; a plunger-mountingportion 4 provided inside themain body 5 from a proximal end thereof toward a distal side thereof; a distal-sideannular rib 7a provided on a side surface of the distal portion of themain body 5, and a proximal-sideannular rib 7b provided on a side surface of the proximal portion of themain body 5.
ๅฆๅพ 1ใๅพ 2 ๅๅพ 5 ๆ็คบ๏ผๆณจๅฐๅจ็จๅซๅ 1 ็ๆ ธๅฟ้จๅ 2 ๅ ทๆไธไธชๅ ไน็ญ็ดๅพๅปถไผธ็ไธปไฝ 5๏ผไธไธช่ฎพ็ฝฎๅจไธปไฝ 5 ่ฟ็ซฏไพง็้ฅๅฝข้จๅ 6๏ผๅ ถ็ดๅพๅ่ฟ็ซฏๅ้ฅๅฝขๅๅฐ๏ผไธไธช่ฎพ็ฝฎๅจไธปไฝ 5 ๅ ้จใไป่ฟ็ซฏๅ่ฟ็ซฏไพง็ๆฑๅกๅฎ่ฃ ้จๅ 4๏ผไธไธช่ฎพ็ฝฎๅจไธปไฝ 5 ่ฟ็ซฏ้จๅไพง้ข็่ฟ็ซฏไพง็ฏๅฝข่ 7a๏ผไปฅๅไธไธช่ฎพ็ฝฎๅจไธปไฝ 5 ่ฟ็ซฏ้จๅไพง้ข็่ฟ็ซฏไพง็ฏๅฝข่ 7bใ -
[0060] As shown inFigs. 2 and4 , the plunger-mountingportion 4 is formed as a concave portion, approximately columnar, which is disposed inside themain body 5 and extends from the proximal end of themain body 5 to a position in the vicinity of the distal end thereof. A screwingportion 8 capable of engaging a screwing portion formed at a distal end of a plunger is formed on a side surface of the concave portion. A distal-end surface of the concave portion is formed almost flatly. The plunger-mountingportion 4 does not necessarily have to be formed as the screwing portion, but may be formed as an engaging portion which engages the distal portion of the plunger.
ๅฆๅพ 2 ๅๅพ 4 ๆ็คบ๏ผๆฑๅกๅฎ่ฃ ้จ 4 ๅ่ฟไผผๅๆฑๅฝข็ๅน้ท้จๅ๏ผไฝไบไธปไฝ 5 ๅ ้จ๏ผๅนถไปไธปไฝ 5 ็่ฟ็ซฏๅปถไผธ่ณๅ ถ่ฟ็ซฏ้่ฟใๅน้ท้จๅ็ไพง้ขๅฝขๆๆ่บ็บน้จๅ 8๏ผ่ฏฅ่บ็บน้จๅๅฏไธๆฑๅก่ฟ็ซฏ็่บ็บน้จๅๅฎๅใๅน้ท้จๅ็่ฟ็ซฏ่กจ้ขๅ ไนๅนณๅฆใๆฑๅกๅฎ่ฃ ้จ 4 ๅนถ้ๅฟ ้กปๅฝขๆไธบ่บ็บน้จๅ๏ผไนๅฏไปฅๅฝขๆไธบไธๆฑๅก่ฟ็ซฏ้จๅๅฎๅ็ๅฎๅ้จๅใ -
[0061] The outer diameters of theannular ribs outer cylinder 11 for use in the syringe. Therefore theannular ribs outer cylinder 11. In the embodiment, two annular ribs are formed, but three or more annular ribs may be formed.
ๅคๅพ ็ฏๅฝข่ๆก 7a ๅ 7b ๅฝขๆๅพๆฏๆณจๅฐๅจไฝฟ็จ็ๅค็ญ 11 ็ๅ ๅพ็จๅคงใๅ ๆญค ็ฏ็ถ่ 7aใ7b ๅจๅค็ญ 11 ๅ ๅ็ผฉๅๅฝขใๅจๆฌๅฎๆฝไพไธญ๏ผๅฝขๆๆไธคไธช็ฏ็ถ่๏ผไฝไนๅฏไปฅๅฝขๆไธไธชไปฅไธ็็ฏ็ถ่ใ -
[0062] It is preferable that an elastic material is used to compose thecore part 2. As the elastic material, it is possible to list rubber materials (vulcanized rubber materials are preferable) such as natural rubber, isoprene rubber, butyl rubber, chloroprene rubber, nitrile-butadiene rubber, styrene-butadiene rubber, silicone rubber; styrene elastomer and hydrogenated styrene elastomer; and mixtures of the styrene elastomer and polyolefins such as polyethylene, polypropylene, polybutene, and ฮฑ-olefin copolymers; mixtures of the styrene elastomer and oil such as liquid paraffin, process oil; and mixtures of the styrene elastomer and powdery inorganic substances such as talc, cast, mica, and the like. Further it is possible to use polyvinyl chloride elastomer, olefin elastomer, polyester elastomer, polyamide elastomer, polyurethane elastomer, and mixtures of these elastomers as the materials for thecore part 2. As the elastic material, the diene rubbers and the styrene elastomer are especially preferable because these rubbers or elastomers are favorable in elastic properties and resistant to sterilization by steam.
ไผ้ไฝฟ็จๅผนๆงๆๆๆฅๆๆ่ฏ้จ 2ใไฝไธบๅผนๆงๆๆ๏ผๅฏไปฅๅไธพ๏ผๅคฉ็ถๆฉก่ถใๅผๆไบ็ฏๆฉก่ถใไธๅบๆฉก่ถใๆฐฏไธๆฉก่ถใไธ่ ๆฉก่ถใไธ่ฏๆฉก่ถใ็ก ๆฉก่ถ็ญๆฉก่ถๆๆ๏ผไผ้็กซๅๆฉก่ถๆๆ๏ผ๏ผ่ฏไน็ฏๅผนๆงไฝใๆฐขๅ่ฏไน็ฏๅผนๆงไฝ๏ผ่ฏไน็ฏๅผนๆงไฝไธ่ไน็ฏใ่ไธ็ฏใ่ไธ็ฏใฮฑ-็ฏ็ๅ ฑ่็ฉ็ญ่็ฏ็็ๆททๅ็ฉ๏ผ่ฏไน็ฏๅผนๆงไฝไธๆถฒไฝ็ณ่กใๅ ๅทฅๆฒน็ญๆฒน็ๆททๅ็ฉ๏ผ่ฏไน็ฏๅผนๆงไฝไธๆป็ณ็ฒใ้ธ้ใไบๆฏ็ญ็ฒๆซ็ถๆ ๆบ็ฉ็ๆททๅ็ฉใๅฆๅค๏ผๅฏไปฅไฝฟ็จ่ๆฐฏไน็ฏๅผนๆงไฝใ็ฏ็ๅผนๆงไฝใ่้ ฏๅผนๆงไฝใ่้ ฐ่บๅผนๆงไฝใ่ๆฐจ้ ฏๅผนๆงไฝไปฅๅ่ฟไบๅผนๆงไฝ็ๆททๅ็ฉไฝไธบ่ฏ้จ 2 ็ๆๆใไฝไธบๅผนๆงๆๆ๏ผ็นๅซไผ้ไบ็ฏๆฉก่ถๅ่ฏไน็ฏๅผนๆงไฝ๏ผๅ ไธบ่ฟไบๆฉก่ถๆๅผนๆงไฝๅ ทๆ่ฏๅฅฝ็ๅผนๆง๏ผๅนถไธ่่ธๆฑฝ็ญ่ใ -
[0063] It is essential that theslidable coating film 3 is formed at the annular ribs. More specifically, it is essential that the slidable coating film is formed at the distal-sideannular rib 7a and the proximal-sideannular rib 7b.
ๅฟ ้กปๅจ็ฏ็ถ่ไธๅฝขๆๆปๅจๆงๆถ่ 3ใๅ ทไฝ่่จ๏ผๅฟ ้กปๅจ่ฟไฝไพง็ฏ็ถ่ 7a ๅ่ฟไฝไพง็ฏ็ถ่ 7b ไธๅฝขๆๆปๅจๆงๆถ่ใ -
[0064] The thickness of theslidable coating film 3 is set favorably to the range of 1 to 20ยตm and more favorably to the range of 3 to 10ยตm. When the thickness of theslidable coating film 3 is not less than 1ยตm, theslidable coating film 3 works on a sufficiently high slidable performance. When the thickness of theslidable coating film 3 is not more than 10ยตm, theslidable coating film 3 can be securely formed as the rough surface attributed to the presence of the fine particle of the silicone resin contained therein without adversely affecting the elasticity of the gasket
ๆปๅจๆถ่ 3 ็ๅๅบฆไผ้่ฎพๅฎๅจ 1 ่ณ 20ฮผm ็่ๅดๅ ๏ผๆดไผ้่ฎพๅฎๅจ 3 ่ณ 10ฮผm ็่ๅดๅ ใๅฝๆปๅจๆถ่ 3 ็ๅๅบฆไธๅฐไบ 1ฮผm ๆถ๏ผ ๆปๅจๆถ่ 3 ๅฏๅๆฅ่ถณๅค้ซ็ๆปๅจๆง่ฝใๅฝๆปๅจๆถ่ 3 ็ๅๅบฆไธๅคงไบ 10ฮผm ๆถ๏ผ็ฑไบๅ ถไธญๅซๆ็็ก ๆ ่ๅพฎ็ฒ็ๅญๅจ๏ผ ๆปๅจๆถ่ 3 ๅฏไปฅๅฏ้ ๅฐๅฝขๆ็ฒ็ณ่กจ้ข๏ผ่ไธไผๅฏนๅซๅ็ๅผนๆงไบง็ไธๅฉๅฝฑๅใ -
[0065] Theslidable coating film 3 is composed of the silicone rubber as its main component and contains the carbon nanotubes and the fine particles of the silicone resin. In other words, theslidable coating film 3 is composed of the coating film made of the silicone rubber, the carbon nanotubes and the fine particles of the silicone resin both held by the coating film. The coating film disposed on the surface of the slidable coating film is flexible. Further the slidable coating film is highly slidable owing to the rough surface thereof formed of the fine particles of the silicone resin contained therein. Furthermore, the carbon nanotubes contained in the slidable coating film impart a strength thereto to such an extent that the slidable coating film stands up a resistance force generated when theslidable coating film 3 slides in contact with the inner surface of theouter cylinder 11. The slidable coating film can be formed by applying the (slidable) composition on the core part of the gasket and hardening it
ๆปๅจๆถ่ 3 ไปฅ็ก ๆฉก่ถไธบไธป่ฆๆๅ๏ผๅนถๅซๆ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่ๅพฎ็ฒใๆขๅฅ่ฏ่ฏด๏ผ ๆปๅจๆถ่ 3 ็ฑ็ก ๆฉก่ถๆถๅฑใ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่ๅพฎ็ฒๆๆ๏ผ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่ๅพฎ็ฒๅ่ขซๆถๅฑๆไฟๆใๆปๅจๆถ่่กจ้ข็ๆถๅฑๅ ทๆๆ้งๆงใๆญคๅค๏ผ็ฑไบๆปๅจๆถ่่กจ้ข็ฑ็ก ๆ ่ๅพฎ็ฒๆๆ๏ผไฝฟๅ ถๅ ทๆ่ฏๅฅฝ็ๆปๅจๆงใๆญคๅค๏ผๆปๅจๆถ่ไธญๅซๆ็็ขณ็บณ็ฑณ็ฎก่ตไบๅ ถไธๅฎ็ๅผบๅบฆ๏ผไฝฟๅ ถ่ฝๅคๆฟๅๆปๅจๆถ่ 3 ไธๅค็ญ 11 ๅ ่กจ้ขๆปๅจๆฅ่งฆๆถไบง็็้ปๅใๆปๅจๆถ่ๅฏไปฅ้่ฟๅฐ๏ผๆปๅจ๏ผ็ปๅ็ฉๆถ่ฆๅจๅซ็็่ฏ้จๅนถไฝฟๅ ถ็กฌๅๆฅๅฝขๆใ -
[0066] The coefficient of dynamic friction of the slidable coating film to be formed on the gasket is favorably not more than 0.15 and more favorably not more than 0.13, when the coefficient of dynamic friction thereof is measured in accordance with the method of JIS K 7125.
ๅฝๆ็ ง JIS K 7125 ็ๆนๆณๆต้ๅ ถๅจๆฉๆฆ็ณปๆฐๆถ๏ผๅฝขๆๅจๅซๅไธ็ๅฏๆปๅจๆถ่็ๅจๆฉๆฆ็ณปๆฐไผ้ไธบไธ่ถ ่ฟ 0.15๏ผๆดไผ้ไธบไธ่ถ ่ฟ 0.13ใ -
[0067] As the silicone rubber which is used as the main component of theslidable coating film 3, it is preferable to use the hardened solvent-based silicone rubber. A liquid organic polysiloxane compound is used as the solvent-based silicone rubber. Therefore the hardened liquid organic polysiloxane compound is preferable as the silicone rubber. The above-described organic polysiloxane compounds can be preferably used. More specifically, the hardened liquid organic polysiloxane compound is preferably the crosslinked organic polysiloxane compound. The Young's modulus of the silicone rubber is favorably not more than 3,000 MPa and more favorably not more than 1,000 MPa.
ไฝไธบๆปๅจๆถ่ 3 ไธป่ฆๆๅ็็ก ๆฉก่ถ๏ผไผ้ไฝฟ็จๅบๅ็ๆบถๅๅ็ก ๆฉก่ถใ็ฑไบๆบถๅๅ็ก ๆฉก่ถไฝฟ็จๆถฒๆๆๆบ่็ก ๆฐง็ทๅๅ็ฉ๏ผๅ ๆญคไผ้ไฝฟ็จๅบๅ็ๆถฒๆๆๆบ่็ก ๆฐง็ทๅๅ็ฉใไผ้ไฝฟ็จไธ่ฟฐๆๆบ่็ก ๆฐง็ทๅๅ็ฉใๆดๅ ทไฝๅฐ๏ผไผ้ไฝฟ็จๅบๅ็ๆถฒๆๆๆบ่็ก ๆฐง็ทๅๅ็ฉไบค่ๆๆบ่็ก ๆฐง็ทๅๅ็ฉใ็ก ๆฉก่ถ็ๆจๆฐๆจก้ไผ้ไธบ 3000MPa ไปฅไธ๏ผๆดไผ้ไธบ 1000MPa ไปฅไธใ -
[0068] Theslidable coating film 3 contains a large number of fine particles of the silicone resin held by the coating film of the silicone rubber. Theslidable coating film 3 has the rough surface attributed to the presence of the fine particles of the silicone resin contained therein. Owing to the rough surface, theslidable coating film 3 has a stable slidableness.
ๆปๅจๆงๆถ่ 3 ไธญ๏ผ็ก ๆฉก่ถๆถ่ไธ้็ๆๅคง้็็ก ๆ ่ๅพฎ็ฒใ็ฑไบ็ก ๆ ่ๅพฎ็ฒ็ๅญๅจ๏ผ ๆปๅจๆงๆถ่ 3 ่กจ้ขๅ็ฐ็ฒ็ณๅบฆใๆญฃๆฏ็ฑไบ่ฏฅ็ฒ็ณๅบฆ๏ผ ๆปๅจๆงๆถ่ 3 ๆๅ ทๆ็จณๅฎ็ๆปๅจๆงใ -
[0069] The surface roughness (Ra, measuring method: JIS B 0601: 1994) of theslidable coating film 3 is favorably in the range of 1.7 to 4.5ยตm and more favorably in the range of 2.0 to 3.0ยตm. The surface roughness Ra1 described in is sufficiently higher than the surface roughness of 0.1 to 1.5ยตm. The detail of the fine particle of the silicone resin is as described previously. The size of the fine particle of the silicone resin is set to the range of 0.5 to 10ยตm and favorably to the range of 2 to 8ยตm. The ratio of the average diameter of the fine particle of the silicone resin to the average film thickness (average film thickness including fine particles) of theslidable coating film 3 is set favorably to 0.2 to 1.5, more favorably to 0.3 to 1.2, and most favorably to 0.4 to 1.0. When the above-described ratio is below 1.5, the rough surface does not cause a decrease in the air-tightness of theslidable coating film 3. When the ratio is above 0.2, the surface of theslidable coating film 3 can be roughened to a sufficiently hight extent The fine particles of the silicone resin are adhesive to the coating film of the silicone rubber. The content of the fine particles of the silicone resin is 3 to 60% of the weight (weight after slidable coating film hardens) of the slidable coating film and 2 to 60% in a volume ratio. The above-described fine particles of the silicone resin are used in the present invention.
ๆปๅจๆถ่ 3 ็่กจ้ข็ฒ็ณๅบฆ(Ra๏ผๆตๅฎๆนๆณ๏ผJIS B 0601:1994)ไผ้ไธบ 1.7๏ฝ4.5ฮผm๏ผๆดไผ้ไธบ 2.0๏ฝ3.0ฮผmใ ่ฟ้ซไบ 0.1 ่ณ 1.5ฮผm ็่กจ้ข็ฒ็ณๅบฆใ็ก ๆ ่ๅพฎ็ฒ็่ฏฆ็ปๆ ๅตๅฆไธๆ่ฟฐใ็ก ๆ ่ๅพฎ็ฒ็ๅฐบๅฏธ่ฎพๅฎไธบ 0.5 ่ณ 10ฮผm ็่ๅด๏ผไผ้ไธบ 2 ่ณ 8ฮผm ็่ๅดใ็ก ๆ ่ๅพฎ็ฒ็ๅนณๅ็ฒๅพไธๆปๅจๆถ่ 3 ็ๅนณๅ่ๅ๏ผๅ ๅซๅพฎ็ฒ็ๅนณๅ่ๅ๏ผ็ๆฏๅผไผ้ไธบ 0.2 ่ณ 1.5๏ผๆดไผ้ไธบ 0.3 ่ณ 1.2๏ผๆไผ้ไธบ 0.4 ่ณ 1.0ใๅฝไธ่ฟฐๆฏไพไฝไบ 1.5 ๆถ๏ผ็ฒ็ณ่กจ้ขไธไผๅฏผ่ดๆปๅจๆถ่ 3 ็ๆฐๅฏๆงไธ้ใๅฝ่ฏฅๆฏไพ้ซไบ 0.2 ๆถ๏ผ ๆปๅจๆถ่ 3 ็่กจ้ขๅฏไปฅ่พพๅฐ่ถณๅค้ซ็็ฒ็ณๅบฆใ็ก ๆ ่ๅพฎ็ฒไธ็ก ๆฉก่ถๆถ่ๅ ทๆ่ฏๅฅฝ็็ฒๅๆงใ็ก ๆ ่ๅพฎ็ฒ็ๅซ้ไธบๆปๅจๆถ่้้๏ผๆปๅจๆถ่ๅบๅๅ็้้๏ผ็ 3%่ณ 60%๏ผไฝ็งฏๆฏไธบ 2%่ณ 60%ใๆฌๅๆไธญไฝฟ็จไธ่ฟฐ็ก ๆ ่ๅพฎ็ฒใ -
[0070] Because thegasket 1 of the present invention has the above-describedslidable coating film 3 formed thereon, thegasket 1 has a stable slidableness without applying a lubricant to the sliding surface thereof and is capable of maintaining sealing performance of a space for accommodating a medicine. Because theslidable coating film 3 contains the fine particles, it has the rough surface as shown inFig. 9 .
ๆฌๅๆ็ๅซ็ 1๏ผ็ฑไบๅ ถ่กจ้ขๅฝขๆๆไธ่ฟฐๆปๅจๆงๆถ่ 3๏ผๅ ๆญคๅณไฝฟๆปๅจ้ขๆชๆถๆทๆถฆๆปๅ๏ผไนๅ ทๆ็จณๅฎ็ๆปๅจๆง๏ผ่ฝๅค็ปดๆ่ฏๅๆถ็บณ็ฉบ้ด็ๅฏๅฐๆงใ็ฑไบๆปๅจๆงๆถ่ 3 ๅซๆๅพฎ็ฒ๏ผๅ ๆญคๅ ถ่กจ้ขๅ็ฐๅฆๅพ 9 ๆ็คบ็็ฒ็ณ็ถๆใ -
[0071] Theslidable coating film 3 contains a large number of the carbon nanotubes held by the coating film of the silicone rubber. The above-described carbon nanotubes are used. It is preferable that the content of the carbon nanotube is 0.01 to 3% of the weight (weight of fine particle after it hardens) of the slidable coating film and 0.004 to 5% thereof in a volume ratio.
ๆปๅจๆถ่ 3 ๅซๆๅคง้็็ขณ็บณ็ฑณ็ฎก๏ผ่ฟไบ็ขณ็บณ็ฑณ็ฎก่ขซ็ก ๆฉก่ถๆถ่ๆไฟๆใ็ขณ็บณ็ฑณ็ฎก็ไฝฟ็จๆนๆณๅฆไธๆ่ฟฐใ็ขณ็บณ็ฑณ็ฎก็ๅซ้ไผ้ไธบๆปๅจๆถ่้้๏ผๅบๅๅๅพฎ็ฒ็้้๏ผ็ 0.01๏ผ ่ณ 3๏ผ ๏ผไฝ็งฏๆฏไธบ 0.004๏ผ ่ณ 5๏ผ ใ -
[0072] It is preferable that theslidable coating film 3 contains the powder of the resin of the polyolefin family. The kind of the fine particles of the resin of the olefin family to be used in the present invention is previously described. It is preferable that the content of the powder of the resin of the polyolefin family is set to the range of 3 to 60% of the weight (weight of fine particle after it hardens) of the slidable coating film and to the range of 4 to 65% thereof in a volume ratio.
ๆปๅจๆถ่ 3 ไผ้ๅซๆ่็ฏ็็ฑปๆ ่็ฒๆซใๆฌๅๆไธญไฝฟ็จ็็ฏ็็ฑปๆ ่ๅพฎ็ฒ็็ง็ฑปๅทฒๅจไธๆ่ฟฐๅใ่็ฏ็็ฑปๆ ่็ฒๆซ็ๅซ้ไผ้ไธบๆปๅจๆถ่้้๏ผๅพฎ็ฒๅบๅๅ็้้๏ผ็ 3%่ณ 60%๏ผไฝ็งฏๆฏไผ้ไธบ 4%่ณ 65%ใ -
[0073] It is preferable that theslidable coating film 3 contains the powder of the mica. The kind of the mica to be used in the present invention is previously described. It is preferable that the content of the powder of the mica is set to the range of 1 to 40% of the weight (weight of fine particle after it hardens) of the slidable coating film and 0.4 to 15% thereof in a volume ratio.
ๆปๅจๆถ่ 3 ไผ้ๅซๆไบๆฏ็ฒใๆฌๅๆไธญไฝฟ็จ็ไบๆฏ็ง็ฑปๅทฒๅจไธๆ่ฟฐๅใไบๆฏ็ฒ็ๅซ้ไผ้่ฎพๅฎไธบๆปๅจๆถ่้้๏ผๅบๅๅๅพฎ็ฒ็้้๏ผ็ 1%่ณ 40%็่ๅด๏ผไฝ็งฏๆฏไธบ 0.4%่ณ 15%ใ -
[0074] Theslidable coating film 3 may contain the surface active agent The kind of the surface active agents to be used in the present invention is previously described. It is preferable that the content of the surface active agent is set to the range of 0.05 to 5% of the weight of (weight of fine particle after it hardens) of the slidable coating film.
ๆปๅจๆถ่ 3 ๅฏๅซๆ่กจ้ขๆดปๆงๅใๆฌๅๆไธญไฝฟ็จ็่กจ้ขๆดปๆงๅ็็ง็ฑปๅทฒๅจไธๆ่ฟฐๅใ่กจ้ขๆดปๆงๅ็ๅซ้ไผ้ไธบๆปๅจๆถ่้้๏ผๅบๅๅ็ๅพฎ็ฒ้้๏ผ็ 0.05๏ฝ5๏ผ ็่ๅดใ -
[0075] Theslidable coating film 3 may contain the adhesion-improving agent The kind of the adhesion-improving agent to be used in the present invention is previously described. It is preferable that the content of the adhesion-improving agent is set to the range of 10 to 50% of the weight of (weight of fine particle after it hardens) the slidable coating film.
ๆปๅจๆงๆถ่ 3 ๅฏๅซๆ้็ๅๆนๅๅใๆฌๅๆไธญไฝฟ็จ็้็ๅๆนๅๅ็็ง็ฑปๅทฒๅจไธๆ่ฟฐๅใ้็ๅๆนๅๅ็ๅซ้ไผ้ไธบๆปๅจๆงๆถ่้้๏ผๅบๅๅ็ๅพฎ็ฒ้้๏ผ็ 10๏ผ ่ณ 5โโ0๏ผ ใ -
[0076] Theslidable coating film 3 may contain the catalyst for obtaining the silicone rubber of a condensation type by means of a crosslinking reaction. The kind of the catalyst to be used in the present invention is previously described.
ๆปๅจๆงๆถ่ 3 ไธญๅฏไปฅๅซๆ็จไบ้่ฟไบค่ๅๅบๅพๅฐ็ผฉๅๅ็ก ๆฉก่ถ็ๅฌๅๅใๆฌๅๆไธญไฝฟ็จ็ๅฌๅๅ็็ง็ฑปๅทฒๅจไธๆไธญๆ่ฟฐใ -
[0077] The method of forming theslidable coating film 3 is described below.
ไปฅไธๅฏนๆปๅจๆงๆถ่ 3 ็ๅฝขๆๆนๆณ่ฟ่ก่ฏดๆใ -
[0078] Initially the above-described composition is prepared.
้ฆๅ ๅถๅคไธ่ฟฐ็ปๅ็ฉใ -
[0079] The slidable coating film is obtained by applying the composition to the clean surface of the gasket and hardening it At this time, the composition can be applied to the surface of the gasket by carrying out a known method such as a dip coating method, a spraying method, and the like. It is preferable that a coating solution is sprayed to the surface of the object to be coated with the object being rotated (at 100 to 600 rpm). It is preferable to heat a portion of the gasket to be coated to 50 to 100ยฐC before the coating solution is sprayed thereto. Thereby the composition can be rapidly fixed to the surface of the portion of the gasket to be coated. Therefore it is easy to carry out this method.
ๅฐ็ปๅ็ฉๆถ่ฆไบๅซ็็ๆธ ๆด่กจ้ขๅนถไฝฟๅ ถๅบๅ๏ผๅณๅฏ่ทๅพๆปๅจๆงๆถ่ใๆญคๆถ๏ผๅฏไปฅ้่ฟๆตธๆถๆณใๅทๆถๆณ็ญๅทฒ็ฅๆนๆณๅฐ็ปๅ็ฉๆถ่ฆไบๅซ็่กจ้ขใไผ้ๅจๆ่ฝฌ๏ผ100 ่ณ 600 rpm๏ผ็็ถๆไธ๏ผๅฐๆถๆๆบถๆถฒๅทๆถไบๅพ ๆถ่ฆ็ฉไฝ่กจ้ขใๅทๆถๆถๆๆบถๆถฒไนๅ๏ผไผ้ๅฐๅพ ๆถ่ฆ็ๅซ็้จๅๅ ็ญ่ณ 50 ่ณ 100ยฐCใ่ฟๆ ท๏ผ็ปๅ็ฉๅฏไปฅๅฟซ้ๅบๅไบๅพ ๆถ่ฆๅซ็้จๅ็่กจ้ขไธใๅ ๆญค๏ผ่ฏฅๆนๆณๆไบๆไฝใ -
[0080] As the method of hardening the composition, it may be left at a normal temperature, but it is preferable to heat it The method of thermally hardening the composition is not limited to a specific method, provided that the base material of the gasket is not modified or deformed. It is possible to adopt conventional methods of drying the composition by hot air, drying the composition by an oven utilizing infrared rays or by a drier which is used under a reduced pressure. The composition can be hardened in a short period of time by using the coating solution containing the silane coupling agent In forming the slidable coating film on the gasket, the concentration of the mixed solution is appropriately controlled and the dipping method, the spraying method or the like is carried out
ๅบๅ็ปๅ็ฉ็ๆนๆณ๏ผๅฏไปฅ็ฝฎไบๅธธๆธฉไธ๏ผไฝๆๅฅฝๅ ็ญใ็ญๅบๅ็ปๅ็ฉ็ๆนๆณไธๅฑ้ไบ็นๅฎๆนๆณ๏ผๅช่ฆๅซ็็ๅบๆไธๅ็ๆนๆงๆๅๅฝขๅณๅฏใๅฏไปฅ้็จๅธธ่งๆนๆณ๏ผไพๅฆ็จ็ญ้ฃๅนฒ็ฅ็ปๅ็ฉใ็จ็บขๅค็บฟ็ค็ฎฑๅนฒ็ฅ็ปๅ็ฉๆๅจๅๅไธไฝฟ็จ็ๅนฒ็ฅๅจๅนฒ็ฅ็ปๅ็ฉใไฝฟ็จๅซๆ็ก ็ทๅถ่ๅ็ๆถๅฑๆบถๆถฒ๏ผๅฏไปฅๅจ็ญๆถ้ดๅ ไฝฟ็ปๅ็ฉๅบๅใๅจๅซ็ไธๅฝขๆๆปๅจๆถ่ๆถ๏ผๅบ้ๅฝๆงๅถๆททๅๆบถๆถฒ็ๆตๅบฆ๏ผๅนถ้็จๆตธๆธๆณใๅทๆถๆณ็ญๆนๆณใ -
[0081] As shown inFig. 5 , thesyringe 10 which is an embodiment of the medical appliance of the present invention includes anouter cylinder 11, for use in the syringe, which has a needle-mountingportion 15 disposed at a distal side thereof and aflange 16 disposed at a proximal end thereof; agasket 1, for use in the syringe, which is capable of liquid-tightly and airtightly sliding on aninner surface 12 of theouter cylinder 11; aplunger 17 which is or can be mounted on thegasket 1; a sealingmember 18 for sealing the needle-mountingportion 15 of theouter cylinder 11; and a medicine-accommodatingportion 19, for accommodating amedicine 26, which is surround with the sealingmember 18, theinner surface 12 of the outer cylinder 11 (and the inner surface of the slidable coating film 3), and thegasket 1. Instead of the sealingmember 18, a needle may be mounted on the needle-mountingportion 15. As shown inFig. 5 , the sealingmember 18 into which a double ended needle can be directly inserted is preferable.
ๅฆๅพ 5 ๆ็คบ๏ผไฝไธบๆฌๅๆๅป็ๅจๆขฐ็ไธไธชๅฎๆฝไพ็ๆณจๅฐๅจ 10 ๅ ๆฌ๏ผ็จไบๆณจๅฐๅจ็ๅค็ญ 11๏ผๅ ถ่ฟ็ซฏไพง่ฎพๆ้ๅฎ่ฃ ้จๅ 15๏ผ่ฟ็ซฏ่ฎพๆๅธ็ผ 16๏ผ็จไบๆณจๅฐๅจ็ๅซๅ 1๏ผๅ ถ่ฝๅคๅจๅค็ญ 11 ็ๅ ่กจ้ข 12 ไธๆถฒๅฏไธๆฐๅฏๅฐๆปๅจ๏ผ ๆฑๅก 17๏ผๅ ถๅฎ่ฃ ๅจๆๅฏๅฎ่ฃ ๅจๅซๅ 1 ไธ๏ผๅฏๅฐไปถ 18๏ผ็จไบๅฏๅฐๅค็ญ 11 ็้ๅฎ่ฃ ้จๅ 15๏ผไปฅๅ็จไบๅฎน็บณ่ฏ็ฉ 26 ็่ฏ็ฉๅฎน็บณ้จ 19๏ผ่ฏฅ่ฏ็ฉๅฎน็บณ้จ 19 ่ขซๅฏๅฐไปถ 18ใๅค็ญ 11 ็ๅ ่กจ้ข 12๏ผไปฅๅๆปๅจๆถ่ 3 ็ๅ ่กจ้ข๏ผๅๅซๅ 1 ๅ ๅดใ้คไบๅฏๅฐไปถ 18 ไนๅค๏ผ่ฟๅฏไปฅๅฐ้ๅคดๅฎ่ฃ ๅจ้ๅฎ่ฃ ้จ 15 ไธใๅฆๅพ 5 ๆ็คบ๏ผๅฏ็ดๆฅๆๅ ฅๅๅคด้็ๅฏๅฐไปถ 18 ๆฏไผ้็ใ -
[0082] As shown inFig. 5 , the above-described medical appliance is apre-filled syringe 25 including thesyringe 10 and themedicine 26.
ๅฆๅพ 5 ๆ็คบ๏ผไธ่ฟฐๅป็ๅจๆขฐไธบๅ ๆฌๆณจๅฐๅจ 10 ๅ่ฏ็ฉ 26 ็้ขๅ ๅผๆณจๅฐๅจ 25ใ -
[0083] Theouter cylinder 11 for use in the syringe has the needle-mountingportion 15 disposed at the distal portion thereof and theflange 16 disposed at the proximal end thereof. Theouter cylinder 11 is made of a material transparent or semitransparent It is preferable that theouter cylinder 11 is made of a material having low oxygen permeability or vapor permeability. It is preferable that the material of theouter cylinder 11 has glass transition point or a melting point not less than 110ยฐC.
ๆณจๅฐๅจ็จ็ๅค็ญ 11 ๅจๅ ถ่ฟ็ซฏ่ฎพๆ้ๅฎ่ฃ ้จ 15๏ผๅจๅ ถ่ฟ็ซฏ่ฎพๆๅธ็ผ 16ใ ๅค็ญ 11 ็ฑ้ๆๆๅ้ๆๆๆๅถๆใ ๅค็ญ 11 ไผ้็ฑ้ๆฐงๆงๆ้ๆนฟๆงไฝ็ๆๆๅถๆใๅค็ญ 11 ็ๆๆไผ้็ป็ๅ่ฝฌๅ็นๆ็็นไธไฝไบ 110ยฐCใ -
[0084] As the material to form theouter cylinder 11, the following resins are preferable: polyolefin such as polypropylene, polyethylene, poly (4-methylpentene-1), and cyclic polyolefin; polyesters such as polyethylene terephthalate, polyethylene naphthalate, and non-crystalline polyarylate; polystyrene; polyamide; polycarbonate, polyvinyl chloride; acrylic resin; acrylonitrile-butadiene-styrene copolymer, and non-crystalline polyetherimide. The polypropylene, the poly (4-methylpentene-1), the cyclic polyolefin, the polyethylene naphthalate, and the non-crystalline polyetherimide are especially preferable because these resins are transparent and resistant to steam sterilization under pressure. These resins can be used as a material to form not only the outer cylinder but also containers capable of accommodating medicines.
ไฝไธบๅค็ญ 11 ็ๆๆๆๆ๏ผไผ้ไปฅไธๆ ่๏ผ่ไธ็ฏใ่ไน็ฏใ่๏ผ4-็ฒๅบๆ็ฏ-1๏ผใ็ฏ็ถ่็ฏ็็ญ่็ฏ็๏ผ่ๅฏน่ฏไบ็ฒ้ ธไนไบ้้ ฏใ่่ไบ็ฒ้ ธไนไบ้้ ฏใ้ๆถๆ่่ณ้ ฏ็ญ่้ ฏ๏ผ่่ฏไน็ฏ๏ผ่้ ฐ่บ๏ผ่็ขณ้ ธ้ ฏใ่ๆฐฏไน็ฏ๏ผไธ็ฏ้ ธๆ ่๏ผไธ็ฏ่ -ไธไบ็ฏ-่ฏไน็ฏๅ ฑ่็ฉใ้ๆถๆ่้้ ฐไบ่บใ่ไธ็ฏใ่๏ผ4-็ฒๅบๆ็ฏ-1๏ผใ็ฏ็ถ่็ฏ็ใ่่ไบ็ฒ้ ธไนไบ้้ ฏใ้ๆถๆ่้้ ฐไบ่บ็ญๆ ่็ฑไบ้ๆๆงๅฅฝไธ่้ซๅ่ธๆฑฝ็ญ่๏ผๅ ๆญคๅฐคไธบไผ้ใ่ฟไบๆ ่ไธไป ๅฏ็จไฝๅค็ญ็ๆๆๆๆ๏ผ่ฟๅฏ็จไฝๅฎน็บณ่ฏ็ฉ็ๅฎนๅจ็ๆๆๆๆใ -
[0085] Thegasket 1, for use in the syringe, having theslidable coating film 3 is used in the embodiment of the present invention. The construction of thegasket 1, for use in the syringe, having theslidable coating film 3 is as described above.
ๆฌๅๆๅฎๆฝไพไธญ๏ผ้็จๅ ทๆๆปๅจๆงๆถ่ 3 ็ๆณจๅฐๅจ็จๅซ็ 1ใๅ ทๆๆปๅจๆงๆถ่ 3 ็ๆณจๅฐๅจ็จๅซ็ 1 ็็ปๆๅฆไธๆ่ฟฐใ -
[0086] As shown inFig. 5 , theplunger 17 has a sectionally cross-shapedmain body 20 extended axially; a plunger-side screwing portion 21, provided at a distal portion thereof, which engages the plunger-mountingportion 4; adisk portion 22, for pressing use, which is disposed at a proximal end of themain body 20; and a rib formed midway on themain body 20.
ๅฆๅพ 5 ๆ็คบ๏ผ ๆฑๅก 17 ๅ ทๆ่ฝดๅๅปถไผธ็ๆช้ขๅๅๅญๅฝข็ไธปไฝ 20๏ผ่ฎพ็ฝฎๅจๅ ถ่ฟ็ซฏ้จ็ๆฑๅกไพง่บ็บน้จ 21๏ผๅ ถไธๆฑๅกๅฎ่ฃ ้จ 4 ๆฅๅ๏ผ่ฎพ็ฝฎๅจไธปไฝ 20 ่ฟ็ซฏ็็จไบๆๅ็็็ถ้จ 22๏ผไปฅๅๅจไธปไฝ 20 ไธญ้จๅฝขๆ็่ๆกใ -
[0087] Themedicine 26 is contained in thesyringe 10 of this embodiment As themedicine 26, it is possible to use a liquid medicine insoluble in water, a liquid medicine having a high adsorbability, a liquid medicine containing a surface active agent and having a low viscosity and a high degree of penetration, and liquid medicines containing an electrolytic substance, vitamins, minerals, and antibiotics. It is also possible to use powdery medicine such as protein preparation, a freeze-drying agent A liquid drug is also used as themedicine 26.
ๆฌๅฎๆฝไพ็ๆณจๅฐๅจ 10 ๅ ่ฃ ๆ่ฏ็ฉ 26ใไฝไธบ่ฏ็ฉ 26๏ผๅฏไปฅไฝฟ็จไธๆบถไบๆฐด็่ฏๆถฒใๅธ้ๆง้ซ็่ฏๆถฒใๅซๆ่กจ้ขๆดปๆงๅ็ไฝ็ฒๅบฆใ้ซๆธ้ๆง็่ฏๆถฒใไปฅๅๅซๆ็ต่งฃ่ดจใ็ปด็็ด ใ็ฟ็ฉ่ดจใๆ็็ด ็ญ็่ฏๆถฒใๆญคๅค๏ผ่ฟๅฏไปฅไฝฟ็จ่็ฝ่ดจๅถๅใๅปๅนฒๅ็ญ็ฒ็ถ่ฏ็ฉไฝไธบ่ฏ็ฉ 26ใ -
[0088] As the material composing theplunger 17 and the sealingmember 18, it is preferable to use hard resin or semi-hard resin such as high-density polyethylene, polypropylene, polystyrene, polyethylene terephthalate, and the like.
ไฝไธบๆๆๆฑๅก 17 ๅๅฏๅฐไปถ 18 ็ๆๆ๏ผไผ้ไฝฟ็จ็กฌ่ดจๆ ่ๆๅ็กฌ่ดจๆ ่๏ผไพๅฆ้ซๅฏๅบฆ่ไน็ฏใ่ไธ็ฏใ่่ฏไน็ฏใ่ๅฏน่ฏไบ็ฒ้ ธไนไบ้้ ฏ็ญใ -
[0089] The above-described syringe is an example of medical appliances which move in contact with the inner surface of a medical member. The medical appliances of any types can be used, provided that they slidably contact the inner surface of the medical member. For example, the medical appliance may be a rubber stopper-provided vial, a transfusion bag, a blood collection tube, a decompression blood collection tube. The medical appliance of the present invention may be an O-ring, a plug, a lid, and the like, provided that these medical appliances slidably contact the medical member. For example, the medical appliance may be a rubber stopper of the vial, the lid of the transfusion bag, and the like.
ไธ่ฟฐๆณจๅฐๅจๆฏไธๅป็้จไปถๅ ่กจ้ขๆฅ่งฆๅนถ็งปๅจ็ๅป็ๅจๆขฐ็ไธไธชไพๅญใไปปไฝ็ฑปๅ็ๅป็ๅจๆขฐๅๅฏไฝฟ็จ๏ผๅช่ฆๅฎไปฌ่ฝๅคๆปๅจๅฐๆฅ่งฆๅป็้จไปถ็ๅ ่กจ้ขๅณๅฏใไพๅฆ๏ผๅป็ๅจๆขฐๅฏไปฅๆฏๅธฆๆฉก่ถๅก็่ฏ็ถใ่พๆถฒ่ขใ้่ก็ฎกใๅๅ้่ก็ฎกใๆฌๅๆ็ๅป็ๅจๆขฐๅฏไปฅๆฏ O ๅฝข็ฏใๅกๅญใ็ๅญ็ญ๏ผๅช่ฆ่ฟไบๅป็ๅจๆขฐ่ฝๅคๆปๅจๅฐๆฅ่งฆๅป็้จไปถๅณๅฏใไพๅฆ๏ผๅป็ๅจๆขฐๅฏไปฅๆฏ่ฏ็ถ็ๆฉก่ถๅกใ่พๆถฒ่ข็็ๅญ็ญใ -
[0090] The medical appliance of the present invention may move in contact with the inner surface of a body lumen. The medical appliance which moves in contact with the inner surface of the body lumen includes a catheter, a guide wire, a vasodilating device, and the like. The medical appliance of the present invention may move in contact with the inner surface of the medical member and that of the lumen. The medical appliance which moves in contact with the inner surface of the lumen includes the catheter which is inserted into another catheter (for example, guiding catheter), the guide wire, the vasodilating device, and the like, the distal ends of which are guided to a desired portion of the lumen.
ๆฌๅๆ็ๅป็ๅจๆขฐๅฏไปฅไธไฝ่ ๅ ่กจ้ขๆฅ่งฆๅนถ็งปๅจใไธไฝ่ ๅ ่กจ้ขๆฅ่งฆๅนถ็งปๅจ็ๅป็ๅจๆขฐๅ ๆฌๅฏผ็ฎกใๅฏผไธใ่ก็ฎกๆฉๅผ ่ฃ ็ฝฎ็ญใๆฌๅๆ็ๅป็ๅจๆขฐๅฏไปฅไธๅป็ๆไปถ็ๅ ่กจ้ขๅไฝ่ ๅ ่กจ้ขๆฅ่งฆๅนถ็งปๅจใไธไฝ่ ๅ ่กจ้ขๆฅ่งฆๅนถ็งปๅจ็ๅป็ๅจๆขฐๅ ๆฌๆๅ ฅๅ ถไปๅฏผ็ฎก๏ผไพๅฆๅฏผๅผๅฏผ็ฎก๏ผ็ๅฏผ็ฎกใๅฏผไธใ่ก็ฎกๆฉๅผ ่ฃ ็ฝฎ็ญ๏ผๅ ถ่ฟ็ซฏ่ขซๅผๅฏผ่ณไฝ่ ็ๆ้้จไฝใ -
[0091] An embodiment in which the medical appliance of the present invention is applied to the guide wire is described below with reference toFig. 6 .
ไธ้ข๏ผๅ็ งๅพ6ๅฏนๅฐๆฌๅๆ็ๅป็ๅจๆขฐๅบ็จไบๅฏผไธ็ๅฎๆฝๆนๅผ่ฟ่ก่ฏดๆใ -
[0092] Fig. 6 is a sectional view an embodiment of the guide wire of the present invention.
ๅพ6ๆฏๆฌๅๆ็ๅฏผไธ็ไธไธชๅฎๆฝไพ็ๅ้ขๅพใ -
[0093] Aguide wire 50 of this embodiment has aninner core 52 and aslidable coating film 53 covering theinner core 52. Theslidable coating film 53 is comprised of the silicone rubber, the carbon nanotube, and the fine particle of the silicone resin. In this embodiment, theslidable coating film 53 is composed of silicone rubber, and contains carbon nanotubes and fine particles of silicone resin.
ๆฌๅฎๆฝไพ็ๅฏผไธ 50 ๅ ทๆๅ ่ฏ 52 ๅๅ ่ฆๅ ่ฏ 52 ็ๆปๅจๆถ่ 53ใ ๆปๅจๆถ่ 53 ็ฑ็ก ๆฉก่ถใ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่ๅพฎ็ฒๆๆใๅจๆฌๅฎๆฝไพไธญ๏ผ ๆปๅจๆถ่ 53 ็ฑ็ก ๆฉก่ถๆๆ๏ผๅนถๅ ๅซ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่ๅพฎ็ฒใ -
[0094] The guide wire of the embodiment shown inFig. 6 has theinner core 52 including amain body 52a having a higher rigidity and a distal portion 52b, formed integrally with themain body 52a, which has a smaller diameter than themain body 52a and a lower rigidity; a high X-ray opaque portion 54 disposed at a distal end of theinner core 52; and aslidable coating film 53 coating the entireinner core 52 having the high X-ray opaque portion 54 provided at the distal end thereof. Because theslidable coating film 53 contains fine particles, theslidable coating film 53 has a rough surface as shown inFig. 10 .
ๅพ 6 ๆ็คบๅฎๆฝไพ็ๅฏผไธๅ ทๆๅ ่ฏ 52๏ผๅ ่ฏ 52 ๅ ๆฌๅๆง่พ้ซ็ไธปไฝ 52a ๅไธไธปไฝ 52a ไธไฝๆๅ็่ฟ็ซฏ้จ 52b๏ผ่ฟ็ซฏ้จ 52b ็็ดๅพๅฐไบไธปไฝ 52a๏ผไธๅๆง่พไฝ๏ผ ๅ ่ฏ 52 ็่ฟ็ซฏ่ฎพ็ฝฎๆ้ซ X ๅฐ็บฟไธ้ๅฐ้จ 54๏ผไปฅๅ่ฆ็ๆดไธชๅ ่ฏ 52 ็ๅฏๆปๅจๆถๅฑ 53๏ผๅ ถไธญ้ซ X ๅฐ็บฟไธ้ๅฐ้จ 54 ่ฎพ็ฝฎๅจๅ ่ฏ 52 ็่ฟ็ซฏใ็ฑไบๅฏๆปๅจๆถๅฑ 53 ไธญๅซๆ็ปๅฐ้ข็ฒ๏ผๅ ๆญคๅ ถ่กจ้ขๅฆๅพ 10 ๆ็คบ่พไธบ็ฒ็ณใ -
[0095] Theinner core 52 of theguide wire 50 has themain body 52a and the distal portion 52b both made of an elastic material and integrally with each other. The diameter of the distal portion 52b is set smaller than that of the distal end of themain body 52a. Therefore the distal portion 52b has a lower rigidity than themain body 52a. The distal portion 52b may be so formed that the diameter thereof becomes gradually smaller from the distal end of themain body 52a. Thereby when a force is applied to the distal end of the distal portion 52b, the distal portion 52b is gradually bent, which allows the operability of the guide wire to be improved.
ๅฏผไธ 50 ็ๅ ่ฏ 52 ็ฑไธปไฝ 52a ๅ่ฟ็ซฏ 52b ็ปๆ๏ผไธค่ ๅ็ฑๅผนๆงๆๆๅถๆ๏ผๅนถไธไฝๆๅใ่ฟ็ซฏ 52b ็็ดๅพๅฐไบไธปไฝ 52a ่ฟ็ซฏ็็ดๅพใๅ ๆญค๏ผ่ฟ็ซฏ 52b ็ๅๅบฆไฝไบไธปไฝ 52aใ่ฟ็ซฏ 52b ็็ดๅพๅฏไปฅ่ฎพ่ฎกๆไปไธปไฝ 52a ่ฟ็ซฏๅผๅง้ๆธๅๅฐใ่ฟๆ ท๏ผๅฝๅฏน่ฟ็ซฏ 52b ็่ฟ็ซฏๆฝๅ ๅๆถ๏ผ่ฟ็ซฏ 52b ไผ้ๆธๅผฏๆฒ๏ผไป่ๆ้ซๅฏผไธ็ๆไฝๆงใ -
[0096] It is preferable that theinner core 52 is made of super-elastic metals or stainless steel. As the super-elastic metals, it is preferable to use a Ti-Ni alloy of 49 - 58 atomic percent of Ni, a Cu-Zn alloy of 38.5 - 41.5 wt% of Zn, a Cu-Zn-X alloy of 1 - 10 wt% of X (X = Be, Si, Sn, Al, Ga), and a Ni-Al alloy of 36 - 38 atomic percent of Al. The Ti-Ni alloy is especially favorable.
ๅ ่ฏ 52 ไผ้็ฑ่ถ ๅผนๆง้ๅฑๆไธ้้ขๅถๆใไฝไธบ่ถ ๅผนๆง้ๅฑ๏ผไผ้ไฝฟ็จ Ni ๅซ้ไธบ 49 - 58 ๅๅญ็พๅๆฏ็ Ti-Ni ๅ้ใZn ๅซ้ไธบ 38.5 - 41.5 ้้็พๅๆฏ็ Cu-Zn ๅ้ใX ๅซ้ไธบ 1 - 10 ้้็พๅๆฏ็ Cu-Zn-X ๅ้๏ผX = BeใSiใSnใAlใGa๏ผไปฅๅ Al ๅซ้ไธบ 36 - 38 ๅๅญ็พๅๆฏ็ Ni-Al ๅ้ใTi-Ni ๅ้ๅฐคไธบ็ๆณใ -
[0097] The outer diameter of themain body 52a of theinner core 52 is set favorably to the range of 0.10 to 1.00mm and more favorably to 0.15 to 0.40mm. The length of themain body 52a thereof is set favorably to the range of 1000 to 4000mm and more favorably to the range of 1500 to 3000mm. The buckling strength (yield stress at load-applied time) of themain body 52a thereof is set favorably to the range of 30 to 100 Kg/mm2 (22 degree C) and more favorably to the range of 40 to 55 Kg/mm2. The restoring stress (yield stress at load-removed time) of themain body 52a thereof is set favorably to the range of 20 to 80 Kg/mm2 (22 degree C) and more favorably to the range of 30 to 35 Kg/mm2.
ๅ ่ฏ 52 ็ไธปไฝ 52a ็ๅคๅพไผ้่ฎพๅฎไธบ 0.10 ่ณ 1.00mm๏ผๆดไผ้่ฎพๅฎไธบ 0.15 ่ณ 0.40mmใ ไธปไฝ 52a ็้ฟๅบฆไผ้่ฎพๅฎไธบ 1000 ่ณ 4000mm๏ผๆดไผ้่ฎพๅฎไธบ 1500 ่ณ 3000mmใ ไธปไฝ 52a ็ๆๅผฏๅผบๅบฆ๏ผๆฝๅ ่ฝฝ่ทๆถ็ๅฑๆๅบๅ๏ผไผ้่ฎพๅฎไธบ 30 ่ณ 100Kg/ mmยฒ ๏ผ22โ๏ผ็่ๅด๏ผๆดไผ้่ฎพๅฎไธบ 40 ่ณ 55Kg/ mmยฒ ็่ๅดใๅ ถไธปไฝ 52a ็ๆขๅคๅบๅ(ๅธ่ฝฝๆถ็ๅฑๆๅบๅ)ไผ้่ฎพๅฎไธบ 20๏ฝ80Kg/mm 2 (22โ)็่ๅด๏ผๆดไผ้่ฎพๅฎไธบ 30๏ฝ35Kg/mm 2 ็่ๅดใ -
[0098] The outer diameter of the distal portion 52b of theinner core 52 is set favorably to the range of 0.03 to 0.15mm and more favorably to the range of 0.05 to 0.10mm. The length of the distal portion 52b thereof is set favorably to the range of 10 to 300mm and more favorably to the range of 50 to 150mm. The bending load of the distal portion 52b thereof is set favorably to the range of 0.1 to 10g and more favorably to the range of 0.3 to 6.0g. The restoring stress of the distal portion 52b thereof is set favorably to the range of 0.1 to 10g and more favorably to the range of 0.3 to 6.0g.
ๅ ่ฏ 52 ็่ฟ็ซฏ้จ 52b ็ๅคๅพไผ้่ฎพๅฎๅจ 0.03 ่ณ 0.15mm ็่ๅดๅ ๏ผๆดไผ้่ฎพๅฎๅจ 0.05 ่ณ 0.10mm ็่ๅดๅ ใๅ ถ่ฟ็ซฏ้จ 52b ็้ฟๅบฆไผ้่ฎพๅฎๅจ 10 ่ณ 300mm ็่ๅดๅ ๏ผๆดไผ้่ฎพๅฎๅจ 50 ่ณ 150mm ็่ๅดๅ ใๅ ถ่ฟ็ซฏ้จ 52b ็ๅผฏๆฒ่ฝฝ่ทไผ้่ฎพๅฎๅจ 0.1 ่ณ 10g ็่ๅดๅ ๏ผๆดไผ้่ฎพๅฎๅจ 0.3 ่ณ 6.0g ็่ๅดๅ ใๅ ถ่ฟ็ซฏ้จ 52b ็ๆขๅคๅบๅไผ้่ฎพๅฎๅจ 0.1 ่ณ 10g ็่ๅดๅ ๏ผๆดไผ้่ฎพๅฎๅจ 0.3 ่ณ 6.0g ็่ๅดๅ ใ -
[0099] The above-described outer diameter of the distal portion of the inner core does not necessarily have to be entirely set to the above-described range, but may be partly set to the above-described range. The restoring stress of the main body of the inner core and that of the distal portion thereof do not necessarily have to be set to an equal value, but it is preferable to devise a method of allowing the main body of the inner core and the distal portion thereof to obtain a suitable property at a proper diameter by changing the restoring stress thereof in various thermal treatment conditions. That is, it is preferable to separately thermally treat the main body of the inner core and the distal portion thereof in such a way that the main body thereof has a larger restoring stress and that the distal portion thereof is flexible. The inner core does not necessarily have to be made of one wire, but the inner core may be composed of a plurality of parallel or twisted wires so that the above-described function of the inner core, namely, the property thereof changes stepwise or successively.
ไธ่ฟฐๅ ่ฏ่ฟ็ซฏ้จๅ็ๅคๅพไธๅฟ ๅฎๅ จ่ฎพๅฎๅจไธ่ฟฐ่ๅดๅ ๏ผไนๅฏไปฅ้จๅ่ฎพๅฎๅจไธ่ฟฐ่ๅดๅ ใๅ ่ฏไธปไฝ็ๆขๅคๅบๅๅ่ฟ็ซฏ้จๅ็ๆขๅคๅบๅไธๅฟ ่ฎพๅฎไธบ็ธ็ญๅผ๏ผไฝไผ้่ฎพ่ฎกไธ็งๆนๆณ๏ผ้่ฟๅจไธๅ็็ญๅค็ๆกไปถไธๆนๅๅ ่ฏไธปไฝๅๅ ถ่ฟ็ซฏ้จๅ็ๆขๅคๅบๅ๏ผไฝฟๅ ่ฏไธปไฝๅๅ ถ่ฟ็ซฏ้จๅๅจๅ้็็ดๅพไธ่ทๅพๅ้็ๆง่ฝใไนๅฐฑๆฏ่ฏด๏ผไผ้ๅๅซๅฏนๅ ่ฏไธปไฝๅๅ ถ่ฟ็ซฏ้จๅ่ฟ่ก็ญๅค็๏ผไฝฟๅพไธปไฝ้จๅๅ ทๆ่พๅคง็ๆขๅคๅบๅ๏ผ่่ฟ็ซฏ้จๅๅ ทๆๆ้งๆงใๅ ่ฏไธๅฟ ็ฑไธๆ น้ๅฑไธๅถๆ๏ผไนๅฏไปฅ็ฑๅคๆ นๅนณ่กๆ็ปๅ็้ๅฑไธ็ปๆ๏ผไป่ไฝฟๅ ่ฏ็ไธ่ฟฐๅ่ฝ๏ผๅณๅ ถๆง่ฝ๏ผ้ๆญฅๆ่ฟ็ปญๅฐๅๅใ -
[0100] In the embodiment shown inFig. 6 , the high X-ray opaque portion 54 fixed to the distal end of theinner core 52 is made of the annular metal member having high radiographic visualization. More specifically, the high X-ray opaque portion 54 is formed of a pipe-shaped metal member. As metals having the high radiographic visualization, gold, platinum, lead, silver, bismuth, and tungsten are favorable. Gold is especially favorable.
ๅจๅพ 6 ๆ็คบ็ๅฎๆฝไพไธญ๏ผๅบๅฎๅจๅ ่ฏ 52 ่ฟ็ซฏ็้ซ X ๅฐ็บฟไธ้ๆง้จๅ 54 ็ฑๅ ทๆ้ซ X ๅฐ็บฟๆพๅฝฑๆง็็ฏๅฝข้ๅฑๆไปถๅถๆใๆดๅ ทไฝๅฐ่ฏด๏ผ้ซ X ๅฐ็บฟไธ้ๆง้จๅ 54 ็ฑ็ฎก็ถ้ๅฑๆไปถๅถๆใไฝไธบๅ ทๆ้ซ X ๅฐ็บฟๆพๅฝฑๆง็้ๅฑ๏ผไผ้้ใ้ใ้ ใ้ถใ้ๅ้จใๅฐคๅ ถไผ้้ใ -
[0101] The high X-ray opaque portion 54 is fixed to the distal end of theinner core 52 by means of mechanical crimping, plating or soldered to an evaporated metal.
้ซ X ๅฐ็บฟไธ้ๆๅบฆ้จๅ 54 ้่ฟๆบๆขฐๅๆฅใ็ต้ๆ็ๆฅๅฐ่ธๅ้ๅฑ็ๆนๅผๅบๅฎๅฐๅ ๆ ธ 52 ็่ฟ็ซฏใ -
[0102] The outer diameter of the high X-ray opaque portion 54 is set favorably to the range of 0.20 to 0.90mm and more favorably to the range of 0.25 to 0.40mm. The inner diameter of the high X-ray opaque portion 54 is set favorably to the range of 0.04 to 0.16mm and more favorably to the range of 0.06 to 0.11mm. The length of the high X-ray opaque portion 54 is set favorably to the range of 1.00 to 10.00mm and more favorably to the range of 1.5 to 4.0mm.
้ซ X ๅฐ็บฟไธ้ๆๅบฆ้จๅ 54 ็ๅคๅพไผ้่ฎพๅฎๅจ 0.20 ่ณ 0.90 ๆฏซ็ฑณ็่ๅดๅ ๏ผๆดไผ้่ฎพๅฎๅจ 0.25 ่ณ 0.40 ๆฏซ็ฑณ็่ๅดๅ ใ้ซ X ๅฐ็บฟไธ้ๆๅบฆ้จๅ 54 ็ๅ ๅพไผ้่ฎพๅฎๅจ 0.04 ่ณ 0.16 ๆฏซ็ฑณ็่ๅดๅ ๏ผๆดไผ้่ฎพๅฎๅจ 0.06 ่ณ 0.11 ๆฏซ็ฑณ็่ๅดๅ ใ้ซ X ๅฐ็บฟไธ้ๆๅบฆ้จๅ 54 ็้ฟๅบฆไผ้่ฎพๅฎๅจ 1.00 ่ณ 10.00 ๆฏซ็ฑณ็่ๅดๅ ๏ผๆดไผ้่ฎพๅฎๅจ 1.5 ่ณ 4.0 ๆฏซ็ฑณ็่ๅดๅ ใ -
[0103] The high X-ray opaque portion 54 may be composed of a coiled narrow wire made of the above-described metal having a high radiographic visualization. The narrow wire having a diameter of 0.02 to 0.10mm can be preferably used. The length of the high X-ray opaque portion 54 wound around theinner core 52 in the range from the distal end thereof is set to the range of 1.0 to 10.0mm and favorably to the range of 1.5 to 4.0mm.
้ซ X ๅฐ็บฟไธ้ๆง้จๅ 54 ๅฏ็ฑไธ่ฟฐๅ ทๆ้ซ X ๅฐ็บฟๆพๅฝฑๆง็้ๅฑๅถๆ็่บๆ็ถ็ปไธๆๆใไผ้ไฝฟ็จ็ดๅพไธบ 0.02 ่ณ 0.10 ๆฏซ็ฑณ็็ปไธใ้ซ X ๅฐ็บฟไธ้ๆง้จๅ 54 ไปๅ ถ่ฟ็ซฏ่ตท็ผ ็ปๅจๅ ่ฏ 52 ไธ็้ฟๅบฆ่ฎพๅฎไธบ 1.0 ่ณ 10.0 ๆฏซ็ฑณ๏ผไผ้่ฎพๅฎไธบ 1.5 ่ณ 4.0 ๆฏซ็ฑณใ -
[0104] It is preferable that as shown inFig. 6 , theslidable coating film 53 coating the entireinner core 52 has an almost uniform outer diameter, including the distal portion thereof. The outer diameter of theslidable coating film 53 is set almost uniformly over the whole length thereof by adjusting the thickness thereof in such a way that a stepped portion of the high X-ray opaque portion 54 formed at the distal end of theinner core 52 does not adversely affect the outer configuration of theguide wire 50.
ๅฆๅพ 6 ๆ็คบ๏ผ่ฆ็ๆดไธชๅ ่ฏ 52 ็ๆปๅจๆถๅฑ 53๏ผๅ ๆฌๅ ถ่ฟ็ซฏ้จๅ๏ผไผ้ๅ ทๆๅ ไนๅๅ็ๅคๅพใ ๆปๅจๆถๅฑ 53 ็ๅคๅพ้่ฟ่ฐ่ๅ ถๅๅบฆ๏ผไฝฟๅ ถๅจๆดไธช้ฟๅบฆไธๅ ไนๅๅๅฐ่ฎพ็ฝฎ๏ผไฝฟๅพๅจๅ ่ฏ 52 ่ฟ็ซฏๅฝขๆ็้ซ X ๅฐ็บฟไธ้ๅฐ้จๅ 54 ็ๅฐ้ถ้จๅไธไผๅฏนๅฏผไธ 50 ็ๅคๅฝขไบง็ไธๅฉๅฝฑๅใ -
[0105] As theslidable coating film 53, it is possible to preferably use the same slidable coating film as theslidable coating film 3 formed on the above-described gasket
ไฝไธบๆปๅจๆถ่ 53๏ผไผ้ไฝฟ็จไธไธ่ฟฐๅซ็ไธๅฝขๆ็ๆปๅจๆถ่ 3 ็ธๅ็ๆปๅจๆถ่ใ -
[0106] The outer diameter of theslidable coating film 53 is set to the range of 0.25 to 1.04mm and favorably to the range of 0.30 to 0.64mm. The thickness of theinner core 52 disposed around themain body 52a is set to the range of 0.25 to 1.04mm and favorably to the range of 0.30 to 0.64mm.
ๆปๅจๆถ่ 53 ็ๅคๅพ่ฎพๅฎไธบ 0.25๏ฝ1.04mm ็่ๅด๏ผไผ้ไธบ 0.30๏ฝ0.64mm ็่ๅดใ้ ็ฝฎๅจไธปไฝ 52a ๅจๅด็ๅ ่ฏ 52 ็ๅๅบฆ่ฎพๅฎไธบ 0.25๏ฝ1.04mm ็่ๅด๏ผไผ้ไธบ 0.30๏ฝ0.64mm ็่ๅดใ -
[0107] It is preferable that the distal end of the guide wire 50 (distal end of slidable coating film 53) is curved, namely, hemispherical as shown inFig. 6 to prevent walls of blood vessels from being damaged and improve the operability of theguide wire 50.
ๅฏผไธ 50 ็่ฟ็ซฏ๏ผๅฏๆปๅจๆถ่ 53 ็่ฟ็ซฏ๏ผไผ้ไธบๅผฏๆฒ็๏ผๅณๅฆๅพ 6 ๆ็คบ็ๅ็ๅฝข๏ผไปฅ้ฒๆญข่ก็ฎกๅฃๅๆๅนถๆ้ซๅฏผไธ 50 ็ๅฏๆไฝๆงใ -
[0108] In theguide wire 50 of this embodiment, the entireinner core 52 is covered with theslidable coating film 53. But the mode of theguide wire 50 is not limited to this mode. A part of theinner core 52 may be covered with theslidable coating film 53. For example, only the distal portion or only the main body of theinner core 52 may be covered with theslidable coating film 53.
ๅจๆฌๅฎๆฝไพ็ๅฏผไธ 50 ไธญ๏ผๆดไธชๅ ่ฏ 52 ๅ่ขซๅฏๆปๅจ็ๆถๅฑ 53 ่ฆ็ใไฝๅฏผไธ 50 ็ๅฝขๆไธ้ไบๆญคใ ๅ ่ฏ 52 ็ไธ้จๅไนๅฏไปฅ่ขซๅฏๆปๅจ็ๆถๅฑ 53 ่ฆ็ใไพๅฆ๏ผไนๅฏไปฅไป ๅ ่ฏ 52 ็่ฟ็ซฏ้จๅๆไธปไฝ้จๅ่ขซๅฏๆปๅจ็ๆถๅฑ 53 ่ฆ็ใ -
[0109] The examples of the present invention are described below.
ไธ้ขๅฏนๆฌๅๆ็ๅฎๆฝไพ่ฟ่ก่ฏดๆใ -
[0110] A surface active agent (nonionic surface active agent, commercial name: "Reodoll AO-15V" produced by Kao Co., Ltd.) was added to a solvent (toluene). After the carbon nanotubes were added to the solvent, the solution was stirred to prepare a liquid in which the carbon nanotubes were preferably dispersed. The solvent-based silicone rubber (commercial name: "YSR 3022" containing 30 wt% of silicone rubber component such as polyalkylsiloxane or the like produced by GE Toshiba Silicone Co., Ltd.) was added to the liquid in which the carbon nanotubes had been dispersed. Thereafter a filler (fine particle of silicone resin, powder of mica, powdery resin of polyolefin family), an adhesion-improving agent (commercial name "XC9603", containing silane coupling agent, which was produced by GE Toshiba Silicone Co., Ltd.), a catalyst (commercial name "YC6831", containing dialkyl tin compounds, which was produced by GE Toshiba Silicone Co., Ltd.) were added to the liquid. Thereby the (slidable) composition of each of the examples of the present invention and the comparison examples was prepared.
ๅฐ่กจ้ขๆดปๆงๅ๏ผ้็ฆปๅญ่กจ้ขๆดปๆงๅ๏ผๅๅๅ๏ผโReodoll AO-15Vโ๏ผ่ฑ็ๆ ชๅผไผ็คพ็ไบง๏ผๅ ๅ ฅๆบถๅ๏ผ็ฒ่ฏ๏ผไธญใๅฐ็ขณ็บณ็ฑณ็ฎกๅ ๅ ฅๆบถๅๅ๏ผๆ ๆๆบถๆถฒ๏ผไฝฟๅ ถ่พพๅฐ็ขณ็บณ็ฑณ็ฎก่ฏๅฅฝๅๆฃ็ๆบถๆถฒ็ถๆใๅฐๆบถๅๅ็ก ๆฉก่ถ๏ผๅๅๅ๏ผโYSR 3022โ๏ผๅซๆ 30 wt%็็ก ๆฉก่ถๆๅ๏ผไพๅฆ่็ทๅบ็ก ๆฐง็ท็ญ๏ผGE ไธ่ๆๆบ็ก ๆ ชๅผไผ็คพ็ไบง๏ผๅ ๅ ฅๅฐ็ขณ็บณ็ฑณ็ฎกๅๆฃ็ๆบถๆถฒไธญใ้ๅ๏ผๅฐๅกซๆ๏ผ็ก ๆ ่ๅพฎ็ฒใไบๆฏ็ฒใ่็ฏ็็ฑป็ฒๆซๆ ่๏ผใ้็ๅๆนๅๅ๏ผๅๅๅโXC9603โ๏ผๅซ็ก ็ทๅถ่ๅ๏ผGE ไธ่ๆๆบ็ก ๆ ชๅผไผ็คพ็ไบง๏ผๅๅฌๅๅ๏ผๅๅๅโYC6831โ๏ผๅซไบ็ทๅบ้กๅๅ็ฉ๏ผGE ไธ่ๆๆบ็ก ๆ ชๅผไผ็คพ็ไบง๏ผๅ ๅ ฅๅฐไธ่ฟฐๆถฒไฝไธญ๏ผๅถๅคๅบๆฌๅๆๅฎๆฝไพๅๆฏ่พไพ็๏ผๅฏๆปๅจ๏ผ็ปๅ็ฉใ -
[0111] As the fine particle of the silicone resin, "Tospearl 145" ((commercial name) produced by GE Toshiba Silicone Co., Ltd.) was used. The "Tospearl 145" consisted of polymethyl silsesquioxane having an average diameter of 4.5ยตm and true specific gravity of 1.32 (25ยฐC). As the powdery mica, the unswelling-type mica (commercial name: "PDM-5B" consisting of fluorine phlogopite produced by Topy Kogyo Co., Ltd., average diameter: 6ยตm) was used. As the powdery resin of the polyolefin family, powder of polyethylene (spherical, average diameter 5ยตm) was used.
็ก ๆ ่ๅพฎ็ฒไฝฟ็จไบโTospearl 145โ๏ผๅๅๅ๏ผGE ไธ่ๆๆบ็ก ๆ ชๅผไผ็คพ็ไบง๏ผใโTospearl 145โ็ฑ่็ฒๅบๅๅ็ก ๆฐง็ทๆๆ๏ผๅนณๅ็ฒๅพ 4.5ฮผm๏ผ็ๆฏ้ 1.32๏ผ25โ๏ผใไบๆฏ็ฒไฝฟ็จไบ้่จ่ๅไบๆฏ๏ผๅๅๅโPDM-5Bโ๏ผ็ฑไธ่ๅทฅไธๆ ชๅผไผ็คพ็ไบง๏ผ็ฑๆฐ้ไบๆฏๆๆ๏ผๅนณๅ็ฒๅพ 6ฮผm๏ผใ่็ฏ็็ฑป็ฒๆซๆ ่ไฝฟ็จไบ่ไน็ฏ็ฒๆซ๏ผ็ๅฝข๏ผๅนณๅ็ฒๅพ 5ฮผm๏ผใ -
[0112] In all the examples and the comparison examples, the amount of the toluene was adjusted so that the content of the solvent-based silicone rubber contained in the composition was 10 wt%. The components of the compositions of examples and comparison examples and compounding rates thereof are as shown in table 1a and 1b ofFig. 7 andFig. 8 .
ๆๆๅฎๆฝไพๅๆฏ่พไพไธญ๏ผๅ่ฐๆด็ฒ่ฏ็็จ้๏ผไฝฟ็ปๅ็ฉไธญๆๅซๆบถๅๅ็ก ๆฉก่ถ็ๅซ้ไธบ 10wt๏ผ ใๅฎๆฝไพๅๆฏ่พไพ็็ปๅ็ฉ็็ปๅๅๅ ถ้ ๅๆฏไพๅๅซๅฆๅพ 7 ๅๅพ 8 ็่กจ 1a ๅ 1b ๆ็คบใ -
[0113] The following three kinds of carbon nanotubes were used: Type A (used in only example 15) having an average diameter of about 70nm (aboutฯ 20 to 120nm) and an average length of about 0.1mm; Type B (used in only example 16) having an average diameter of about 350nm (about ฯ 200 to 500nm) and an average length of about 0.1mm; and Type C (used in all of examples and comparison examples other than 15 and 16) having an average diameter of about 150nm (aboutฯ 100 to 200nm) and an average length of about 0.1mm.
ๆ็จ็็ขณ็บณ็ฑณ็ฎกๆไปฅไธไธ็ง๏ผA ๅ๏ผๅช็จไบๅฎๆฝไพ 15๏ผ๏ผๅนณๅ็ดๅพ็บฆไธบ 70nm๏ผ็บฆ ฯ20 ่ณ 120nm๏ผ๏ผๅนณๅ้ฟๅบฆ็บฆไธบ 0.1mm๏ผB ๅ๏ผๅช็จไบๅฎๆฝไพ 16๏ผ๏ผๅนณๅ็ดๅพ็บฆไธบ 350nm๏ผ็บฆ ฯ200 ่ณ 500nm๏ผ๏ผๅนณๅ้ฟๅบฆ็บฆไธบ 0.1mm๏ผC ๅ๏ผ็จไบ้คๅฎๆฝไพ 15 ๅ 16 ไนๅค็ๆๆๅฎๆฝไพๅๆฏ่พไพ๏ผ๏ผๅนณๅ็ดๅพ็บฆไธบ 150nm๏ผ็บฆ ฯ100 ่ณ 200nm๏ผ๏ผๅนณๅ้ฟๅบฆ็บฆไธบ 0.1mmใ -
[0114] The coefficient of dynamic friction of each composition was measured in accordance with the method of JIS K 7125 by using a tribo-gear (Tribo-gear TYPE-14DR manufactured by HEIDON).
ๆ นๆฎ JIS K 7125 ็ๆนๆณ๏ผไฝฟ็จๆฉๆฆ้ฝฟ่ฝฎ(HEIDON ๅถ้ ็ Tribo-gear TYPE-14DR)ๆต้ๆฏ็ง็ปๅ็ฉ็ๅจๆฉๆฆ็ณปๆฐใ -
[0115] More specifically, the composition of each of the examples 1 through 16 and the comparison examples 1 through 13 was sprayed to a substrate consisting of butyl rubber (hardness: A70, Raโ0.4ยตm). The components and compounding rates of each composition are as shown in table 1a and 1b. The prepared sample of each composition was brought into contact with a stainless steel terminal (ฯ 10mm, Raโ 0.4ยตm) for measuring the coefficient of friction of each composition. The coefficient of friction of each sample was measured when the sample was slid 10mm at a speed of 100mm/minute, with a load of 200g being vertically applied to the terminal. After the terminal was slid, the surface state of the coating film was visually checked. The coefficient of dynamic friction of the substrate made of butyl rubber was 1.42, when the coating agent was not applied thereto.
ๅ ทไฝ่่จ๏ผๅฐๅฎๆฝไพ 1 ่ณ 16 ๅๆฏ่พไพ 1 ่ณ 13 ็็ปๅ็ฉๅทๆถๅฐ็ฑไธๅบๆฉก่ถ๏ผ็กฌๅบฆ๏ผA70๏ผRaโ0.4ฮผm๏ผๅถๆ็ๅบๆไธใๅ็ปๅ็ฉ็ๆๅๅ้ ๆฏๅฆ่กจ 1a ๅ 1b ๆ็คบใๅฐๅถๅคๅฅฝ็ๅ็ปๅ็ฉ็ๆ ทๅไธไธ้้ข็ซฏๅญ๏ผ ฯ10mm ๏ผRaโ0.4ฮผm๏ผๆฅ่งฆ๏ผๆต้ๅ็ปๅ็ฉ็ๆฉๆฆ็ณปๆฐใไปฅ 100mm/ๅ้็้ๅบฆๅฐๆ ทๅๆปๅจ 10mm๏ผๅนถๅจ็ซฏๅญไธๅ็ดๆฝๅ 200g ็่ด่ฝฝ๏ผๆต้ๅๆ ทๅ็ๆฉๆฆ็ณปๆฐใๆปๅจ็ซฏๅญๅ๏ผ็ฎ่งๆฃๆฅๆถ่็่กจ้ข็ถๆใๆชๆถ่ฆๆถๅฑๅๆถ๏ผไธๅบๆฉก่ถๅบๆ็ๅจๆฉๆฆ็ณปๆฐไธบ 1.42ใ -
[0116] Fig. 9 shows the image of the coating film, made of the composition of the example 1, which was formed on the substrate of the butyl rubber. The image was obtained by using an electron microscope.
ๅพ9ไธบๅฎๆฝไพ1็็ปๅ็ฉๅจไธๅบๆฉก่ถๅบๆไธๅฝขๆ็ๆถ่็ๅพๅ๏ผ่ฏฅๅพๅๆฏ้่ฟ็ตๅญๆพๅพฎ้่ทๅพ็ใ -
[0117] From the comparison between the composition of the examples 1, 7 through 14 and that of the comparison example 7; between the composition of the example 2 and that of the comparison example 8; between the composition of the example 3 and that of the comparison example 9; between the composition of the example 4 and that of the comparison example 10; between the composition of the example 5 and that of the comparison example 12; and between the composition of the example 6 and that of the comparison example 13, it was confirmed that the coefficient of dynamic friction decreased owing to the addition of the carbon nanotube to the rubber component (solvent-based silicone rubber). It could be also confirmed that the slidableness-improving effect can be favorably obtained when the mixing amount of the carbon nanotube for 100 parts by weight of the solvent-based silicone rubber is in the range of 0.01 to 2 parts by weight It could be confirmed from the results of the composition of the examples 1 through 6 that the compositions show a low coefficient of dynamic friction owing to the addition of the carbon nanotube to the rubber component, even though the compositions of the powder of the silicone resin, polyethylene, and mica changed to some extent
้่ฟๆฏ่พๅฎๆฝไพ1ใ7่ณ14็็ปๅ็ฉไธๆฏ่พไพ7็็ปๅ็ฉใๅฎๆฝไพ2็็ปๅ็ฉไธๆฏ่พไพ8็็ปๅ็ฉใๅฎๆฝไพ3็็ปๅ็ฉไธๆฏ่พไพ9็็ปๅ็ฉใๅฎๆฝไพ4็็ปๅ็ฉไธๆฏ่พไพ10็็ปๅ็ฉใๅฎๆฝไพ5็็ปๅ็ฉไธๆฏ่พไพ12็็ปๅ็ฉใๅฎๆฝไพ6็็ปๅ็ฉไธๆฏ่พไพ13็็ปๅ็ฉ๏ผๅฏไปฅ็กฎ่ฎค๏ผ็ฑไบๅจๆฉก่ถ็ปๅ๏ผๆบถๅๅ็ก ๆฉก่ถ๏ผไธญๆทปๅ ไบ็ขณ็บณ็ฑณ็ฎก๏ผๅ ๆญคๅจๆฉๆฆ็ณปๆฐ้ไฝไบใ่ฟๅฏไปฅ่ฏๅฎ๏ผๅฝ็ขณ็บณ็ฑณ็ฎก็ๆททๅ้ไธบ100้้ไปฝๆบถๅๅ็ก ๆฉก่ถ็0.01่ณ2้้ไปฝๆถ๏ผๅฏไปฅ่ฏๅฅฝๅฐ่ทๅพๆนๅๆปๅจๆง็ๆๆใไปๅฎๆฝไพ1่ณ6็็ปๅ็ฉ็็ปๆๅฏไปฅ่ฏๅฎ๏ผ็ฑไบๅจๆฉก่ถ็ปๅไธญๆทปๅ ไบ็ขณ็บณ็ฑณ็ฎก๏ผๅณไฝฟ็ก ๆ ่็ฒๆซใ่ไน็ฏๅไบๆฏ็ๆๅๅ็ไธๅฎ็จๅบฆ็ๅๅ๏ผ็ปๅ็ฉไป่กจ็ฐๅบ่พไฝ็ๅจๆๆฉๆฆ็ณปๆฐใ -
[0118] From the comparison between the composition of the example 2 and that of the comparison example 8, it was confirmed that the addition of the carbon nanotube to the rubber component caused the coefficient of dynamic friction to decrease to a higher extent than the extent of the effect which can be brought about by the addition of PTFE to the rubber component
้่ฟๅฎๆฝไพ 2 ๅๆฏ่พไพ 8 ็็ปๅ็ฉ็ๆฏ่พ๏ผๅฏไปฅ็กฎ่ฎค๏ผๅจๆฉก่ถ็ปๅไธญๆทปๅ ็ขณ็บณ็ฑณ็ฎกๅฏไฝฟๅจๆฉๆฆ็ณปๆฐ้ไฝๅฐๆฏๅจๆฉก่ถ็ปๅไธญๆทปๅ PTFE ๆดๆๆ็็จๅบฆใ -
[0119] From the experimental result of the composition of the comparison example 11, it was confirmed that when the amount of the filler added to 100 parts by weight of the solvent-based silicone rubber is not less than 100 parts by weight, peel-off (decrease of wear resistance) of the coating film occurred. From the comparison of the compositions of the example 1, 15, 16, it could be confirmed that the slidableness of the composition could be improved by the addition of the carbon nanotube to the rubber component although the diameters of the carbon nanotubes were different from one another.
ไปๆฏ่พไพ11็็ปๅ็ฉ็ๅฎ้ช็ปๆๅฏ็กฎ่ฎค๏ผๅฝ็ธๅฏนไบ100้้ไปฝๆบถๅๅ็ก ๆฉก่ถ๏ผๅกซๆ็ๆทปๅ ้ไธไฝไบ100้้ไปฝๆถ๏ผไผๅ็ๆถ่ๅฅ็ฆป๏ผ่็ฃจๆงไธ้๏ผใไปๅฎๆฝไพ1ใ15ใ16็็ปๅ็ฉ็ๆฏ่พๅฏ็กฎ่ฎค๏ผๅฐฝ็ฎก็ขณ็บณ็ฑณ็ฎก็็ดๅพๅไธ็ธๅ๏ผไฝ้่ฟๅจๆฉก่ถ็ปๅไธญๆทปๅ ็ขณ็บณ็ฑณ็ฎกๅฏไปฅๆนๅ็ปๅ็ฉ็ๆปๅจๆงใ -
[0120] The core part of a gasket for use in a syringe having the configuration shown inFigs. 1 and 2 was formed by using butyl rubber. The core part was formed by press-molding a vulcanizing rubber composition composed of the butyl rubber and additives added thereto. As the configuration of the obtained core part, it had a length of 20mm, an outer diameter of 23.7mm at distal-side and proximal-side annular ribs, a length of 10mm between the center of the distal-side annular rib and the center of the proximal-side annular rib, an outer diameter of 21.5mm at a same diameter portion of the core part which extend from the distal-side annular rib to the proximal-side annular rib, a length (depth) of 8mm in the plunger-mounting concave portion having a female screw at an inner side thereof, an inner diameter of 14.5mm at the distal side of the plunger-mounting concave portion, and an inner diameter of 15mm at the rear side of the plunger-mounting concave portion.
ๅพ 1ใๅพ 2 ๆ็คบ็ปๆ็ๆณจๅฐๅจ็จๅซๅ็่ฏ้จ้็จไธๅบๆฉก่ถๅถๆใ่ฏฅ่ฏ้จ็ฑไธๅบๆฉก่ถๅๅ ถๆทปๅ ็ๆทปๅ ๅๆๆ็็กซๅๆฉก่ถ็ปๅ็ฉๅๅถๆๅ่ๆใๆ่ทๅพ็ๆ ธๅฟ้จๅ็็ปๆไธบ๏ผ้ฟๅบฆไธบ 20mm๏ผ่ฟ็ซฏไพงๅ่ฟ็ซฏไพง็ฏๅฝข่็ๅคๅพไธบ 23.7mm๏ผ่ฟ็ซฏไพง็ฏๅฝข่็ไธญๅฟไธ่ฟ็ซฏไพง็ฏๅฝข่็ไธญๅฟไน้ด็้ฟๅบฆไธบ 10mm๏ผไป่ฟ็ซฏไพง็ฏๅฝข่ๅปถไผธ่ณ่ฟ็ซฏไพง็ฏๅฝข่็ๆ ธๅฟ้จๅ็็ธๅ็ดๅพ้จๅ็ๅคๅพไธบ 21.5mm๏ผๆฑๅกๅฎ่ฃ ๅน้จ็้ฟๅบฆ๏ผๆทฑๅบฆ๏ผไธบ 8mm๏ผๆฑๅกๅฎ่ฃ ๅน้จ็่ฟ็ซฏไพงๅ ๅพไธบ 14.5mm๏ผๆฑๅกๅฎ่ฃ ๅน้จๅไพงๅ ๅพไธบ 15mmใ -
[0121] At a room temperature and a normal pressure, the composition of the example 1 was sprayed to the core part of the gasket formed as described above. Thereafter the composition was dried at 110ยฐC for 10 minutes. Thereby the gasket for use in the syringe was formed.
ๅจๅฎคๆธฉๅธธๅไธ๏ผๅฐๅฎๆฝไพ1็็ปๅ็ฉๅทๆถๅฐไธ่ฟฐๅฝขๆ็ๅซ็็่ฏ้จใไนๅ๏ผๅจ110โไธๅนฒ็ฅ10ๅ้ใ็ฑๆญค๏ผๅฝขๆๆณจๅฐๅจ็จๅซ็ใ -
[0122] The average thickness of the slidable coating film formed on the core member was about 7ยตm. The ratio of the diameter of the fine particle to the average film thickness of the slidable coating film was about 0.7.
ๅฝขๆไบ่ฏๆไธ็ๆปๅจๆงๆถ่็ๅนณๅๅๅบฆ็บฆไธบ 7ฮผm๏ผๅพฎ็ฒ็ดๅพไธๆปๅจๆงๆถ่ๅนณๅ่ๅไนๆฏ็บฆไธบ 0.7ใ -
[0123] A gasket for use in a syringe of the comparison example 14 was formed in a manner similar to that used in the example 17 except that the composition of the comparison example 7 was used. The average thickness of the slidable coating film formed on the core member was about 7ยตm.
้ค้็จๆฏ่พไพ 7 ็็ปๅ็ฉๅค๏ผๅ ถไปไธๅฎๆฝไพ 17 ๅๆ ทๅฐๅฝขๆๆฏ่พไพ 14 ็ๆณจๅฐๅจ็จๅซๅใๅจ่ฏๆไธๅฝขๆ็ๆปๅจๆงๆถ่็ๅนณๅๅๅบฆ็บฆไธบ 7ฮผmใ -
[0124] A syringe (30ml, silicone oil was applied to syringe manufactured by Terumo Kabushiki Kaisha) in which a gasket made of SEBS thermoplastic elastomer was mounted was used in the comparison example 15.
ๆฏ่พไพ 15 ไธญไฝฟ็จไบๅฎ่ฃ ไบ SEBS ็ญๅกๆงๅผนๆงไฝๅถๅซๅ็ๆณจๅฐๅจ(Terumo Kabushiki Kaisha ๅถ๏ผ30ml๏ผๆถๆ็ก ๆฒน็ๆณจๅฐๅจ)ใ -
[0125] Except that the composition was not applied to the core member, a gasket made of butyl rubber formed in a manner similar to that used in the example 17 was used in the comparison example 16.
้คไบๆชๅฐ็ปๅ็ฉๆถ่ฆๅฐ่ฏไปถไธไนๅค๏ผๅจๅฏนๆฏไพ 16 ไธญไฝฟ็จไบไปฅไธๅฎๆฝไพ 17 ไธญๆไฝฟ็จ็ๆนๅผ็ฑปไผผ็ๆนๅผๅฝขๆ็็ฑไธๅบๆฉก่ถๅถๆ็ๅซๅใ -
[0126] Polypropylene (produced by Nippon Polychem Co., Ltd.) was injection-molded to form outer cylinders, for use in a syringe, which had a configuration shown inFig. 5 . The cylindrical portion of the outer cylinder for use in the syringe had an inner diameter of 23.5mm and a length of 95mm. Polypropylene (produced by Nippon Polychem Co., Ltd.) was injection-molded to form plungers shown inFig. 5 .
ๅฐ่ไธ็ฏ๏ผๆฅๆฌ Polychem ๆ ชๅผไผ็คพๅถ้ ๏ผๆณจๅกๆๅ๏ผๅถๆๅฆๅพ 5 ๆ็คบๅฝข็ถ็ๆณจๅฐๅจๅค็ญใๆณจๅฐๅจๅค็ญ็ๅๆฑ้จๅๅ ๅพไธบ 23.5mm๏ผ้ฟๅบฆไธบ 95mmใๅฐ่ไธ็ฏ๏ผๆฅๆฌ Polychem ๆ ชๅผไผ็คพๅถ้ ๏ผๆณจๅกๆๅ๏ผๅถๆๅฆๅพ 5 ๆ็คบ็ๆฑๅกใ -
[0127] The gaskets of the example 17 and the comparison examples 14 through 16 and the plungers were mounted on the outer cylinders to form some syringes. Silicone oil was applied to the inner surface of the outer cylinder of the comparison example 15. Except the syringe of the comparison example 5, the syringes were sterilized by autoclaving. Thereafter the following evaluations were made.
ๅฐๅฎๆฝไพ17ใๆฏ่พไพ14่ณ16็ๅซๅๅๆจๆๅฎ่ฃ ๅฐๅค็ญไธ๏ผๅถๆๆณจๅฐๅจใๆฏ่พไพ15็ๅค็ญๅ ่กจ้ขๆถๆนไบ็ก ๆฒนใ้คๆฏ่พไพ5็ๆณจๅฐๅจๅค๏ผๅ ถไฝๆณจๅฐๅจๅ้็จ้ซๅ็ญ่ๅจ่ฟ่ก็ญ่ใไนๅ๏ผ่ฟ่กไบไปฅไธ่ฏไผฐใ -
[0128] The sliding resistance value in each syringe was measured by an autograph (AG-IS manufactured by Shimazu Seisakusho Co., Ltd.). More specifically, with the distal end of each syringe and the proximal end of the plunger fixed to a fixing portion of the autograph to which an object to be measured is fixed, the plunger was moved downward 30mm at a speed of 50mm/minute to measure a maximum sliding resistance value (maximum stress [N] required in section of 0 to 30mm) and an average sliding resistance value (average sliding resistance value [N] in section of 25 to 50mm). Table 2 shows the results.Table 2 Example 17 ็คบไพ 17 Comparison Example 14 ๆฏ่พไพ14 Comparison Example 15 ๆฏ่พไพ15 Comparison Example 16 ๆฏ่พไพ16 Maximum sliding resistance value (N)
ๆๅคงๆปๅจ้ปๅๅผ๏ผN๏ผ5.8 11.5 20 93.7 Average sliding resistance value (N)
ๅนณๅๆปๅจ้ปๅๅผ๏ผN๏ผ4.9 10.2 0.7 90.5
ไฝฟ็จ่ชๅจ็ปๅพไปช๏ผๅฒๆดฅๅถไฝๆๆ ชๅผไผ็คพๅถ้ ๏ผAG-IS๏ผๆต้ๅๆณจๅฐๅจ็ๆปๅจ้ปๅๅผใๅ ทไฝ่่จ๏ผๅฐๅๆณจๅฐๅจ็ๅ็ซฏๅๆฑๅก็่ฟ็ซฏๅบๅฎๅจ่ชๅจ็ปๅพไปช็ๅบๅฎ้จไธ๏ผๅนถๅฐๅพ ๆต็ฉๅบๅฎๅจๅบๅฎ้จไธ๏ผไปฅ 50mm/ๅ้็้ๅบฆไฝฟๆฑๅกๅไธ็งปๅจ 30mm๏ผๆต้ๆๅคงๆปๅจ้ปๅๅผ๏ผ0 ่ณ 30mm ๆช้ขๆ้็ๆๅคงๅบๅ[N]๏ผๅๅนณๅๆปๅจ้ปๅๅผ๏ผ25 ่ณ 50mm ๆช้ข็ๅนณๅๆปๅจ้ปๅๅผ[N]๏ผใ็ปๆๅไบ่กจ 2ใ ่กจ 2 -
[0129] As shown in table 2, the syringe using the gasket of the example 17 had smaller maximum and average sliding resistance values than the syringes using the gaskets of the comparison examples. In addition, the syringe of the example 17 had a small difference between the maximum sliding resistance value and the average sliding resistance value. Thus there is little fear that a liquid medicine was discharged from the syringe when an operation of pressing the plunger starts, which allowed the liquid medicine to be discharged safely and easily.
ๅฆ่กจ2ๆ็คบ๏ผไฝฟ็จๅฎๆฝไพ17็ๅซ็็ๆณจๅฐๅจ๏ผๅ ถๆๅคงๆปๅจ้ปๅๅผๅๅนณๅๆปๅจ้ปๅๅผๅๅฐไบไฝฟ็จๆฏ่พไพ็ๅซ็็ๆณจๅฐๅจใๆญคๅค๏ผๅฎๆฝไพ17็ๆณจๅฐๅจ็ๆๅคงๆปๅจ้ปๅๅผไธๅนณๅๆปๅจ้ปๅๅผไนๅทฎ่พๅฐใๅ ๆญค๏ผๅจๅผๅงๆจๅๆฑๅก็ๆไฝๆถ๏ผๅ ไนไธ็จๆ ๅฟ่ฏๆถฒไผไปๆณจๅฐๅจไธญๅทๅบ๏ผไป่ๅฏไปฅๅฎๅ จ่ฝปๆพๅฐๅทๅบ่ฏๆถฒใ -
[0130] As a material to form an outer cylinder for use in a syringe, annular polypropylene (ZEONEX: registered trademark produced by Zeon Corporation) was injection-molded to form the outer cylinder for use in the syringe having a configuration shown inFig. 5 . Except that the outer cylinder for use in the syringe was used, the sliding resistance values of the gaskets for syringes of the example 17 and the comparison examples 14 through 16 were measured in a manner similar to that used in theexperiment 1. Table 3 shows the results.Table 3 Example 17 ็คบไพ 17 Comparison Example 14 ๆฏ่พไพ14 Comparison Example 15 ๆฏ่พไพ15 Comparison Example 16 ๆฏ่พไพ16 Maximum sliding resistance value (N)
ๆๅคงๆปๅจ้ปๅๅผ๏ผN๏ผ3.6 4.8 2.1 23.1 Average sliding resistance value (N)
ๅนณๅๆปๅจ้ปๅๅผ๏ผN๏ผ2.0 3.6 0.6 17.0
ไฝไธบๆณจๅฐๅจๅค็ญ็ๅฝขๆๆๆ๏ผ้็จ็ฏ็ถ่ไธ็ฏ๏ผZEONEX๏ผๆฅๆฌ็็ฟๆ ชๅผไผ็คพ็ไบง็ๆณจๅๅๆ ๏ผๆณจๅกๆๅ๏ผๅฝขๆๅฆๅพ 5 ๆ็คบๅฝข็ถ็ๆณจๅฐๅจๅค็ญใ้คไบไฝฟ็จ่ฏฅๆณจๅฐๅจๅค็ญไนๅค๏ผไธๅฎ้ช 1 ๅๆ ทๅฐๆตๅฎไบๅฎๆฝไพ 17 ๅๆฏ่พไพ 14๏ฝ16 ็ๆณจๅฐๅจ็จๅซๅ็ๆปๅจ้ปๅๅผ๏ผ็ปๆ็คบไบ่กจ 3ใ ่กจ 3 -
[0131] A base material of a guide wire including an inner core made of Ni-Ti having an outer diameter of 0,889 mm (0.035 inches) and a length of 450mm and a polyurethane coating film formed on the surface of the inner core was prepared. After the composition of the example 1 was applied to the entire outer surface of the base material of the guide wire by using a dip coating method at a room temperature and a normal pressure, the composition was dried at 110ยฐC for 10 minutes to obtain a guide wire of the present invention.
ๅถๅคๅฏผไธๅบๆ๏ผๅ ถๅ ๆฌๅคๅพไธบ 0.889 ๆฏซ็ฑณ๏ผ0.035 ่ฑๅฏธ๏ผใ้ฟๅบฆไธบ 450 ๆฏซ็ฑณ็้้ๅ้ๅ ่ฏ๏ผๅนถๅจๅ ่ฏ่กจ้ขๅฝขๆ่ๆฐจ้ ฏๆถ่ใๅจๅฎคๆธฉๅธธๅไธ๏ผ้็จๆตธๆถๆณๅฐๅฎๆฝไพ 1 ็็ปๅ็ฉๆถ่ฆๅฐๅฏผไธๅบๆ็ๆดไธชๅค่กจ้ขไธ๏ผ็ถๅๅจ 110ยฐC ไธๅนฒ็ฅ 10 ๅ้๏ผๅณๅพๅฐๆฌๅๆ็ๅฏผไธใ -
[0132] The average thickness of the slidable coating film formed on the surface of the inner core was about 5ยตm. The ratio of the diameter of the fine particle to the average film thickness of the slidable coating film was 1.Fig. 10 shows the image of the guide wire of this embodiment obtained by using an electron microscope.
ๅ ่ฏ่กจ้ขๅฝขๆ็ๆปๅจๆถ่ๅนณๅๅๅบฆ็บฆไธบ 5ฮผm๏ผๅพฎ็ฒ็ดๅพไธๆปๅจๆถ่ๅนณๅ่ๅไนๆฏไธบ 1ใๅพ 10 ไธบๆฌๅฎๆฝไพๅฏผไธ็็ตๅญๆพๅพฎ้็ ง็ใ -
[0133] A guide wire of the comparison example 17 was formed in a manner similar to that used in the example 18 except that the composition of the comparison example 7 was used. The average thickness of the slidable coating film formed on the core member was about 7ยตm.
ๆฏ่พไพ 17 ็ๅฏผไธ๏ผ้ค้็จๆฏ่พไพ 7 ็็ปๆๅค๏ผๅ ถไฝไธๅฎๆฝไพ 18 ็ธๅ๏ผๅถๆๆฏ่พไพ 17 ็ๅฏผไธใๅจ่ฏๆไธๅฝขๆ็ๆปๅจๆงๆถ่็ๅนณๅๅๅบฆ็บฆไธบ 7ฮผmใ -
[0134] A guide wire of the comparison example 18 was formed in a manner similar to that used in the example 18 except that reactive silicone oil was applied to the core member instead of coating the core member with the composition.
ๆฏ่พไพ 18 ็ๅฏผไธไปฅไธๅฎๆฝไพ 18 ไธญ็ธไผผ็ๆนๅผๅฝขๆ๏ผไธๅไนๅคๅจไบๅฐๅๅบๆง็ก ๆฒนๆฝๅ ๅฐ่ฏๆไปถไธ๏ผ่ไธๆฏ็จ็ปๅ็ฉๆถ่ฆ่ฏๆไปถใ -
[0135] A guide wire (only inner core) of the comparison example 19 was formed in a manner similar to that used in the example 18 except that the composition was not applied to the core member of the guide wire.
ๆฏ่พไพ 19 ็ๅฏผไธ ( ไป ๆๅ ่ฏ ) ไปฅไธๅฎๆฝไพ 18 ไธญๆไฝฟ็จ็ๆนๅผ็ฑปไผผ็ๆนๅผๅฝขๆ๏ผๅชๆฏๆชๅฐ็ปๅ็ฉๆถ่ฆๅฐๅฏผไธ็่ฏๆไปถไธใ -
[0136] The sliding resistance value of each of guide wires of the example 18 and the comparison examples 17 through 19 was measured by the autograph (Autograph AG-IS manufactured by Shimazu Seisakusho Co., Ltd.) by sliding the guide wires on the inner surface of a dilator (made of polypropylene) which is used when the guide wire is inserted into a human body.
ไฝฟ็จ่ชๅจ็ปๅพไปช๏ผๅฒๆดฅๅถไฝๆๅถ้ ็่ชๅจ็ปๅพไปช AG-IS๏ผๆต้ๅฎๆฝไพ 18 ๅๆฏ่พไพ 17 ่ณ 19 ็ๅๅฏผไธ็ๆปๅจ้ปๅๅผ๏ผๆนๆณๆฏๅฐๅฏผไธๅจๆๅ ฅไบบไฝๆถไฝฟ็จ็ๆฉๅผ ๅจ๏ผ่ไธ็ฏๅถๆ๏ผ็ๅ ่กจ้ขไธๆปๅจใ -
[0137] More specifically, the dilator was fixed to a jig (jig for curving the central portion of the body thereof into a circle having a radius of 25mm). After the guide wire was inserted into the dilator, the distal end of the guide wire was fixed to the fixing portion of the autograph to which an object to be measured is fixed. In this state, the guide wire was pulled upward 100mm at a speed of 100mm/minute to measure a maximum sliding resistance value (maximum stress [gf] required in section of 0 to 100mm) and an average sliding resistance value (average sliding resistance value [gf] in section of 5 to 100mm). Table 4 shows the results.Table 4 Example 18 ็คบไพ 18 Comparison Example 17 ๆฏ่พไพ17 Comparison Example 18 ๆฏ่พไพ18 Comparison Example 19 ๆฏ่พไพ19 Maximum sliding resistance value(gf)
ๆๅคงๆปๅจ้ปๅๅผ(gf)5.8 10.2 19.9 50.9 Average sliding resistance value (gf)
ๅนณๅๆปๅจ้ปๅๅผ๏ผgf๏ผ5.0 9.0 17.3 39.4
ๅ ทไฝๆฅ่ฏด๏ผๅฐๆฉๅผ ๅจๅบๅฎๅจๅคนๅ ท๏ผ็จไบๅฐๅ ถไธปไฝไธญๅฟ้จๅๅผฏๆฒๆๅๅพไธบ 25mm ็ๅๅฝข็ๅคนๅ ท๏ผไธใๅฐๅฏผไธๆๅ ฅๆฉๅผ ๅจๅ๏ผๅฐๅฏผไธ่ฟ็ซฏๅบๅฎๅจๅบๅฎๆๅพ ๆต็ฉ็่ชๅจ็ปๅพไปช็ๅบๅฎ้จๅไธใๅจๆญค็ถๆไธ๏ผไปฅ 100mm/ๅ้็้ๅบฆๅฐๅฏผไธๅไธๆๅจ 100mm๏ผๆต้ๆๅคงๆปๅจ้ปๅๅผ๏ผ0 ่ณ 100mm ๆช้ขๆ้็ๆๅคงๅบๅ[gf]๏ผๅๅนณๅๆปๅจ้ปๅๅผ๏ผ5 ่ณ 100mm ๆช้ข็ๅนณๅๆปๅจ้ปๅๅผ[gf]๏ผใ็ปๆๅฆ่กจ 4 ๆ็คบใ ่กจ 4 -
[0138] It was confirmed that the guide wire (guide wire coated with composition of example 1) had slidableness improved over that of the comparison example 17 (guide wire coated with composition of comparison example 7), the comparison example 18 (guide wire having reactive silicone oil applied to inner core thereof), and the comparison example 19 (non-coated guide wire). It was confirmed that the guide wire of the example 18 had improved slidableness owing to the addition of the carbon nanotube to the rubber component
็ป่ฏๅฎ๏ผๆฌๅฏผไธ๏ผๅฎๆฝไพ1็ปๅ็ฉๆถ่ฆ็ๅฏผไธ๏ผ็ๆปๅจๆงไผไบๅฏนๆฏไพ17๏ผๅฏนๆฏไพ7็ปๅ็ฉๆถ่ฆ็ๅฏผไธ๏ผใๅฏนๆฏไพ18๏ผๅ ่ฏๆถ่ฆๅๅบๆง็ก ๆฒน็ๅฏผไธ๏ผๅๅฏนๆฏไพ19๏ผๆ ๆถๅฑๅฏผไธ๏ผใ็ป่ฏๅฎ๏ผๅฎๆฝไพ18็ๅฏผไธ็ฑไบๅจๆฉก่ถ็ปๅไธญๆทปๅ ไบ็ขณ็บณ็ฑณ็ฎก๏ผๆปๅจๆงๆๆๆ้ซใ -
[0139] The medical appliance-coating composition of the present invention contains the solvent-based silicone rubber as its main component and in addition the carbon nanotubes and the fine particles of the silicone resin.
ๆฌๅๆ็ๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉไปฅๆบถๅๅ็ก ๆฉก่ถไธบไธป่ฆๆๅ๏ผ่ฟๅซๆ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่ๅพฎ็ฒใ -
[0140] Therefore the coating film made of the medical appliance-coating composition has a high degree of slidableness and strength and is capable of imparting a sufficiently high degree of slidableness to the medical appliance.
ๅ ๆญค๏ผ็ฑ่ฏฅๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉๅฝขๆ็ๆถ่ๅ ทๆ้ซ็ๆปๅจๆงๅๅผบๅบฆ๏ผ่ฝๅค่ตไบๅป็ๅจๆขฐ่ถณๅค้ซ็ๆปๅจๆงใ -
[0141] The medical appliance of the present invention moves in contact with the inner surface of the medical member or the inner surface of the lumen and has the slidable coating film formed at the portion thereof which contacts the medical member or the lumen. The slidable coating film is composed of the silicone rubber and contains the carbon nanotubes and the fine particles of the silicone resin.
ๆฌๅๆ็ๅป็ๅจๆขฐไธๅป็็จ้จไปถ็ๅ ่กจ้ขๆ็ฎก่ ็ๅ ่กจ้ขๆฅ่งฆ็งปๅจ๏ผๅนถๅจไธๅป็็จ้จไปถๆ็ฎก่ ๆฅ่งฆ็้จๅๅฝขๆๆๆปๅจๆงๆถ่ใ่ฏฅๆปๅจๆงๆถ่็ฑ็ก ๆฉก่ถๆๆ๏ผๅนถๅซๆ็ขณ็บณ็ฑณ็ฎกๅ็ก ๆ ่ๅพฎ็ฒใ -
[0142] Therefore the slidable coating film formed on the medical appliance has a high degree of slidableness and strength. Thus the medical appliance keeps a sufficient degree of slidableness for a long time.
ๅ ๆญค๏ผๅจๅป็ๅจๆขฐไธๅฝขๆ็ๆปๅจๆถ่ๅ ทๆ่พ้ซ็ๆปๅจๆงๅๅผบๅบฆ๏ผไฝฟๅป็ๅจๆขฐ่ฝๅค้ฟๆถ้ดไฟๆ่ถณๅค็ๆปๅจๆงใ
โข ็คบไพ 1 ่ณ 16 ๅๆฏ่พ็คบไพ 1 ่ณ 13
โข ๅฎ้ช 1
โข ๅฎ้ช 2
โข ๅฎ้ช 3
โข ๅฎ้ช 4
Claims (17)
ๆๅฉ่ฆๆฑ ๏ผ17๏ผ
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้่ๅๆๅ
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Claims (17)
ๆๅฉ่ฆๆฑ ๏ผ17๏ผ
ๆๅฉ่ฆๆฑ ๏ผ17๏ผ
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ปไบบ
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- A medical appliance-coating composition for imparting slidableness to said medical appliance which contains a solvent-based silicone rubber, carbon nanotubes, and fine particles of silicone resin, having an average diameter of as to 30 ยตm.
ไธ็ง็จไบ่ตไบๅป็ๅจๆขฐๆปๅจๆง็ๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉ๏ผๅ ถๅ ๅซๆบถๅๅ็ก ๆฉก่ถใ็ขณ็บณ็ฑณ็ฎกๅๅนณๅ็ดๅพไธบ็บฆ 30ฮผm ็็ก ๆ ่็ป้ข็ฒใ - A medical appliance-coating composition according to claim t wherein said solvent-based silicone rubber is silicone resin having polysiloxane as a basic structure thereof; and a content of said silicone resin having said polysiloxane as said basic structure thereof is 10 to 70 wt% in said medical appliance-coating composition.
ๆ นๆฎๆๅฉ่ฆๆฑ 1 ๆ่ฟฐ็ๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉ๏ผๅ ถไธญๆ่ฟฐๆบถๅๅ็ก ๆฉก่ถไธบๅ ทๆ่็ก ๆฐง็ทไฝไธบๅบๆฌ็ปๆ็็ก ๆ ่๏ผๅนถไธๆ่ฟฐๅ ทๆ่็ก ๆฐง็ทไฝไธบๅบๆฌ็ปๆ็็ก ๆ ่ๅจๆ่ฟฐๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉไธญ็ๅซ้ไธบ 10 ่ณ 70wt๏ผ ใ - A medical appliance-coating composition according to claim 1 or 2, wherein said carbon nanotubes have an average diameter set to less than 800nm and an average fiber length set to less than 2mm and are contained at 0.01 to 2 wt% in said medical appliance-coating composition.
ๆ นๆฎๆๅฉ่ฆๆฑ 1 ๆ 2 ๆ่ฟฐ็ๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉ๏ผๅ ถไธญๆ่ฟฐ็ขณ็บณ็ฑณ็ฎก็ๅนณๅ็ดๅพ่ฎพๅฎไธบๅฐไบ 800nm๏ผๅนณๅ็บค็ปด้ฟๅบฆ่ฎพๅฎไธบๅฐไบ 2mm๏ผๅนถไธๅจๆ่ฟฐๅป็ๅจๆขฐๆถๅฑ็ปๅ็ฉไธญ็ๅซ้ไธบ 0.01 ่ณ 2wt๏ผ ใ - A medical appliance-coating composition according to any one of claims 1 through 3, wherein said fine particles of said silicone resin having an average diameter set to 0.5 to 30ยตm are contained at 0.2 to 50 wt% in said medical appliance-coating composition.
ๆ นๆฎๆๅฉ่ฆๆฑ 1 ่ณ 3 ไธญไปปไธ้กน็ๅป็ๅจๆขฐๆถๆ็ปๅ็ฉ๏ผๅ ถไธญๅนณๅ็ดๅพ่ฎพๅฎไธบ 0.5 ่ณ 30ฮผm ็ๆ่ฟฐๆๆบ็ก ๆ ่็ป้ข็ฒๅจๆ่ฟฐๅป็ๅจๆขฐๆถๆ็ปๅ็ฉไธญ็ๅซ้ไธบ 0.2 ่ณ 50wt๏ผ ใ - A medical appliance-coating composition according to any one of claims 1 through 4, wherein said medical appliance-coating composition contains a surface active agent.
ๆ นๆฎๆๅฉ่ฆๆฑ1่ณ4ไธญไปปไธ้กน็ๅป็ๅจๆขฐๆถๆ็ปๅ็ฉ๏ผๅ ถไธญๆ่ฟฐๅป็ๅจๆขฐๆถๆ็ปๅ็ฉๅซๆ่กจ้ขๆดปๆงๅใ - A medical appliance-coating composition according to any one of claims 1 through 4, wherein said medical appliance-coating composition contains a nonionic surface active agent.
ๆ นๆฎๆๅฉ่ฆๆฑ1่ณ4ไธญไปปไธ้กน็ๅป็ๅจๆขฐๆถๆ็ปๅ็ฉ๏ผๅ ถไธญๆ่ฟฐๅป็ๅจๆขฐๆถๆ็ปๅ็ฉๅซๆ้็ฆปๅญ่กจ้ขๆดปๆงๅใ - A medical appliance-coating composition according to any one of claims 1 through 6, wherein said medical appliance-coating composition contains powder of polyolefin resin or/ and powder of mica.
7.ๆ นๆฎๆๅฉ่ฆๆฑ1่ณ6ไธญไปปๆไธ้กนๆ่ฟฐ็ๅป็ๅจๆขฐๆถๆ็ปๅ็ฉ๏ผๅ ถไธญๆ่ฟฐๅป็ๅจๆขฐๆถๆ็ปๅ็ฉๅซๆ่็ฏ็ๆ ่็ฒๆซๆ/ๅไบๆฏ็ฒๆซใ - A medical appliance-coating composition according to claim 7, wherein said medical appliance-coating composition contains 0.1 to 50 wt% of said powder of said polyolefin resin or said powder of said mica.
ๆ นๆฎๆๅฉ่ฆๆฑ 7 ็ๅป็ๅจๆขฐๆถๆ็ปๅ็ฉ๏ผๅ ถไธญๆ่ฟฐๅป็ๅจๆขฐๆถๆ็ปๅ็ฉๅซๆ 0.1 ่ณ 50wt๏ผ ็ๆ่ฟฐ่็ฏ็ๆ ่็ฒๆซๆๆ่ฟฐไบๆฏ็ฒๆซใ - A medical appliance-coating composition according to any one of claims 1 through 8, wherein said medical appliance-coating composition contains a silane coupling agent.
9.ๆ นๆฎๆๅฉ่ฆๆฑ1่ณ8ไธญไปปไธ้กนๆ่ฟฐ็ๅป็ๅจๆขฐๆถๆ็ปๅ็ฉ๏ผๅ ถไธญๆ่ฟฐๅป็ๅจๆขฐๆถๆ็ปๅ็ฉๅซๆ็ก ็ทๅถ่ๅใ - A medical appliance, having a slidable coating film formed thereon, which moves in contact with an inner surface of a medical member or an inner surface of a body lumen,
ไธ็งๅป็ๅจๆขฐ๏ผๅ ถๅฝขๆๆๆปๅจๆงๆถ่๏ผ่ฏฅๆถ่ไธๅป็ๆไปถ็ๅ ่กจ้ขๆไฝ่ ็ๅ ่กจ้ขๆฅ่งฆๅนถ็งปๅจ๏ผ
wherein said slidable coating film is disposed at a portion, of said medical appliance, which contacts said medical member or said body lumen; and said slidable coating film is comprised of a composition according to claim 1.
ๅ ถไธญๆ่ฟฐๅฏๆปๅจๆถ่่ฎพ็ฝฎๅจๆ่ฟฐๅป็ๅจๆขฐ็ไธๆ่ฟฐๅป็ๆไปถๆๆ่ฟฐไฝ่ ๆฅ่งฆ็้จๅ๏ผๅนถไธๆ่ฟฐๅฏๆปๅจๆถ่็ฑๆ นๆฎๆๅฉ่ฆๆฑ1็็ปๅ็ฉๆๆใ - A medical appliance according to claim 10, wherein said silicone rubber has polysiloxane as a basic structure thereof.
ๆ นๆฎๆๅฉ่ฆๆฑ10็ๅป็ๅจๆขฐ๏ผๅ ถไธญๆ่ฟฐ็ก ๆฉก่ถๅ ทๆ่็ก ๆฐง็ทไฝไธบๅ ถๅบๆฌ็ปๆใ - A medical appliance according to claim 10 or 11, wherein said carbon nanotubes have diameters set to less than 800nm and an average fiber length set to less than 2mm and are contained at 0.01 to 3 wt% in said slidable coating film.
ๆ นๆฎๆๅฉ่ฆๆฑ 10 ๆ 11 ็ๅป็ๅจๆขฐ๏ผๅ ถไธญๆ่ฟฐ็ขณ็บณ็ฑณ็ฎก็็ดๅพ่ฎพๅฎไธบๅฐไบ 800nm๏ผๅนณๅ็บค็ปด้ฟๅบฆ่ฎพๅฎไธบๅฐไบ 2mm๏ผๅนถไธๅจๆ่ฟฐๅฏๆปๅจๆถ่ไธญ็ๅซ้ไธบ 0.01 ่ณ 3wt๏ผ ใ - A medical appliance according to any one of claims 10 through 12, wherein said fine particles of said silicone resin have an average diameter set to 1 to 30ยตm and are contained at 3 to 60 wt% in said slidable coating film.
ๆ นๆฎๆๅฉ่ฆๆฑ 10 ่ณ 12 ไธญไปปไธ้กน็ๅป็ๅจๆขฐ๏ผๅ ถไธญๆ่ฟฐๆๆบ็ก ๆ ่็ๆ่ฟฐ็ป้ข็ฒๅ ทๆๅนณๅ็ดๅพ่ฎพๅฎไธบ 1 ่ณ 30ฮผm ๅนถไธๅจๆ่ฟฐๅฏๆปๅจๆถ่ไธญ็ๅซ้ไธบ 3 ่ณ 60wt๏ผ ใ - A medical appliance according to any one of claims 10 through 13, wherein said slidable coating film contains powder of polyolefin resin or/and powder of mica.
ๆ นๆฎๆๅฉ่ฆๆฑ10่ณ13ไธญไปปไธ้กน็ๅป็ๅจๆขฐ๏ผๅ ถไธญๆ่ฟฐๅฏๆปๅจๆถ่ๅซๆ่็ฏ็ๆ ่็ฒๆซๆ/ๅไบๆฏ็ฒๆซใ - A medical appliance according to any one of claims 10 through 14, wherein said slidable coating film has a rough surface attributed to presence of said fine particle of said silicone resin and/or said carbon nanotubes contained therein.
ๆ นๆฎๆๅฉ่ฆๆฑ10่ณ14ไธญไปปไธ้กน็ๅป็ๅจๆขฐ๏ผๅ ถไธญๆ่ฟฐๅฏๆปๅจๆถ่็ฑไบๅ ถไธญๅ ๅซ็ๆ่ฟฐ็ก ้ ฎๆ ่็ๆ่ฟฐ็ป้ข็ฒๅ/ๆๆ่ฟฐ็ขณ็บณ็ฑณ็ฎก็ๅญๅจ่ๅ ทๆ็ฒ็ณ่กจ้ขใ - A medical appliance according to any one of claims 10 through 15, wherein said medical member is an outer cylinder for use in a syringe; and said medical appliance is a gasket for use in said syringe.
16.ๆ นๆฎๆๅฉ่ฆๆฑ10่ณ15ไธญไปปไธ้กนๆ่ฟฐ็ๅป็ๅจๅ ท๏ผๅ ถไธญ๏ผ ๆ่ฟฐๅป็็จๆไปถๆฏๆณจๅฐๅจ็จๅค็ญ๏ผๆ่ฟฐๅป็ๅจๅ ทๆฏๆ่ฟฐๆณจๅฐๅจ็จๅซๅใ - A medical appliance according to any one of claims 10 through 15, wherein said medical appliance is a guide wire or a catheter for inserting said body lumen.
ๆ นๆฎๆๅฉ่ฆๆฑ10่ณ15ไธญไปปไธ้กน็ๅป็ๅจๅ ท๏ผๅ ถไธญๆ่ฟฐๅป็ๅจๅ ทๆฏ็จไบๆๅ ฅๆ่ฟฐไฝ็ฎก็ๅฏผไธๆๅฏผ็ฎกใ